Ganoderic Acid D is a tetracyclic triterpenoid derived from Ganoderma lucidum, known for its role as an apoptosis inducer. This compound facilitates the upregulation of SIRT3 protein expression, leading to enhanced deacetylation of cyclophilin D (CypD). Ganoderic Acid D effectively disrupts energy metabolism in colon cancer cells by inhibiting glucose uptake, lactate production, and the synthesis of pyruvate and acetyl-CoA. Additionally, it demonstrates potent apoptotic effects in HeLa human cervical carcinoma cells, making it a valuable reagent for cancer research applications.
Ganoderic Acid D is a tetracyclic triterpenoid derived from Ganoderma lucidum, known for its role as an apoptosis inducer. This compound facilitates the upregulation of SIRT3 protein expression, leading to enhanced deacetylation of cyclophilin D (CypD). Ganoderic Acid D effectively disrupts energy metabolism in colon cancer cells by inhibiting glucose uptake, lactate production, and the synthesis of pyruvate and acetyl-CoA. Additionally, it demonstrates potent apoptotic effects in HeLa human cervical carcinoma cells, making it a valuable reagent for cancer research applications.
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