Catalog No.
Product Name
Application
Product Information
Citations
-
Graft Protective Agent
N-Octanoyl dopamine is a graft protective agent that enhances contractile function in heart transplant recipients, particularly those from brain-dead donors. This compound functions by inhibiting cytokine production in activated T-cells, along with reducing MHC class II expression and adhesion molecules in interferon-gamma-stimulated endothelial cells. Its unique properties support research into transplant immunology and cardiac preservation. -
Anti-Inflammatory Agent
Damascenone is a complex of E-isomer and Z-isomer variants, derived from Epipremnum pinnatum, known for its anti-inflammatory properties. This compound exhibits significant biological activity, making it a valuable candidate for research focused on inflammatory pathways and mechanisms. Its potential applications include investigations into new anti-inflammatory therapies and understanding the underlying biology of inflammation-related conditions. -
Anti-Inflammatory Agent
5-PAHSA is an anti-inflammatory agent that enhances insulin sensitivity and exhibits neuroprotective effects. In studies involving high-fat diet-induced diabetic mice, 5-PAHSA demonstrated significant oral activity in reducing inflammation and preserving neuronal function. This compound is suitable for research focused on neurological dysfunction associated with diabetes. -
Endogenous Metabolite
NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity. -
Anti-Inflammatory Agent
Paranyline hydrochloride is an anti-inflammatory agent that exhibits topical antiallodynic activity. It is primarily utilized in research exploring pain modulation and inflammation pathways. This compound is valuable for studying the mechanisms underlying chronic pain and developing therapeutic strategies for inflammatory conditions. -
Anti-inflammatory Agent
3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent that targets tight junction regulatory pathways in intestinal epithelial cells. This compound enhances intestinal barrier integrity and reduces epithelial permeability, thereby improving intestinal inflammation. 3-Aminobenzoic acid is valuable in research focused on gut health, and its analogs can serve as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, demonstrating potential anticonvulsant effects. -
Anti-inflammatory Agent
α-Viniferin is an anti-inflammatory compound derived from the root of Caragana chamlagu. It demonstrates significant potential in modulating inflammatory pathways, making it valuable for research into inflammatory diseases. Its biological activity suggests applications in both pharmacological studies and the development of therapeutic agents targeting inflammation-related conditions. -
Arginase
Arginase, Microorganism (immobilized) is an enzyme that plays a crucial role in the urea cycle, catalyzing the hydrolysis of L-arginine to produce L-ornithine and urea. This enzyme is utilized in various biochemical applications, including studies of nitrogen metabolism and modulation of nitric oxide production. Its immobilized form enhances stability and facilitates its use in industrial processes and research settings. -
Antidiabetic/Anti-inflammatory Agent
9-PAHPA is a fatty acid ester of hydroxy fatty acids (FAHFA) that exhibits significant antidiabetic and anti-inflammatory properties. This compound modulates metabolic processes and inflammation pathways, making it a valuable tool for research in metabolic disorders and chronic inflammatory conditions. Its unique mechanism as an endogenous lipid positions it as a promising candidate for studies focused on therapeutic interventions in diabetes and related inflammatory diseases. -
Anti-Inflammatory reagent
9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) known for its anti-inflammatory properties. It exerts its effects by inhibiting cytokine production, notably reducing the expression of IL-1β and IL-6. Additionally, 9-OAHSA functions as a protective agent, preventing apoptotic cell death in colon carcinoma cells, making it a valuable tool for research in inflammation and cancer biology. -
Anti-Inflammatory Agent
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting cytokine production, particularly reducing the expression of IL-1β and IL-6. This compound is relevant for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Lipoxin B4 (LXB4) is an anti-inflammatory agent derived from the metabolism of arachidonic acid. It effectively reduces leukocyte infiltration and mucus secretion in the nasal mucosa while inhibiting mast cell and eosinophil degranulation in the upper airway. Additionally, LXB4 mitigates airway inflammation, mucus metaplasia, and hyper-responsiveness in the lower airway, demonstrating significant mucosal protective actions. Its properties make it a valuable tool for research into allergic inflammation in the upper and lower respiratory tracts. -
Endogenous Antiinflammatory Mediator
Resolvin E1 (RvE1) is an endogenous anti-inflammatory mediator derived from eicosapentaenoic acid (EPA). It plays a critical role in the resolution of inflammation by inhibiting polymorphonuclear leukocyte (PMN) transendothelial migration and reducing leukocyte infiltration. Additionally, RvE1 suppresses dendritic cell migration and interleukin-12 (IL-12) production, making it a valuable tool for studying inflammatory processes and potential therapeutic interventions in chronic inflammatory diseases. -
Anti-inflammatory Agent
Oxycinchophen functions as an anti-inflammatory agent, demonstrating significant uricosuric activity. It effectively displaces urate from albumin and displays a high affinity for the DNSA-binding site on the albumin molecule. This compound is suitable for research applications focused on inflammation and gout treatment mechanisms. -
Anti-inflammatory Agent
5-Hydroxy-8-methoxypsoralen, a metabolite of Xanthotoxin, functions as a potent anti-inflammatory agent through its inhibition of cytochrome P-450 enzymes. This compound is primarily utilized in the treatment of dermatological conditions such as psoriasis, eczema, and vitiligo, often in conjunction with phototherapy. Its biological activity supports ongoing research in skin inflammation and dermatological therapies. -
Anti-Inflammatory Agent
Desmethyl Ketoprofen is an anti-inflammatory agent that primarily targets pathways involved in inflammation modulation. It exhibits significant anti-inflammatory activities, making it valuable for research in angiogenesis-related disorders and associated pathologies. This compound is essential for studies investigating the effects of inflammation on tissue repair and vascular dynamics. -
Anti-inflammatory Agent
2′-Hydroxydihydrochalcone is an anti-inflammatory agent that exerts its effects through the modulation of inflammatory pathways. This compound is particularly valuable in research investigating mechanisms of inflammation and potential therapeutic applications for inflammatory diseases. It can be synthesized via the reduction of flavone, highlighting its utility in chemical biology studies. -
COX Inhibitor
1-Oxo Ibuprofen is a cyclooxygenase (COX) inhibitor, specifically targeting COX-1 and COX-2 enzymes. As a degradation product and potential impurity of Ibuprofen, it demonstrates significant anti-inflammatory activity with IC50 values of 13 μM for COX-1 and 370 μM for COX-2. This compound is useful for research applications involving the study of prostaglandin synthesis and the metabolic pathways of nonsteroidal anti-inflammatory drugs. -
Anti-inflammatory Agent
6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, functions primarily as an anti-inflammatory agent. Its biological activity is attributed to its role in modulating leukocyte recruitment and activation. This compound is commonly utilized in research applications focused on inflammation, immune response, and related signaling pathways. -
Drug Metabolite
Carvedilol Glucuronide is a significant metabolite of the β/α-1 adrenergic receptor antagonist, Carvedilol. This compound demonstrates key biological activity by modulating β-adrenergic signaling and exhibits potential application in studying the metabolic pathway of Carvedilol. Research indicates that Carvedilol can inhibit lipid peroxidation and has properties as an antihypertensive agent, as well as an autophagy inducer that affects the NLRP3 inflammasome. Carvedilol Glucuronide serves as an important reagent for investigating drug metabolism and pharmacokinetics in cardiovascular research. -
Immunoproteasome Activator
Immunoproteasome Activator 1 is a selective activator of the immunoproteasome that enhances the presentation of MHC-I-bound peptides by over 100-fold. This compound functions by binding to the proteasome structural subunit PSMA1, facilitating the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes. Its significant biological activity makes it valuable for research focused on immune response modulation and antigen processing. -
E3 Ligase Ligand
RA190-PEG1-NH2 is an E3 ligase ligand and a derivative of RA190. This compound is utilized in the synthesis of FKBP12 PROTAC degrader RAFKBP12, facilitating targeted protein degradation through the modulation of E3 ligase activity. Its application supports research into the development of proteolysis-targeting chimeras (PROTACs) and advances studies in cellular protein regulation. -
PKM2 Kinase Inhibitor
PKM2-IN-3 is a selective inhibitor of the PKM2 kinase, demonstrating an IC50 value of 4.1 μM. This compound exhibits notable anti-neuroinflammatory effects by disrupting PKM2-mediated glycolysis and inhibiting NLRP3 activation. PKM2-IN-3 is suitable for research applications focused on metabolic regulation and neuroinflammation pathways. -
NRF2 Activator
ML334 is a potent NRF2 activator that functions by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity to the Keap1 Kelch domain of 1 μM, ML334 effectively promotes NRF2 expression and its subsequent nuclear translocation, thereby enhancing antioxidant response element (ARE) activity. This compound is valuable for research applications focused on oxidative stress, neuroprotection, and cellular responses to environmental stimuli. -
Nrf2 Activator
Nrf2 activator-6 is a tetrahydroisoquinoline compound that functions as an activator of the Nrf2 pathway. It exhibits an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction, thereby promoting the transcriptional activation of antioxidant response elements. This compound is valuable in research applications focused on oxidative stress, inflammation, and neuroprotection. -
Nrf2 activator
Nrf2 activator-7 is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. By significantly enhancing Nrf2 signaling, it promotes the expression of antioxidant and cytoprotective genes. This reagent is valuable in research focused on oxidative stress, inflammation, and cellular defense mechanisms. -
PROTAC Linker
(3R,4R)-3-Methyl-4-piperidinol serves as a PROTAC linker, facilitating the targeted degradation of proteins through the proteasome pathway. This compound is essential in the synthesis of innovative PROTAC molecules, such as the BCL6 Degrader-3. Its application in chemical biology aids in studying protein interactions and degradation mechanisms, contributing significantly to drug discovery research. -
PROTAC IKZF1/IKZF3 Degrader
(Rac)-Cemsidomide is a PROTAC degrader targeting IKZF1 and IKZF3, exhibiting potent antitumor activity through its molecular glue mechanism. This compound demonstrates a GI50 of 0.05 nM in NCIH929.1 cells, making it a valuable tool for research applications focused on the degradation of Ikaros and Aiolos proteins. Its unique properties facilitate investigations into mechanisms of action related to targeted protein degradation in cancer therapies. -
Molecular Glue
Acetyl-cyclosporin A aldehyde is a derivative of Cyclosporin A featuring an acetyl group and a reducing aldehyde moiety. This compound serves as a molecular glue by effectively inhibiting calmodulin and binding to cyclophilin, which can influence the nuclear translocation of NF-AT and may lead to mitochondrial damage. Its unique properties make it valuable for research applications aimed at understanding calcium signaling pathways and mitochondrial dynamics in various biological contexts. -
Covalent Ligand
EN171 is a covalent ligand that selectively modifies cysteine residues C38 and C96 on the 14-3-3 protein, thereby promoting its interactions with estrogen receptor α (ERα), YAP, and TAZ. This modulation leads to a reduction in transcriptional activity associated with both estrogen signaling and the Hippo pathway. EN171 serves as a molecular glue, enhancing native protein interactions, and acts as a covalent recruiter of 14-3-3 in heterobifunctional applications, facilitating the cytosolic sequestering of nuclear neo-substrates such as BRD4 and BCL6. -
PROTAC Linker
tert-Butyl 6-aminocaproate is a PROTAC linker that facilitates the development of targeted protein degraders. This compound plays a crucial role in the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling selective degradation of target proteins. Its utility in chemical research supports the exploration of innovative therapeutic strategies through targeted protein modulation. -
Anti-inflammatory Agent
BI-L-45 XX is an orally active anti-inflammatory agent that targets and inhibits the release of neutrophil enzymes as well as chemotaxis. This compound is particularly useful for investigating mechanisms underlying adjuvant-induced arthritis and other inflammatory conditions. Its ability to modulate neutrophil activity makes it a valuable tool in the study of inflammatory pathways. -
TRP-2 Derived Peptide
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from tyrosinase-related protein 2, corresponding to residues 181-188. This peptide contains the primary reactive epitope recognized by anti-B16 cytotoxic T lymphocytes (CTLs) and is designed to conform to the MHC class I H2-Kb binding motif. TRP-2 (181-188) is essential for studies in immunology and cancer research, particularly in the context of melanoma and anti-tumor immune responses. -
Anti-inflammatory agents
2-Hydroxy-4-methoxybenzoic acid potassium primarily functions as an anti-inflammatory agent. As a significant phytoconstituent derived from Decalepis arayalpathra, it exhibits a range of biological activities, including anti-inflammatory, antipyretic, antioxidant, and anti-diabetic effects. This compound is valuable for researchers investigating mechanisms of inflammation and related metabolic disorders. Its diverse pharmacological potential makes it a useful tool in therapeutic studies and drug development. -
Anti-inflammatory Compound
2′-Hydroxydaidzein is an anti-inflammatory compound that acts as a metabolite. It effectively inhibits the release of chemical mediators from inflammatory cells and significantly reduces the secretion of lysozyme and β-glucuronidase from rat neutrophils stimulated with fMLP/CB. This reagent is valuable for research applications related to inflammation and immune response modulation. -
Anti-inflammatory compound
β-Amyrin is a natural triterpenoid compound that exhibits anti-inflammatory properties. It effectively mitigates amyloid β (Aβ)-induced impairments in long-term potentiation (LTP), making it a promising candidate for Alzheimer's disease research. Additionally, β-Amyrin demonstrates protective activity against pulmonary fibrosis and possesses notable antibacterial capabilities, supporting its potential applications in various areas of biological and medicinal research. -
G6PD Inhibitor
6-Aminonicotinamide is a competitive inhibitor of glucose-6-phosphate dehydrogenase (G6PD) with a Ki value of 0.46 μM. This powerful antimetabolite of nicotinamide induces ATP depletion, enhancing the efficacy of DNA-crosslinking chemotherapy agents such as Cisplatin. Its ability to modulate metabolic pathways makes it a valuable tool in cancer research and therapeutic applications. -
Nox2 Inhibitor
CPP11G is a selective inhibitor of NADPH oxidase 2 (Nox2), exhibiting an IC50 of 20 μM. This compound is valuable for the investigation of inflammatory diseases, such as vasculitis and atherosclerosis, as well as conditions characterized by Nox2 overactivation, including ischemia-reperfusion injury. Its potential applications in research can aid in understanding the role of Nox2 in various pathological processes. -
Nox Inhibitor
VAS2870 is a selective inhibitor of NADPH oxidase (NOX), primarily targeting NOX1 and NOX2 isoforms. This compound exhibits strong antioxidant properties and effectively reduces reactive oxygen species (ROS) production. VAS2870 is widely utilized in research related to oxidative stress, inflammation, and various pathological conditions associated with NOX activity. -
NOX1/4 Inhibitor
GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies. -
Nox1 Inhibitor
NoxA1ds is a selective inhibitor of NADPH oxidase 1 (NOX1), with an IC50 of 20 nM. It effectively inhibits NOX1-derived superoxide production in HT-29 human colon cancer cells. Additionally, NoxA1ds reduces VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro. This reagent is valuable for research into hypertension, atherosclerosis, and cancer biology. -
Nox Inhibitor
NADPH oxidase-IN-1 is an orally active inhibitor of NADPH oxidase (Nox), specifically targeting Nox2 and Nox4 with IC50 values of 1.9 μM and 2.47 μM, respectively. This compound is notable for its ability to penetrate the blood-brain barrier, making it relevant for studies involving neuronal inflammation. NADPH oxidase-IN-1 effectively suppresses the production of pro-inflammatory cytokines and inhibits LPS-mediated microglial migration, demonstrating promising in vivo efficacy for potential therapeutic applications in neuroinflammatory conditions. -
Capsaicinoid Analog
Nordihydrocapsaicin is a capsacinoid analog known for its pungent properties and oral bioactivity. This compound exhibits potential anti-cancer activities and is derived from both fresh and processed peppers. It may induce a burning sensation upon consumption, making it relevant for research in pain mechanisms and anti-tumor effects. -
NOX1/4 Inhibitor
GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties. -
Nox2/4 Inhibitor
GLX481304 is a selective inhibitor of Nox2 and Nox4, exhibiting an IC50 of 1.25 μM. This compound effectively suppresses reactive oxygen species (ROS) production in isolated mouse cardiomyocytes and enhances cardiac contractility. GLX481304 is applicable in research focused on ischemic heart injury, providing valuable insights into oxidative stress-related pathophysiology. -
NOX1 Inhibitor/ROS Inhibitor
Fluoflavine is a selective inhibitor of NOX1 and reactive oxygen species (ROS) production. This compound effectively reduces ROS levels, NOX1-mediated signaling pathways, and prevents retinal ganglion cell death induced by oxygen-glucose deprivation. In preclinical studies, Fluoflavine has demonstrated the ability to inhibit NADPH oxidase activity and mitigate pathological retinal neovascularization in models of oxygen-induced retinopathy. It is a valuable tool for investigating retinal ischemia-reperfusion injury and proliferative retinopathy. -
NOX2 Inhibitor
NOX2-IN-2 diTFA is a potent inhibitor of NOX2, specifically targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. This compound effectively inhibits reactive oxygen species (ROS) production derived from NOX2 in cellular environments. It is valuable for research applications focused on oxidative stress and related signaling pathways. -
Intermediate
8-Hydroxycoumarin is an important intermediate in the microbial transformation of quinolones. It serves as a valuable building block in organic synthesis and is utilized in research focusing on metabolic pathways of various compounds. Its unique structural properties enable exploration in pharmacology and biochemistry, facilitating the study of enzymatic processes and potential therapeutic agents. -
NADPH Oxidase Inhibitor
NOX2-IN-3 is a selective inhibitor of NADPH Oxidase 2 (NOX2). This compound has been shown to enhance the sensitivity of tumor cells to MRTX1133, indicating its potential role in cancer research. NOX2-IN-3 may be valuable for studies focused on oxidative stress and its implications in tumor biology. -
CBR1 Inhibitor
YF-Mo1 is a selective inhibitor of the carbonyl reductase 1 (CBR1), exhibiting an IC50 value of 1.1 μM. This compound demonstrates potential in modulating CBR1 activity, which is significant in metabolic processes and drug metabolism. YF-Mo1 is valuable for research exploring the role of CBR1 in various physiological and pathological conditions, offering insights into metabolic therapies and drug interactions.
