RA190-PEG1-NH2

Catalog No.: A77342
E3 Ligase Ligand
RA190-PEG1-NH2 is an E3 ligase ligand and a derivative of RA190. This compound is utilized in the synthesis of FKBP12 PROTAC degrader RAFKBP12, facilitating targeted protein degradation through the modulation of E3 ligase activity. Its application supports research into the development of proteolysis-targeting chimeras (PROTACs) and advances studies in cellular protein regulation.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRA190-PEG1-NH2 is an E3 ligase ligand and a derivative of RA190. This compound is utilized in the synthesis of FKBP12 PROTAC degrader RAFKBP12, facilitating targeted protein degradation through the modulation of E3 ligase activity. Its application supports research into the development of proteolysis-targeting chimeras (PROTACs) and advances studies in cellular protein regulation.
Product Information
Catalog NumA77342
FormulaC32H31Cl4N3O3
Molecular Weight647.42
CAS Number2375455-68-6
SMILESNCCOCCN[C@H](C(N1C/C(C(/C(C1)=C/C2=CC(Cl)=C(Cl)C=C2)=O)=C\C3=CC=C(Cl)C(Cl)=C3)=O)CC4=CC=CC=C4
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