Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory agent
DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is an organic compound known for its anti-inflammatory properties. It exhibits protective effects on intestinal epithelial cells, making it valuable for research related to inflammation and gut health. This reagent is useful in studying the pathways involved in inflammatory responses and exploring therapeutic solutions for inflammatory disorders. -
Anti-inflammatory Agent
Lupeol acetate is a derivative of Lupeol that functions as an anti-inflammatory agent. It exhibits significant biological activity by down-regulating the expression of inflammatory cytokines and inhibiting osteoclast production, thereby improving symptoms of rheumatoid arthritis. Additionally, Lupeol acetate shows antibacterial and anti-trypanosomic properties and has been observed to inhibit spermatogenesis in male rats, potentially leading to infertility. This compound is suitable for research applications related to inflammation, cancer, and reproductive health. -
Anti-inflammatory Agent
β-Amyrin acetate is a triterpenoid recognized for its anti-inflammatory properties. This compound exhibits a range of biological activities, including antifungal, anti-diabetic, and anti-hyperlipidemic effects. Research indicates that β-Amyrin acetate can inhibit HMG-CoA reductase activity by binding to the hydrophobic cleft of the enzyme, making it a valuable candidate for studies related to lipid metabolism and inflammation management. -
EGFR/HER2/CDK9/COX-2 Inhibitor
CDK9-IN-41 is a potent inhibitor of CDK9, EGFR, HER2, and COX-2, exhibiting IC50 values of 192.81 nM, 254.03 nM, 238.81 nM, and 775 nM respectively. This compound demonstrates significant antitumor activity across various cancer cell lines, including leukemia, colon, melanoma, ovarian, and breast cancer. It serves as a valuable tool for exploring the role of these kinases in cancer biology and therapeutic applications. -
HER2-TLR7/8 Conjugate
MC-Val-Cit-PAB-Amide-TLR7 Agonist 4 is a HER2-targeted TLR7 and TLR8 immune agonist conjugate. This compound activates Toll-like receptors, enhancing immune responses through the stimulation of both innate and adaptive immunity. It is primarily utilized in research applications aimed at cancer immunotherapy, particularly in enhancing the immune system's ability to target HER2-expressing tumors. -
Anti-EGFR/CD47 Antibody
Vislarafusp alfa is a humanized IgG1κ antibody targeting both EGFR and CD47. This novel bispecific antibody exhibits potential for modulating tumor immune evasion and promoting anti-tumor responses, making it significant in cancer research applications. Its unique mechanism of action presents valuable opportunities for studying combination therapies and understanding the interplay between immune checkpoint regulators and growth factor signaling pathways. -
Peptide Toxin
Candidalysin is a cytolytic peptide toxin derived from the pathogenic fungus Candida albicans, primarily targeting epithelial cells. This peptide is known for its ability to activate the EGFR-MAPK signaling pathway, which leads to increased expression of matrix metalloproteinases (MMPs) and calcium influx, as well as modulation of the c-Fos transcription factor through p38 MAPK and ERK1/2. Candidalysin plays a critical role in both mucosal and systemic infections by stimulating NLRP3 inflammasome activation, promoting inflammatory responses, neutrophil recruitment, and Th17 immunity. Additionally, it induces lactate dehydrogenase (LDH) release, resulting in membrane damage and cytotoxicity. -
Molecular Glue
MNN-02-155 is a bivalent molecular glue that binds simultaneously to p300/CBP and BCL6. This compound effectively activates the BCL6-target reporter gene, leading to significant induction of cell death. MNN-02-155 is particularly relevant for research into diffuse large B cell lymphomas (DLBCLs), providing insights into potential therapeutic strategies involving BCL6 modulation. -
Molecular Glue
TCIP3 is a bivalent molecular glue that targets p300/CBP and BCL6. By redirecting p300 and CBP, TCIP3 activates programmed cell death genes that are typically suppressed by the oncogenic driver BCL6, making it a valuable tool for investigating diffuse large B cell lymphomas (DLBCLs). Importantly, TCIP3 demonstrates no toxicity to non-transformed tonsillar lymphocytes or fibroblasts, ensuring the safety of experimental applications. -
RNA Modifying Substance
N4-Acetylcytidine is an RNA-modifying nucleoside metabolite produced during tRNA degradation, primarily via N-acetyltransferase 10 and additional enzymes. This compound has been shown to enhance NLRP3 inflammasome activation through the upregulation and release of HMGB1. N4-Acetylcytidine plays a crucial role in modifying the stability and translation efficiency of mRNA, tRNA, and rRNA, particularly in relation to enterovirus 71 RNA. Its applications extend to research in cancer, neuroinflammatory diseases, viral infections, and obesity. -
NCD38 Enantiomer
(1R,2S)-NCD38 TFA is a selective inhibitor of Lysine-specific demethylase 1 (LSD1). This enantiomeric form of NCD38 TFA exhibits potent biological activity, primarily in the modulation of epigenetic regulation through LSD1 inhibition. It is applicable in research focused on cancer biology, developmental studies, and potential therapeutic interventions targeting LSD1-related pathways. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
SIK Inhibitor
YKL-05-093 is a selective SIK (Salt-Induced Kinase) inhibitor, demonstrating a binding affinity (Kd) of 7.1 nM for SIK2. This compound effectively reduces the phosphorylation levels of HDAC4, HDAC5, and CRTC2, while inhibiting SOST expression and stimulating RANKL expression both in vitro and in vivo. YKL-05-093 is suitable for research applications focusing on bone diseases and related signaling pathways. -
PRMT5 Inhibitor
PRMT5-IN-53 is a potent, orally bioavailable inhibitor of PRMT5, exhibiting pIC50 values of ≥ 9.7 against both human and mouse PRMT5. It demonstrates high affinity for the PRMT5:MEP50 complex with a KD of 11.3 pM. This compound effectively inhibits PRMT5 in the intestines of murine models, leading to a significant reduction in the number and size of polyps while minimizing systemic hematological toxicity. PRMT5-IN-53 is particularly valuable for research in colorectal cancer, especially in the context of familial adenomatous polyposis (FAP). -
Anti-inflammatory
(2R)-Octyl-α-hydroxyglutarate sodium is the sodium salt derivative of (2R)-Octyl-α-hydroxyglutarate, functioning primarily as an anti-inflammatory agent. This compound demonstrates significant biological activity in modulating inflammatory responses, making it valuable in various research applications focused on inflammation and related pathways. -
DR4 Ligand
SC-67655 is a potent pentapeptide ligand targeting the MHC class II haplotype DR4 (DR4 Dw4 or DRB 1*0401) with an IC50 of 50 nM. This stable compound is suitable for research applications focusing on autoimmune diseases, facilitating the exploration of immune responses and potential therapeutic interventions. -
Anti-inflammatory Agent
NPB-1575 is a potent, orally bioavailable anti-inflammatory agent that effectively targets neuroinflammation. It functions by activating the IRS2/Nrf2/NF-κB signaling axis, thereby combating ferroptosis and providing neuroprotection. NPB-1575 demonstrates efficacy in mitigating cerebral ischemic injury and enhancing neurological outcomes, making it a valuable tool for research focused on ischemic stroke and related neurodegenerative conditions. -
Nrf2 Activator/ROS Inhibitor
L-Cystine disodium monohydrate primarily functions as an Nrf2 activator and ROS inhibitor. It elevates Nrf2 protein expression and activates the Nrf2 transcription factor, leading to reduced reactive oxygen species (ROS) generation and protection against apoptosis caused by oxidants and Doxorubicin. Additionally, when combined with L-theanine, it enhances the production of antigen-specific IgG by increasing glutathione levels and promoting T helper 2-mediated responses in mice. This compound is valuable for research into cystinuria and the molecular mechanisms underlying kidney stone formation. -
Nrf2 Inhibitor
Nrf2-IN-4 is a potent Nrf2 inhibitor that induces ferroptosis through the inhibition of the Nrf2 pathway. By disrupting iron homeostasis and facilitating ferritin degradation, Nrf2-IN-4 triggers ferroptotic cell death. Additionally, it promotes lysosome activation by enhancing iron-dependent reactive oxygen species (ROS) production and acidification. Due to its significant antitumor efficacy, Nrf2-IN-4 is a valuable tool for studying breast cancer and exploring therapeutic strategies targeting the Nrf2 pathway. -
Nrf2 Activator/ROS Inhibitor
L-Cystine is an effective Nrf2 activator and reactive oxygen species (ROS) inhibitor. This extracellular form of L-Cysteine elevates Nrf2 protein expression and facilitates its transcriptional activity, thereby reducing ROS generation and providing protection against oxidant- or Doxorubicin-induced apoptosis. Additionally, L-Cystine has been shown to enhance antigen-specific IgG production and T helper 2 mediated responses through increased glutathione levels in murine models. This makes L-Cystine a valuable reagent for research in cystinuria and kidney stone formation. -
Nrf2-Gpx4 Activator
Gingerenone A is an Nrf2-Gpx4 activator that triggers ferroptosis in liver tissue, demonstrating significant potential for therapeutic intervention in liver damage. This compound exhibits notable anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging properties observed in murine models, making it valuable for research in oxidative stress regulation and associated diseases. Its oral bioactivity further enhances its applicability in in vivo studies. -
Nox2 Inhibitor
gp91 ds-tat is a specific inhibitor of NADPH oxidase 2 (Nox2), effectively blocking the production of superoxide generated by this enzyme. This bioactive peptide has demonstrated the ability to reduce reactive oxygen species (ROS), lipid peroxidation, and iron levels induced by high glucose conditions. Additionally, gp91 ds-tat inhibits homocysteine-induced activation of NLRP3 inflammasomes and restores the activity of lysosomal TRPML1 channels. Research applications include studies on Alzheimer's disease, glomerular inflammation, and cardiovascular disease, with implications for improving cerebrovascular and cognitive functions in APP/PS1 mouse models. -
Endogenous Metabolite; Nrf2 Activator; ROS Inhibitor
L-Cystine hydrochloride is an endogenous metabolite that serves as a potent Nrf2 activator and reactive oxygen species (ROS) inhibitor. It enhances Nrf2 protein expression, facilitating transcriptional responses that combat oxidative stress. Research indicates that L-Cystine hydrochloride reduces ROS generation and protects cells from apoptosis induced by oxidants or Doxorubicin. Additionally, its combination with L-theanine has been shown to boost antigen-specific IgG production by elevating glutathione levels and promoting T helper 2 (Th2) responses. This compound has significant potential for studying cystinuria and kidney stone formation. -
Nucleoside Reverse Transcriptase Inhibitor
Stavudine is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that selectively targets HIV-1 and HIV-2. In addition to its antiviral properties, Stavudine inhibits mitochondrial DNA replication and has been shown to reduce NLRP3 inflammasome activation while modulating Amyloid-β autophagy. Furthermore, Stavudine is associated with the induction of apoptosis, making it a valuable tool for research in HIV treatment and cellular apoptosis mechanisms. -
Keap1/Nrf2 Activator
Sweroside, a potent Keap1/Nrf2 activator, is an iridoid glycoside that enhances Nrf2 nuclear translocation by competing with Keap1. This compound exhibits diverse biological activities, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while regulating lipid metabolism. Sweroside's ability to inhibit oxidative stress and NLRP3-mediated pyroptosis, alongside its activation of the SIRT1 and AMPK/mTOR pathways, makes it valuable for investigating conditions such as myocardial ischemia-reperfusion injury, leukemia, acute lung injury, and non-alcoholic fatty liver disease. -
Anti-inflammatory Agent
Ligustrazine, an alkylpyrazine derived from Ligusticum chuanxiong, functions primarily as an anti-inflammatory agent. This compound has demonstrated notable anti-inflammatory and potential nootropic activities in preclinical studies with rat models. It is utilized in research focused on inflammatory pathways and cognitive enhancement, providing valuable insights into therapeutic applications in neuroprotection and inflammation modulation. -
Anti-inflammatory Agent
Lutein, a xanthophyll carotenoid, acts as a potent anti-inflammatory agent. It demonstrates significant biological activities, including antioxidant and anti-apoptotic effects, primarily by modulating reactive oxygen species (ROS) levels. Lutein is particularly noted for its protective benefits on ocular health and exhibits neuroprotective and antidepressant-like effects in the brain. This compound is biologically active when administered orally, making it a valuable reagent for studies in inflammation and neuroprotection. -
Keap1-Nrf2 Agonist
Methyl 3,4-dihydroxybenzoate functions as a Keap1-Nrf2 agonist, promoting the activation of the Nrf2 pathway. This compound exhibits significant antioxidant and anti-inflammatory properties, making it valuable in research focused on oxidative stress and cellular defense mechanisms. It is primarily utilized in studies investigating the neuroprotective effects of polyphenols and their potential therapeutic applications in various diseases. -
COX Inhibitor
[8]-Shogaol is a potent inhibitor of cyclooxygenase (COX), specifically targeting COX-2 with an IC50 of 17.5 μM. This compound exhibits significant antiplatelet properties (IC50=5 μM) and demonstrates anti-cancer and anti-inflammatory activities. Additionally, [8]-Shogaol modulates key signaling pathways by inhibiting TAK1, IKK, and Akt, thereby influencing MAPK signaling and alleviating synovitis. Its unique pharmacological profile makes it a valuable reagent for research in cancer, inflammation, and cardiovascular diseases. -
COX Inhibitor
Diclofenac potassium is a potent nonselective inhibitor of cyclooxygenase (COX) enzymes, demonstrating IC50 values of 4 nM for human COX-1 and 1.3 nM for human COX-2 in CHO cells, along with 5.1 μM and 0.84 μM for ovine COX-1 and COX-2, respectively. This reagent exhibits significant anti-inflammatory properties and is particularly effective in inducing apoptosis in neural stem cells through the activation of the caspase cascade. It is widely used in research studies focusing on inflammatory pathways and neural stem cell biology. -
Non-Steroidal Anti-Inflammatory Agent
Glafenine hydrochloride is a non-selective non-steroidal anti-inflammatory agent and a dual inhibitor of COX-1 and COX-2 enzymes. It demonstrates anti-inflammatory, anti-proliferative, and anti-migratory effects by disrupting the arachidonic acid metabolic pathway and decreasing prostaglandin synthesis. This compound induces cell cycle arrest in vascular smooth muscle and endothelial cells, while also lowering Tenascin levels in the extracellular matrix. Glafenine hydrochloride is applicable in the study of inflammatory diseases, vascular restenosis, and cystic fibrosis. -
Anti-Inflammatory Agent
Proanthocyanidins are a class of polyphenolic compounds characterized by their electrophilic flavanyl units, primarily recognized for their anti-inflammatory properties. They exhibit strong antioxidant activity and have been shown to possess anticancer effects, as well as cardioprotective, antibacterial, and antifungal activities. Research applications include their potential use in treating conditions such as chronic venous insufficiency, capillary fragility, sunburn, and retinopathy. -
Molecular Glues
Lenalidomide hemihydrate functions as a molecular glue through its activity as an immunomodulator. This compound selectively binds to the ubiquitin E3 ligase cereblon (CRBN), leading to the ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 complex. Lenalidomide hemihydrate is effective in inhibiting the proliferation of mature B-cell lymphomas, including multiple myeloma, and promotes the release of IL-2 from T cells, making it a valuable tool in cancer research. -
Anti-inflammatory Agent
Seselin is an anti-inflammatory agent that exerts its effects through multiple biological pathways. It has demonstrated potential in anticancer, antinociceptive, and antifungal activities. Seselin is suitable for research applications focused on inflammation and pain management. Its oral bioavailability enhances its utility in vivo studies. -
Anti-Inflammatory Agent
Nepetoidin B is an anti-inflammatory agent that exerts its effects by modulating the NF-κB and Nrf2/HO-1 signaling pathways. In addition to its anti-inflammatory properties, Nepetoidin B also demonstrates antifungal and antibacterial activities. This natural compound, derived from Salvia plebeia R. Br., is suitable for research applications focused on inflammation and infectious diseases. -
Anti-inflammatory Agent
Myristinin A is a flavan compound that exhibits anti-inflammatory properties by selectively inhibiting COX-2 activity, with an IC50 value of 16.9 μg/mL. It reduces the production of prostaglandin E2 (PGE2) and inhibits phospholipase A2 (PLA2), effectively blocking the release of inflammatory mediators. Additionally, Myristinin A demonstrates antifungal activity against Candida albicans, with an IC50 of 8.8 μg/mL. This compound is valuable for research into inflammation and infection, particularly in conditions such as rheumatoid arthritis. -
CXCR Inhibitor
Corydalmine, a CXCR inhibitor, demonstrates significant antifungal activity by inhibiting spore germination in various plant pathogenic and saprophytic fungi. Additionally, it serves as an oral analgesic agent, exhibiting potent analgesic effects. Corydalmine has been shown to alleviate Vincristine-induced neuropathic pain in murine models through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, making it a valuable tool for pain research and therapeutic applications. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-3 is a dual inhibitor targeting CYP51 and PD-L1, exhibiting potent antifungal activity with IC50 values of 0.205 μM and 0.039 μM, respectively. This compound induces early apoptosis in fungal cells by reducing levels of intracellular IL-2, NLRP3, and NF-κBp65 proteins. Additionally, CYP51/PD-L1-IN-3 causes mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately resulting in fungal lysis and cell death. This compound serves as a valuable tool for research in fungal infections and immune modulation. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-2 is a quinazoline compound that functions as a dual inhibitor of CYP51 and PD-L1, exhibiting IC50 values of 0.263 μM and 0.017 μM, respectively. It displays notable antifungal activity by triggering early apoptosis in fungal cells, leading to significant reductions in intracellular IL-2, NLRP3, and NF-κBp65 protein levels. Additionally, CYP51/PD-L1-IN-2 induces mitochondrial damage and reactive oxygen species (ROS) accumulation, culminating in fungal lysis and subsequent cell death. This compound is valuable for research exploring antifungal mechanisms and cancer immunotherapy. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-1 is a dual inhibitor targeting both CYP51 and PD-L1, exhibiting an IC50 of 0.884 μM for CYP51 and 0.083 μM for PD-L1. This quinazoline compound demonstrates notable antifungal activity by inducing early apoptosis in fungal cells while significantly reducing intracellular levels of IL-2, NLRP3, and NF-κBp65. Additionally, CYP51/PD-L1-IN-1 contributes to mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately leading to fungal lysis and cell death. This compound is valuable for research focused on antifungal therapies and immune modulation. -
CXCR Inhibitor
Corydalmine hydrochloride is a potent CXCR inhibitor that demonstrates significant biological activity by inhibiting spore germination in certain plant pathogenic and saprophytic fungi. Additionally, it exhibits notable analgesic properties, effectively alleviating Vincristine-induced neuropathic pain in murine models. This effect is mediated through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, highlighting its potential applications in pain management research and fungal inhibition studies. -
Anti-inflammatory/Anti-microbial Agent
Nyasol is a bioactive compound known for its anti-inflammatory and antimicrobial properties. It demonstrates significant antifungal, antibacterial, and antileishmanial activities, alongside hyaluronidase inhibition. Nyasol effectively inhibits the binding of leukotriene B4 (LTB4) to human neutrophils and suppresses neuroinflammatory responses by inhibiting I-κB degradation in lipopolysaccharide-stimulated BV-2 microglial cells. This compound is valuable in research focused on inflammatory diseases and microbial infections. -
iNOS Inhibitor
Myricadenin A is an inhibitor of inducible nitric oxide synthase (iNOS), demonstrating effective inhibition of nitric oxide production with an EC₅₀ value of 18.1 μM. Additionally, it exhibits moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and shows weak antibacterial activity against tuberculosis (MIC = 80.0 μg/mL). Myricadenin A is suitable for studies focused on inflammation and oxidative stress. -
iNOS/COX-2 Inhibitor
Ermanin is a flavonoid extracted from Tanacetum microphyllum, known for its potent inhibitory effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Its biological activities include anti-inflammatory, anti-tuberculous, and anti-viral/bacterial properties, making it a valuable reagent in research related to inflammation and infectious diseases. Ermanin is useful for exploring the pathways associated with nitric oxide production and prostaglandin synthesis in various biological contexts. -
LCMV Glycoprotein Peptides Frgment
LCMV gp33-41 is a peptide fragment derived from the glycoprotein of the lymphocytic choriomeningitis virus (LCMV), specifically a carboxyl-extended 9-amino acid sequence. This peptide is restricted by MHC class I H-2Db molecules, facilitating its recognition and presentation to cytotoxic T lymphocytes. LCMV gp33-41 is pivotal for immunological research applications, including the study of T cell responses and viral pathogenesis. -
STING Agonist
c-di-AMP disodium is a cyclic dinucleotide serving as a STING agonist, which interacts with the STING protein to activate the TBK1-IRF3 signaling pathway. This activation leads to the production of type I interferons and tumor necrosis factor, playing a pivotal role in the immune response. In addition to its function in immune modulation, c-di-AMP is a bacterial second messenger that regulates various physiological processes in Gram-positive bacteria, including growth and virulence. Its properties also make it an effective mucosal adjuvant for enhancing both humoral and cellular immune responses in research applications. -
Exotoxin
LLO (91-99), a peptide derived from the exotoxin listeriolysin O, acts as a class I MHC-restricted T-cell epitope. This peptide is processed by antigen-presenting cells, binding to MHC class I molecules to elicit cytotoxic T lymphocyte (CTL) responses. LLO (91-99) is instrumental in research focused on Listeria infections, such as listeriosis, by facilitating the clearance of Listeria from infected cells. -
COX Inhibitor
α-Spinasterol is a selective inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 16.17 μM and 7.76 μM, respectively. This compound demonstrates a range of biological activities, including antibacterial, anti-inflammatory, antidepressant, and antioxidant effects. Furthermore, it can effectively cross the blood-brain barrier and has shown potential in improving diabetes in murine models, making it a valuable tool for research in inflammatory disorders and neurological conditions. -
Immunoactive Peptide
ESAT6 Epitope is an immunoactive peptide derived from the early secreted antigen target gene 6 (ESAT6), specifically designed to bind with high affinity to major histocompatibility complex (MHC) class I, exhibiting an IC50 of 180 nM. This epitope plays a crucial role in enhancing BCG-induced cellular immunity against Mycobacterium tuberculosis. It is valuable in studies focused on T cell-mediated immune responses and tuberculosis vaccine development. -
Immunosuppressant/Anti-inflammatory Agent
Umirolimus is a macrocyclic triene lactone derivative of Rapamycin that functions as a potent immunosuppressant and anti-inflammatory agent. Its high lipophilicity enhances its efficacy in targeted drug delivery systems, making it suitable for use in drug-eluting stents (DES). Umirolimus is utilized in various research applications focused on transplantation, cardiovascular interventions, and inflammatory disease models.
