Catalog No.
Product Name
Application
Product Information
Citations
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Diterpenoid
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis. -
COX Inhibitor
Oxaprozin is a potent, orally active cyclooxygenase (COX) inhibitor, demonstrating IC50 values of 2.2 μM for human platelet COX-1 and 36 μM for IL-1-stimulated human synovial cell COX-2. This compound exhibits significant anti-inflammatory activity and is known to inhibit the activation of NF-κB, promoting cell apoptosis. The inhibition of the Akt/IKK/NF-κB signaling pathway is a key mechanism underlying its anti-inflammatory properties, making Oxaprozin valuable for research in inflammation and related disorders. -
Dual COX-2/EGFR Inhibitor
Melafolone is a potent dual inhibitor of COX-2 and EGFR, displaying IC50 values of 13.2 μM for COX-2 and 17.4 μM for EGFR. This compound enhances the efficacy of anti-PD-1 therapy by promoting vascular normalization and downregulating PD-L1 through the PI3K/Akt signaling pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone is suitable for applications in lung cancer research. -
Anti-inflammatory Agent
Antcin K is a selective inhibitor targeting multiple signaling pathways, including PI3K/Akt, NF-κB, MEK1/2-ERK, p38, and AP-1. It upregulates IL-10 expression, effectively inhibiting pro-inflammatory factor production, reducing monocyte adhesion, and minimizing tissue damage, while promoting myogenesis. Antcin K exhibits robust anti-inflammatory and tissue protective properties, making it valuable for research applications related to inflammation-associated diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury. -
Nrf2/HO-1 Activator
Nrf2/HO-1 activator 2 is a difluoro-substituted compound that functions as a potent activator of the Nrf2/HO-1 signaling pathway. It exhibits neuroprotective and antioxidant properties by promoting the phosphorylation of ERK1/2, JNK, and Akt, particularly in PC12 cells. This compound is valuable for research on neurodegenerative conditions, including Parkinson's disease. -
COX Inhibitor
Oxaprozin potassium is a potent cyclooxygenase (COX) inhibitor, demonstrating IC50 values of 2.2 μM for human platelet COX-1 and 36 μM for IL-1-stimulated human synovial cell COX-2. It not only exhibits anti-inflammatory activity but also inhibits the activation of NF-κB, inducing cell apoptosis. The inhibition of the Akt/IKK/NF-κB pathway is a key mechanism contributing to its anti-inflammatory effects, making it a valuable tool for research in inflammation and related cellular processes. -
Anti-inflammatory Agent
Secologanic acid is a secoiridoid glycoside that acts as an anti-inflammatory agent. It inhibits nitric oxide (NO) production and modulates the expression of AKT and phosphorylated AKT (p-AKT). This compound demonstrates significant anti-inflammatory activity, making it valuable for research in chronic inflammatory conditions and related therapeutic applications. -
Anti-CXCR4 Antibody
LY-2624587 is a humanized IgG4 monoclonal antibody that antagonizes CXCR4. By blocking the interaction between SDF-1 and CXCR4, it inhibits SDF-1-induced GTP binding, significantly reducing cell migration and promoting apoptosis in human lymphoma and leukemia cells. Additionally, LY-2624587 impedes CXCR4 and SDF-1-mediated signaling pathways, including the activation of MAPK and AKT. This reagent is valuable for research applications involving human hematological malignancies, particularly acute myeloid leukemia (AML). -
CXCR4 Antagonist.
BPRCX807 is a selective and potent antagonist of the CXC chemokine receptor type 4 (CXCR4). It effectively inhibits CXCL12-mediated phosphorylation of ERK and Akt, leading to significant suppression of primary tumor growth. This compound is applicable for research in hepatocellular carcinoma, providing insights into its therapeutic potential in cancer treatment. -
PD-1/PD-L1 Inhibitor
PD-1/PD-L1-IN-54 is an inhibitor of the PD-1/PD-L1 interaction, targeting immune checkpoints critical for tumor immune evasion. With a KD of 55.8 μM for PD-1 and 46.4 μM for PD-L1, and an IC50 of 88.6 μM, this compound enhances CD8+ T cell activation and promotes the secretion of key cytokines such as IFN-γ and IL-2. Furthermore, PD-1/PD-L1-IN-54 exhibits anticancer properties by inhibiting tumor cell proliferation and inducing apoptosis, while also modulating T cell immunity via the PI3K/Akt signaling pathway. -
TLR2 Agonist
Pam2CSK4 is a TLR2 agonist that activates immune signaling pathways, leading to the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in macrophage cell lines through TBK1 and MyD88. This compound stimulates the NF-κB and Bruton's tyrosine kinase pathways in platelets, enhancing interactions between platelets and endothelial cells. Pam2CSK4 promotes the expansion of myeloid-derived suppressor cells (MDSCs) and can suppress anti-tumor immune responses in the tumor microenvironment. Its applications span various diseases, including thromboinflammatory conditions, sepsis, atherosclerosis, and certain cancers, making it a valuable tool in immunological and therapeutic research. -
IL-13 Inhibitor
IL13Rα2 D1 is a potent inhibitor of the IL-13/IL13Rα2 signaling pathway. It effectively suppresses IL-13-induced cellular processes, including adhesion, migration, invasion, and proliferation. Additionally, IL13Rα2 D1 inhibits the phosphorylation of key signaling proteins such as FAK, Src, AKT, and ERK1/2, as well as the expression of matrix metalloproteinases (MMPs). This compound is valuable for research focused on cancer biology, particularly in the context of colorectal cancer. -
CXCR4 Inhibitor
Hit 14 is a selective inhibitor of C-X-C chemokine receptor type 4 (CXCR4), demonstrating an IC50 value of 254 nM. This compound effectively inhibits the migration and invasion of MDA-MB-231 cells, highlighting its potential in cancer research. Furthermore, Hit 14 modulates Akt phosphorylation and exhibits anti-inflammatory properties, demonstrating efficacy in reducing ear swelling and damage in mouse models. Its diverse biological activities make it a valuable tool for studies related to cancer metastasis and inflammation. -
COX-2 Inhibitor
Withangulatin A is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating significant potential in the modulation of inflammatory and tumorigenic processes. This compound also interferes with the MAPK, NF-κB, and Akt/mTOR/p70S6K signaling pathways, thereby exhibiting notable antitumor and anti-inflammatory activities. Additionally, Withangulatin A has been shown to possess trypanocidal effects, making it useful for research in cancer, inflammation, and parasitic diseases. -
Anti-inflammatory Agent
Oleanolic acid 28-O-β-D-glucopyranoside, a pentacyclic triterpenoid, primarily acts as an anti-inflammatory agent. It has demonstrated the ability to inhibit inflammatory responses in ulcerative colitis models, enhance intestinal epithelial barrier function, and modulate gut microbiota. The compound's mechanism involves the modulation of the PI3K-AKT and MAPK signaling pathways. Oleanolic acid 28-O-β-D-glucopyranoside is valuable for research into inflammatory diseases, particularly colitis. -
PI3K/Akt/mTOR signaling pathway Inhibitor, TLR4 signaling Inhibitor
25(R,S)-Ruscogenin is a potent inhibitor of the PI3K/Akt/mTOR and TLR4 signaling pathways. This compound effectively suppresses hepatocellular carcinoma (HCC) metastasis by decreasing the expression of matrix metalloproteinases (MMP-2 and MMP-9), uPA, VEGF, and HIF-1α. Additionally, 25(R,S)-Ruscogenin mitigates LPS-induced apoptosis in pulmonary endothelial cells, highlighting its potential for applications in cancer research and inflammatory disease studies. -
Antiinflammatory Agent
Ethyl linoleate, an unsaturated fatty acid derivative, acts as an anti-inflammatory agent by inhibiting the Akt/GSK3β/β-catenin signaling pathway and blocking NF-κB activation. Additionally, it induces heme oxygenase-1 and inhibits tyrosinase, contributing to its whitening and anti-inflammatory properties. Ethyl linoleate promotes absorption of compounds and has notable implications for atherosclerosis research. Its applications extend to the study of various inflammatory diseases and cosmetic formulations. -
Anti-inflammatory Reagent
Syringaresinol is a lignan-type phytochemical that primarily targets anti-inflammatory pathways. It effectively inhibits the NF-κB and AKT signaling pathways in IL-1β-activated mouse chondrocytes, demonstrating significant anti-inflammatory activity. Additionally, Syringaresinol enhances the phosphorylation of AMPK and eNOS while increasing intracellular Ca2+ levels in HUVECs. Its ability to attenuate the progression of osteoarthritis in mouse models of DMM-induced osteoarthritis makes it a valuable reagent for research focused on OA. -
Anti-inflammatory/Oxidant
Astringin is a natural flavonoid compound that primarily targets inflammatory pathways and oxidative stress. It exhibits significant anti-inflammatory, antioxidant, and anti-apoptotic activities, while also functioning as a ferroptosis inhibitor. Research applications include its potential use in studying diseases characterized by oxidative damage and inflammation, such as acute lung injury. -
Anti-inflammatory Agent
Strictosamide is a natural compound isolated from Nauclea officinalis, primarily functioning as an anti-inflammatory agent. It exhibits multiple biological activities, including analgesic properties, anti-Plasmodium effects, antifungal activity, and the promotion of wound healing. This compound is valuable for research in inflammation, pain management, and infectious disease studies. -
Inflammatory Modulator
Cholesta-3,5-diene is an inflammatory modulator that primarily targets immune cells, including neutrophils, to enhance wound healing processes. It facilitates neutrophil chemotaxis and fibroblast migration by activating chemokine receptor-mediated signaling pathways, such as the PI3K/Akt pathway. This compound can be utilized in topical applications for wound repair and exhibits potential therapeutic benefits in managing chronic ulcers and skin lesions. -
Anti-Inflammatory/Immunosuppressive Signal
Phosphatidylserine is a phospholipid that serves as an important anti-inflammatory and immunosuppressive signal. It is known to facilitate membrane translocation and activate protein kinase C, which is integral to Akt signaling through its interaction with PIP3. Additionally, localized exposure to phosphatidylserine promotes microglial phagocytosis, aiding in synaptic refinement, and acts as a pro-coagulant factor in the extracellular space by signaling for the clearance of apoptotic cells. This reagent has significant implications in research focused on inflammation regulation and immune response modulation. -
Anti-inflammatory And Antioxidant
Tamarixetin, a 4'-O-Methyl Quercetin derivative, serves as a potent inhibitor of the caseinolytic protease P (ClpP) and exhibits significant anti-inflammatory and antioxidant properties. This natural flavonoid effectively inhibits ClpP's hydrolytic activity towards the substrate Suc-LY-AMC with an IC50 of 49.73 μM, making it relevant for research involving Staphylococcus aureus infections. Additionally, Tamarixetin demonstrates the ability to inhibit tumor cell growth, induce apoptosis, and induce cell cycle arrest, while also preventing cardiac hypertrophy through the modulation of NFAT and AKT signaling pathways. -
Anticancer/Anti-inflammatory/Anti-diabetic Agent
Phellopterin is a furocoumarin compound recognized for its anticancer, anti-inflammatory, and anti-diabetic activities. It functions as a partial agonist of central benzodiazepine receptors and demonstrates significant anti-inflammatory properties by modulating key pathways such as SIRT1 and TLR4/NF-κB, which may aid in conditions like chronic inflammation and atopic dermatitis. Additionally, Phellopterin has been shown to inhibit ovarian cancer progression through the PU.1/CLEC5A/PI3K-AKT signaling loop and promotes adipocyte differentiation, contributing to its anti-diabetic effects. This compound is valuable for research in cancer, inflammation, diabetes management, and antiviral studies. -
Anti-neuroinflammatory Agent
2-O-Methylatromentin is an anti-neuroinflammatory agent that effectively inhibits the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, in lipopolysaccharide (LPS)-induced BV-2 microglial cells. This compound is valuable for research into neuroinflammatory diseases, providing insights into the mechanisms underlying inflammation in the central nervous system. Its efficacy in modulating inflammatory responses makes it a useful tool for investigating potential therapeutic strategies in neuroinflammatory conditions. -
TNF Receptor
SYLQDSVPDSFQD is an anchor-modified peptide designed for high-affinity binding to the TNF receptor, specifically DR4. This DR4-restricted MHC class II peptide is utilized in research for studying immune responses and the modulation of TNF-mediated signaling pathways. Its enhanced binding properties make it a valuable tool for investigating therapeutic strategies in inflammation and cancer research. -
COX-2 Inhibitor
Ataquimast is a selective COX-2 inhibitor that effectively suppresses the release of leukotrienes, TNF-α, and GM-CSF. Its mechanism supports research into inflammatory responses and has potential applications in the study of advanced estrogen receptor-positive breast cancer. This compound may aid in elucidating the role of COX-2 in tumor progression and therapeutic resistance. -
Selective Intranasal TLR7 Agonist
GSK2245035 maleate is a selective intranasal agonist of Toll-Like receptor 7 (TLR7), exhibiting potent Type-1 interferon (IFN) stimulating activity with pEC50 values of 9.3 for IFNα and 6.5 for TNFα. This compound effectively reduces allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is primarily utilized in research focused on asthma and other Th2-mediated allergic responses. -
Anti-inflammatory Agent
Anti-inflammatory Agent 22 is an orally active compound targeting the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production, demonstrated by an IC50 of 14.6 μM. This agent exhibits preventive effects on lymphedematous tissue by suppressing adipogenesis. Additionally, Anti-inflammatory Agent 22 has been shown to reduce limb lymphedema volume in murine models, making it a valuable tool for research into inflammatory conditions and lymphedema management. -
Anti-inflammatory Agent
Anti-inflammatory Agent 15 is a potent compound targeting inflammation through inhibition of nitric oxide synthase (iNOS). It demonstrates significant antimycobacterial activity against Mycobacterium tuberculosis strains H37Rv and M299, with MIC50 values of 2.3 μM and 7.8 μM, respectively. This agent effectively reduces pro-inflammatory cytokines TNF-α and IL-1β, making it a valuable tool for researching tuberculosis and related inflammatory pathways. -
Anti-inflammatory Agent
3-O-Caffeoyl-5-O-feruloylquinic acid is a phenolic compound with potent anti-inflammatory properties, primarily targeting free radical scavenging mechanisms. It effectively regulates inflammatory pathways by inhibiting TNF-α-induced production of reactive oxygen species (ROS) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs). This compound is valuable in research applications focused on oxidative stress and inflammation pathways, offering insights into potential therapeutic strategies for inflammatory disorders. -
COX-2 Inhibitor
COX-2-IN-60 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating an IC50 of 0.06 μM and approximately 100-fold selectivity over COX-1. This compound significantly reduces oxidative stress and neuroinflammatory cytokines, effectively counteracting epileptogenesis. In preclinical studies utilizing a pilocarpine-induced seizure mouse model, COX-2-IN-60 exhibited substantial anticonvulsant effects while protecting against hippocampal injury. Its application in research relates to neuroinflammatory pathways and epilepsy mechanisms. -
TLR Inhibitor
ETI60 is a selective Toll-like receptor (TLR) inhibitor that primarily targets the nucleoside-binding Site I on TLR7 and TLR9, with IC50 values of 0.68 μM and 0.12 μM, respectively. This compound effectively inhibits endosomal TLR-mediated pro-inflammatory signaling, demonstrating nanomolar activity in cellular, biophysical, and in vivo assays. ETI60 modulates the expression of inflammation-related genes and has shown efficacy in alleviating symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE). This reagent is valuable for research involving autoimmune and inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 104 is a potent anti-inflammatory compound that specifically inhibits TNF-α synthesis and release in the human macrophage cell line U937, with an IC50 value of 0.024 nM. This agent demonstrates significant biological activity by reducing eosinophil levels in rat lungs by 63%, making it a valuable tool for studying inflammatory responses and evaluating therapeutic strategies in related research applications. -
Anti-inflammatory Agent
Anti-inflammatory Agent 55 is a derivative of Coixol that primarily inhibits the NF-κB signaling pathway. It effectively reduces the expression of pro-inflammatory markers such as iNOS, TNF-α, IL-6, and IL-1β. This compound significantly decreases LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 value of 0.8 μM and demonstrates noteworthy in vivo anti-inflammatory effects in a mouse auricular edema model, making it a valuable tool for research in inflammation and immune responses. -
Keap1/Nrf2/ARE Activator
Keap1/Nrf2/ARE Activator 2 is a potent activator of the Keap1/Nrf2/ARE signaling pathway, promoting Nrf2 nuclear translocation. This compound has been demonstrated to upregulate antioxidant genes, thereby enhancing cellular defense against oxidative stress. Additionally, it exhibits significant neuroprotective effects against H2O2- and Scopolamine-induced neuronal injury in PC12 cells, as well as alleviating memory impairment and neuroinflammation associated with cognitive dysfunction in zebrafish models. Keap1/Nrf2/ARE Activator 2 is a valuable tool for research into Alzheimer's disease and associated neurodegenerative conditions. -
Anti-inflammatory Agent
Siaresinolic acid is an anti-inflammatory compound derived from the leaves of Sabicea grisea. It exhibits significant antinociceptive properties by modulating ATP-dependent potassium channels and inhibiting the influx of leukocytes, plasma leakage, and the production of pro-inflammatory mediators such as TNF-α and IL-1β. Importantly, Siaresinolic acid demonstrates a lack of cytotoxicity in murine macrophages and does not affect locomotor activity even at elevated doses. This compound is suitable for research applications involving pleurisy and pain management. -
Anti-inflammatory agent
Taxamairin B is a potent anti-inflammatory agent that targets proinflammatory cytokine production. It effectively reduces the expression of TNF-α, IL-1β, and IL-6, as well as the oxidative stress markers nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW264.7 macrophage cells. Additionally, Taxamairin B demonstrates significant protective effects in models of LPS-induced acute lung injury in mice, making it a valuable compound for research on inflammatory pathways and potential therapeutic applications. -
Anti-inflammatory Agent
Oleracone is an alkaloid derived from Portulaca oleracea L. that functions as an anti-inflammatory agent. It demonstrates potent anti-inflammatory effects in the RAW 264.7 macrophage model, effectively inhibiting nitric oxide production and reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone is suitable for researching inflammatory diseases and exploring potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 54, a derivative of Coixol, targets the NF-κB signaling pathway to exert its anti-inflammatory effects. This compound effectively downregulates pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β. Notably, anti-inflammatory agent 54 inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates significant in vivo anti-inflammatory activity in a mouse model of auricular edema. -
Proinflammatory Cytokine Inhibitor
Semapimod is a potent inhibitor of proinflammatory cytokine production, targeting Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM. It effectively inhibits the production of key cytokines such as TNF-α, IL-1β, and IL-6, as well as p38 MAPK activity and nitric oxide production in macrophages. This compound holds promise for research in various inflammatory and autoimmune disorders. -
Antioxidant/Anti-inflammatory/Anti-fibrotic Agent
7-O-Galloyl-D-sedoheptulose is a polyphenolic compound recognized for its antioxidant, anti-inflammatory, and anti-fibrotic properties. It lowers serum levels of glucose, leptin, insulin, and pro-inflammatory cytokines such as TNF-α and IL-6, while increasing adiponectin levels. This compound effectively reduces reactive oxygen species (ROS) and lipid peroxidation by inhibiting the expression of NADPH oxidase components. Additionally, it down-regulates NF-κB signaling and relevant fibrotic markers, highlighting its potential applications in studying type 2 diabetes and associated complications in hepatic and pancreatic tissues. -
Anti-inflammatory Agents
CZEN-002 is a derivative of alpha-melanocyte-stimulating hormone that acts as an anti-inflammatory agent by inhibiting the production of TNF-α. It exhibits both anti-inflammatory and antibacterial properties, making it a valuable tool for researching inflammatory diseases and potential therapeutic interventions. Its mechanism of action opens avenues for studies related to immune response modulation and pathogen resistance. -
NO、TNF-α、IL-12 Inhibitor
(R)-5,7-Dimethoxyflavanone acts as an inhibitor of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-12 (IL-12), demonstrating significant anti-inflammatory properties. In biological assays, this compound exhibits potent antimutagenic activity, effectively reducing MeIQ-induced mutagenesis in the Ames test using S. typhimurium strains TA100 and TA98. Its capacity to modulate inflammatory mediators makes it a valuable tool in research focused on inflammation and mutagenesis. -
TLR Inhibitor
ETI41 is a selective Toll-like receptor (TLR) inhibitor that targets the nucleoside-binding Site I on TLR7 and TLR9, demonstrating IC50 values of 0.63 μM and 0.16 μM, respectively, while sparing surface TLRs. This compound effectively inhibits endosomal TLR-mediated pro-inflammatory signaling, displaying potent nanomolar activity across cellular, biophysical, and in vivo assays. ETI41 suppresses the expression of inflammation-associated genes and improves symptoms in murine models of psoriasis and systemic lupus erythematosus (SLE). It is valuable for research into autoimmune and inflammatory diseases. -
Anti-inflammatory Agent
HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 17 is a potent orally active compound that targets inflammatory pathways by inhibiting the release of pro-inflammatory cytokines IL-6 and TNF-α. In vitro studies demonstrate its ability to reduce inflammation without inducing cytotoxicity. Additionally, anti-inflammatory agent 17 exhibits significant anti-inflammatory activity in vivo, making it a valuable tool for research into acute lung injury (ALI) and other inflammatory conditions. -
Anti-CD274/TNFRSF9 Antibody
Solabafusp alfa is a humanized IgG4κ type antibody that specifically targets CD274 (also known as PD-L1) and TNFRSF9 (also known as 4-1BB). This compound is significant for its potential to modulate immune responses, making it a valuable tool in cancer research and immunotherapy studies. It can be utilized to explore pathways related to immune checkpoint inhibition and T-cell activation. An appropriate isotype control for this antibody is Human IgG4 (S228P) kappa. -
Anti-inflammatory Agent
CX-659S is an orally active 5-carboxamide uracil derivative with anti-inflammatory properties. It effectively inhibits lipid peroxidation with an IC50 of 5.9 μM and reduces the infiltration of neutrophils and eosinophils. CX-659S also inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α, making it a valuable tool for research on inflammatory conditions. -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research.
