Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Fluorofenidone is an orally active anti-inflammatory agent that exhibits anti-fibrotic and antioxidant properties. It functions by downregulating ACSL4 expression, upregulating GPX4, and inhibiting the NF-κB signaling pathway, thereby alleviating inflammation and fibrosis. In preclinical models, Fluorofenidone has demonstrated efficacy in ameliorating cholestasis and fibrosis by modulating the hepatic Erk/Egr-1 signaling and TGFβ1/Smad pathways. This compound is particularly relevant for research into chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF), and non-small cell lung cancer (NSCLC). -
Anti-inflammatory Agent
L-Ornithine 2-oxoglutarate primarily functions as an anti-inflammatory agent. This compound, a salt of amino acids, exhibits antioxidant properties and plays a role in stimulating insulin and growth hormone production. Additionally, L-Ornithine 2-oxoglutarate enhances intracellular amino acid transport, thereby promoting protein synthesis. It is suited for research applications focusing on metabolic disorders, inflammation, and muscle physiology. -
Anti-Inflammatory Agent
IGF-I (30-41) is a fragment of Insulin-like Growth Factor I comprising amino acids 30 to 41, primarily targeting anti-inflammatory pathways. This peptide exhibits significant biological activities, including anabolic, antioxidant, and cytoprotective effects. It is utilized in research applications aimed at understanding inflammation and related pathophysiological conditions. -
Anti-inflammatory Agent
Cinnamtannin D1 is a polyphenolic compound recognized for its anti-inflammatory properties, primarily through its immunosuppressive effects. It modulates the Th17/Treg balance by inhibiting AHR expression, subsequently downregulating p-STAT3/RORγt and promoting Treg differentiation via p-STAT5/Foxp3. Cinnamtannin D1 has demonstrated significant protective effects against apoptosis and oxidative stress in INS-1 cells and primary murine islets exposed to palmitic acid. Its efficacy in the collagen-induced arthritis model underscores its potential for research in rheumatoid arthritis. -
Anti-inflammatory/Anticancer/Neuroprotective Agent
5-OH-HxMF is a hydroxylated polymethoxyflavone that exhibits significant anti-inflammatory and anticancer properties. Additionally, it demonstrates neuroprotective and neurotrophic activities, making it a valuable reagent for research in inflammation, cancer biology, and neurodegenerative diseases. Its multifaceted biological effects support its use in studies aimed at understanding and developing therapies for various pathologies. -
Anti-Inflammatory Agent
Picrasidine I is a dimeric alkaloid known for its anti-inflammatory properties, primarily acting through the modulation of key signaling pathways. It induces cell cycle arrest and apoptosis by downregulating the ERK and Akt pathways. Additionally, Picrasidine I inhibits the activation of MAPKs and NF-κB, reduces reactive oxygen species generation, and suppresses the expression of c-Fos and NFATc1, making it a valuable tool for research in inflammation and osteoclastogenesis. -
Anti-inflammatory Agent/Anticancer Agent
Cryptolepine is a multi-potent alkaloid that serves as an anti-inflammatory and anticancer agent. It functions primarily as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, and MAPK while activating AMPKα1/2, leading to various biological effects including DNA intercalation and inhibition of topoisomerase II. These activities result in disrupted mitochondrial dynamics and induction of apoptosis in cancer cells. Cryptolepine shows promise in research applications focusing on tumors such as melanoma and hepatocellular carcinoma, as well as in studies related to malaria, inflammatory diseases, and diabetes. -
Anti-Inflammatory Compounds
Anti-inflammatory agent 47 is a potent anti-inflammatory and antioxidant compound that targets inflammatory pathways. It inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO), thereby suppressing neuronal apoptosis through the modulation of inflammatory and apoptotic signaling cascades. This compound is applicable in research focused on neurodegenerative diseases, particularly Parkinson's Disease (PD). -
Anticancer/Anti-inflammatory Agent
Perezone is a sesquiterpenoid benzoquinone derived from the roots of Acourtia species, acting as an anticancer and anti-inflammatory agent. It effectively inhibits the proliferation of leukemia cell line K-562 and human glioma cell line U-251, with an IC50 of 6.83 μM. Furthermore, Perezone upregulates the expression of apoptosis-related genes, including caspase 3, 8, and 9, while also exhibiting significant antioxidant and anti-inflammatory properties. This compound is of interest in cancer research and potential therapeutic applications. -
Antitumor/Anti-inflammatory Agent
Antitumor agent-56 is a triptolide derivative that functions primarily as an antitumor and anti-inflammatory agent. This compound demonstrates significant inhibitory effects on melanoma proliferation while also exhibiting nitric oxide release activities. Antitumor agent-56 is suitable for various research applications in cancer biology and therapeutic development. -
Anti-Inflammatory Agent
2,4′-Dihydroxybenzophenone acts as an anti-inflammatory agent by targeting the hydrophobic pocket of MD2, effectively inhibiting the dimerization of TLR4. This compound demonstrates significant biological activity by suppressing LPS-induced mitochondrial reactive oxygen species (mtROS) production and attenuating the inflammatory response through downregulation of pro-inflammatory mediators, including MyD88, p-IRAK4, and NF-κB. Additionally, 2,4′-Dihydroxybenzophenone serves as an effective UV absorber, enhancing its utility in research on oxidative stress and inflammation. -
Anti-inflammatory Agent
Regaloside C is an anti-inflammatory agent that exhibits antioxidant properties by scavenging ABTS and DPPH free radicals. It targets multiple molecular pathways, including TNF-α, MMP-2, ERα, AKT1, TLR4, and HSP90-α. This compound is relevant for research focused on inflammatory diseases and may provide insights into therapeutic approaches for managing chronic inflammation. -
Antioxidant/Anti-inflammatory Agent
Pinus pinaster bark extract serves as a potent antioxidant and anti-inflammatory agent. This extract demonstrates neuroprotective effects by enhancing the activity of toll-like receptors (TLR), leading to increased production of interleukin-10 (IL-10). It is utilized in research applications focused on inflammatory responses and neurodegenerative diseases, making it a valuable tool for understanding cellular protection mechanisms. -
Anti-Inflammatory Agent
4-Methoxylonchocarpin is an orally active anti-inflammatory agent that primarily targets Toll-like Receptor 4 (TLR4). This compound effectively inhibits the binding of lipopolysaccharides (LPS) to TLR4, leading to the suppression of NF-κB activation and the downregulation of pro-inflammatory cytokines such as TNF and IL-6. Additionally, 4-Methoxylonchocarpin reduces the phosphorylation of TGF-beta activated kinase 1 and mitigates the expression of IL-1β, IL-17A, and TNF in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model, demonstrating its potential in anti-inflammatory research applications. -
Anti-inflammatory Agent
Chlojaponilactone B is a lindenane-type sesquiterpenoid known for its anti-inflammatory properties. This compound functions by inhibiting Toll-like receptor 4 (TLR4), leading to a decrease in reactive oxygen species (ROS) production and downregulation of the NF-κB pathway. Consequently, it reduces the expression of pro-inflammatory cytokines, including iNOS, nitric oxide (NO), COX-2, IL-6, and TNF-α. Chlojaponilactone B is a valuable tool for research into inflammation and related pathways. -
Anti-inflammatory Agent
Ganglioside GD1a functions as an anti-inflammatory agent by modulating the toxic effects induced by E. coli lipopolysaccharide (LPS). It prevents the translocation of TLR4 into lipid rafts, thereby reducing LPS-induced cytotoxicity and the production of reactive oxygen species. Ganglioside GD1a is valuable for research applications focused on inflammatory signaling and cellular response mechanisms. -
Inflammatory Corpuscles Inhibitor
JC2-11 is an inhibitor of inflammatory corpuscles that targets domain-containing proteins NLRC4 and AIM2, as well as non-canonical inflammatory pathways. This compound is effective in reducing the secretion of caspase-1 (p20) and the cleavage of gasdermin D (GSDMD), leading to decreased release of IL-1β and lactate dehydrogenases (LDH) from inflammatory bodies. JC2-11 also disrupts the activation of inflammatory corpuscles by inhibiting reactive oxygen species production and caspase-1 activity, making it a valuable tool for research into inflammation and related diseases. -
Anti-inflammatory Agent
Maresin 2 is a pro-resolving mediator derived from human macrophages, primarily acting as an anti-inflammatory agent. This compound belongs to the maresin family of lipid mediators, biosynthesized from docosahexaenoic acid (DHA). Maresin 2 plays a crucial role in tissue inflammation resolution and has potential applications in research focused on inflammatory diseases and regenerative medicine. -
Anti-inflammatory Agent
NLRP3-IN-72 is a benzimidazole derivative that functions as an anti-inflammatory agent by specifically targeting the NLRP3 inflammasome. It demonstrates significant biological activity with an IC50 of 0.3 μM for inhibiting NLRP3-mediated IL-1β secretion, a PD50 of 0.4 μM for protecting against pyroptosis, and an EC50 of 0.6 μM for the induction of heme oxygenase-1 (HO-1). These properties make NLRP3-IN-72 a valuable tool for research into inflammatory processes and potential therapeutic interventions. -
Anti-inflammatory Agent
Macarangin is an anti-inflammatory agent isolated from propolis. It exhibits significant DPPH radical-scavenging activity and demonstrates anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome. This compound is valuable for research applications focused on inflammation pathways and oxidative stress. -
Anti-inflammatory Agent
Sulindac sodium is an orally active nonsteroidal anti-inflammatory agent that exerts its effects through the inhibition of cyclooxygenase enzymes, leading to decreased prostaglandin synthesis. This compound demonstrates significant anti-inflammatory and immunomodulatory properties, making it valuable for investigating conditions such as arthritis, gout, and various cancers including colorectal cancer (CRC) and lung cancer. Its diverse mechanisms of action and potential therapeutic applications contribute to its utility in cancer and inflammation research. -
Inflammatory Cytokine Inhibitor
JTE-607 is a selective inhibitor targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3), demonstrating potent suppression of inflammatory cytokine synthesis. This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated human peripheral blood mononuclear cells (PBMCs) with IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 is utilized in research applications focused on understanding and mitigating inflammatory responses and endotoxin shock. -
Anti-inflammatory Agent
Hydrocortisone hemisuccinate is a glucocorticoid steroid that acts as an anti-inflammatory agent, exhibiting significant immunomodulatory properties. It effectively inhibits the bioactivity of interleukin-6 (IL-6) and interleukin-3 (IL-3) with IC50 values of 6.7 μM and 21.4 μM, respectively. This compound is applicable in research focused on ulcerative colitis and recurrent oral ulcers, providing a valuable tool for studying inflammatory conditions and potential therapeutic interventions. -
Anti-Inflammatory Agent
Magnesium sulfate is an effective anti-inflammatory agent and a potent inhibitor of L-type calcium channels. It exhibits diverse biological activities including anticonvulsant, vasodilatory, and neuroprotective effects. This compound is commonly utilized in research related to conditions such as preeclampsia and eclampsia, providing valuable insights into therapeutic interventions and underlying mechanisms of these disorders. -
Anti-inflammatory Agent
Lipoxin A4 (LXA4) is an endogenous eicosanoid mediator with significant anti-inflammatory and pro-resolving activity. It modulates inflammatory responses by inhibiting proliferation and cytokine/chemokine production in human epidermal keratinocytes through the ERK1/2 and NF-kB signaling pathways. Additionally, Lipoxin A4 effectively reduces serum amyloid A (SAA)-induced IL-8 release, demonstrating an IC50 of 25.74 nM. This compound serves as a valuable tool for research in inflammation and resolution processes. -
Anti-inflammatory Agent
Lauroyl-L-carnitine chloride is an anti-inflammatory agent that acts as an orally active metabolite. It has been shown to significantly enhance the expression of the anti-inflammatory cytokine IL-10, thereby exerting beneficial effects in inflammatory conditions. Research indicates that Lauroyl-L-carnitine chloride may alleviate symptoms associated with Crohn's-like colitis, making it a valuable tool for studying inflammatory bowel disease. -
Anti-inflammatory Agent
Militarine is an anti-inflammatory agent that primarily targets the NF-κB signaling pathway. It demonstrates significant biological activity by alleviating PM2.5-induced inflammatory injury and inhibiting cell migration in human alveolar epithelial A549 cells. Additionally, Militarine functions as a plant growth inhibitor, affecting the elongation of radicles and hypocotyls in various plant species. This compound is suitable for research applications related to PM2.5-induced pulmonary diseases and plant physiology studies. -
Anti-inflammatory Agent
Regaloside B is a phenylpropanoid with significant anti-inflammatory activity. Isolated from Lilium longiflorum, it effectively inhibits the expression of key inflammatory markers including VCAM-1, iNOS, and COX-2, as well as modulating the mRNA levels of various chemokines and angiogenic factors such as CXCL9, CXCL10, and IL8. Regaloside B is a useful reagent for research applications focused on osteogenic differentiation and inflammation-related studies. -
Anti-inflammatory agent
Hesperetin 7-O-glucoside is an anti-inflammatory flavonoid monoglucoside that exhibits orally active antihypertensive properties. It inhibits human intestinal maltase and HMG-CoA reductase with Ki values of 1.8 mM and 9.8 μM, respectively. Additionally, Hesperetin 7-O-glucoside demonstrates antibacterial activity and has been shown to regulate intestinal flora and support metabolic homeostasis in murine models. This compound is valuable for research applications in inflammation, metabolic regulation, and gut microbiota studies. -
Anti-neuroinflammatory Agent
Murrayafoline A is a carbazole alkaloid that functions as an anti-neuroinflammatory agent by directly targeting Specificity protein 1 (Sp1) and inhibiting the NF-κB and MAPK signaling pathways. This compound induces G0/G1-phase cell cycle arrest in PDGF-stimulated vascular smooth muscle cells and promotes the degradation of β-catenin, thereby attenuating the Wnt/β-catenin pathway. Additionally, Murrayafoline A enhances contractility in rat ventricular myocytes and activates L-type calcium currents through protein kinase C activation. Researchers can utilize Murrayafoline A to investigate inflammation, vascular complications, and colon cancer. -
Anti-inflammatory
Eupafolin, also known as Nepetin or 6-Methoxyluteolin, is a natural flavonoid derived from Eupatorium ballotaefolium HBK, recognized for its potent anti-inflammatory properties. It effectively inhibits the secretion of pro-inflammatory cytokines IL-6, IL-8, and MCP-1, exhibiting IC50 values of 4.43 μM, 3.42 μM, and 4.17 μM, respectively, in ARPE-19 cells. Eupafolin serves as a valuable research compound for studying inflammation and related pathways in various biological contexts. -
Anti-inflammatory Agent
Noreugenin is a phenolic compound that serves as an anti-inflammatory agent by inhibiting myeloperoxidase activity and reducing proinflammatory cytokines IL-1β and IL-17A in LPS-induced murine pleurisy. Additionally, it diminishes apoptosis and necrosis while lowering lipid peroxidation and modulating antioxidant enzyme activities (CAT, SOD, GST). With its anti-inflammatory and antioxidant properties, Noreugenin is valuable for investigating various inflammatory conditions, including pleurisy. -
Anti-inflammatory Agent
(±)-Lisofylline is an anti-inflammatory agent that acts by inhibiting the generation of phosphatidic acid and free fatty acids. It effectively blocks the release of pro-inflammatory cytokines, making it relevant for research in oxidative tissue injury, cancer chemotherapy responses, and experimental sepsis. Additionally, (±)-Lisofylline has applications in studies related to Type 1 diabetes. -
Anti-Inflammatory Compound
12-Oxo phytodienoic acid (12-OPDA) is an anti-inflammatory compound derived from plant lipids. It effectively suppresses neuroinflammation by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-κB) and p38 mitogen-activated protein kinase (MAPK) pathways in lipopolysaccharide (LPS)-activated cells. This compound is valuable for research related to neurodegenerative diseases, enabling the exploration of therapeutic strategies targeting inflammatory responses. -
Anti-inflammatory Agents
Xanthomicrol is a monoamine oxidase (MAO) inhibitor derived from the resin of the Chinese bellflower (Scrophulariaceae family). It exhibits significant anti-inflammatory and anti-tumor activities, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells, respectively. Xanthomicrol has been shown to reduce both iNOS protein and mRNA levels, as well as COX-2 protein levels. Additionally, it diminishes the production of the pro-inflammatory cytokine IL-1β and upregulates the antioxidant enzyme HO-1, making it a valuable tool for research in inflammatory and cancer-related studies. -
Anti-inflammatory agent
Docosahexaenoyl serotonin (DHA-5-HT) functions as an anti-inflammatory agent through its inhibition of interleukin-17 (IL-17). This endogenous conjugate of n-3 fatty acid and serotonin exhibits significant anti-inflammatory properties. It is utilized in research to explore mechanisms related to inflammation and potential therapeutic applications for inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory Agent 42 (Compound 10j) is designed to inhibit pro-inflammatory cytokines, specifically targeting tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). This compound demonstrates significant efficacy in reducing cytokine expression in lipopolysaccharide (LPS)-stimulated macrophages, making it a valuable tool for research in inflammation and immune response studies. Its application extends to investigations aimed at understanding chronic inflammatory diseases and exploring therapeutic interventions. -
Anti-Inflammatory Compound
Cynandione A is an acetophenone compound with anti-inflammatory properties. It has been shown to protect hepatocytes and cortical neurons from toxicity, as well as improve neurological deficits in a rat model of cerebral ischemia. Additionally, Cynandione A exerts significant anti-inflammatory effects through the activation of macrophage α7 nAChR and the expression of IL-10, making it a valuable tool for research in neuroprotection and inflammation. -
Anti-inflammatory Agent
Hydrocortisone hemisuccinate hydrate serves as an orally active glucocorticoid anti-inflammatory agent, primarily targeting and inhibiting pro-inflammatory cytokines such as IL-6 and IL-3 with IC50 values of 6.7 μM and 21.4 μM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory activities, making it valuable in research applications related to ulcerative colitis and recurrent oral ulcers. Its ability to modulate inflammation positions it as a key reagent for studies in inflammatory disease pathways. -
Anti-inflammatory Agent
4-Ethoxybenzaldehyde is an anti-inflammatory agent that serves as a derivative of benzaldehyde. This compound effectively inhibits the production of key inflammatory mediators, including prostaglandin E2 (PGE2), IL-6, and IL-8, induced by ultraviolet radiation (UVR). Its demonstrated efficacy and safety profile make it valuable for reducing facial redness in topical formulations, notably in oil-in-water emulsions at a concentration of 1%. 4-Ethoxybenzaldehyde is suitable for research on chronic inflammatory skin diseases. -
Anti-inflammatory Agent
Arvelexin is an anti-inflammatory agent that primarily acts by inhibiting NF-κB activation. Isolated from Brassica rapa L. (Brassicaceae), Arvelexin also downregulates the expression of IL-8, making it a valuable compound for research into colonic inflammation. This compound is of interest for studies focused on inflammatory pathways and potential therapeutic applications in inflammatory bowel disease and related disorders. -
Oxidative Stress Modulator/Anti-inflammatory Agent
Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 64 targets the inhibition of pro-inflammatory cytokines, specifically IL-6 and TNF-α. This compound exhibits both antioxidant and anti-inflammatory activity in vitro and in vivo, making it a valuable tool for studying inflammatory processes. Additionally, it has been shown to significantly reduce paw edema, highlighting its potential utility in therapeutic research for inflammatory diseases. -
Pro-Inflammatory Peptide
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a potent leukocyte chemoattractant. It plays a significant role in mediating inflammatory responses and can be employed in research related to various immune system disorders, including allergic asthma. This reagent is ideal for studies investigating the mechanisms of inflammation and the effects of immune modulation. -
Anti-inflammatory Agent
Tiopropamine is an anti-inflammatory agent primarily targeting histamine receptors. It exhibits significant potential in modulating inflammatory responses, making it a valuable tool for studying various inflammatory conditions. Its ability to influence histamine activity facilitates research into novel therapeutic strategies for related diseases. -
Anti-inflammatory Agent
Pibaxizine is an orally active anti-inflammatory agent that functions as a histamine receptor antagonist. It effectively mitigates bronchoconstriction induced by histamine, making it a valuable tool for studies related to inflammation and immunology. Pibaxizine is particularly relevant in research focused on respiratory conditions, including asthma, where it can aid in understanding inflammatory pathways and potential therapeutic interventions. -
Anti-inflammatory Agent
Dimephosphon is an anti-inflammatory agent that exhibits antihistamine and antiserotonin activity. It is effective in preserving spinal cord conduction and decreasing the excitability of spinal motor neurons near lesions. Additionally, Dimephosphon activates lymphatic vessel movement, thereby enhancing lymphatic circulation. This compound is useful in research focused on inflammatory edema, acute spinal cord injury, and lymphatic circulation disorders. -
Anti-Inflammatory Agent
Cicloprofen is a non-steroidal anti-inflammatory drug (NSAID) that primarily targets cyclooxygenase (COX) enzymes, inhibiting prostaglandin synthesis. This compound demonstrates significant anti-inflammatory and analgesic activities, making it effective for alleviating pain and inflammation in various conditions. Its applications in biochemical research include studies on pain pathways and the mechanism of action of NSAIDs in inflammation management. -
Inflammatory Cell Activation Inhibitor
CI-959 is an inhibitor of inflammatory cell activation, primarily targeting signaling pathways involved in immune response modulation. It demonstrates significant anti-inflammatory and anti-allergic properties by reducing the production of reactive oxygen species in neutrophils, inhibiting neutrophil adhesion, and blocking histamine release from mast cells. CI-959 also effectively suppresses the release of inflammatory mediators, including histamine, leukotrienes, and thromboxane, from guinea pig and human lung tissues. This compound is valuable for research focused on inflammatory and allergic diseases, particularly asthma. -
Anti-Inflammatory Agent/Anti-Tumor Agent
AHR-1911 is a thiourea derivative characterized by its anti-inflammatory and anti-tumor properties, primarily functioning through inhibition of protein synthesis. This compound demonstrates potential in enhancing healing in burned skin and exhibits histamine-like effects upon intradermal administration. Research has shown that AHR-1911 can effectively inhibit tumor growth and may also lower arterial pressure in certain animal models, making it valuable for investigations into inflammation and oncology.
