Catalog No.
Product Name
Application
Product Information
Citations
-
Anti-inflammatory effect
Hericene A is a phenolic compound derived from Hericium erinaceus, demonstrating potent anti-inflammatory activity. It effectively modulates cytokine secretion, exhibiting moderate inhibition of TNF-α, IL-6, and nitric oxide (NO). This compound is valuable for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
RPR-106541 is a 17-thiosteroid that functions primarily as an anti-inflammatory agent by exerting potent glucocorticosteroid activity. It has been shown to influence carbohydrate and lipid metabolism, making it relevant for research in metabolic disorders and inflammatory conditions. This compound is useful for studies investigating the mechanisms of inflammation and the modulation of metabolic pathways. -
Anti-inflammatory Agent
CK-17 is a potent anti-inflammatory agent that exhibits oral bioactivity. It effectively inhibits ocular inflammation induced by lens protein, endotoxin, and IL-1, demonstrating approximately twice the potency of Prednisolone in mitigating IL-1-induced responses. This compound serves as a valuable tool for researchers investigating inflammation pathways and potential therapeutic interventions in ocular diseases. -
Anti-inflammatory Pterocarpan
1,11b-Dihydro-11b-hydroxymedicarpin is a pterocarpan derivative known for its anti-inflammatory properties. This compound exerts its biological activity by activating the Notch and Wnt canonical signaling pathways, promoting bone healing and mitigating the effects of arthritis. In preclinical models, it inhibits the expansion of TH17 cells and reduces pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17A, while simultaneously enhancing the anti-inflammatory cytokine IL-10. These characteristics make it a valuable reagent for research applications focused on inflammatory diseases and bone regeneration. -
Anti-inflammatory Agent
Corylin is an orally active flavonoid that functions as an anti-inflammatory agent, primarily targeting IL-6-induced STAT3 signaling. It exhibits multiple biological activities, including anticancer effects and the modulation of hyperlipidemia and insulin resistance. Additionally, Corylin promotes adipocyte browning and enhances lipolysis through SIRT1 or β3-AR-dependent pathways, making it a valuable tool for research in metabolic disorders and inflammation. -
Anti-inflammatory Agent
Bellidifolin is an orally active anti-inflammatory agent that demonstrates antiproliferative and antioxidant properties. It modulates crucial signaling pathways, including STAT3, PI3K-Akt, mTOR, and BRD4, while inhibiting the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exhibits significant antifibrotic effects, and offers protective benefits to the heart, liver, and nervous system. This compound is valuable for research into diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy, and ischemic cranial nerve injury. -
Anti-Inflammatory Agent
MMPP is an anti-inflammatory agent that primarily targets the inhibition of STAT3 activity. It effectively prevents lipopolysaccharide (LPS)-induced mortality by modulating the inflammatory response. This compound is useful in research focused on understanding the mechanisms of inflammation and developing therapeutic interventions for inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 92 is a porphyrin derivative that functions as an anti-inflammatory agent. This compound demonstrates significant anti-inflammatory properties, particularly in alleviating ulcerative colitis by inhibiting the STAT3-EPHX2 signaling pathway. It is a valuable tool for research into inflammation-related disorders and therapeutic interventions. -
Anti-inflammatory Agent
Fluorofenidone is an orally active anti-inflammatory agent that exhibits anti-fibrotic and antioxidant properties. It functions by downregulating ACSL4 expression, upregulating GPX4, and inhibiting the NF-κB signaling pathway, thereby alleviating inflammation and fibrosis. In preclinical models, Fluorofenidone has demonstrated efficacy in ameliorating cholestasis and fibrosis by modulating the hepatic Erk/Egr-1 signaling and TGFβ1/Smad pathways. This compound is particularly relevant for research into chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF), and non-small cell lung cancer (NSCLC). -
Antiinflammatory Agent
Resolvin D3 (RvD3) is a bioactive mediator derived from docosahexaenoic acid (DHA) with potent anti-inflammatory properties. This compound plays a crucial role in resolving inflammation, making it particularly relevant for research into inflammatory conditions such as arthritis. By modulating immune responses, Resolvin D3 facilitates the resolution of inflammation, providing insights into therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Fmoc-Leucine, an anti-inflammatory agent, functions primarily as a selective ligand for PPARγ, with a binding affinity (Ki) of 15 μM. It promotes both extracellular Ca2+ influx and intracellular Ca2+ release while exhibiting insulin-sensitizing effects with minimal fatogenic activity. This compound demonstrates unique self-assembly characteristics, forming transient gels, stable gels, or crystals/2D sheets under varying conditions. Fmoc-Leucine is valuable for research related to diabetes, colitis, and bladder cancer. -
Anti-inflammatory Agent
Hexadecanamide is a fatty acid amide that serves as an anti-inflammatory agent, exhibiting protective effects against Staphylococcus aureus and SARA-induced mastitis. It functions by suppressing S. aureus-mediated NF-κB activation and enhancing blood-milk barrier integrity. Additionally, Hexadecanamide activates PPARα and has been shown to improve sperm motility in vitro. This compound is relevant for research applications involving mastitis and asthenozoospermia. -
Anti-Inflammatory/Cancer Agent
Norathyriol is a natural metabolite derived from Mangifera, exhibiting significant anti-inflammatory and anticancer properties. It functions as a noncompetitive inhibitor of α-glucosidase with an IC50 value of 3.12 μM. Additionally, Norathyriol inhibits the peroxisome proliferator-activated receptors (PPARs) α, β, and γ, with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively. This compound demonstrates a range of biological activities, including antioxidant, antimicrobial, and antibacterial effects, making it valuable for diverse research applications in inflammation and cancer therapeutics. -
Anti-inflammatory
1-O-Hexadecylglycerol serves as an anti-inflammatory agent by upregulating PPAR-γ expression and inhibiting prostaglandin E2 (PGE2) synthesis. This compound demonstrates significant biological activity in reducing inflammation and is suitable for various research applications focused on inflammatory processes. Its efficacy is noted in oral administration, facilitating its potential use in preclinical studies and therapeutic exploration. -
Anti-inflammatory Agent
Adelmidrol is an anti-inflammatory agent that primarily targets peroxisome proliferator-activated receptor gamma (PPARγ). This compound mediates significant reductions in NF-κB translocation and COX-2 expression, contributing to its anti-inflammatory effects. Adelmidrol is utilized in research focused on inflammation pathways and therapeutic potential in various inflammatory conditions. -
Anti-Inflammatory Agent
3-Aminoisobutyric acid is an anti-inflammatory agent that exhibits both anti-inflammatory and antioxidant properties. It enhances the expression of genes associated with brown adipocytes in white adipose tissue and promotes fatty acid β-oxidation in hepatocytes. Additionally, 3-Aminoisobutyric acid mitigates insulin resistance and inflammation triggered by palmitate or a high-fat diet through an AMPK-PPARδ-dependent pathway in murine models. This compound also serves as a catabolic metabolite of thymine and valine within skeletal muscle, making it relevant for metabolic research. -
Anti-Inflammatory Agent
Romazarit, a PPARα agonist, serves as an effective anti-inflammatory agent with demonstrated antirheumatic properties. In studies, Romazarit has been shown to inhibit the development of hindpaw inflammation at a dosage of 30 mg/kg in an adjuvant arthritis model. This compound is of interest for research applications focusing on inflammatory diseases and therapeutic interventions in arthritis. -
Anti-inflammatory Agent
(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside functions as an anti-inflammatory agent. This diarylheptanol glycoside, derived from Tacca plantaginea, effectively inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 9.4 μM. Additionally, it activates PPAR transcriptional activity (EC50 = 9.9 μM) and exhibits a specific activating effect on PPAR β(δ) with an EC50 of 23.1 μM. Non-toxic to cells at tested concentrations, this compound is suitable for research on inflammatory conditions. -
Anti-inflammatory Agent
3-Demethylcolchicine is an anti-inflammatory agent known for its potent tubulin-binding activity. This colchicine metabolite effectively inhibits carrageenan-induced edema in rat paw models, making it valuable for research into inflammatory responses. Additionally, the presence of a hydroxyl group on its carbocyclic ring enhances its ability to scavenge free radicals, contributing to its therapeutic potential. 3-Demethylcolchicine serves as a key reagent in studies focused on inflammation and oxidative stress. -
Anti-inflammatory compound
U-83836E is an anti-inflammatory compound that exhibits both anti-inflammatory and antioxidant activities. It effectively reduces lung inflammation by inhibiting oxidative stress and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on asthma and lung inflammation in various animal models. -
Anti-inflammatory Agent
Kumujian A (1-Ethoxycarbonyl-β-carboline) is an anti-inflammatory agent that effectively inhibits superoxide anion generation with an IC50 of 4.87 μg/mL and elastase release with an IC50 of 6.29 μg/mL. This compound is valuable for research applications focused on understanding inflammation pathways and developing potential therapeutic strategies for inflammatory diseases. -
Nonsteroidal Anti-inflammatory Agent
Feprazone is a nonsteroidal anti-inflammatory agent that targets cyclooxygenase-2 (COX-2), exhibiting significant analgesic and antipyretic properties. This compound has been shown to mitigate oxidative stress induced by free fatty acids by reducing mitochondrial reactive oxygen species (ROS) production. Additionally, Feprazone inhibits the expression of matrix metalloproteinases MMP-2 and MMP-9, while suppressing adipogenesis and promoting lipolysis in differentiating 3T3-L1 adipocytes. It is valuable for research applications focused on atherosclerosis and obesity. -
Anti-Inflammatory Compound
Dapsone hydroxylamine (DDS-NOH) is an anti-inflammatory compound that primarily targets catalase (CAT) activity. It inhibits CAT activity and reduces the generation of reactive oxygen species, contributing to its anti-inflammatory properties. Dapsone hydroxylamine is utilized in research applications focused on oxidative stress and inflammation modulation. -
Anti-Neuroinflammatory Agent
LZWL02003 is an anti-neuroinflammatory agent that targets neuroinflammatory pathways. It demonstrates protective effects against MPP+-induced neuronal damage and significantly reduces reactive oxygen species (ROS) levels. Additionally, LZWL02003 enhances cognitive functions such as memory, learning, and physical performance in a Rotenone-induced parkinsonism model in rats. This compound is valuable for research into neurodegenerative diseases and potential therapeutic interventions. -
Anti-inflammatory Agent
3′-Oxolutein is an anti-inflammatory agent and a metabolite of dietary lutein. It effectively reduces glutamate-induced reactive oxygen species (ROS) production and pro-inflammatory cytokine secretion in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels while enhancing thiol concentrations. This compound is suitable for research focused on inflammation and oxidative stress responses. -
Anti-inflammatory Agent
Pholidotol C is a stilbene compound that serves as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. It demonstrates significant antioxidant properties, with IC50 values of 28.6 μM for NO production and 21.9 μM for DPPH free radical scavenging. Pholidotol C's mechanisms include the inhibition of NO production in activated macrophages and effective free radical scavenging. This compound is valuable for research in inflammation-related diseases and can be extracted from the dried whole plant of Pholidota chinensis. -
Anti-inflammatory Agent
Anti-inflammatory agent 21 is an orally active compound that targets the inflammatory response through its inhibitory effects on nitric oxide production, demonstrating an IC50 value of 0.76 μM. This agent induces reactive oxygen species accumulation and effectively blocks the NF-κB/MAPK signaling pathway. Research applications include investigating its potential to mitigate cartilage destruction and reduce inflammatory cell infiltration in models of arthritis. -
Anti-inflammatory Agent
Dihydromyristicin is a plant-derived flavonoid known for its potent anti-inflammatory effects. It exerts its biological activity by attenuating endotoxic inflammation through the suppression of reactive oxygen species (ROS)-mediated activation of the PI3K/Akt/NF-κB signaling pathways. This compound is valuable in research applications focusing on inflammation-related studies and potential therapeutic interventions. -
Anti-Inflammatory Agent
Linocinnamarin is a natural product derived from Fragaria ananassa Duch and functions as an anti-inflammatory agent. It demonstrates significant anti-inflammatory activity by inhibiting the antigen-stimulated increase in intracellular free Ca2+ concentration and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on inflammation pathways and the potential therapeutic effects of natural anti-inflammatory substances. -
Dual-target Anti-inflammatory Peptide
Pegtarazimod is a dual-target anti-inflammatory peptide that regulates both the complement system and neutrophil-associated inflammatory pathways. It demonstrates significant biological activity by reducing reactive oxygen species (ROS) production and lowering neutrophil elastase levels in vivo, thereby mitigating inflammatory responses. Pegtarazimod has shown improved survival rates in multiple in vivo models of acute graft-versus-host disease (aGVHD) and exhibits efficacy against herpes simplex virus type 1 infections by inhibiting the activation of the C1 complex. This reagent is applicable in research focused on aGVHD, acute pulmonary diseases, and skin infections caused by herpes simplex virus type 1. -
Antiinflammatory Agent
Timosaponin E2 is an anti-inflammatory agent that functions by inhibiting the production of reactive oxygen species. This compound demonstrates significant potential in modulating inflammatory responses, making it valuable for research in oxidative stress-related diseases and therapeutic exploration. Its biochemical properties make it a suitable candidate for further investigation in the development of anti-inflammatory therapies. -
Anti-inflammatory Agent
Zaluzanin C is a sesquiterpene lactone that acts as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting mitochondrial reactive oxygen species (mtROS) production and blocking the NF-κB signaling pathway, leading to a reduction in TNF-α levels. Additionally, Zaluzanin C has been shown to prevent the differentiation of 3T3-L1 preadipocytes into mature adipocytes, making it a valuable reagent for research in inflammation and adipogenesis. -
Anti-inflammatory Agent
8-Deoxylactucin is an orally active sesquiterpene lactone that functions as an anti-inflammatory agent by inhibiting LPS-induced nitric oxide production in RAW264.7 macrophages, with an IC50 of 4.35 μM. It exerts its effects primarily by blocking the NF-κB signaling pathway. Additionally, 8-Deoxylactucin has demonstrated hepatoprotective properties in a murine model of acute hepatitis induced by LPS and D-galactosamine. This compound is valuable for research on inflammatory diseases and liver injury mechanisms. -
Anti-inflammatory Agent
Artocarpesin is a flavonoid compound that acts as an anti-inflammatory agent. It exhibits inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) by downregulating the production of nitric oxide (NO), prostaglandin E2 (PGE2), and reactive oxygen species (ROS) through the inhibition of COX-2 and iNOS expression. Additionally, Artocarpesin impedes platelet aggregation via the modulation of cyclic nucleotides and MAPK pathways, making it a valuable reagent for research in cardiovascular diseases and inflammation-related studies. -
Anti-inflammatory Agent
3,5,6,7,8,3',4'-Heptemthoxyflavone is a flavonoid with potent anti-inflammatory properties, functioning as a CREB activator. This compound exhibits anti-tumor and neuroprotective activities by inhibiting collagenase activity and enhancing type I procollagen synthesis in human dermal fibroblast neoblast (HDFn) cells. Additionally, it promotes the expression of brain-derived neurotrophic factor (BDNF) via the cAMP/ERK/CREB signaling pathway and decreases phosphodiesterase activity in C6 glioma cells, making it a valuable tool for research in inflammation and neurobiology. -
Anti-Inflammatory Agent
Anti-inflammatory agent 33 is a potent inhibitor of the p38α MAPK pathway. It effectively suppresses nitric oxide (NO) production and reduces the expression of iNOS, COX-2, and phosphorylated p38α and MK2 in response to lipopolysaccharide (LPS) stimulation. This compound demonstrates significant anti-inflammatory activity, making it valuable for research into inflammatory processes and potential therapeutic applications. -
Inflammatory Pathway Inhibitor, Oxidative Stress Inhibitor, Cancer Pathway Inhibitor
Matairesinol is an orally active bioactive compound that functions as an inflammatory pathway, oxidative stress, and cancer pathway inhibitor. It effectively inhibits the phosphorylation of MAPK, JNK, and NF-κB, while downregulating RANKL-induced NFATc1 expression and activity, and suppressing the activation of the PI3K/AKT/FOXO1 pathway. Matairesinol is applicable in research on sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis, and various cancer models. -
Anti-Inflammatory Agent
Isodorsmanin A is an anti-inflammatory agent that effectively suppresses the production of inflammatory mediators and pro-inflammatory cytokines. This compound inhibits the phosphorylation of c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase (MAPK), contributing to its anti-inflammatory effects. Isodorsmanin A is useful in research applications focused on inflammation-related disorders and the investigation of signaling pathways involved in inflammatory responses. -
Antiinflammatory Agent
n-Butyl α-D-fructofuranoside is an anti-inflammatory agent that enhances Nrf2 activity through the activation of JNK pathways. This compound, derived from the root barks of Ulmus davidiana var. japonica, exhibits significant anti-inflammatory properties, making it a valuable tool for studying inflammation and oxidative stress in various biological systems. Its potential applications include the investigation of cellular responses to inflammation and the modulation of antioxidant pathways. -
Anti-Inflammatory Agent
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets the STIM-1, NFATc3, and MAPK pathways. It effectively scavenges free radicals and exhibits a specific inhibitory effect on oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Through upregulation of miR-185, Rhamnocitrin inhibits STIM-1-mediated store-operated calcium entry, which prevents NFATc3 translocation to the nucleus and reduces the expression of downstream inflammatory factors. Additionally, it induces heme oxygenase HO-1 expression and modulates the ERK/p38 MAPK pathway, mitigating the production of pro-inflammatory cytokines and adhesion molecules. Rhamnocitrin is suitable for research focused on endothelial-related inflammatory diseases and neuroprotection. -
Anti-Inflammatory Agent
Andrograpanin is a bioactive compound derived from Andrographis paniculata, acting primarily as an anti-inflammatory agent. This molecule demonstrates significant anti-inflammatory and anti-infectious properties, making it a valuable tool for research in inflammatory diseases and infections. Its mechanism of action enables the modulation of inflammatory pathways, providing insight for therapeutic development in related conditions. -
Anti-inflammatory/Anti-fibrotic Agent
GDC-3280 is an orally active anti-inflammatory and anti-fibrotic agent that operates primarily through the inhibition of the ASK1-p38 MAPK pathway. It effectively mitigates the inflammatory and fibrotic responses associated with silicosis and influences macrophage polarization. GDC-3280 is a valuable tool for research aimed at understanding and developing therapeutic strategies for inflammatory and fibrotic diseases. -
Anti-inflammatory Agent
Selenomethylene blue is an antioxidant with potent anti-inflammatory properties. It has been shown to effectively inhibit inflammatory paw edema in rodent models, making it a valuable tool for studying inflammation-related pathways. Its applications extend to research in chronic inflammatory conditions and potential therapeutic interventions. -
Anti-Inflammatory Agent
Comanthoside B is a flavonoid glycoside derived from the aerial parts of Ruellia tuberosa L. It exhibits significant anti-inflammatory and antiseptic properties, making it a valuable reagent for studies focused on inflammation-related pathways. Its biological activity supports its use in exploring therapeutic strategies for inflammatory conditions. -
Anti-inflammatory agent
Hentriacontane is a long-chain alkane that acts as an anti-inflammatory agent by inhibiting the NF-κB signaling pathway. Its bioactivity encompasses not only anti-inflammatory effects but also antitumor and antibacterial properties. This compound is valuable for research applications focused on inflammation modulation, cancer biology, and antimicrobial studies. -
Nonsteroidal Anti-inflammatory Agent
Oxyphenbutazone monohydrate is a nonsteroidal anti-inflammatory agent that functions as a non-selective inhibitor of cyclooxygenase (COX). It exhibits significant anti-inflammatory properties, making it a valuable reagent in pharmacological research. Additionally, Oxyphenbutazone monohydrate has been shown to selectively target and eliminate non-replicating Mycobacterium tuberculosis, highlighting its potential in tuberculosis research and therapy development. -
Anti-inflammatory Agent
5'-Methoxynobiletin is a polymethoxyflavone that acts as a potent anti-inflammatory agent. Isolated from A. conyzoides, this compound exhibits significant antinociceptive properties, making it valuable for research focused on pain management and inflammation. Its efficacy in modulating inflammatory pathways positions it as an important tool for scientists investigating anti-inflammatory mechanisms and therapeutic applications. -
Anti-inflammatory compound
Batatasin I is an anti-inflammatory compound derived from the tuberous roots of Dioscorea batatas. This natural product exhibits notable antifungal activity and has been shown to modulate inflammatory processes. Batatasin I is applicable in research focused on inflammatory diseases and may serve as a lead compound for the development of new therapeutic agents in this area. -
Anti-inflammatory Agent
Methylarbutin functions as an anti-inflammatory agent, demonstrating significant anti-inflammatory properties. It has been shown to possess urinary antiseptic activity, making it a useful compound in research focused on inflammatory conditions and urinary tract health. Methylarbutin can be utilized in studies aimed at elucidating mechanisms involved in inflammation and infection. -
Anti-inflammatory/immunomodulator
Isozaluzanin C is a dehydrozaluzanin C derivative that acts as an anti-inflammatory agent and immunomodulator. Isolated from Saussurea lappa, it has demonstrated the ability to ameliorate tissue damage in various organs, including the lung, kidney, and liver, in murine models of LPS-induced or CRKP infection. This compound is valuable for research on bacterial infections and sepsis, providing insights into the mechanisms underlying inflammatory responses.
