Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Anti-inflammatory agent 46, a potent nitric oxide (NO) inhibitor, targets inducible nitric oxide synthase (iNOS) to modulate inflammatory responses. This compound demonstrates significant anti-inflammatory activity, effectively reducing swelling in murine models at a dosage of 10 mg/kg. It is a valuable tool for researching the mechanisms of inflammation and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Triterpenoid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is an anti-inflammatory triterpenoid that effectively inhibits nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated Raw264.7 macrophages. This compound is particularly relevant for research investigating the modulation of inflammatory pathways, making it a valuable tool for studies focused on inflammatory diseases and therapeutic development. Its mechanism of action supports exploration into potential anti-inflammatory therapies. -
Anti-inflammatory Agent
Anti-inflammatory agent 80 (Compound 2/2f) is an effective anti-inflammatory compound that also exhibits notable anti-tumor activity. Isolated from Cynanchum limprichtii Schltr., this agent is valuable for research in inflammation and cancer biology. Its ability to modulate inflammatory responses makes it a potential candidate for further studies in therapeutic applications related to inflammatory diseases and tumor progression. -
Anti-Inflammatory Agent
Randaiol is an anti-inflammatory agent derived from the stem bark of Magnolia officinalis, exhibiting significant antioxidant properties. This compound effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide production, thereby mitigating inflammatory responses. Randaiol is valuable for research applications focused on inflammation pathways and oxidative stress regulation. -
Anti-inflammatory Agent
Scutebarbatine X is a neo-clerodane diterpenoid derived from Scutellaria barbatae, exhibiting significant anti-inflammatory activity. This compound has been shown to modulate inflammatory pathways, making it a valuable tool for investigating inflammatory diseases. Research applications include studying cellular responses in inflammation and evaluating potential therapeutic interventions for associated disorders. -
Inflammatory Pathway Inhibitor
(E)-Sinapoyl glucose is an inhibitor of inflammatory pathways, specifically targeting nitric oxide (NO) production. It demonstrates an IC50 value of 38.32 µM in RAW 264.7 macrophage cells, highlighting its potential in modulating inflammatory responses. This compound is valuable for research into inflammatory diseases and their underlying mechanisms. -
Anti-inflammatory Agent
Tetrandrine 2'-N-α-oxide is a bisbenzylisoquinoline alkaloid known for its anti-inflammatory properties. Isolated from the roots of Stephania tetrandra, this compound may be utilized in studies investigating inflammatory diseases and their underlying mechanisms. Its ability to modulate inflammatory pathways makes it a valuable tool for researchers in the field of inflammatory responses. -
Anti-Inflammatory Agent
Morachalcone A is a naturally occurring compound that functions as an aromatase inhibitor, exhibiting an IC50 value of 4.6 mM. It possesses significant anti-inflammatory and potential anticancer activities by inhibiting lipopolysaccharide-induced nitric oxide production. Morachalcone A is valuable for research focused on inflammation and cancer biology. -
Anti-inflammatory Agent
2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone is an acetophenone derivative primarily functioning as an anti-inflammatory agent. It exhibits significant anti-inflammatory and antioxidant activities, including the inhibition of LPS-induced nitric oxide production with an IC50 of 34.5 μM, and a SC50 value of 0.15 mM for DPPH free radical scavenging. This compound is valuable for investigating mechanisms underlying inflammation and oxidative stress in various research settings. -
Anti-inflammatory Agent
12-Acetoxyganoderic acid D is a triterpenoid compound derived from Ganoderma sinense, primarily known for its anti-inflammatory properties. It effectively inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, demonstrating its potential as a therapeutic agent. This compound is valuable for research in inflammation and related biological pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 19 is a potent anti-inflammatory agent that targets HMGB1-induced inflammation. With an IC50 of 36.00 μM, it effectively inhibits the downstream inflammatory response, making it a valuable tool in the study of chronic inflammatory conditions. This compound is suitable for research applications related to inflammatory diseases, including COVID-19 and sepsis. -
Anti-inflammatory Agent
Apterin is a natural compound that functions as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. In RAW264.7 cells, Apterin demonstrates significant inhibitory activity with an IC50 value of 41.8 μM. This compound is useful for research focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Anti-inflammatory Agent 65 is a Hederagonic acid derivative that exhibits significant anti-inflammatory activity. This compound effectively inhibits the release of nitric oxide (NO) and prevents the nuclear translocation of IRF3 and p65. By disrupting the STING/IRF3/NF-κB signaling pathway, Anti-inflammatory Agent 65 significantly reduces the inflammatory response, making it a valuable tool for studying inflammation-related conditions and potential therapeutic interventions. -
Anti-inflammatory Agent
Anti-inflammatory agent 63 is an anti-inflammatory compound that specifically inhibits nitric oxide (NO) production in RAW264.7 cells induced by lipopolysaccharide (LPS), with an EC50 value of 5.33±0.57 μM. This reagent is valuable for research applications focused on inflammation mechanisms and the modulation of immune responses. Its potency makes it a useful tool for investigating potential therapeutic strategies against inflammatory diseases. -
Anti-inflammatory Agent
1-O-Caffeoylglycerol is an anti-inflammatory compound derived from Sorghum bicolor. It demonstrates significant inhibition of LPS-induced nitric oxide production, with an IC50 value of 18.5 μM, and effectively reduces iNOS protein expression in a dose-dependent manner. This reagent is suitable for studies focused on inflammatory conditions and the exploration of potential therapeutic applications in related research fields. -
Non-steroidal Anti-inflammatory Agent
Pirprofen is an orally active non-steroidal anti-inflammatory agent that functions as a reversible inhibitor of prostaglandin synthetase. Its key biological activities include anti-inflammatory, analgesic, and antipyretic effects, while also inhibiting leucocyte chemotaxis and the secondary phase of platelet aggregation triggered by collagen and arachidonic acid. This compound is of particular interest for research focused on inflammatory diseases and associated mechanisms. Note that pirprofen may also induce hepatotoxicity, warranting careful consideration in experimental applications. -
Anti-Inflammatory Agent
Apyramide is an anti-inflammatory agent that acts as a prodrug of indomethacin. It serves as a potent and nonselective inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting significant blood-brain barrier permeability. Apyramide is primarily utilized in research applications focused on inflammation modulation and pain relief. -
Anti-inflammatory agent
Ketoprofen (lysinate) is a non-steroidal anti-inflammatory agent primarily targeting cyclooxygenase enzymes. It exhibits potent inhibitory activity with IC50 values of 2 nM for COX-1 and 26 nM for COX-2. This compound is valuable for research applications in inflammation, immunology, and metabolic diseases such as obesity, making it an essential tool for exploring pathways in these biological contexts. -
Anti-inflammatory Compound
Amfenac sodium is an orally active anti-inflammatory compound known for its potent analgesic and antipyretic properties. It acts by inhibiting the cyclooxygenase enzymes, thereby reducing inflammatory responses. This reagent is valuable for research applications related to both acute and chronic inflammation, facilitating a deeper understanding of inflammatory pathways and potential therapeutic interventions. -
Anti-inflammatory Agent
Daturaolone is a natural triterpenoid known for its anti-inflammatory properties. It primarily exerts its biological activity through inhibitory effects on COX-1, which plays a crucial role in inflammatory responses. This compound is of interest in research applications focused on understanding and developing therapies for pain management and various inflammatory conditions. -
Anti-inflammatory Agent
AHR-6293 is a potent anti-inflammatory agent that functions primarily through modulation of the aryl hydrocarbon receptor (AhR). This compound demonstrates superior anti-inflammatory effects compared to its predecessor AHR-5850, making it a valuable tool in the study of inflammatory pathways. AHR-6293 is not indicated for the inhibition of platelet aggregation, allowing for specific applications in inflammation research and therapeutic exploration. -
Anti-inflammatory Compound
Isoscoparin-7-O-glucoside is a flavonoid compound with a primary mechanism of COX-2 inhibition, demonstrating notable anti-inflammatory properties. This compound has a significant positive correlation with total phenolic content, suggesting its potential efficacy in reducing inflammation. Isoscoparin-7-O-glucoside is suitable for research applications focused on the mechanistic understanding of inflammatory processes. -
Anti-inflammatory Agent
COX-2/NO-IN-1 is an orally bioavailable inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), demonstrating an IC50 of 3.52 μM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research in inflammation-related pathways and therapeutic interventions for various inflammatory diseases. Its dual inhibition of iNOS and COX-2 positions COX-2/NO-IN-1 as a promising candidate for studies aimed at understanding and mitigating inflammatory responses. -
Anti-inflammatory Compound
Amfenac is a potent anti-inflammatory compound that exhibits antipyretic and analgesic properties. This orally active agent is primarily utilized in research related to acute and chronic inflammation, providing insights into inflammation-related mechanisms and potential therapeutic interventions. -
Anti-inflammatory Agent
Loxoprofenol-SRS tromethamine is an active metabolite of Loxoprofen that functions as a non-steroidal anti-inflammatory drug (NSAID). It exhibits potent anti-inflammatory and analgesic properties, making it suitable for various research applications in inflammation and pain management studies. This compound offers the advantages of intravenous administration, ensuring rapid action in therapeutic contexts. -
Anti-inflammatory Agent
Glucametacine is an anti-inflammatory agent that primarily targets cyclooxygenase enzymes. It exhibits significant anti-inflammatory activity, making it suitable for research involving the modulation of pain and inflammation pathways. This compound can be utilized in various biological studies focusing on chronic inflammatory conditions and related therapeutic approaches. -
Anti-Inflammatory Agent
COX-2-IN-32 is a potent inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), primarily targeting inflammatory pathways. This compound demonstrates significant anti-inflammatory activity by reducing the production of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with an IC50 value of 11.2 μM. COX-2-IN-32 is useful for research applications focused on inflammation and related signaling pathways. -
Anti-Inflammatory Agent
Loxoprofen sodium (dihydrate) is a non-steroidal anti-inflammatory agent that functions primarily as a nonselective inhibitor of cyclooxygenase (COX) enzymes. It exhibits significant analgesic and antipyretic properties, with IC50 values of 6.5 μM for COX-1 and 13.5 μM for COX-2. Loxoprofen sodium has demonstrated the ability to reduce atherosclerosis and possesses antitumor activity, making it a valuable compound for research in inflammation, pain management, and cancer therapeutics. -
Non-Steroidal Anti-Inflammatory Agent
AHR-10037 is a non-steroidal anti-inflammatory agent that exhibits low gastric toxicity. As a prodrug, it is converted in vivo to a cyclooxygenase inhibitor, effectively reducing inflammation and pain. This compound is useful in the study of inflammatory conditions and related therapeutic applications. -
Anti-inflammatory Agent
Tiaprofenic acid-d3 is a deuterium-labeled derivative of Tiaprofenic acid, a nonsteroidal anti-inflammatory drug (NSAID) that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity and is utilized in the treatment of various rheumatic diseases. Tiaprofenic acid-d3 is particularly useful in research applications involving metabolic studies and pharmacokinetic investigations of NSAIDs. -
Antioxidant/Anti-inflammatory/Antipyretic/Analgesic Agent
β-Selinene is a sesquiterpene that acts as a potent antioxidant, anti-inflammatory, antipyretic, and analgesic agent. It demonstrates significant antioxidant activity by scavenging free radicals and chelating pro-oxidative metal ions. Additionally, β-selinene inhibits cyclooxygenase (COX) activity and reduces the synthesis of pro-inflammatory prostaglandins, contributing to its anti-inflammatory properties. Furthermore, it regulates the thermoregulatory set point in the hypothalamus while inhibiting inflammatory mediators, providing antipyretic and analgesic effects. This compound is valuable for research applications focused on oxidative stress, inflammation, and pain management. -
Anti-inflammatory Agent
Isonixin is a non-steroidal anti-inflammatory agent that targets cyclooxygenase enzymes. Its primary biological activity involves the inhibition of prostaglandin synthesis, leading to reduced inflammation and pain. Isonixin is widely used in research applications focused on elucidating mechanisms of pain and inflammatory responses, making it a valuable tool for scientific studies in these areas. -
Anti-inflammatory Agent
Anti-inflammatory agent 8 is a tilomisole-based benzimidazothiazole derivative targeting the COX-2 enzyme with enhanced selectivity over COX-1, exhibiting an IC50 of 0.09 nM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into mechanisms of inflammation and related pathophysiological conditions. Its oral bioavailability supports its utility in in vivo studies. -
Anti-inflammatory Agent
Cinmetacin is an orally active anti-inflammatory agent that selectively targets cyclooxygenase (COX). Its mechanism of action involves the inhibition of prostaglandin synthesis, making it effective in modulating inflammatory responses. This compound shows promise for research applications related to inflammatory diseases, including arthritis, by providing insights into COX-mediated pathways and potential therapeutic interventions. -
Anti-inflammatory Agent
Buddlejasaponin IV is an anti-inflammatory agent that demonstrates cytotoxic effects on cancer cells. This compound modulates inflammatory pathways, making it a valuable tool in research focused on inflammation-related diseases and cancer therapies. Its biological activity supports investigations into therapeutic strategies for managing inflammation and tumorigenesis. -
Nonsteroidal Anti-Inflammatory Drug
Miroprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) that functions primarily as an analgesic. It demonstrates significant anti-inflammatory and analgesic properties, along with anti-platelet activity. Miroprofen is utilized in research applications aimed at understanding pain mechanisms and the role of inflammation in various disease models. -
Anti-inflammatory Agent
Anti-inflammatory agent 10 is a tilomisole-based benzimidazothiazole derivative designed to selectively inhibit the COX-2 enzyme over COX-1. This selectivity contributes to its anti-inflammatory properties, making it a valuable tool for research on inflammation-related pathways. Anti-inflammatory agent 10 is orally active, facilitating in vivo studies targeting inflammation and related diseases. -
Anti-inflammatory Agent
(S)-Otenaproxesul is an anti-inflammatory agent that primarily targets cyclooxygenase enzymes. It has demonstrated potential protective effects against gastric damage, making it a valuable substance for research into gastrointestinal health. This compound is suitable for studies investigating inflammation-related conditions and the development of novel therapeutic strategies. -
Nonsteroidal Anti-inflammatory Agent
Oxindanac is a nonsteroidal anti-inflammatory agent that primarily targets the inhibition of serum thromboxane B2 (TxB2) production. This compound effectively reduces edema and demonstrates significant analgesic properties. Oxindanac is utilized in research to study inflammation and pain management pathways, contributing valuable insights into therapeutic strategies for various inflammatory conditions. -
Analgesic Antiinflammatory Agent
Tomoxiprole is an analgesic anti-inflammatory agent that selectively inhibits cyclooxygenase-2, with an IC50 value of 7 nM. Its precise inhibition of this enzyme leads to reduced inflammatory responses and pain relief. Tomoxiprole is primarily utilized in research focused on pain management and the modulation of inflammatory pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 9 is a tilomisole-based benzimidazothiazole derivative that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme over cyclooxygenase-1 (COX-1). This compound demonstrates significant anti-inflammatory activity, making it a valuable tool in the study of inflammation-related pathways and therapeutic interventions. Its oral bioavailability facilitates in vivo research applications, contributing to investigations in both pharmacology and medicinal chemistry. -
Anti-inflammatory Agent
MBL-1 is an orally active anti-inflammatory agent that targets the hCOX-2 protein, demonstrating an IC50 of 5.77 μM. This compound effectively reduces the production of key pro-inflammatory mediators, including nitrogen oxide (NO), reactive oxygen species (ROS), IL-1β, and IL-18, by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 has shown protective effects against dextran sulfate sodium (DSS)-induced colitis, making it a valuable tool for research into ulcerative colitis and related inflammatory conditions. -
Anti-inflammatory Agent
NCX 2121 (NO-indomethacin) is an anti-inflammatory agent that acts primarily by inhibiting the production of pro-inflammatory mediators. It effectively inhibits the growth of PaCa-2 pancreatic cancer cells, exhibiting an IC50 value of 82 μM. This compound is utilized in research focusing on inflammation-related pathways and cancer biology. -
Anti-Inflammatory Agent
M-5011 is a potent orally active anti-inflammatory agent that targets the modulation of inflammatory pathways. This compound exhibits significant antinociceptive effects, demonstrated by its inhibition of kaolin-induced writhing in experimental models. Additionally, M-5011 effectively reduces peritoneal levels of 6-keto-PGF1 alpha while exhibiting low ulcerogenic potential. Its pharmacological profile includes notable anti-inflammatory, anti-pyretic, and analgesic properties, making it valuable for research into pain and inflammation mechanisms. -
Anti-inflammatory Effect, Antioxidant Activity
Prifelone is a di-tert-butylphenol known for its anti-inflammatory effects and antioxidant activity. It demonstrates the ability to inhibit guinea pig lung oxygenase and bovine seminal vesicle cyclooxygenase, making it a valuable tool for research into inflammatory processes and oxidative stress. Its applications include investigations into inflammation-related diseases and the development of therapeutic strategies targeting these pathways. -
Anti-Inflammatory Agent
BF389 is an orally active anti-inflammatory agent that functions as an inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), demonstrating IC50 values of 4 µg/mL for COX-1 and 8 µg/mL for COX-2. This compound exhibits significant anti-inflammatory activity making it suitable for research in arthritis and other inflammatory conditions. BF389 may serve as a valuable tool in the investigation of therapeutic strategies targeting inflammation-related pathways. -
Non-steroidal Anti-inflammatory Reagent
Piketoprofen is a non-steroidal anti-inflammatory agent primarily targeting the cyclooxygenase-2 (COX-2) enzyme. It exhibits significant analgesic and anti-inflammatory activity, making it suitable for research applications related to soft tissue rheumatism. Piketoprofen-amide, a prodrug form, offers enhanced delivery and efficacy in COX-2 inhibition, providing valuable insights into therapeutic strategies for inflammatory conditions. -
Non-steroidal Anti-inflammatory Agent
Ketoprofen sodium is a non-steroidal anti-inflammatory agent that primarily targets cyclooxygenase (COX) enzymes, demonstrating inhibitory activity with IC50 values of 2 nM for COX-1 and 26 nM for COX-2. This compound is valuable in the study of inflammatory processes, immunological responses, and metabolic disorders, including obesity. Its potent anti-inflammatory properties make it a relevant tool in research aimed at understanding and mitigating these conditions. -
Anti-Inflammatory Agent
Methylprednisolone aceponate is a glucocorticoid with a specific mechanism of action as a selective glucocorticoid receptor ligand, primarily functioning as an anti-inflammatory agent. It exhibits weak systemic effects, making it particularly useful in the treatment of localized inflammatory conditions. This compound is valuable for research applications targeting eczema and other inflammatory skin disorders, aiding in the understanding of their pathophysiology and potential treatments. -
Anti-inflammatory Agent
Isoflupredone acetate is a corticosteroid with potent anti-inflammatory properties. It modulates inflammatory responses and is utilized in research related to ketosis, musculoskeletal disorders, hypersensitivity, and various inflammatory diseases in animals such as cows, horses, and pigs. This compound serves as a valuable tool for studying the mechanisms of inflammation and therapeutic interventions in veterinary medicine.
