Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Aloesone is a phenolic compound that serves as an anti-inflammatory agent. It effectively inhibits the production of reactive oxygen species (ROS), the release of nitric oxide (NO), M1 polarization, and apoptosis in LPS-stimulated RAW264.7 cells. This compound exhibits notable anti-inflammatory and antioxidant properties, making it a valuable tool for research in inflammation and oxidative stress. -
Anti-inflammatory Agent
[D-Leu-4]-OB3 is an anti-inflammatory agent that selectively inhibits the expression of pro-inflammatory, proliferative, and metastatic genes while downregulating PD-L1 expression. Additionally, it promotes the expression of pro-apoptotic genes, contributing to its potential in cancer research. This compound is valuable for studies focused on inflammatory responses and cancer progression. -
Anti-inflammatory Agent
Delphinidin-3-sambubioside chloride is a naturally occurring anthocyanin recognized for its anti-inflammatory properties. This compound effectively inhibits the release of inflammatory factors induced by lipopolysaccharides (LPS) and demonstrates the ability to reduce hepatic lipid accumulation in high-fat diet rat models. Delphinidin-3-sambubioside chloride is extracted from Hibiscus sabdariffa L. and serves as a valuable tool for studying inflammation-related biological processes. -
Anti-inflammatory Agent
Brazilein is an anti-inflammatory agent that targets Na+,K+-ATPase with an IC50 of 500 μM. It exhibits potent neuroprotective activities by reducing iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells and modulating inflammatory cytokines such as TNF-α and IL-6. Brazilein has been shown to decrease cerebral infarction volume and enhance neurological function in models of cerebral ischemia-reperfusion injury. Additionally, it induces apoptosis in splenic lymphocytes and can affect immune responses and organ weights, making it valuable for research in neurobiology, cardiovascular health, and inflammatory disorders. -
Anti-inflammatory Agent
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that serves as an anti-inflammatory agent through the inhibition of α-glucosidase. This compound exhibits hypoglycemic properties and demonstrates chemopreventive potential by inducing apoptosis and causing G2/M phase cell cycle arrest. Its biological activities make it a valuable tool for research in inflammation and metabolic disorders. -
Anti-inflammatory Agent
Taurodeoxycholate-d6 sodium is an anionic detergent derived from bile salts, functioning primarily as an anti-inflammatory agent. This compound promotes the isolation of membrane proteins, particularly in the inner mitochondrial membrane, making it essential for studies in cellular biology. Furthermore, Taurodeoxycholate-d6 demonstrates notable anti-inflammatory and neuroprotective properties, positioning it as a valuable tool for research applications focused on inflammation and neuroprotection pathways. -
Anti-inflammatory Agent
Lactucin is a recognized anti-inflammatory agent that promotes apoptosis in cancer cells. Additionally, it exhibits analgesic, anticancer, and antimalarial properties, making it a versatile compound for various biological research applications. Its multifaceted activity provides valuable insights into potential therapeutic interventions for inflammatory diseases and cancer. -
Anticancer/Anti-inflammatory Agent
Isoangustone A is an effective anticancer and anti-inflammatory agent that promotes apoptosis and autophagic cell death in cancer cells. This compound is of interest for research applications aimed at understanding cancer biology and developing potential therapeutic strategies. Its dual action highlights its relevance in the study of cancer progression and inflammation-mediated diseases. -
Anti-Inflammatory Agent
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid known for its anti-inflammatory properties. It induces apoptosis via the reversal of mitotic exit, demonstrating significant antiplasmodial activity. This compound is valuable for research applications related to gastrointestinal disorders, inflammatory conditions such as arthritis, and various cancer types. -
Anti-inflammatory Agent
Taurodeoxycholic acid is an anionic bile salt with anti-inflammatory properties, primarily targeting inflammation pathways. It demonstrates significant neuroprotective effects and is utilized in the isolation of membrane proteins, including those from the inner mitochondrial membrane. This compound is valuable for research applications involving membrane biochemistry and neuroinflammation studies. -
Anti-inflammatory Drug
Taurochenodeoxycholic acid sodium is a bile acid derivative that exhibits anti-inflammatory properties through the modulation of immune responses. This compound has been shown to induce apoptosis and plays a significant role in reducing inflammation. Its biological activities make it a valuable reagent for research applications focused on understanding inflammatory diseases and potential therapeutic strategies. -
Anti-inflammatory Agent
Lonicerin, also known as Veronicastroside, is a flavonoid recognized for its anti-inflammatory properties. It inhibits xanthine oxidase with an IC50 of 37.4 µg/mL and suppresses alginate secretion protein (AlgE). Lonicerin demonstrates a broad spectrum of biological activities, including antimicrobial effects against Pseudomonas aeruginosa and Candida albicans, as well as antioxidant and neuroprotective effects. Its diverse applications make it valuable in research focused on inflammation, infection, and oxidative stress. -
Anti-inflammatory agent
Hederacoside C is a potent anti-inflammatory agent that targets the MAPK/NF-κB signaling pathway. It exerts its biological activity by inhibiting the activation of this pathway, resulting in a reduction of inflammation. In addition to its anti-inflammatory properties, Hederacoside C also demonstrates antibacterial activity, making it a valuable compound for research applications focused on inflammatory diseases and infections. -
Inflammatory Biomarker
8-Bromo-2'-deoxyguanosine is a halogenated DNA adduct associated with inflammation, serving as an early biomarker for oxidative tissue damage linked to inflammatory processes. Its formation precedes the generation of other oxidative and nitrative stress products and can be synthesized through the MPO-H2O2-Cl−-Br− system. This compound plays a critical role in detecting early DNA modifications using the monoclonal antibody mAb8B3, suitable for preclinical research. Additionally, its urinary levels are significantly elevated in various inflammatory disease models, making 8-Bromo-2'-deoxyguanosine valuable for investigations into inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin injuries. -
Anti-Inflammatory Agent
Vitisin A is a resveratrol tetramer with potent anti-inflammatory properties. It exerts its biological activity by inhibiting LPS-induced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production through the down-regulation of ERK1/2, p38, and NF-κB signaling pathways. Additionally, Vitisin A demonstrates antioxidative, anticancer, and neuroprotective effects while also inhibiting adipocyte differentiation. This compound is derived from the roots of Vitis vinifera and serves as a valuable reagent for research in inflammation and related diseases. -
Anti-inflammatory Agent
24-O-Acetyllycoclavanol is a triterpenoid compound that functions as an anti-inflammatory agent by selectively targeting the NF-κB and ERK1/2 signaling pathways. Its biological activity includes the inhibition of lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to decreased production of inflammatory mediators like nitric oxide (NO), IL-1β, and IL-8. This compound is particularly relevant for research applications in the context of inflammatory bowel disease (IBD) and can be isolated from the ethyl acetate extract of Lycopodium clavatum. -
Anti-inflammatory Agent
Anti-inflammatory agent 31 is a derivative of andrographolide that functions primarily by inhibiting NF-κB activation through the upstream blockade of the PI3K/Akt and ERK1/2 MAPK signaling pathways. This compound exhibits notable anti-inflammatory activity, promoting the recovery of intracellular glutathione (GSH) levels. Additionally, anti-inflammatory agent 31 demonstrates a protective effect on liver cells, making it a valuable tool for research applications in inflammation and hepatoprotection. -
Antioxidant/Anti-inflammatory/Anticancer Agent
Licoflavanone, a flavanone with antioxidant, anti-inflammatory, and anticancer properties, is isolated from the leaf extract of Glycyrrhiza glabra. It exerts its anticancer effects by downregulating the mTOR/PI3K/AKT signaling pathway, leading to inhibition of cancer cell proliferation, migration, and invasion. Additionally, Licoflavanone activates pro-apoptotic factors such as Bax and Bad, along with multiple caspase enzymes. Its anti-inflammatory activity involves reducing NF-κB nuclear translocation and decreasing the phosphorylation of p38, JNK, and ERK1/2, ultimately inhibiting pro-inflammatory cytokines, COX-2, and iNOS expression. This compound is utilized in research on nasopharyngeal carcinoma and its underlying mechanisms. -
Anti-inflammatory Agent
Centaureidin is an orally active anti-inflammatory agent derived from Bidens pilosa, exhibiting an EC50 of 0.9 μg/mL as an IFN-promoter. This compound activates the Rho signaling pathway, resulting in actin and tubulin disassembly, which leads to dendritic retraction and the formation of stress fibers in melanocytes. Centaureidin demonstrates potent inhibitory effects on tumor cell growth and has been shown to significantly reduce paw edema in murine models, highlighting its potential utility in inflammatory and anticancer research. -
Anti-inflammatory Agent
(7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one is an anti-inflammatory agent targeting hepatic stellate cells. With an IC50 of 25.2 μM against TGF-β-induced HSC-T6 cells, this compound is instrumental in studies related to liver fibrosis by inhibiting excessive cell proliferation. Isolated from the dried aerial parts of Penthorum chinense Pursh, it holds potential for research into liver fibrosis-related conditions. -
Anti-Inflammatory Agent
Triamcinolone acetonide is a potent anti-inflammatory agent that primarily targets fibroblast growth factor (bFGF) signaling pathways. It effectively inhibits bFGF-induced proliferation of retinal endothelial cells, promotes macrophage activation with anti-inflammatory properties, and reduces chondrocyte viability, contributing to cartilage degradation. This compound is valuable for research applications related to various inflammatory conditions, including atopic dermatitis. -
Anti-inflammatory Agents
Balsalazide disodium is a prodrug that releases mesalamine in the colon, primarily targeting anti-inflammatory pathways. It exhibits significant anti-inflammatory activity in conditions such as colitis and demonstrates potential anticancer effects through modulation of the IL-6/STAT3 signaling pathway. This compound is useful in research focused on gastrointestinal disorders and cancer therapy. -
Anti-inflammatory Agent
Luteolin 5-O-glucoside is a potent anti-inflammatory agent derived from Cirsium maackii. This compound effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide production and tert-butyl hydroperoxide (t-BHP)-induced reactive oxygen species generation. Additionally, Luteolin 5-O-glucoside downregulates the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages, making it valuable for research in inflammatory pathways and related conditions. -
Anti-inflammatory Agent
Ajugol is an orally active iridoid glycoside that functions as an anti-inflammatory agent. It activates TFEB-mediated autophagy and lysosomal biogenesis, contributing to its protective effects on cellular homeostasis. Ajugol demonstrates significant potential for research in conditions such as asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis due to its dual role in promoting autophagy and mitigating inflammation. -
Nonsteroidal Anti-inflammatory Agent
2-Ethoxybenzamide is a nonsteroidal anti-inflammatory agent that exhibits both analgesic and antipyretic activities. Its mechanism involves the induction of melanin synthesis through the phosphorylation of cAMP response element-binding protein (CREB). This compound is valuable for research focused on hypopigmentation and inflammation-related diseases, providing insights into therapeutic applications and biological pathways involved in these conditions. -
Anti-inflammatory Agent
Salsalate is an anti-inflammatory agent primarily targeting the modulation of cytokine expression without direct cyclooxygenase inhibition. This compound exhibits significant anti-inflammatory effects and has been shown to lower blood glucose levels, enhance insulin sensitivity, and mitigate the effects of metabolic disorders associated with high-fat diets. Salsalate is utilized in research pertaining to type 2 diabetes, atherosclerosis, and non-alcoholic steatohepatitis, demonstrating its potential in the management of metabolic disorders. -
Anti-inflammatory Agent
Anti-inflammatory Agent 58 is a potent inhibitor of IL-1β, demonstrating an IC50 of 1.08 μM. This compound effectively reduces pro-inflammatory gene expression, limits protein secretion, and inhibits NF-κB phosphorylation. It is suitable for research applications focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Pseudoginsenoside RT4 is an orally active tetracyclic triterpenoid with notable anti-inflammatory properties. It effectively reduces the levels of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, while enhancing IL-10 levels. Additionally, Pseudoginsenoside RT4 modulates gut microbiota composition, making it a valuable reagent for research related to ulcerative colitis and other inflammatory conditions. Its multifaceted mechanism of action positions it as a significant tool in the study of anti-inflammatory pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 59 is a selective inhibitor of interleukin-1 beta (IL-1β) with an IC50 of 2.28 μM. This compound effectively reduces pro-inflammatory gene expression and protein secretion while inhibiting NF-κB phosphorylation. It serves as a valuable tool in the study of inflammatory pathways and may aid in the development of new therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Acutissimalignan B is a bioactive compound recognized for its role as an anti-inflammatory agent. It effectively reduces the mRNA expression of key inflammatory cytokines, including inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). Additionally, Acutissimalignan B inhibits the phosphorylation of IκBα and the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, thereby demonstrating potential utility in neuroinflammation research and related disease models. -
Anti-inflammatory Agent
Linderaspirone A is a natural compound derived from the roots of Lindera aggregate that functions as an anti-inflammatory agent. It exhibits significant inhibitory effects on the production of pro-inflammatory mediators, including prostaglandin E2 (PGE2), TNF-α, and IL-6. This compound can be utilized in research applications focused on understanding the mechanisms of inflammation and developing therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Peptide
IIIM1 is an orally active anti-inflammatory peptide that functions by stimulating the proliferation of regulatory T cells and promoting the production of RA1. This molecule effectively ameliorates symptoms associated with experimental autoimmune encephalomyelitis (EAE) by regulating cytokine balance. IIIM1 is a valuable tool for research focused on multiple sclerosis (MS) and its underlying immunological mechanisms. -
Anti-Inflammatory Agent
Dactyllactone A is an isoquinoline alkaloid derived from Dactylicapnos scandens that functions as a potent anti-inflammatory agent. It effectively inhibits the expression of pro-inflammatory cytokines such as IL-1β and prostaglandins, including PGE2. This compound is valuable for research applications focused on inflammatory pathways and the exploration of therapeutic interventions in inflammatory diseases. -
Anti-inflammatory Agent
Lithocholic amide-C2-N(didecane) is a derivative of lithocholic acid designed as an anti-inflammatory agent. This compound exhibits the ability to spontaneously form lipid nanoparticles in aqueous environments, facilitating skin penetration and targeting deeper dermal layers. It demonstrates significant anti-inflammatory activity against psoriasis-like chronic skin conditions by inhibiting keratinocyte proliferation, downregulating mRNA expression of the EphA2 receptor, and reducing serum levels of pro-inflammatory cytokines, including IL-1α, IL-1β, and IFN-γ, through modulation of the Th17/Th2 inflammatory pathway. This makes Lithocholic amide-C2-N(didecane) a valuable tool for researching inflammatory skin disorders. -
Anti-Inflammatory Agent
Anti-inflammatory agent 102 is a selective inhibitor of the ASK1/p38 MAPKs/NF-κB signaling pathway, exerting notable anti-inflammatory effects. It significantly reduces the release of nitric oxide (NO), reactive oxygen species (ROS), and key inflammatory cytokines, including IL-6, TNF-α, and IL-1β. This compound is valuable for research applications focused on inflammatory diseases, particularly ulcerative colitis (UC). -
Anti-inflammatory/hepatoprotective Agent
Isostrictiniin is a polyphenolic compound derived from Nymphaea candida, functioning as an anti-inflammatory and hepatoprotective agent. It enhances the expression of Nrf2 and HO-1 while inhibiting Keap1, leading to the reduction of phosphorylation levels of key proteins such as JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin effectively decreases pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and PGE2, demonstrating protective effects against acute lung injury induced by LPS and acute alcoholic liver injury. Its multifaceted activities encompass anti-inflammatory, antioxidant, and anti-fibrotic properties, making it a valuable tool in biochemical research. -
Anti-inflammatory Agent
(E/Z)-3-Hydroxylicochalcone A is a flavonoid with potent anti-inflammatory properties, primarily derived from licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). This compound effectively inhibits lipid peroxidation in rat liver microsomes and has been shown to reduce the production of reactive oxygen species (ROS), nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) induced by lipopolysaccharide (LPS). Its versatile biological activity makes (E/Z)-3-Hydroxylicochalcone A a valuable reagent for research into oxidative stress and inflammation-related pathways. -
Anti-inflammatory Agent
TNF-α/IL-1β/IL-6-IN-1 is an anti-inflammatory agent that targets pro-inflammatory cytokines. It effectively downregulates the expression of TNF-α, IL-1β, and IL-6, while also inhibiting reactive oxygen species (ROS) production. Additionally, TNF-α/IL-1β/IL-6-IN-1 enhances cholesterol efflux by upregulating ABCG1. This reagent is suitable for research focused on inflammatory and lipid metabolic diseases, including atherosclerosis. -
Anti-inflammatory Agent
Olcorolimus is a derivative of Rapamycin that functions as an anti-inflammatory agent. It effectively reduces levels of IL-4 and IL-5, as well as the presence of eosinophils, neutrophils, and lymphocytes, while also inhibiting cellular fibronectin, lung epithelial cell proliferation, and mucus hypersecretion in Ovalbumin-sensitized BALB/c mice. This compound is valuable for research in the fields of inflammation and immunology, particularly for models related to asthma. -
Anti-Inflammatory Agent
Hedycoronen A is a potent anti-inflammatory agent targeting the inhibition of pro-inflammatory cytokines such as IL-6, IL-12 p40, and TNF-α. It demonstrates effective inhibitory activity in LPS-stimulated bone marrow-derived dendritic cells (BMDCs), with IC50 values of 9.1 μM, 5.6 μM, and 46.0 μM, respectively. This compound is isolated from the plant Hedychium coronarium and is valuable for research focused on inflammatory pathways and therapeutic interventions. -
Inflammatory Cytokine Inhibitor
JTE-607 free base is a selective inhibitor of inflammatory cytokine synthesis, targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3). This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10, in LPS-stimulated human peripheral blood mononuclear cells (PBMCs), achieving IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 free base demonstrates potential utility in research aimed at understanding and mitigating inflammatory responses, particularly in the context of endotoxin shock. -
Anti-inflammatory Agent
Polyandric acid A is a clerodane diterpenoid identified for its anti-inflammatory properties. It is derived from the Australian medicinal plant D. polyandra and has been shown to inhibit the secretion of pro-inflammatory cytokines. This compound has potential applications in research focused on inflammation-related pathways and therapeutic interventions for inflammatory diseases. -
Anti-inflammatory effect
Hericene A is a phenolic compound derived from Hericium erinaceus, demonstrating potent anti-inflammatory activity. It effectively modulates cytokine secretion, exhibiting moderate inhibition of TNF-α, IL-6, and nitric oxide (NO). This compound is valuable for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
RPR-106541 is a 17-thiosteroid that functions primarily as an anti-inflammatory agent by exerting potent glucocorticosteroid activity. It has been shown to influence carbohydrate and lipid metabolism, making it relevant for research in metabolic disorders and inflammatory conditions. This compound is useful for studies investigating the mechanisms of inflammation and the modulation of metabolic pathways. -
Anti-inflammatory Agent
CK-17 is a potent anti-inflammatory agent that exhibits oral bioactivity. It effectively inhibits ocular inflammation induced by lens protein, endotoxin, and IL-1, demonstrating approximately twice the potency of Prednisolone in mitigating IL-1-induced responses. This compound serves as a valuable tool for researchers investigating inflammation pathways and potential therapeutic interventions in ocular diseases. -
Anti-inflammatory Pterocarpan
1,11b-Dihydro-11b-hydroxymedicarpin is a pterocarpan derivative known for its anti-inflammatory properties. This compound exerts its biological activity by activating the Notch and Wnt canonical signaling pathways, promoting bone healing and mitigating the effects of arthritis. In preclinical models, it inhibits the expansion of TH17 cells and reduces pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17A, while simultaneously enhancing the anti-inflammatory cytokine IL-10. These characteristics make it a valuable reagent for research applications focused on inflammatory diseases and bone regeneration. -
Anti-inflammatory Agent
Corylin is an orally active flavonoid that functions as an anti-inflammatory agent, primarily targeting IL-6-induced STAT3 signaling. It exhibits multiple biological activities, including anticancer effects and the modulation of hyperlipidemia and insulin resistance. Additionally, Corylin promotes adipocyte browning and enhances lipolysis through SIRT1 or β3-AR-dependent pathways, making it a valuable tool for research in metabolic disorders and inflammation. -
Anti-inflammatory Agent
Bellidifolin is an orally active anti-inflammatory agent that demonstrates antiproliferative and antioxidant properties. It modulates crucial signaling pathways, including STAT3, PI3K-Akt, mTOR, and BRD4, while inhibiting the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exhibits significant antifibrotic effects, and offers protective benefits to the heart, liver, and nervous system. This compound is valuable for research into diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy, and ischemic cranial nerve injury. -
Anti-Inflammatory Agent
MMPP is an anti-inflammatory agent that primarily targets the inhibition of STAT3 activity. It effectively prevents lipopolysaccharide (LPS)-induced mortality by modulating the inflammatory response. This compound is useful in research focused on understanding the mechanisms of inflammation and developing therapeutic interventions for inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 92 is a porphyrin derivative that functions as an anti-inflammatory agent. This compound demonstrates significant anti-inflammatory properties, particularly in alleviating ulcerative colitis by inhibiting the STAT3-EPHX2 signaling pathway. It is a valuable tool for research into inflammation-related disorders and therapeutic interventions.
