Catalog No.
Product Name
Application
Product Information
Citations
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Immunosuppressant/Anti-inflammatory Agent
Umirolimus is a macrocyclic triene lactone derivative of Rapamycin that functions as a potent immunosuppressant and anti-inflammatory agent. Its high lipophilicity enhances its efficacy in targeted drug delivery systems, making it suitable for use in drug-eluting stents (DES). Umirolimus is utilized in various research applications focused on transplantation, cardiovascular interventions, and inflammatory disease models. -
Anti-inflammatory Agent
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) primarily functions as an anti-inflammatory agent. This bioactive compound, derived from Eupatorium odoratum, demonstrates significant anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor properties. It modulates the NF-κB signaling pathway to exert its anti-inflammatory effects and enhances coagulation time through the endogenous coagulation pathway. Additionally, Scutellarein tetramethyl ether has been shown to inhibit the proliferation of HepG2 liver cancer cells, with an IC50 value of 20.08 μg/mL, making it relevant for cancer research and therapeutic studies. -
Anti-Inflammatory Agent
Ramifenazone, a pyrazole derivative, functions as a non-steroidal anti-inflammatory agent (NSAID) primarily through the inhibition of cyclooxygenase enzymes, leading to reduced prostaglandin synthesis. It exhibits significant analgesic, antipyretic, anti-inflammatory, and antimicrobial activities, making it valuable for various research applications in inflammation and pain management studies. Its multifaceted properties support its use in investigating therapeutic approaches for inflammatory diseases and related conditions. -
Anti-inflammatory Agent
2′-Hydroxygenistein is an anti-inflammatory compound derived from the natural sources Crotalaria pallida and C. assamica. It demonstrates concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, exhibiting IC50 values of 5.9 ± 1.4 μM and 9.7 ± 3.5 μM, respectively. This compound serves as a valuable tool for research applications in inflammation studies and the modulation of immune responses. -
Anti-inflammatory/Antimicrobial Agent
Myricetin 3-O-glucoside, a flavonol derived from Tibouchina paratropica and Hakmeitau beans, primarily functions as an anti-inflammatory and antimicrobial agent. This compound demonstrates notable anti-Leishmanial activity, making it a valuable tool for studying inflammatory pathways and infectious diseases in research. Its diverse biological properties contribute to investigations in pharmacology and natural product chemistry. -
Antiviral/Anti-inflammatory Agent
Retusin, also known as Quercetin-3,3',4',7-tetramethylether, is a natural compound derived from the leaves of Talinum triangulare. It exhibits antiviral and anti-inflammatory properties, making it a valuable reagent for research into viral infections and inflammatory conditions. This compound’s dual activity supports investigations aimed at elucidating the mechanisms underlying viral pathogenesis and the inflammatory response. -
Anti-inflammatory Agent
Morelloflavone is an anti-inflammatory agent that exhibits significant antioxidative and antiviral properties. This compound has been shown to modulate inflammatory pathways, making it valuable for research into inflammatory diseases and potential therapeutic applications. Its diverse biological activities make Morelloflavone a relevant candidate for studies focused on oxidative stress and inflammation-related mechanisms. -
Anti-Inflammatory Agent
Triptohypol C is a Tripterin derivative that functions as a potent anti-inflammatory agent by specifically targeting Nur77. It exhibits a Kd value of 0.87 μM, facilitating the modulation of inflammatory responses through enhanced interactions between Nur77 and TRAF2 as well as p62/SQSTM1. This compound is valuable for research applications focusing on inflammation and related signaling pathways. -
Anti-inflammatory and Analgesic Agent
Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent that selectively reduces the pro-inflammatory cytokine TNF-α. This compound demonstrates efficacy in alleviating various forms of pain, including neuropathic and inflammatory pain, as well as reducing croton oil-induced ear edema. Additionally, Deoxyartemisinin exhibits anti-ulcer properties, making it a valuable tool for research focused on inflammatory diseases, pain management, and gastric ulcers. -
Anti-Neuroinflammatory Agent
7-Deoxy-trans-dihydronarciclasine is an alkaloid that serves as an anti-neuroinflammatory agent through its inhibition of the tobacco mosaic virus (TMV), exhibiting an IC50 of 1.80 μM. This compound has demonstrated a reduction in amyloid-beta (Aβ) and amyloid precursor protein (APP) levels within the cerebral cortex of Tg2576 mice. Its properties make it a valuable tool for research into neuroinflammation and related pathways in neurodegenerative conditions. -
Anti-inflammatory Agent
NAA-004 is a novel azo compound that acts as an anti-inflammatory agent by linking 5-aminosalicylic acid and 4-aminophenylacetic acid through an azo bond. It demonstrates significant oral bioactivity and effectively inhibits colon damage, intracavitary fluid accumulation, and myeloperoxidase (MPO) activity. This compound is suitable for research applications focused on colitis and related gastrointestinal disorders. -
Anti-inflammatory Agent
Asperilin is a sesquiterpene lactone known for its anti-inflammatory properties, acting as a hydroxyl radical scavenger. This compound has been shown to increase lipid peroxidation levels in liver microsomes while significantly reducing liver glutathione (GSH) levels and enhancing glutathione peroxidase (GPx) activity. Asperilin is suitable for research focused on inflammatory conditions and related biochemical pathways. -
Anticancer/anti-inflammatory Agent
(rel)-Salcolin A is a flavonoid lignan recognized for its anticancer and anti-inflammatory properties. It demonstrates significant cytotoxicity against anaplastic thyroid carcinoma (HTH83) and papillary thyroid carcinoma (TPC1) cells, with IC50 values of 66.69 μM and 56.12 μM, respectively. Additionally, (rel)-Salcolin A effectively inhibits LPS-induced nitric oxide production with an IC50 of 14.65 μM. This compound induces necroptosis in thyroid cancer cells and offers neuroprotective effects against glutamate-induced damage, with an E50 value of 47.44 μM. It is suitable for research applications involving thyroid cancer, inflammation, and neuroprotection and can be derived from the leaves of Casearia arborea and the stems of Zea mays. -
Anti-inflammatory Agent
Betulonaldehyde is a pentacyclic triterpenoid primarily known for its anti-inflammatory properties. It exhibits potent antiplasmodial activity with an IC50 of 3.36 µg/mL and demonstrates cytotoxic effects against NCI H187 lung cancer cells and Vero cells, with IC50 values of 19.23 and 17.09 µg/mL, respectively. Additionally, Betulonaldehyde effectively inhibits inflammation induced by Phorbol 12-myristate 13-acetate in murine models, making it a valuable compound for research in inflammatory responses and cancer biology. -
Anti-inflammatory Quassinoid
Shinjulactone M is a quassinoid with potent anti-inflammatory properties, primarily targeting inflammatory pathways. This compound is isolated from various parts of Ailanthus species and has demonstrated beneficial effects in research related to chronic bronchitis, epilepsy, and asthma. Additionally, it possesses febrifuge and anthelmintic activities, making it a valuable reagent for studies exploring its therapeutic potential in inflammatory and infectious diseases. -
Antiviral/Anti-Inflammatory Glycoprotein
Lactoferrin from Bovine Milk is a multifunctional iron-binding glycoprotein that exhibits antiviral and anti-inflammatory properties. Released by neutrophils, it plays a crucial role in inhibiting microbial and viral adhesion, as well as entry into host cells. This compound is also known to prevent cell adhesion and growth, contributing to its potential anti-cancer and immunomodulatory effects. Lactoferrin is widely applied in research focused on immune response modulation and pathogen resistance. -
Anti-inflammatory Agent
Astin C is a cyclopeptide derived from Aster tataricus that acts as an anti-inflammatory agent. It specifically inhibits the cGAS-STING signaling pathway, preventing the recruitment of IRF3 to the STING signalosome, thereby modulating the innate inflammatory response. Astin C is valuable for research into autoimmune diseases and cancer, making it a key reagent for studying inflammation-related mechanisms. -
Anti-inflammatory/Antiinfection Agent
Forsyshiyanine A is a triterpenoid alkaloid known for its anti-inflammatory and antiviral properties. It effectively inhibits the release of β-glucuronidase from rat polymorphonuclear leukocytes, thereby demonstrating notable anti-inflammatory activity. Forsyshiyanine A also exhibits antiviral efficacy, with an EC50 of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 of 7.3 μM against influenza A virus (H1N1), reducing viral load through disruption of viral replication and entry. This compound is valuable for research in the fields of inflammation and infection. -
Anti-Inflammatory Agent
Agathisflavone is a flavonoid compound primarily recognized for its anti-inflammatory properties. It exhibits a range of biological activities, including antioxidant, antiviral, antiparasitic, cytotoxic, neuroprotective, and hepatoprotective effects. Research indicates that Agathisflavone may enhance tissue repair processes, particularly in spinal cord injury models in rodents, making it a valuable reagent for studies in inflammation and regenerative medicine. -
Anti-inflammatory/Hemostatic Agent
Ethyl 10-bromodecanoate is an anti-inflammatory and hemostatic agent that targets pathways involved in inflammation and blood coagulation. It is structurally related to linolenic acid and exhibits notable antibacterial properties, making it a valuable compound for research into inflammatory responses and hemostasis. This reagent is suitable for studies focused on elucidating the molecular mechanisms of anti-inflammatory effects and potential therapeutic applications in hemostatic disorders. -
Anti-inflammatory Agent
1-Terpineol is a lipid-soluble monoterpenoid alcohol recognized for its anti-inflammatory properties. This compound exhibits significant antibacterial and antioxidant activities, making it valuable for various research applications. It is commonly explored in studies related to inflammation and oxidative stress management. -
Antimicrobial and Anti-inflammatory Agent
1-Hydroxy-2-methylanthraquinone targets various biological pathways as an antimicrobial and anti-inflammatory agent. This compound demonstrates significant antimicrobial and antioxidant properties, making it useful for studies related to infection control and inflammation modulation. Its pesticidal activity further broadens its applicability in agricultural research and product development. -
Anti-inflammatory Agent
Anti-inflammatory agent 14, also known as compound 28, is a potent anti-inflammatory compound that inhibits inflammation-related pathways. It exhibits a minimum inhibitory concentration (MIC50) of 2 μM against Mycobacterium tuberculosis strain H37Rv, demonstrating significant antibacterial properties. This reagent is valuable for research applications focused on anti-inflammatory therapies and tuberculosis studies. -
Anti-inflammatory Agent
2-Methyldecalin is a chemical compound known for its anti-inflammatory properties. It exhibits significant antioxidant and antibacterial activities, making it a valuable reagent for studies related to inflammatory conditions. This compound is suitable for various research applications aimed at understanding and mitigating inflammation-related disorders. -
Anti-inflammatory Agent
Vasicinolone is a natural alkaloid that functions primarily as an anti-inflammatory agent. It demonstrates significant anti-inflammatory and antimicrobial activity, making it valuable for research applications related to inflammation and infection. Its potential use in therapeutic development highlights its importance in the study of chronic inflammatory conditions. -
Anti-inflammatory Agent
Anti-inflammatory agent 94 (compound 4b) is a potent cannabinoid ligand targeting the CB1 and CB2 receptors, exhibiting Kis of 29 nM and 8 nM, respectively. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for studying inflammation-related processes. Its application in research may enhance understanding of cannabinoid signaling and its therapeutic potential in inflammatory conditions. -
Inflammatory Peptide
Peptide 78 is an inflammatory peptide that functions as a chemotactic cytokine, belonging to the IL-8 or C-X-C chemokine supergene family. This 78 amino acid protein is essential for the recruitment of neutrophils to sites of inflammation, particularly in rheumatoid arthritis (RA) pathology. Its role in promoting neutrophil migration makes Peptide 78 a valuable tool for research into inflammatory diseases and immune responses. -
Anti-inflammatory agent
Emorfazone is a non-steroidal anti-inflammatory drug that functions primarily through the inhibition of bradykinin-like substances and kininogen release. This compound exhibits notable anti-inflammatory and analgesic properties, making it a valuable tool for research on pain management and inflammatory conditions. Its oral activity further expands its application in pharmacological studies aimed at understanding inflammatory pathways. -
Non-steroidal Anti-inflammatory Agent
Zoliprofen is a non-steroidal anti-inflammatory agent that primarily acts by antagonizing bradykinin, leading to significant suppression of bradykinin-induced edema and pain responses. It also exhibits a moderate inhibitory effect on arachidonic acid-induced edema and pain, while additionally inhibiting PGE2 synthesis in bovine vesicular gland microsomes. This dual action makes Zoliprofen a valuable tool for research applications focused on pain management and inflammatory processes. -
Anti-inflammatory Agent
3-Hydroxyxanthone is a xanthone compound recognized for its anti-inflammatory properties. It effectively inhibits NADPH-catalyzed lipid peroxidation in human umbilical vein endothelial cells (HUVECs) and suppresses TNF-alpha-induced ICAM-1 expression. This compound is utilized in research focused on understanding inflammatory processes and vascular endothelial function. -
Anti-Inflammatory Agent
Cholesterol sulfate is a naturally occurring cholesterol derivative that functions as a DOCK2 inhibitor, exhibiting IC50 values of 2 μM for mouse targets and 2.9 μM for human targets. This compound shows significant anti-inflammatory activity by limiting neutrophil infiltration and mitigating intestinal inflammation and damage. Additionally, it activates protein kinase C (PKC), facilitating squamous cell differentiation and inhibiting skin carcinogenesis. Cholesterol sulfate is relevant for research applications in conditions such as actinic keratitis, ulcerative colitis, and skin cancer, and it plays a role in regulating cholesterol homeostasis and cellular metabolism via the AMPK-Sirt1 pathway. -
Anti-neuroinflammatory Agent
SB26019 is a potent anti-neuroinflammatory agent that primarily targets NF-κB activation. It functions by promoting the formation of monomeric α-tubulin, which in turn inhibits the translocation of the p65 subunit of NF-κB. This mechanism underscores its potential application in neuroscience research, particularly in studies related to neuroinflammation and associated disorders. -
Anti-inflammatory Agent
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside that acts as an anti-inflammatory agent by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, demonstrating 56.9% inhibition at a concentration of 25 μg/mL. This compound can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia, a member of the Rosaceae family. Due to its biological activity, it is of interest in research focused on inflammation and immune response modulation. -
Anti-inflammatory Drug
Regaloside A is a phenylpropanoid with notable anti-inflammatory properties. It demonstrates significant DPPH radical scavenging activity, with a measured efficacy of 58.0% at a concentration of 160 ppm. This compound is useful in investigating anti-inflammatory mechanisms and for potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Ciwujianoside C3 is an orally active compound that functions as an anti-inflammatory agent. Isolated from the leaves of Acanthopanax henryi Harms, this reagent demonstrates significant anti-inflammatory properties while also enhancing object recognition memory. Its biological activity supports research in neuroprotection and cognitive enhancement studies. -
Anti-inflammatory Drug
Ikarisoside A is a natural flavonol glycoside known for its anti-inflammatory properties. This compound exhibits significant activity in reducing inflammation, making it valuable for research focused on inflammatory diseases and related therapeutic applications. Its mechanism of action may involve the modulation of inflammatory pathways, providing insights for the development of new anti-inflammatory treatments. -
Anti-inflammatory Agent
Damnacanthol is a natural product derived from Damnacanthus major, acting primarily as an anti-inflammatory agent. It exhibits potent anti-15-lipoxygenase activity and effectively inhibits nitric oxide production in LPS-activated RAW 264.7 macrophage cells. This compound is suited for research applications focused on inflammation and related pathways. -
Anti-inflammatory Agent
Cauloside D is a triterpene glycoside derived from Caulophyllum robustum Max, known for its potent anti-inflammatory properties. It modulates inflammatory responses by inhibiting the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines. This compound serves as a valuable tool for research into inflammatory diseases and therapeutic interventions targeting inflammatory pathways. -
Anti-inflammatory Agent
5,7,8-Trimethoxyflavone is a flavonoid compound known for its anti-inflammatory properties. Isolated from Andrographis echioides, this compound effectively inhibits nitric oxide (NO) production with an IC50 of 39.1 μM. It is utilized in research applications focused on understanding the mechanisms of inflammation and exploring potential therapeutic avenues for inflammatory diseases. -
Anti-Inflammatory Agent
Amaroswerin is a bioactive secoiridoid glucoside derived from Swertia mussotii, acting primarily as an anti-inflammatory agent. It exhibits multiple biological activities, including anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory effects. Amaroswerin effectively inhibits nitric oxide (NO) release in RAW264.7 cells, demonstrating an IC50 value of 5.42 μg/mL, making it a valuable tool for research in inflammation and related health conditions. -
Anti-inflammatory Agent
(+)-Rhododendrol is an anti-inflammatory compound primarily known for its ability to inhibit nitric oxide (NO) production. This property makes it a valuable reagent in research focused on inflammatory processes and related pathways. Its use is particularly relevant in studies investigating the mechanisms of inflammation and potential therapeutic interventions. -
Anti-inflammatory Agent
Anti-inflammatory agent 18, an established anti-inflammatory agent, demonstrates inhibitory activity with an IC50 of 15.94 μM against HMGB1-induced later inflammation. This compound is valuable in research applications focused on later inflammatory diseases, including coronavirus-related conditions such as COVID-19 and sepsis. Its mechanism of action supports investigations into potential therapeutic strategies for managing chronic inflammatory responses. -
Anti-inflammatory Agent
2α-Acetoxy-14,15-cyclopimara-7β,16-diol is an anti-inflammatory agent that demonstrates a unique mechanism by inhibiting nitric oxide (NO) production in LPS-induced RAW264.7 macrophages. This compound exhibits a modest inhibition rate of 28.1%, indicating potential for further investigation in inflammation-related research. Naturally sourced from the ethanol extract of Caesalpinia minax Hance seeds, it offers a promising avenue for studying anti-inflammatory pathways and therapeutic applications. -
Anti-inflammatory Agent
Abiesadine I is a diterpenoid with anti-inflammatory properties, primarily acting as an inhibitor of lipopolysaccharide (LPS)-induced nitric oxide (NO) production. With an IC50 value greater than 100 μg/mL, Abiesadine I exhibits significant efficacy in RAW264.7 macrophages, making it a valuable tool for research applications focused on inflammation and immune response modulation. This compound is isolated from Abies georgei and is useful for investigating signaling pathways involved in inflammatory processes. -
Anti-inflammatory Agent
Isofouquierol is a selective inhibitor of nitric oxide (NO) production, primarily targeting the inducible nitric oxide synthase (iNOS) pathway. This compound demonstrates significant anti-inflammatory activity by effectively reducing NO overproduction. Isofouquierol is applicable in research focusing on inflammation-related diseases, including chronic inflammation and immune disorders. -
Anti-inflammatory Agent
Deltoin is a coumarin derivative that functions as an anti-inflammatory agent. It has demonstrated the ability to inhibit nitric oxide production, contributing to its anti-inflammatory effects. Research indicates that Deltoin significantly reduces paw edema, highlighting its potential applications in studying inflammatory processes and developing therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Balanophonin B is a selective inhibitor of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, exhibiting an IC50 of 1.46 μg/mL. Isolated from Lithocarpus pachylepis, this compound effectively reduces NO production in LPS-stimulated RAW264.7 macrophages, demonstrating significant anti-inflammatory activity. Balanophonin B is valuable for anti-inflammatory drug development and serves as a tool in the biological activity research of natural lignan compounds. -
Anti-inflammatory/Antitumor Agent
Rabdoternin E is an ent-kaurane-type diterpenoid known for its anti-inflammatory and antitumor properties. It effectively inhibits nitric oxide production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with an IC50 of 2.3 μM. Additionally, Rabdoternin E demonstrates cytotoxicity against human tumor cell lines, HL-60 and SW-480, with IC50 values of 2.6 μM and 4.1 μM, respectively. This compound can be naturally sourced from the aerial parts of Isodon rosthornii, a member of the Lamiaceae family. -
Anti-inflammatory Agent
2-Oxostenine is a stenine-type alkaloid that exhibits anti-inflammatory properties. It has been shown to weakly inhibit lipopolysaccharide-induced nitric oxide production, thereby contributing to its potential role in managing inflammatory responses. This compound is suitable for research applications focused on understanding inflammation and evaluating novel anti-inflammatory agents. -
Anti-Inflammatory Agent
PPM-18 (NSC 73233) is a potent anti-inflammatory agent that inhibits nitric oxide synthase (iNOS) expression by preventing NF-κB from binding to its promoter. This compound has demonstrated the ability to induce autophagy and apoptosis in bladder cancer cells, mediated through reactive oxygen species (ROS) and AMP-activated protein kinase (AMPK) signaling pathways. PPM-18 is valuable for researchers studying inflammation and cancer therapeutics.
