ARL 17477

Catalog No.: A65115
NOS1Inhibitor
ARL 17477 is a dual inhibitor targeting neuronal nitric oxide synthase (NOS1) and the autophagy-lysosomal system. This compound exhibits significant anticancer activity and effectively inhibits tumor growth, particularly in KRAS-mutated cancers. Its potential applications include studies on cancer progression and therapeutic resistance, making it a valuable tool in cancer research.
Grouped product items
Size Price Stock Qty
5mg
$105.00
In stock
10mg
$175.00
In stock
25mg
$385.00
In stock
50mg
$605.00
In stock
100mg
$960.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionARL 17477 is a dual inhibitor targeting neuronal nitric oxide synthase (NOS1) and the autophagy-lysosomal system. This compound exhibits significant anticancer activity and effectively inhibits tumor growth, particularly in KRAS-mutated cancers. Its potential applications include studies on cancer progression and therapeutic resistance, making it a valuable tool in cancer research.
Product Information
Catalog NumA65115
FormulaC20H22Cl3N3S
Molecular Weight442.83
CAS Number866914-87-6
SMILES[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2
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