NOS-IN-1 is a potent and orally bioavailable inhibitor of nitric oxide synthase (NOS) isoforms, demonstrating inhibitory constants (IC50) of 0.1 μM for human inducible NOS (hiNOS), 1.1 μM for endothelial NOS (heNOS), and 0.2 μM for neuronal NOS (hnNOS). This compound is valuable for studying nitric oxide signaling pathways and exploring therapeutic options in diseases associated with dysregulated nitric oxide levels, such as cardiovascular disorders and neurodegenerative diseases. Its selective inhibition of NOS isoforms can aid in elucidating the specific roles of nitric oxide in various biological processes.
NOS-IN-1 is a potent and orally bioavailable inhibitor of nitric oxide synthase (NOS) isoforms, demonstrating inhibitory constants (IC50) of 0.1 μM for human inducible NOS (hiNOS), 1.1 μM for endothelial NOS (heNOS), and 0.2 μM for neuronal NOS (hnNOS). This compound is valuable for studying nitric oxide signaling pathways and exploring therapeutic options in diseases associated with dysregulated nitric oxide levels, such as cardiovascular disorders and neurodegenerative diseases. Its selective inhibition of NOS isoforms can aid in elucidating the specific roles of nitric oxide in various biological processes.
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