NOS1-IN-1 is a selective and cell-permeable inhibitor of neuronal nitric oxide synthase (nNOS), displaying a Ki of 120 nM. This compound demonstrates significant selectivity, with a 2617-fold preference over endothelial nitric oxide synthase (eNOS) and a 325-fold selectivity over inducible nitric oxide synthase (iNOS), evidenced by Ki values of 39 μM and 325 μM, respectively. NOS1-IN-1 is valuable for research on neurological disorders, including cerebral palsy, by enabling the exploration of nNOS-related pathways in disease mechanisms.
NOS1-IN-1 is a selective and cell-permeable inhibitor of neuronal nitric oxide synthase (nNOS), displaying a Ki of 120 nM. This compound demonstrates significant selectivity, with a 2617-fold preference over endothelial nitric oxide synthase (eNOS) and a 325-fold selectivity over inducible nitric oxide synthase (iNOS), evidenced by Ki values of 39 μM and 325 μM, respectively. NOS1-IN-1 is valuable for research on neurological disorders, including cerebral palsy, by enabling the exploration of nNOS-related pathways in disease mechanisms.
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