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Catalog No.
Product Name
Application
Product Information
Citations
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NO Production Inhibitor
Lethedoside A is a natural flavonoid identified as an inhibitor of nitric oxide (NO) production, specifically targeting lipopolysaccharide (LPS)-induced pathways in RAW 264.7 cells. Its primary biological activity involves the modulation of inflammatory responses, making it a valuable tool for research into nitric oxide signaling and inflammatory diseases. This compound is applicable in studies exploring mechanisms of immune regulation and the development of anti-inflammatory strategies. -
Nitric Oxide Synthase Inhibitor
ONO-1714 is an orally active inhibitor of nitric oxide synthase, which plays a crucial role in nitric oxide production. This compound demonstrates significant biological activities, including the attenuation of endotoxin-induced acute lung injury, reduction of intestinal ischemia-reperfusion injury, and repression of biliary carcinogenesis. It is a valuable reagent for research applications focusing on inflammatory responses and tissue protection mechanisms. -
NO Synthase Inhibitor
S-MTC is a selective inhibitor of type I nitric oxide synthase (NOS), primarily targeting the enzymatic production of nitric oxide. This compound has been shown to effectively modulate nitric oxide levels in various biological systems and is valuable for studies investigating vascular function, neurobiology, and inflammation. S-MTC serves as a crucial tool in research aimed at understanding the role of nitric oxide in physiological and pathological processes. -
NO Inhibitor
(-)-Cryptamide C is a potent inhibitor of nitric oxide (NO) production. Derived from the Periostracum cicadae, this dopamine enantiomer trimer demonstrates significant anti-inflammatory activity. It serves as a valuable tool for studying inflammatory diseases and their underlying mechanisms. -
NO Synthase Inhibitor
nNOS-IN-5 is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki value of 22 nM. This compound demonstrates remarkable selectivity, exhibiting a 900-fold preference for nNOS over human endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is suitable for research applications related to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, providing valuable insights into nNOS's role in neurobiology and associated pathologies. -
iNOS Inhibitor
2-Iminopiperidine hydrochloride is a potent inhibitor of inducible nitric oxide synthase (iNOS). This compound is utilized in research to explore nitric oxide-mediated processes in various conditions, including arthritis, inflammatory bowel disease, diabetes, allodynia, and cerebral ischemia, as well as other central nervous system disorders. Its role in modulating nitric oxide production makes it a valuable tool for investigating the underlying mechanisms of inflammation and neuroprotection. -
NOS Inhibitor
L-NIO is a potent, non-selective nitric oxide synthase (NOS) inhibitor that acts by inhibiting the NADPH-dependent activity of the enzyme. It displays inhibition constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms, respectively. L-NIO has been shown to induce focal ischemic infarcts in rat models, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. Its ability to effectively modulate NOS activity positions it as a significant reagent in cardiovascular and neurobiological research applications. -
NO Production Inhibitor
Bisacurone is a natural terpenoid that acts as a nitric oxide production inhibitor. It demonstrates potent inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production, with an IC50 value of 29.8 μM. Bisacurone is useful in research settings focused on inflammation and related pathways. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-2 is a selective inhibitor of the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity with a KD of 21 nM. This cyclic peptide is both reduction-resistant and oxidatively stable, making it suitable for various biological assays. Its ability to inhibit SPSB2-iNOS interactions positions it as a valuable tool in research focused on nitric oxide signaling and related pathophysiological processes. -
NO Production Inhibitor
Nitric oxide production-IN-1 is a potent inhibitor of nitric oxide (NO) synthesis, isolated from Tupistra chinensis. It effectively reduces NO production in rat abdominal macrophages stimulated by lipopolysaccharide (LPS). This compound is valuable for research applications investigating inflammatory processes and the regulation of nitric oxide in various biological contexts. -
iNOs Inhibitor
iNOs-IN-7 is a potent inhibitor of inducible nitric oxide synthase (iNOS), a critical enzyme involved in the production of nitric oxide during inflammatory responses. This compound has demonstrated efficacy in modulating inflammatory pathways and is valuable for research applications related to inflammatory diseases and pain management. Its use may facilitate the exploration of therapeutic strategies targeting iNOS in various pathological conditions. -
NO Production Inhibitor
19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide is a potent nitric oxide (NO) production inhibitor, primarily targeting lipopolysaccharide-activated macrophages. As a metabolite of Neoandrographolide, it exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory responses and related pathways. Its ability to modulate NO levels in immune cells supports investigations into various conditions involving excessive inflammation and immune dysregulation. -
iNOS Inhibitor
Hirundigoside E is an iNOS inhibitor that exhibits significant anti-inflammatory activity. It effectively suppresses lipopolysaccharide (LPS)-induced iNOS protein expression in macrophages. This compound is suitable for research focused on understanding and mitigating inflammatory diseases. -
NO Synthase Inhibitor
Inflexuside B is an abietane diterpenoid that functions as a potent inhibitor of nitric oxide (NO) synthase. Isolated from the aerial parts of Isodon inflexus, Inflexuside B demonstrates significant inhibitory activity against LPS-activated NO synthase in RAW264.7 macrophages. This compound serves as a valuable tool in research focused on inflammatory pathways and nitric oxide-related signaling mechanisms. -
NOS Inhibitor
hnNOS-IN-2 is a selective inhibitor of human neuronal nitric oxide synthase (hnNOS), demonstrating excellent metabolic stability. This compound is primarily utilized in research focusing on neurodegenerative diseases, offering insights into the role of nitric oxide in neuronal function and pathology. Its inhibition capability provides a valuable tool for studying the therapeutic potential in various neurological disorders. -
nNOS Inhibitor
NOS-IN-4 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with an IC50 value of 4.00 μM, effectively reducing nNOS enzyme activity. It has been shown to offer neuroprotective effects, particularly in the context of MPTP-induced dopamine depletion in murine models. This compound is valuable for studying neurodegenerative disorders and the associated pathophysiological mechanisms. -
NO Inhibitor
Physalin O is a natural compound derived from Physalis angulata, functioning primarily as a nitric oxide (NO) inhibitor. It exhibits notable cytotoxicity against Hep G2 and MCF-7 cancer cell lines, with IC50 values of 31.1 µM and 11.4 µM, respectively. In addition to its anti-cancer properties, Physalin O demonstrates significant anti-inflammatory activities through the inhibition of NO production, making it a valuable tool in related research applications. -
NO Production Inhibitor
Pratialin B is a C14-polyacetylenol glycoside analog that acts as an inhibitor of nitric oxide (NO) production. Isolated from the roots of Codonopsis pilosula, Pratialin B demonstrates weak inhibitory effects on LPS-induced NO production. This compound serves as a valuable tool for investigations into inflammatory processes and the modulation of nitric oxide signaling pathways in biological research. -
NO Synthase Inhibitor
Cycloneroside D is a novel sesquiterpene aminoglycoside identified from the deep-sea fungus Trichoderma sp. SCSIOW21, serving as a nitric oxide synthase inhibitor. It demonstrates significant anti-inflammatory activity, with an IC50 value of 42.0 μM for nitric oxide production inhibition in RAW 264.7 macrophage cells. This compound is suitable for research applications focusing on inflammatory pathways and nitric oxide-related signaling. -
NO Synthase Inhibitor
Phenylaminojuglone AJ-2 is a potent nitric oxide synthase inhibitor that modulates various targets, including soluble guanylate cyclase and calcium channels. It effectively blocks extracellular Ca2+ influx, thereby regulating the NO-sGC-cGMP signaling pathway and inhibiting both pharmacological and electromechanical contractions of smooth muscle. This compound is particularly relevant for research investigating intestinal spasm and related gastrointestinal disorders. -
AQP9 Inhibitor
HTS13286 is a selective inhibitor of aquaporin 9 (AQP9), targeting water and glycerol transport in cells. This compound effectively attenuates lipopolysaccharide (LPS)-induced nitric oxide (NO) production and reduces glucose output in response to inflammatory stimuli. HTS13286 is valuable for research applications related to endotoxin shock and the study of metabolic dysregulation in inflammatory conditions. -
NO Production Inhibitor
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor, exhibiting an IC50 of 310 μM against LPS-induced NO production. This compound, isolated from the aerial parts of Isodon japonicus, effectively suppresses NO synthesis in LPS-stimulated macrophages while demonstrating a lack of cytotoxic effects. Its properties make it a valuable tool for research focusing on inflammatory responses and nitric oxide signaling pathways. -
nNOS-Capon Inhibitor
ZLc-002 is a selective inhibitor of nNOS-Capon coupling, primarily targeting the nitric oxide synthase pathway. This compound demonstrates significant potential in suppressing inflammatory nociception as well as chemotherapy-induced neuropathic pain. ZLc-002 is valuable for research applications related to anxiety disorders and inflammatory conditions, making it an essential reagent for exploring pain mechanisms and therapeutic strategies. -
Nitric Qxide Production Inhibitor
Mudanpioside F is a monoterpene glycoside that serves as an inhibitor of nitric oxide production, specifically targeting LPS-induced pathways. It displays potent activity with an IC50 of 18.65 ± 2.1 μM, making it a valuable tool for investigating nitric oxide modulation. This compound is particularly relevant in studies related to inflammation and immune response, providing insights into the signaling mechanisms involving nitric oxide. -
nNOS Inhibitor
Nω-allyl-L-arginine is a competitive and reversible inhibitor of neuronal nitric oxide synthase (nNOS). This compound effectively inactivates nNOS in a time-dependent manner while serving as a substrate that generates L-arginine, acrolein, and water. Its role in nitric oxide signaling pathways makes it valuable for research into neurovascular functions and related pathophysiological conditions. -
NO Synthase Inhibitor
L-NAME is a nitric oxide synthase (NOS) inhibitor with an IC50 of 70 μM. This compound acts as a precursor to the more potent NOS inhibitor L-NOARG, which has an IC50 of 1.4 μM. L-NAME requires hydrolysis by cellular esterases to achieve its full inhibitory activity. It is commonly utilized in research to induce hypertension and preeclampsia models, facilitating studies on cardiovascular health and nitric oxide signaling pathways. -
Neuroinflammation Inhibitors
Stephalonine P is a hasubanan-type alkaloid that serves as a neuroinflammation inhibitor. It exhibits significant anti-inflammatory properties by inhibiting nitric oxide production in lipopolysaccharide-activated BV2 microglia, with an IC50 value of 34.01 μM. By reducing microglial activation, Stephalonine P provides neuroprotective effects, which are particularly relevant in the context of stroke and other neuroinflammation-related diseases. This compound can be isolated from the plant Stephania japonica and is valuable for research into neuroinflammatory mechanisms and therapeutic interventions. -
NO Synthesis Inhibitor
Kadsulignan H is a lignan that functions as a nitric oxide (NO) synthesis inhibitor. It effectively inhibits NO production in BV-2 cells, demonstrating an IC50 value of 14.1 μM. This compound is valuable for research applications focused on inflammatory processes and neurological studies where modulation of nitric oxide levels is relevant. -
NO Synthase Inhibitor
Harzianol A is a potent inhibitor of nitric oxide (NO) synthase. Isolated from Trichoderma sp. SCSIOW21, this compound demonstrates significant anti-inflammatory activity by effectively reducing NO production. Harzianol A is suitable for research applications focused on nitrosative stress and inflammatory pathways. -
NO Synthase Inhibitor
L-NABE is a selective inhibitor of nitric oxide (NO) synthase, effectively modulating the production of nitric oxide in biological systems. This compound exhibits significant vasoconstrictive properties, contributing to endothelium-dependent vasoconstriction and inhibiting relaxation responses. L-NABE is primarily utilized in research to study vascular physiology and the role of nitric oxide in cardiovascular conditions. -
NO Synthase Inhibitor
Harzianoside A is a diterpene aminoglycoside that acts as a nitric oxide synthase inhibitor. It effectively reduces the production of nitric oxide, making it a valuable tool for investigating anti-inflammatory mechanisms. This compound is useful in research focused on inflammation and related pathophysiological conditions. -
NO Inhibitor
Geranyl ferulate, a derivative of ferulic acid isolated from Zingiber officinale, serves as a nitric oxide (NO) inhibitor. This compound demonstrates a significant inhibitory effect on NO production, making it valuable for research related to nitric oxide signaling pathways. Its potential applications extend to studies focused on inflammatory processes, vascular biology, and related therapeutic interventions. -
NO Inhibitor
Thunalbene is a stilbene derivative that acts as a nitric oxide (NO) inhibitor. It demonstrates a moderate inhibitory effect on nitric oxide production, making it a valuable tool for studies examining NO-related pathways. Additionally, Thunalbene has been shown to be non-cytotoxic, enabling its use in various biological assays without compromising cell viability. -
iNOS/ICAM-1 Inhibitor
Aloenin aglycone is an inhibitor of iNOS and ICAM-1, derived from aloe exudate. It effectively suppresses TNFα-induced NF-κB transcriptional activity with an IC50 of 18.7 μM. Additionally, at a concentration of 10 μM, it significantly reduces the expression of both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) in HepG2 cells following TNFα stimulation. This compound serves as a valuable tool for investigating inflammatory pathways and potential therapeutic interventions in related conditions. -
NO Production Inhibitor
6-Methoxynaringenin is a natural flavonoid that functions as an inhibitor of nitric oxide (NO) production, exhibiting an IC50 of 25.8 μM. This compound is valuable for research focused on cardiovascular health and inflammation, where NO plays a critical role. Its ability to modulate NO levels makes it an important tool for studying various biochemical pathways and therapeutic interventions. -
NO Synthase Inhibitor
Ronopterin is a nitric oxide synthase (NOS) inhibitor, primarily utilized in research investigating the pathophysiology of urogenital and neurological disorders. By inhibiting NO production, Ronopterin modulates crucial signaling pathways, making it a valuable tool for studying conditions linked to dysregulated nitric oxide signaling. Applications include exploring the role of NO in various diseases and assessing therapeutic strategies targeting NOS pathways. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-3 is a selective inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS). This compound binds to the SPSB2 site on iNOS with a dissociation constant (KD) of 7 nM. It demonstrates significant biological activity in modulating nitric oxide production and has potential applications in studies related to inflammation and oxidative stress. -
NOS Inhibitor
NOS-IN-2 is a selective inhibitor of nitric oxide synthase (NOS), primarily targeting inducible nitric oxide synthase (iNOS) with an IC50 of 20 µM, while sparing endothelial nitric oxide synthase (eNOS). Its low toxicity profile makes it suitable for research in inflammatory disorders and related pathways. NOS-IN-2 is an important tool for investigating the role of nitric oxide in various biological processes and for developing therapeutic strategies for conditions associated with elevated iNOS activity. -
NO Synthase Inhibitor
GW 273629 is a selective nitric oxide synthase inhibitor that effectively modulates nitric oxide production. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research investigating inflammation-related pathways and conditions. Its specificity for nitric oxide synthase positions it as a suitable reagent for studies aimed at understanding the role of nitric oxide in various biological processes. -
NO Synthase Inhibitor
Cycloneroside C is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. In studies utilizing RAW 264.7 macrophage cells, it demonstrated an IC50 value of 57.1 μM for the inhibition of nitric oxide production. This compound is primarily applied in research focused on anti-inflammatory mechanisms and potential therapeutic interventions. -
NO Synthase Inhibitor
Harzianoside B is a diterpene aminoglycoside known for its role as a nitric oxide (NO) synthase inhibitor. It effectively reduces NO production, demonstrating an IC50 value near the maximum tested concentration of 100 µM in RAW 264.7 macrophage cells. This compound is valuable for research into anti-inflammatory mechanisms and therapeutic applications. -
NO Synthesis Inhibitor
Schiarisanrin A is a lignan that acts as an inhibitor of nitric oxide (NO) synthesis. It demonstrates a significant inhibitory effect on NO production in BV-2 cells, with an IC50 value of 9.6 μM. This compound may serve as a valuable tool in research focused on inflammatory pathways and neuroprotection. -
iNOS Inhibitor
Myricananin A is a selective inhibitor of inducible nitric oxide synthase (iNOS), effectively modulating nitric oxide production. This compound demonstrates significant anti-inflammatory properties, making it valuable for research in inflammation-related pathways and conditions. Myricananin A serves as a critical tool for elucidating the role of iNOS in various biological processes and may aid in the development of therapeutic strategies targeting iNOS-related diseases. -
NO Synthase Inhibitor
Chloranthalactone E is a labdane diterpene that acts as an inhibitor of nitric oxide synthase (NOS). It effectively reduces nitric oxide production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, making it a valuable tool for studying inflammatory pathways. This compound is useful in research focused on immune responses and the modulation of macrophage activity. -
NO Synthase Inhibitor
Mercaptoethylguanidine (MEG) dihydrobromide is a selective inhibitor of inducible nitric oxide synthase, acting as a peroxynitrite scavenger. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory bowel diseases and related conditions. Its ability to modulate nitric oxide production makes MEG an important reagent for studies focusing on nitric oxide-related pathologies. -
NO Production Inhibitor
Dimeric coniferyl acetate is an inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 7.9 μM in BV-2 microglial cells. This compound is valuable for research applications aimed at understanding the regulation of NO synthesis and its implications in neuroinflammatory processes. Its specificity and potency make it a useful tool for studying the role of NO in cellular signaling and neurobiology. -
Nitric Oxide Inhibitor
(+)-Hannokinol is a nitric oxide inhibitor derived from the fruit of AMOMUM TSAO-KO, a member of the ginger family. This compound effectively inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia, making it a valuable tool for studies related to neuroinflammation and oxidative stress. Its biological activity contributes to research in various fields, including neurobiology and immunology. -
NOS Inhibitor
Guanidino ethyl disulfide is a selective nitric oxide synthase (NOS) inhibitor, showing EC50 values of 110 μM for iNOS, 630 μM for eNOS, and 180 μM for bNOS. This compound effectively inhibits nitrite production in J774.2 macrophages, making it a valuable tool for studying mechanisms of nitric oxide modulation. Guanidino ethyl disulfide can be utilized in research related to circulatory shock, inflammation, and neurological disorders. -
Nitric Oxide Inhibitor
Kansuinine E is a jatrophane-type diterpenoid that acts as a nitric oxide inhibitor with an IC50 of 6.3 μM. Isolated from the roots of Euphorbia kansui, this compound demonstrates significant biological activity by modulating nitric oxide levels. Kansuinine E is primarily utilized in research applications focusing on vascular biology and the study of nitric oxide-related pathways. -
NO Inhibitor
Isolupalbigenin is a nitric oxide (NO) inhibitor that exhibits significant anti-proliferative activity against HL-60 human leukemia cells, with an IC50 value of 5.1 μM. This compound is useful in research applications focused on the modulation of nitric oxide signaling pathways and the exploration of therapeutic strategies for leukemia and related disorders.
