Stephalonine P is a hasubanan-type alkaloid that serves as a neuroinflammation inhibitor. It exhibits significant anti-inflammatory properties by inhibiting nitric oxide production in lipopolysaccharide-activated BV2 microglia, with an IC50 value of 34.01 μM. By reducing microglial activation, Stephalonine P provides neuroprotective effects, which are particularly relevant in the context of stroke and other neuroinflammation-related diseases. This compound can be isolated from the plant Stephania japonica and is valuable for research into neuroinflammatory mechanisms and therapeutic interventions.
Stephalonine P is a hasubanan-type alkaloid that serves as a neuroinflammation inhibitor. It exhibits significant anti-inflammatory properties by inhibiting nitric oxide production in lipopolysaccharide-activated BV2 microglia, with an IC50 value of 34.01 μM. By reducing microglial activation, Stephalonine P provides neuroprotective effects, which are particularly relevant in the context of stroke and other neuroinflammation-related diseases. This compound can be isolated from the plant Stephania japonica and is valuable for research into neuroinflammatory mechanisms and therapeutic interventions.
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