Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Ibrutinib-d5 is a deuterated analog of Ibrutinib, a selective and irreversible inhibitor of Bruton's tyrosine kinase (Btk). This stable isotope-labeled compound is ideal for use in pharmacokinetic studies and metabolic research, enabling accurate tracking of Ibrutinib in biological systems. Its application in cheminformatics and drug metabolism studies aids in gaining insights into the pharmacodynamics and absorption profile of Btk inhibitors. -
Stable Isotope
Alectinib-d8 is a deuterium-labeled variant of Alectinib, a potent and selective inhibitor of anaplastic lymphoma kinase (ALK). This compound exhibits an IC50 of 1.9 nM and a Kd of 2.4 nM in an ATP-competitive context, further inhibiting ALK F1174L and ALK R1275Q with IC50 values of 1 nM and 3.5 nM, respectively. Alectinib is known for its effective penetration of the central nervous system, making it a valuable tool for research into ALK-driven malignancies and CNS-related drug efficacy studies. -
Stable Isotope
Alectinib-d6 is a deuterium-labeled analogue of Alectinib, a selective and potent inhibitor of anaplastic lymphoma kinase (ALK). With an IC50 of 1.9 nM, Alectinib effectively targets ALK, including its resistance mutations ALK F1174L and ALK R1275Q, with IC50s of 1 nM and 3.5 nM, respectively. This compound exhibits significant central nervous system (CNS) penetration, making it a valuable tool for research in cancer biology and drug resistance studies. -
Stable Isotope
Brigatinib-d11 is a deuterium-labeled analog of Brigatinib, a highly selective and potent inhibitor of the anaplastic lymphoma kinase (ALK) with an IC50 of 0.6 nM. This stable isotope labeling allows for advanced tracking and analysis in metabolic studies. Brigatinib-d11 is suitable for research applications focused on non-small cell lung cancer (NSCLC) treatment mechanisms and drug metabolism studies. -
Stable Isotope
Apatinib-d8 free base is a deuterium-labeled form of Apatinib, a potent orally bioavailable tyrosine kinase inhibitor that primarily targets VEGFR-2 with an IC50 of 1 nM. This compound exhibits significant anti-angiogenic activity and is integral to research focused on advanced or metastatic gastric cancer. Additionally, Apatinib-d8 inhibits Ret, c-Kit, and c-Src with IC50 values of 13 nM, 429 nM, and 530 nM, respectively, and effectively obstructs the phosphorylation of VEGFR-2, c-Kit, and PDGFRβ, making it a valuable tool for cancer biology studies. -
Stable Isotope
Toceranib-d8 is a deuterium-labeled derivative of Toceranib, a potent orally active receptor tyrosine kinase (RTK) inhibitor. It effectively targets PDGFR, VEGFR, and Kit, displaying inhibitory constants of 5 nM and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib demonstrates significant antitumor and antiangiogenic properties, making it valuable in research related to canine mast cell tumors and other cancer models. -
Stable Isotope
N-Nitroso-N-methylurea-d5 is a deuterium-labeled derivative of the potent carcinogen and mutagen, N-Nitroso-N-methylurea (NMU). As a direct-acting alkylating agent, it interacts with DNA to induce mutations and has been implicated in the development of cancer and degenerative diseases in various animal tissues. This stable isotope-labeled compound serves as a valuable tool in cancer research, particularly for studying mutagenesis and the mechanisms of carcinogenesis, as well as in synthetic applications related to diazomethane. -
Stable Isotope
Ifosfamide-d4-1 is a deuterium-labeled derivative of ifosfamide, a chemotherapeutic agent targeting DNA replication and repair processes. The stable isotope labeling allows for enhanced tracking and quantification in metabolic studies and pharmacokinetic research. This reagent is valuable for investigations into drug metabolism and efficacy, offering insights into therapeutic dynamics and potential resistance mechanisms. -
Stable Isotope
BS2G Crosslinker-d4 disodium is a deuterium-labeled homobifunctional protein crosslinker, designed for stable isotopic labeling. It reacts with amine groups to facilitate robust protein-protein, peptide, and biomolecule conjugation. This reagent is ideal for applications in structural biology and proteomics, allowing researchers to study protein interactions and dynamics with enhanced specificity and stability. -
Stable Isotope
2’-Oxo Ifosfamide-d4 is a deuterium-labeled derivative of Ifosfamide, an alkylating chemotherapeutic agent. It exhibits significant cytotoxic activity against various tumor types, making it a valuable tool in cancer research. The stable isotope labeling allows for precise pharmacokinetic and metabolic studies of Ifosfamide in biological systems. This reagent is ideal for applications in drug metabolism investigations and biochemical assays focused on cancer therapeutics. -
Stable Isotope
Palmitic acid-13C16 is a stable isotope-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This compound is crucial for metabolic studies as it can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. Research applications include investigations into lipid metabolism, cellular stress responses, and the roles of fatty acids in endocrine signaling pathways. -
Stable Isotope
Palmitic acid-d31 is a deuterium-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. It serves as a stable isotope for metabolic studies, enabling precise tracing in various biological systems. Research indicates that palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for investigations into metabolic regulation and stress responses. -
Stable Isotope
Palmitic acid-13C is the carbon-13 labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This stable isotope is crucial for metabolic studies, enabling researchers to trace lipid metabolism pathways. Notably, palmitic acid can stimulate the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for investigating stress responses in cellular models. -
Stable Isotope
Palmitic acid-13C16 sodium is a stable, isotopically labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This compound is known to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, facilitating studies on metabolic processes and endoplasmic reticulum stress. Its applications extend to various research areas, including lipid metabolism and cellular stress response. -
Stable Isotope
Palmitic acid-d3 is a stable isotope-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This compound is utilized in studies investigating lipid metabolism and the cellular response to stress, as it can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. Palmitic acid-d3 serves as a valuable tool in metabolic research and the examination of fatty acid signaling pathways. -
Stable Isotope
Palmitic acid-1-13C is a stable isotope-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This compound has been shown to promote the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for research on metabolic responses and stress-related cellular pathways. Its use in metabolic studies enhances the understanding of fatty acid metabolism and its implications in various physiological processes. -
Stable Isotope
Palmitic acid-d2 is a deuterium-labeled derivative of the long-chain saturated fatty acid palmitic acid, which is prevalent in both animal and plant systems. This stable isotope is primarily utilized in metabolic studies and tracer experiments to investigate lipid metabolism and hydrolysis pathways. Research indicates that palmitic acid can enhance the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for studies on cellular stress responses and metabolic regulation. -
Stable Isotope
Palmitic acid-d4 is a stable isotope-labeled version of palmitic acid, a long-chain saturated fatty acid prevalent in both plant and animal systems. This compound serves as a valuable tool in metabolic studies, particularly in research examining the pathways of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. Its use in tracer studies aids in understanding fatty acid metabolism and its physiological impacts in various biological contexts. -
Stable Isotope
Palmitic acid-13C2 is a stable isotope-labeled form of palmitic acid, a long-chain saturated fatty acid abundant in various animal and plant sources. It serves as a valuable tool for studying lipid metabolism and related pathways. Research indicates that palmitic acid can upregulate glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it relevant for investigations in cell stress and metabolic regulation. -
Stable Isotope
Palmitic acid-d is a deuterium-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both plant and animal tissues. This stable isotope is utilized in metabolic studies, particularly in tracing lipid metabolism and understanding the regulatory effects of palmitic acid on stress response proteins such as glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. Its application in research aids in elucidating the roles of fatty acids in cellular stress and metabolic regulation. -
Stable Isotope
Palmitic acid-d4-1 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This stable isotope is utilized for metabolic studies and can be used to investigate the lipid metabolism pathways. Research has demonstrated that palmitic acid induces the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, highlighting its role in stress response mechanisms. -
Stable Isotope
Palmitic acid-1,2,3,4-13C4 is a stable isotope-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This compound is utilized in metabolic research to study lipid metabolism and energy homeostasis. Palmitic acid has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for investigating endoplasmic reticulum stress and related signaling pathways. -
Stable Isotope
Hexadecanoate-13C16 potassium is a stable isotope-labeled form of hexadecanoate, specifically featuring a 13C isotope. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. Its ability to modulate these stress-related proteins makes it a valuable tool for research in cellular stress responses and metabolic studies. -
Stable Isotope
Palmitic acid-d2-1 is deuterium-labeled palmitic acid, a long-chain saturated fatty acid present in both animal and plant sources. This reagent is utilized to study the metabolic pathways of lipids and their influence on cellular processes. Palmitic acid has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for research in metabolic regulation and endoplasmic reticulum stress responses. -
Stable Isotope
Palmitic acid-d2-4 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant tissues. This stable isotope is utilized in metabolic studies and can enhance the understanding of lipid metabolism. Additionally, palmitic acid has been shown to upregulate the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, providing insights into cellular stress responses and metabolic regulation. -
Stable Isotope
Palmitic acid-d2-2 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This stable isotope serves as a valuable tool for metabolic studies, allowing for precise tracking and quantification in biological systems. Palmitic acid-d2-2 has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it relevant for research in lipid metabolism and cellular stress responses. -
Stable Isotope
Palmitic acid-d5 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This reagent is primarily utilized as a stable isotope in various biochemical assays. Palmitic acid has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for research in metabolic and cellular stress responses. -
Stable Isotope
Palmitic acid-15,15,16,16,16-d5 is a deuterium-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in animal and plant sources. This stable isotope is utilized in metabolic studies to trace fatty acid metabolism and its impact on cellular processes. It has been shown to upregulate glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) expression in mouse granulosa cells, making it valuable for research in metabolic regulation and cell stress responses. -
Stable Isotope
Palmitic acid-d17 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in animal and plant tissues. This stable isotope is used in metabolic labeling studies to investigate lipogenesis, fatty acid metabolism, and cellular signaling pathways. Its role in inducing the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells highlights its relevance in studies related to endoplasmic reticulum stress and metabolic disorders. -
Stable Isotope
Palmitic acid-d4-2 is a deuterium-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animal and plant sources. This compound serves as a stable isotope for biological studies and is instrumental in investigating metabolic pathways involving fatty acids. Research has shown that palmitic acid can upregulate glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it valuable for studies focused on cellular stress responses and metabolism. -
Stable Isotope
Palmitic acid-9,10-d2 is a deuterium-labeled saturated fatty acid, serving as a stable isotope for biochemical studies. Its primary mechanism involves modulation of cellular stress responses, notably the induction of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP). This compound is instrumental in research applications focused on metabolic pathways, lipid metabolism, and cellular stress mechanisms in both animal and plant systems. -
Stable Isotope
Palmitic acid-d2-5 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This stable isotope serves as a valuable tool in metabolic studies, particularly in tracing lipid metabolism and understanding fatty acid signaling pathways. Research applications include investigating the induction of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in various cellular models, including mouse granulosa cells. -
Stable Isotope
Palmitic acid-d2-3 is a deuterium-labeled derivative of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This isotope-labeled variant allows for precise tracking and analysis in metabolic studies. Palmitic acid is known to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. It serves as a valuable tool in researching lipid metabolism and cellular stress responses. -
Stable Isotope
Palmitic acid-13C sodium is a stable isotope-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant sources. This reagent serves as a valuable tool in metabolic studies, particularly for tracing fatty acid metabolism and evaluating lipid-related biological pathways. Research has demonstrated that palmitic acid can activate the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, contributing to insights in cellular stress responses and metabolic regulation. -
Stable Isotope
Palmitic acid-d9 is a deuterium-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both plant and animal sources. This stable isotope serves as a valuable tool in metabolic studies and can facilitate the investigation of lipid metabolism and cellular signaling pathways. Research has demonstrated that palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it relevant for studies in metabolic and reproductive biology. -
Stable Isotope
Palmitic acid-13C-1 is a stable isotope-labeled form of palmitic acid, a long-chain saturated fatty acid prevalent in both animal and plant tissues. This compound serves as a valuable tool for metabolic studies, particularly in understanding lipid metabolism and cellular stress responses. Palmitic acid-13C-1 can effectively induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells, making it essential for establishing cellular models of steatosis and investigating the underlying biochemical pathways. -
Stable Isotope
Adenine-13C is a stable isotope-labeled form of adenine, a vital purine nucleobase present in DNA and RNA. This labeled compound serves as a key component in cellular metabolism, influencing processes such as ATP synthesis, and acting as a precursor for cofactors like NAD and FAD. Adenine-13C is primarily utilized in metabolic studies and isotopic tracing experiments to investigate cellular functions and biochemical pathways. -
Stable Isotope
Spermine-d8 tetrahydrochloride is a deuterium-labeled form of spermine that serves as a stable isotope in biochemical research. This polyamine acts as a nitric oxide donor, influencing platelet activation in a concentration-dependent manner. Spermine-d8 exhibits multiple biological activities, including antioxidant and anti-inflammatory properties, while also demonstrating inhibitory effects on certain bacterial strains, such as Staphylococcus aureus. Additionally, it impacts immune responses by reversibly inhibiting DNA synthesis, mixed lymphocyte reactions, and the induction of cytolytic lymphocytes in murine spleen cell cultures. -
Stable Isotope
N-Nitrosodiethylamine-d10 is a deuterium-labeled derivative of the potent hepatocarcinogen N-Nitrosodiethylamine. This compound is primarily studied for its role in inducing alterations in nuclear enzymes linked to DNA repair and replication, contributing to tumorigenesis across various animal models. It is found in diverse environmental sources, including tobacco smoke and certain processed foods, highlighting its significance in cancer research and toxicology studies. Research applications encompass the investigation of carcinogenic mechanisms and the impact of environmental exposures on health outcomes. -
Stable Isotope
Thymidine-d3 is a deuterated form of thymidine, serving as a stable isotope in biological research. It acts as a precursor to deoxyribonucleic acid (DNA) and functions effectively as a cell synchronizing agent, promoting studies of cell cycle dynamics. Thymidine-d3 inhibits DNA synthesis, thereby facilitating arrest of cells at the G1/S boundary prior to DNA replication. Its unique isotopic labeling allows for precise tracking in metabolic studies and investigations into DNA synthesis mechanisms. -
Stable Isotope
Docosanoic acid-d4-1 is a stable isotope-labeled form of docosanoic acid, a long-chain saturated fatty acid. This compound is known to inhibit the double-stranded DNA (dsDNA) binding activity of the p53 DNA binding domain, demonstrating a Kd of 12 nM. Due to its unique properties, docosanoic acid-d4-1 is valuable for studies involving lipid metabolism, cholesterol regulation, and the biochemical interactions of p53 in cancer research. -
Stable Isotope
Levomefolic acid-13C,d3 is a deuterium-labeled derivative of 5-methyltetrahydrofolate (Levomefolic acid), a biologically active form of folic acid. This stable isotope is utilized in metabolic studies and tracer experiments, enabling precise quantitative analysis of folate metabolism. Its ability to penetrate the blood-brain barrier supports research into neurological functions and deficiencies associated with folate metabolism. -
Stable Isotope
Docosanoic acid-d3 is a deuterium-labeled derivative of Docosanoic acid (Behenic acid), a long-chain saturated fatty acid. This compound targets the p53 DNA binding domain, inhibiting its double-stranded DNA (dsDNA) binding activity with a dissociation constant (Kd) of 12 nM. Docosanoic acid-d3 serves as a valuable stable isotope for metabolic studies and lipid research, providing insights into fatty acid metabolism and p53-related pathways. It is also noted for its potential effects on cholesterol levels in biological systems. -
Stable Isotope
Guanine-13C is a stable isotope-labeled form of guanine, a fundamental purine component of nucleic acids, including DNA and RNA. This compound features a fused pyrimidine-imidazole ring system with conjugated double bonds, providing a valuable tool for metabolic studies and tracer experiments. Guanine-13C is essential for research applications in genomics, molecular biology, and biochemistry, facilitating the analysis of nucleic acid dynamics and metabolism. -
Stable Isotope
5-Methylcytosine-d4 is a stable isotope-labeled form of 5-Methylcytosine, a significant DNA modification present in both prokaryotic and eukaryotic organisms. It plays a crucial role in the methylation of CpG dinucleotides, contributing to DNA stability and influencing RNA structure and mRNA translation. Additionally, it can be oxidized to form various forms of hydroxymethylated cytosines. This reagent is valuable for applications in epigenetics, developmental biology, and research into diseases such as colorectal cancer and hepatocellular carcinoma. -
Stable Isotope
Adenine-d is a deuterium-labeled form of adenine, a purine nucleobase integral to DNA and RNA structure. This stable isotope serves as a valuable tool in metabolic studies, particularly in cellular respiration and energy transfer processes, as it participates in the formation of ATP and cofactors such as NAD and FAD. Its applications extend to investigating protein synthesis and exploring various biochemical pathways. -
Stable Isotope
Thymidine-13C10,15N2 is a stable isotope-labeled derivative of thymidine, featuring both carbon-13 and nitrogen-15 isotopes. As a specific precursor for deoxyribonucleic acid (DNA), it serves as an effective cell synchronizing agent, facilitating the study of cell cycle dynamics. Thymidine also acts as a DNA synthesis inhibitor, effectively arresting cells at the G1/S boundary prior to DNA replication. This compound is valuable for applications in metabolic tracing and cellular biology research. -
Stable Isotope
Thymidine-13C5 is a stable isotope-labeled form of thymidine, incorporating five carbon-13 atoms. This compound serves as a vital tracer in various biological and biochemical research applications, particularly in studying DNA replication and cellular proliferation dynamics. Thymidine-13C5 is widely utilized in metabolic studies, enabling researchers to investigate nucleotide metabolism and cellular processes with enhanced precision. -
Stable Isotope
Docosanoic acid-d43, a deuterium-labeled derivative of docosanoic acid, serves as a stable isotope for research applications. This long-chain saturated fatty acid is known to inhibit the double-stranded DNA (dsDNA) binding activity of the p53 DNA binding domain, exhibiting a Kd value of 12 nM. While docosanoic acid is characterized by low bioavailability, it has also been associated with increases in cholesterol levels in humans, making it a compound of interest in studies related to lipid metabolism and DNA interactions. -
Stable Isotope
Guanine-13C,15N2 is a stable isotope-labeled version of guanine, incorporating both carbon-13 and nitrogen-15 isotopes. As a key purine nucleobase, guanine is essential in the structure of nucleic acids, including DNA and RNA. This compound is valuable in research applications involving biomolecular studies, metabolic labeling, and tracer studies, facilitating enhanced tracking of nucleic acid dynamics and cellular processes.
