Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Artemether-d3 is the deuterium-labeled derivative of Artemether, designed as a stable isotope for research applications. Artemether is widely recognized for its efficacy as an antimalarial agent, particularly against resistant strains of Plasmodium falciparum. This compound is essential for pharmacokinetic studies and metabolic research involving Artemether, enabling scientists to trace its pharmacological pathways and enhance understanding of its therapeutic mechanisms. -
Stable Isotope
Permethrin-d5 is a deuterium-labeled analog of Permethrin, which acts primarily as a neurotoxic insecticide and acaricide. By prolonging sodium channel activation, it disrupts neuronal function in target species. This stable isotope is useful for studying metabolic pathways and environmental fate in chemical research applications. -
Stable Isotope
Thiabendazole-d4 is a deuterated derivative of Thiabendazole, a compound known for its antiseptic, antifungal, and antiparasitic properties. This stable isotope is primarily utilized in metabolic studies and quantitative analysis of Thiabendazole metabolism and pharmacokinetics. Its incorporation allows for enhanced sensitivity and accuracy in mass spectrometry applications, aiding in the investigation of drug interactions and biological pathways involving this important therapeutic agent. -
Stable Isotope
N-Desethyl amodiaquine-d5 dihydrochloride is a deuterium-labeled form of N-Desethyl amodiaquine dihydrochloride, the principal metabolite of Amodiaquine. This compound serves as an antiparasitic agent and exhibits significant biological activity, with IC50 values of 97 nM against V1/S strains and 25 nM against 3D7 strains. It is primarily utilized in pharmacokinetic studies and metabolic research to trace the bioavailability and metabolic pathways of antimalarial therapies. -
Stable Isotope
Benzyl benzoate-d12 is a deuterium-labeled variant of benzyl benzoate, which is a benzoic acid ester commonly used as a fragrance in cosmetic formulations. This stable isotope is valuable for research applications in studies examining scabies and inflammatory skin conditions associated with Demodex. Its use facilitates tracking and quantification in metabolic processes, enhancing understanding of相关皮肤疾病的生物学机制. -
Stable Isotope
Diethyltoluamide-d7 is a deuterated variant of Diethyltoluamide, a widely used active ingredient in insect repellents. This stable isotope serves as an analytical tool for studying the environmental fate and metabolism of Diethyltoluamide in various biological systems. Its primary applications include determining exposure levels in ecological research and enhancing the understanding of the compound's behavior in complex matrices. -
Stable Isotope
Flufenamic acid-13C6 is a stable isotope-labeled derivative of Flufenamic acid, a non-steroidal anti-inflammatory agent. It primarily targets cyclooxygenase (COX) and activates AMP-activated protein kinase (AMPK), while also modulating various ion channels, including chloride and L-type Ca2+ channels, and non-selective cation channels. Additionally, Flufenamic acid-13C6 binds to the central pocket of TEAD2 YBD, inhibiting TEAD function and impacting TEAD-YAP-dependent biological processes, such as cell migration and proliferation. This compound is valuable for metabolic studies and investigations into inflammatory pathways. -
Stable Isotope
HMMNI-d3 (Hydroxy Dimetridazole-d3) is a stable isotope labeled derivative of HMMNI (Hydroxy dimetridazole). HMMNI itself is a hydroxy metabolite of Dimetridazole, a compound belonging to the nitroimidazole class that is effective against protozoan infections. HMMNI-d3 serves as a valuable tool in biological research, enabling accurate tracking of metabolic pathways and the study of drug metabolism and pharmacokinetics. Its deuterium labeling enhances analytical sensitivity and allows for precise quantification in various experimental contexts. -
Stable Isotope
Pyrimethamine-d3 is a deuterium-labeled derivative of Pyrimethamine, primarily acting as a stable isotope. It targets dihydrofolate reductase (DHFR), thereby inhibiting the synthesis of tetrahydrofolic acid from folic acid, which is crucial for protozoal infections treatment. This compound is valuable for research applications involving metabolic studies, isotopic tracing, and pharmacokinetic assessments in the field of parasitology and microbiology. -
Stable Isotope
Methyl palmitate-d31 is a deuterated analog of methyl palmitate, functioning as a stable isotope. This compound exhibits significant acaricidal properties and has been shown to inhibit phagocytic activity and modulate immune responses. Additionally, methyl palmitate demonstrates anti-inflammatory and antifibrotic effects, making it valuable in various research applications, including studies on immune modulation and inflammation-related pathways. -
Stable Isotope
Estragole-d4 is a deuterated form of Estragole, primarily utilized as a stable isotope for labeling studies. As a volatile terpenoid ether, Estragole exhibits significant biological activities, including the induction of apoptosis and the inhibition of LPS-induced reactive oxygen species (ROS) production. It also activates the Nrf-2 pathway and regulates NF-κB signaling, contributing to its anti-inflammatory, antioxidant, and immunomodulatory properties. Estragole has been investigated for its potential effects on neuronal excitability and gastric ulcer amelioration, making it valuable in various research applications. -
Stable Isotope
Dinotefuran-d3 is a deuterium-labeled derivative of Dinotefuran, a neonicotinoid insecticide. Its primary mechanism involves the inhibition of nicotinic acetylcholine receptors, leading to disruption of the insect nervous system. This stable isotope can be utilized in research applications such as pharmacokinetic studies, environmental fate analyses, and metabolic studies of insecticides. -
Stable Isotope
Benzyl benzoate-d5 is a deuterium-labeled derivative of benzyl benzoate, serving as a stable isotope for research applications. This compound is commonly used as a fragrance ingredient and has potential in the study of scabies and inflammatory skin conditions associated with Demodex. Its isotopic labeling facilitates enhanced tracking and analysis in biological studies, contributing valuable insights into the metabolism and biological interaction of benzyl benzoate in various cosmetic and dermatological research settings. -
Stable Isotope
DL-Methionine-d4 is the deuterated form of the essential amino acid DL-Methionine, which serves as a critical component in protein synthesis and plays a role in oxidative stress defense. This stable isotope can be utilized in metabolic studies and tracer experiments to examine amino acid metabolism. Additionally, DL-Methionine has demonstrated efficacy in eliminating Heterodera rostochiensis in potato plants, highlighting its potential applications in agricultural research. -
Stable Isotope
Endoxifen-d5 is a deuterium-labeled derivative of Endoxifen, a primary active metabolite of tamoxifen. This compound exhibits enhanced affinity and specificity for estrogen receptors while also inhibiting aromatase activity. It serves as a valuable tool for breast cancer research, facilitating studies on estrogen signaling pathways and therapeutic response in hormone-receptor-positive breast cancer models. -
Stable Isotope
Methyl stearate-d35 is a deuterium-labeled variant of methyl stearate, primarily utilized as a stable isotope in research applications. Derived from sources like Rheum palmatum L., this compound serves as a key component in the formulation of biodiesels from soybean and rapeseed. Its stable isotope labeling makes it valuable for tracing studies and metabolic analysis in biochemical research. -
Stable Isotope
Flonicamid-15N18O is a stable isotope-labeled derivative of Flonicamid, which targets hemipterous pests through a distinctive mechanism of action that induces starvation by inhibiting stylet penetration into plant tissues. This novel systemic insecticide demonstrates selective activity, making it a valuable tool for studying insect feeding behavior and pest management strategies. Applications of Flonicamid-15N18O include research into insect physiology, behavioral studies, and the development of integrated pest control methods. -
Stable Isotope
Pyronaridine-d4 tetraphosphate is a deuterium-labeled derivative of the anti-malarial agent Pyronaridine tetraphosphate, targeting malaria and other parasitic infections. It exhibits potent activity against Plasmodium falciparum and Echinococcus granulosus, facilitating research into its pharmacokinetics and metabolic pathways. This stable isotope is valuable for studies in drug metabolism and efficacy in malaria research. -
Stable Isotope
Myristoleyl carnitine-d3 is a deuterium-labeled derivative of myristoleyl carnitine, serving as a stable isotope for tracer studies. This compound is valuable in the investigation of metabolic pathways involving fatty acid metabolism and energy production. Its use in scientific research enables precise measurement of metabolic processes in cellular models and can enhance understanding of cardiometabolic disorders. -
Stable Isotope
Endoxifen-d5 (Z-isomer) is the stable isotope-labeled derivative of the Z-isomer of Endoxifen. This metabolite of Tamoxifen exhibits significant anti-estrogenic activity in breast cancer cells that express the estrogen receptor alpha (ERα), contributing to its therapeutic efficacy in estrogen-sensitive tumors. Additionally, Endoxifen (Z-isomer) demonstrates a concentration-dependent inhibition of the hERG potassium channel, with an IC50 value of 1.6 μM, making it a valuable tool for research into breast cancer treatment and associated cardiotoxic effects. -
Stable Isotope
Piperonyl butoxide-d9 is a deuterium-labeled derivative of Piperonyl butoxide, a known pesticide synergist and food additive. This stable isotope is utilized in biochemical research to study metabolic pathways and enhance the understanding of Piperonyl butoxide's biological effects, which include the activation of c-Jun and ATF-2 in mouse hepatocytes. Research has indicated its potential adverse effects on reproduction, development, and behavior in model organisms, as well as its status as a carcinogen in liver studies involving rats and mice. -
Stable Isotope
Cambendazole-d7 is a deuterium-labeled derivative of Cambendazole, serving as a stable isotope. This compound is useful in studies involving pharmacokinetics and metabolic pathways, allowing for precise tracking of Cambendazole in biological systems. Its incorporation into experiments can enhance the understanding of drug action and distribute in biological matrices. -
Stable Isotope
Carbosulfan-d18 is a deuterium-labeled derivative of Carbosulfan, targeting cytochrome P450 enzymes. It exhibits potent inhibition of CYP3A4 while demonstrating moderate inhibition of CYP1A1/2 and CYP2C19 in pooled human liver microsomes. This reagent is valuable for studies exploring the metabolic activation of Carbosulfan, particularly in human liver systems. -
Stable Isotope
Proguanil-d4 is a deuterium-labeled analog of Proguanil, which serves as an antimalarial proagent. Upon administration, Proguanil is metabolized to its active form, Cycloguanil, which exerts its pharmacological effects through the inhibition of dihydrofolate reductase (DHFR). This stable isotope is utilized in research applications including pharmacokinetic studies and metabolic pathway analysis to understand drug actions and interactions. -
Stable Isotope
Pyridaben-d13 is a deuterium-labeled version of Pyridaben, a potent mitochondrial electron transport inhibitor (METI) and acaricide. This compound selectively targets complex I (NADH dehydrogenase), demonstrating an inhibitory efficacy with an IC50 value of 2.4 nM in rat liver and bovine heart mitochondria. Additionally, Pyridaben-d13 significantly affects mitochondrial nitric oxide synthase (mtNOS) function in rat models, making it a valuable reagent for studies on mitochondrial dysfunction and oxidative stress. -
Stable Isotope
Parbendazole-d3 is a deuterium-labeled derivative of Parbendazole, a potent inhibitor of microtubule assembly. This compound disrupts tubulin stability, demonstrating an effective EC50 of 530 nM, and is known for its broad-spectrum anthelmintic activity. Parbendazole-d3 is utilized in research applications aimed at studying microtubule dynamics and developing anthelmintic therapies. -
Stable Isotope
Hexythiazox-d11 is a deuterium-labeled derivative of Hexythiazox, a selective acaricide targeting mites. It exhibits ovicidal, larvicidal, and nymphicidal activities, making it effective for the chemical control of mite populations on cotton, fruits, and vegetables. Hexythiazox demonstrates a favorable safety profile, being non-toxic to mammals while preserving beneficial insect species and natural mite predators. This isotopically labeled compound is valuable for research applications in pesticide efficacy and environmental impact studies. -
Stable Isotope
Methyl Clonazepam-d3 is a deuterium-labeled derivative of Methylclonazepam, a benzodiazepine that exerts anxiolytic effects. This compound is known to inhibit the absorption of 5-hydroxytryptamine by Schistosoma mansoni, demonstrating potential anti-parasitic activity. Methyl Clonazepam derivatives are valuable tools for research focused on schistosomiasis and related disorders, aiding in the exploration of therapeutic interventions. -
Stable Isotope
DL-Methionine-d3 is a stable isotope-labeled form of the essential amino acid DL-Methionine, which contains sulfur and is known for its role in oxidative stress defense. This compound is primarily utilized in research focusing on metabolic studies and isotopic tracing in biological systems. Additionally, DL-Methionine exhibits efficacy against Heterodera rostochiensis in potato plants, making it pertinent for studies in agronomy and plant defense mechanisms. -
Stable Isotope
2,3-Diphosphoglyceric acid-13C3 is a stable isotope-labeled form of 2,3-Diphosphoglyceric acid, an intermediate in the glycolytic pathway. This compound primarily stabilizes the deoxygenated form of hemoglobin through allosteric binding, thereby facilitating oxygen release to tissues. Additionally, 2,3-Diphosphoglyceric acid exhibits antiparasitic activity and is valuable in research related to Alzheimer's disease, contributing to the understanding of metabolic processes and disease mechanisms. -
Stable Isotope
Temephos-d12 is a deuterated form of Temephos, an organophosphate larvicide. It targets the central nervous system of aquatic larvae, including those of mosquitoes, midges, and black flies, by inhibiting cholinesterase activity. This mechanism leads to larval mortality prior to reaching the adult stage, making Temephos-d12 valuable for research on pesticide efficacy and environmental impact studies. -
Stable Isotope
(-)-Fucose-13C-2 is a stable isotope-labeled derivative of (-)-Fucose, a hexose sugar. This compound is instrumental in studying blood group antigen structure, as well as selectin-mediated leukocyte-endothelial adhesion mechanisms. Additionally, (-)-Fucose-13C-2 has applications in examining host-microbe interactions, contributing to research in immunology, glycobiology, and cellular communication. -
Stable Isotope
HCV-IN-49 is a phosphoramidate ester derivative that functions as an inhibitor of Hepatitis C virus (HCV) protease. This compound exhibits notable antiviral activity and is instrumental in the study of HCV replication and pathogenesis. HCV-IN-49 serves as a valuable tool in research applications focused on HCV treatment development and drug resistance mechanisms. -
Stable Isotope
Faldaprevir-d7 is a deuterated analog of Faldaprevir, designed as a stable isotope for research applications. Its primary mechanism involves targeting the NS3 protease of the hepatitis C virus, facilitating studies in viral replication and protease inhibition. This compound is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of drug behavior in biological systems. -
Stable Isotope
Faldaprevir-d6 is a deuterium-labeled analogue of Faldaprevir, a potent inhibitor of the NS3/4A protease in the hepatitis C virus. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for precise tracking of drug metabolism and clearance in biological systems. Its application in research contributes to a deeper understanding of antiviral drug behavior and efficacy. -
Stable Isotope
Darunavir-d9 is a stable isotope-labeled form of Darunavir, a next-generation HIV protease inhibitor. This compound exhibits significant antiviral activity against both wild-type and mutant HIV strains, displaying an IC50 of 0.003 μM and an IC90 of 0.009 μM while maintaining low cytotoxicity. Darunavir-d9 is primarily utilized in biochemical research applications, including drug metabolism studies and pharmacokinetics for advanced HIV research. -
Stable Isotope
Cabotegravir-d5 is a deuterium-labeled derivative of Cabotegravir, primarily used as a stable isotope. Its unique isotopic composition allows for advanced tracking and analysis in metabolic studies and pharmacokinetic research. This reagent serves as a valuable tool for elucidating the mechanisms of action of integrase inhibitors and for studying their pharmacodynamics in various biological systems. -
Stable Isotope
Rilpivirine-d6 is a deuterated form of Rilpivirine, a selective diarylpyrimidine non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV reverse transcriptase. This compound exhibits potent antiviral activity against both wild-type HIV (EC50=0.4 nM) and various mutant strains (EC50=0.1-2.0 nM). Rilpivirine demonstrates a notable genetic barrier to resistance, making it a valuable tool for research in HIV treatment and resistance profiling. Its isotopic labeling aids in pharmacokinetic and metabolic studies, enhancing understanding of drug behavior in biological systems. -
Stable Isotope
Atazanavir-d5 is a deuterium-labeled derivative of Atazanavir, a highly selective inhibitor of HIV-1 protease. This compound serves as a substrate and inhibitor of the cytochrome P450 enzyme CYP3A4, as well as an inhibitor and inducer of P-glycoprotein (P-gp). Additionally, Atazanavir exhibits activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM, making it valuable for research into HIV and coronavirus-related mechanisms. -
Stable Isotope
Indinavir-d6 is a deuterium-labeled analog of the potent HIV protease inhibitor Indinavir. It specifically targets the HIV protease enzyme, inhibiting viral replication and demonstrating favorable oral bioavailability. This stable isotope is utilized in pharmacokinetic studies, metabolic tracing, and the investigation of drug interactions within HIV research. -
Stable Isotope
Raltegravir-d3 potassium is a deuterium-labeled form of Raltegravir, a potent integrase inhibitor utilized in the treatment of HIV infection. This stable isotope serves as a valuable tool for pharmacokinetic studies and drug metabolism research, providing insights into the biological mechanisms of integrase inhibition. Its labeling facilitates the quantification and tracking of Raltegravir in various biological matrices, aiding researchers in understanding its therapeutic effects and metabolic pathways. -
Stable Isotope
Plerixafor-d4 is a deuterated derivative of Plerixafor, a selective antagonist of the CXCR4 receptor with an IC50 of 44 nM. This compound serves as an immunostimulant and is known for its ability to mobilize hematopoietic stem cells (HSCs). Additionally, Plerixafor has demonstrated efficacy in inhibiting HIV-1 and HIV-2 replication, with an EC50 ranging from 1 to 10 nM. Plerixafor-d4 is useful in research applications requiring stable isotopes for tracking and quantification purposes. -
Stable Isotope
Amprenavir-d4 is a deuterated form of Amprenavir, a potent inhibitor of the HIV protease with a Ki value of 0.6 nM. In addition to its antiviral properties, Amprenavir has been identified as a SARS-CoV 3CLpro inhibitor, demonstrating an IC50 of 1.09 μM. This stable isotope is utilized in chemical research for quantitative analysis and metabolic studies of drug metabolism and pharmacokinetics. -
Stable Isotope
Raltegravir-d4 is a deuterated analog of Raltegravir, which functions as a potent inhibitor of HIV integrase (IN). This stable isotope-labeled compound is designed for use in pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Raltegravir in biological systems. Its application is essential for understanding drug metabolism and interaction mechanisms in HIV treatment protocols. -
Stable Isotope
2-Phenylbutyric acid-d5 is a deuterium-labeled derivative of 2-Phenylbutanoic acid, a monocarboxylic acid known for its interaction with various proteins. This stable isotope is utilized in biological research to study malignant lymphoma and HIV-related diseases. Its labeling enables precise tracking and quantification in biochemical assays, making it a valuable tool for understanding metabolic pathways and disease mechanisms. -
Stable Isotope
Pramipexole-d5 dihydrochloride is a deuterated form of Pramipexole dihydrochloride, a selective agonist of the dopamine D2-type receptor that effectively crosses the blood-brain barrier. With binding affinities (Kis) of 2.2 nM for D2-type receptors, alongside 3.9 nM, 0.5 nM, and 1.3 nM for D2, D3, and D4 receptors respectively, it serves as a valuable tool in research. This reagent is primarily utilized in studies related to Parkinson's disease and restless legs syndrome, facilitating analysis of dopaminergic pathways and receptor interactions. -
Stable Isotope
(R)-3-O-Methyldopa-d3 is a deuterated form of the R-enantiomer of 3-O-Methyldopa, which acts as a metabolite of L-DOPA. The compound exerts its biological activity by competitively inhibiting catechol-O-methyltransferase (COMT), thus influencing the pharmacological effects of both L-DOPA and dopamine. This stable isotope is essential for research applications involving metabolic pathways and neurological studies. -
Stable Isotope
Clomipramine-d3 hydrochloride is a deuterium-labeled analog of Clomipramine hydrochloride, primarily acting as an inhibitor of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) with Ki values of 0.14 nM, 54 nM, and 3 nM, respectively. This stable isotope-labeled compound is valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in neuroscience research. Its specificity and potency make it an essential reagent for investigating the pharmacological effects of antidepressants and their mechanisms of action within the central nervous system. -
Stable Isotope
Zuclopenthixol-d4 succinate is a deuterium-labeled derivative of Zuclopenthixol, a thioxanthene compound that functions primarily as a mixed antagonist of dopamine D1 and D2 receptors. This stable isotope is utilized in pharmacokinetic studies and drug metabolism research, enabling precise tracking of the compound's behavior in biological systems. Its unique isotopic labeling enhances the accuracy of analytical methods in various studies related to neurological disorders and the pharmacodynamics of antipsychotic agents. -
Stable Isotope
Azaperone-d4 is a deuterium-labeled variant of Azaperone, which primarily functions as a dopamine antagonist. It exhibits additional antihistaminic and anticholinergic properties, making it a versatile tool in pharmacological studies. This pyridinylpiperazine and butyrophenone neuroleptic agent also demonstrates antiemetic effects, finding utility chiefly as a tranquilizer in veterinary medicine. Its stable isotope labeling provides valuable support for research applications involving drug metabolism and pharmacokinetics.
