Fig. 1 · Structure
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Toceranib-d8
Stable Isotope
Toceranib-d8 is a deuterium-labeled derivative of Toceranib, a potent orally active receptor tyrosine kinase (RTK) inhibitor. It effectively targets PDGFR, VEGFR, and Kit, displaying inhibitory constants of 5 nM and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib demonstrates significant antitumor and antiangiogenic properties, making it valuable in research related to canine mast cell tumors and other cancer models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1795134-78-9 |
| Applications | Stable Isotope |
| Formula | C22H17D8FN4O2 |
| Molecular Weight | 404.51 |
| SMILES | C(=C1C=2C(NC1=O)=CC=C(F)C2)C3=C(C)C(C(NCCN4C(C(C(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])=O)=C(C)N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.