Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Formamide-d1 is a deuterated form of formamide, serving as a stable isotope. It acts as an effective DNA denaturant, significantly destabilizing DNA structures in buffer solutions, which is crucial for various molecular biology applications. In addition to its role in DNA studies, formamide-d1 can function as a decalcifying agent for rat cardiac cells and is commonly utilized as a solvent for ion compounds, resins, and plasticizers in chemical research. -
Stable Isotope
Taurochenodeoxycholic acid-d9 sodium is a stable isotope-labeled derivative of Taurochenodeoxycholic acid. This compound serves as a key bioactive bile acid found in animal physiology, demonstrating significant biological activities such as apoptosis induction and anti-inflammatory effects. Taurochenodeoxycholic acid-d9 sodium is primarily utilized in research applications focused on bile acid metabolism, immunological studies, and the exploration of therapeutic avenues for inflammation-related diseases. -
Stable Isotope
Formamide-13C,15N is a stable isotope-labeled formamide employed primarily as a solvent and denaturant in molecular biology applications. It effectively destabilizes DNA, facilitating its denaturation in buffer solutions, which is essential for various genetic and biochemical assays. Additionally, Formamide-13C,15N plays a role in cancer research by promoting nucleotide phosphorylation and dephosphorylation processes, and it can be utilized as a decalcifying agent for cardiac tissue studies. Its versatility makes it a valuable reagent in both chemical and biological research. -
Stable Isotope
Momelotinib-d4 dihydrochloride hydrate is a deuterium-labeled derivative of Momelotinib, an ATP-competitive inhibitor of Janus kinases JAK1 and JAK2, exhibiting IC50 values of 11 nM and 18 nM, respectively. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for the elucidation of drug metabolism and biodistribution in various biological systems. Additionally, its limited activity against JAK3 makes it a valuable tool for selective JAK inhibition studies. -
Stable Isotope
D-Mannitol-13C,d2 is a stable isotope-labeled form of D-Mannitol, which serves as an osmotic diuretic and explores its role in cellular osmoregulation. D-Mannitol is utilized in various research applications, including the study of calcium and magnesium absorption, as well as promoting brown adipose tissue formation through the activation of β3-adrenergic receptors. It is also valuable in plant cell culture, helping maintain osmotic balance and protecting cells, particularly when cell walls are compromised. This reagent is essential for researchers investigating metabolic pathways, therapeutic interventions, and plant physiology. -
Stable Isotope
Resiquimod-d5 is a deuterated form of Resiquimod, an agonist of Toll-like receptors 7 and 8 (TLR7/TLR8). This compound is known to enhance the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IFN-α. Resiquimod-d5 serves as a valuable tool in research applications focused on immune response modulation and the study of TLR signaling pathways. -
Stable Isotope
Chloroquine-d5 is a deuterium-labeled analog of Chloroquine, an established antimalarial and anti-inflammatory agent. It functions primarily as an autophagy and toll-like receptor (TLR) inhibitor, making it a valuable tool in various research settings. Notably, Chloroquine-d5 has demonstrated potent in vitro efficacy against SARS-CoV-2 (COVID-19) infection, with an EC50 of 1.13 μM. This stable isotope is particularly useful in tracer studies and pharmacokinetic research involving Chloroquine. -
Stable Isotope
Ethyl glucuronide-d5 is a deuterated analog of ethyl glucuronide, serving as a stable isotope for research applications. Ethyl glucuronide acts as a metabolite of ethanol and functions as a biomarker for alcohol consumption, accumulating in hair and providing insights into long-term alcohol intake. Additionally, ethyl glucuronide serves as an agonist for TLR4, implicating its role in immune response research. -
Stable Isotope
Hydroxychloroquine-d4-1 sulfate is a deuterium-labeled derivative of Hydroxychloroquine, a synthetic antimalarial agent that also targets Toll-like receptor 7/9 (TLR7/9) signaling. This stable isotope variant is essential for pharmacokinetic studies and metabolic research, providing a powerful tool for investigating drug interactions and biological mechanisms. Additionally, Hydroxychloroquine exhibits significant antiviral activity, notably inhibiting SARS-CoV-2 infection in vitro, making it relevant for studies involving viral pathogenesis and therapeutic interventions. -
Stable Isotope
Desethyl chloroquine-d4 is a deuterium-labeled analog of Desethyl chloroquine, a significant metabolite of Chloroquine. This compound acts primarily as an inhibitor of autophagy and toll-like receptors (TLRs), making it valuable for investigations into immune responses and cellular processes. Furthermore, Desethyl chloroquine exhibits notable antiplasmodic activity, facilitating its use in malaria research and related studies on parasite biology. -
Stable Isotope
4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d4 is a stable isotope of Hydroxychloroquine Impurity E. This compound serves as a relevant impurity of Hydroxychloroquine, a synthetic antimalarial agent known for its ability to inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Additionally, Hydroxychloroquine has demonstrated effective antiviral properties against SARS-CoV-2 in vitro, making it a valuable tool for research into antiviral therapies and immunological studies. -
Stable Isotope
Desethyl chloroquine-d5 is a deuterium-labeled form of Desethyl chloroquine, a significant metabolite of chloroquine. It functions as an inhibitor of autophagy and toll-like receptors (TLRs), thereby influencing immune response pathways. This compound exhibits antiplasmodic activity, making it valuable for research in malaria and related fields. Its stable isotope labeling enhances its utility in pharmacokinetic studies and metabolic tracking. -
Stable Isotope
Hydroxychloroquine-d4 sulfate is a deuterium-labeled derivative of Hydroxychloroquine sulfate, known for its role as a synthetic antimalarial agent. This compound exhibits inhibition of Toll-like receptor 7/9 (TLR7/9) signaling pathways and has demonstrated efficacy in inhibiting SARS-CoV-2 infection in vitro. Hydroxychloroquine-d4 sulfate serves as a stable isotope for use in various biochemical and biological research applications. -
Stable Isotope
Chloroquine-d5 diphosphate is a deuterium-labeled form of Chloroquine, functioning as a stable isotope. This compound exhibits potent antimalarial and anti-inflammatory properties, making it relevant for research in malaria treatment and rheumatoid arthritis. Additionally, Chloroquine-d5 diphosphate acts as an inhibitor of autophagy and toll-like receptors (TLRs), and has shown significant efficacy against SARS-CoV-2 in vitro, aiding studies in viral infection mechanisms and therapeutic interventions. -
Stable Isotope
Imiquimod-d9 is a deuterium-labeled analogue of Imiquimod, which acts as a selective agonist of Toll-like receptor 7 (TLR7). This compound demonstrates significant antiviral and antitumor activities in vivo, facilitating immune responses. Imiquimod-d9 is utilized in research focused on external genital and perianal warts, cancer therapies, and potential applications in COVID-19 studies. -
Stable Isotope
Atazanavir-d24 is a deuterium-labeled derivative of Atazanavir, which primarily functions as a selective and orally bioavailable HIV-1 protease inhibitor. This compound also exhibits inhibitory effects on CYP3A4 and P-glycoprotein, making it relevant for studies on drug metabolism and transport. Additionally, Atazanavir demonstrates antiviral activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM and has been implicated in the inhibition of cardiac fibrosis and hyperlipidemia, as well as the induction of cell death in malignant glioma. It serves as a valuable research tool for investigating HIV treatment and related pathophysiological mechanisms. -
Stable Isotope
Trimethylamine N-oxide-d9 is a deuterium-labeled form of Trimethylamine N-oxide, a gut microbiome-dependent metabolite derived from dietary choline and trimethylamine-rich nutrients. This compound has been shown to induce inflammation through the activation of the ROS/NLRP3 inflammasome. Additionally, Trimethylamine N-oxide is involved in accelerating fibroblast-to-myofibroblast differentiation, promoting cardiac fibrosis via the TGF-β/smad2 signaling pathway. It is a valuable reagent for research on metabolic disorders and cardiovascular diseases. -
Stable Isotope
(±)11(12)-EET-d11 is a deuterium-labeled analog of (±)11(12)-EET, which acts as an inhibitor of the NLRP3 inflammasome. This compound is important for studies investigating anti-inflammatory pathways, angiogenesis, and cardioprotection. The stable isotope labeling allows for enhanced tracking and analysis in various biological assays and helps elucidate the role of (±)11(12)-EET in cellular and molecular processes. -
Stable Isotope
L-Lysine6-13C dihydrochloride is a stable isotope-labeled form of the essential amino acid L-Lysine, featuring a carbon-13 isotope. This reagent is valuable in metabolic studies and tracer experiments, enabling researchers to track metabolic pathways and analyze protein synthesis. Its incorporation into biological systems aids in the understanding of amino acid dynamics and nutrition-related research. -
Stable Isotope
3-O-Methyldopa-d3 is a deuterium-labeled analog of 3-O-Methyldopa, a metabolite of L-DOPA that effectively crosses the blood-brain barrier. This compound plays a significant role in inhibiting the astrocyte-mediated neuroprotective effects of L-DOPA on dopaminergic neurons while also exhibiting antidepressant and neuroprotective properties. Its unique isotopic labeling allows for advanced research into nervous system disorders, including depression and Parkinson's disease. -
Stable Isotope
Potassium 1H-indol-3-yl sulfate-d4 is a stable isotope variant of Potassium 1H-indol-3-yl sulfate, a metabolite derived from tryptophan and synthesized by intestinal microorganisms. It interacts with the aryl hydrocarbon receptor (AhR) as a potent endogenous agonist, and is recognized as a urinary toxin. This compound is valuable for research into kidney diseases and the metabolic pathways related to tryptophan metabolism. -
Stable Isotope
Gluconate-13C6 sodium is a stable isotope-labeled derivative of D-Gluconic acid sodium salt. It serves as a valuable tool in metabolic research, allowing for tracking and quantification of glucose derivatives in biological systems. Gluconate-13C6 sodium exerts anti-inflammatory effects by reducing nitric oxide and pro-inflammatory cytokines such as IL-1β and IL-6. Additionally, it exhibits antioxidant properties and demonstrates potential antitumor activity against colorectal cancer, as well as benefits for conditions like osteoarthritis, intestinal damage, and acute lung injury. -
Stable Isotope
Lauroyl-L-carnitine-d9 chloride is a deuterium-labeled derivative of Lauroyl-L-carnitine chloride, functioning as a stable isotope for research. This metabolite exhibits significant biological activity by reversing the downregulation of the IL-10 gene, which is crucial in inflammatory responses. Lauroyl-L-carnitine chloride has shown potential in alleviating symptoms associated with Crohn's-like colitis, making it valuable for studies in gastrointestinal disorders and inflammation. -
Stable Isotope
Lauroyl-L-carnitine-d3 chloride is a deuterium-labeled derivative of Lauroyl-L-carnitine chloride, serving as a stable isotope for metabolic studies. This compound acts as an orally active metabolite, exhibiting a significant ability to reverse the downregulation of IL-10, a key regulatory gene. Research applications include investigations into inflammatory conditions such as Crohn's disease, where Lauroyl-L-carnitine chloride has demonstrated the capacity to alleviate symptoms of Crohn's-like colitis. -
Stable Isotope
Gluconate-1-13C sodium is a stable isotope of D-Gluconic acid, primarily targeting metabolic pathways in biological research. This compound exhibits significant biological activities, including the reduction of nitric oxide and inflammatory cytokines such as IL-1β and IL-6. Additionally, it inhibits ERK phosphorylation, demonstrating potential antioxidant and antiplatelet effects. Research applications include studying its antitumor activity against colorectal cancer and its therapeutic effects in conditions like osteoarthritis, intestinal damage, and acute lung injury. -
Stable Isotope
Balsalazide-d4 is a deuterium-labeled derivative of Balsalazide, primarily utilized as a stable isotope for research applications. This compound has demonstrated potential in suppressing colitis-associated carcinogenesis by modulating the IL-6/STAT3 signaling pathway. Balsalazide-d4 serves as a valuable tool for studying inflammatory responses and cancer development in preclinical models. -
Stable Isotope
Diacerein-d6 is a deuterated isotope of Diacerein, an interleukin-1 beta inhibitor known for its anti-inflammatory properties. This stable isotope plays a critical role in pharmaceutical research and metabolic studies, allowing for precise tracking of Diacerein's biological pathways. Its applications include investigations into joint diseases and related inflammatory conditions. -
Stable Isotope
Avapritinib-d3 is a deuterium-labeled derivative of Avapritinib, a potent and selective inhibitor of mutant kinase targets KIT and PDGFRA. It demonstrates remarkable biological activity with IC50 values of 0.27 nM and 0.24 nM for KIT D816V and PDGFRA D842V mutations, respectively. Avapritinib-d3 binds to the active conformation of these kinases, contributing to its antitumor effects, and it also inhibits the transport functions of ABCB1 and ABCG2. This stable isotope variant is useful for pharmacokinetic studies and tracer applications in chemical research. -
Stable Isotope
GW2580-d6 is a deuterium-labeled variant of GW2580, a selective and orally bioavailable inhibitor of c-Fms kinase. It effectively inhibits human c-Fms kinase in vitro at a concentration of 0.06 μM by acting as a competitive inhibitor of ATP binding, thereby disrupting colony-stimulating factor-1 (CSF-1) signaling pathways. This reagent is valuable for studying signaling processes mediated by c-Fms in various biological contexts and provides insights into macrophage biology and inflammatory responses. -
Stable Isotope
Axitinib-13C,d3 is a stable isotope-labeled version of the multi-targeted tyrosine kinase inhibitor Axitinib, incorporating both carbon-13 and deuterium isotopes. Axitinib exhibits potent inhibitory activity against several receptor tyrosine kinases, with IC50 values of 0.1 nM for VEGFR1, 0.2 nM for VEGFR2, 0.1-0.3 nM for VEGFR3, and 1.6 nM for PDGFRβ. This reagent is particularly valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in drug metabolism and interaction research. -
Stable Isotope
Taurocholic acid-d8 sodium is a deuterium-labeled derivative of taurocholic acid, serving as a stable isotope for research applications. This compound exhibits significant biological activity, including the inhibition of biliary damage induced by hepatic artery ligation, which is attributed to the upregulation of VEGF-A expression. Additionally, taurocholic acid sodium is known for its immunomodulatory effects, making it valuable for studies in hepatobiliary physiology and immune response regulation. -
Stable Isotope
Regorafenib-d3 is a deuterium-labeled derivative of Regorafenib, a multi-targeted receptor tyrosine kinase inhibitor. This stable isotope is primarily utilized as a tracer in pharmacokinetic and metabolic studies. It is instrumental in investigating the pathways of Regorafenib metabolism, enhancing the understanding of its biological activity and therapeutic applications in oncology research. -
Stable Isotope
Fruquintinib-d6 is the deuterated form of Fruquintinib, a highly selective and potent inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 (VEGFR 1/2/3). This compound demonstrates inhibitory activity with IC50 values of 33 nM for VEGFR-1, 0.35 nM for VEGFR-2, and 35 nM for VEGFR-3. Fruquintinib-d6 is primarily utilized in pharmacokinetic studies and metabolic profiling, providing valuable insights for cancer research and therapeutic development. -
Stable Isotope
Taurocholic acid-13C2,15N sodium is a stable isotope-labeled derivative of Taurocholic acid, featuring two carbon-13 and one nitrogen-15 isotope. This reagent is primarily utilized in metabolic studies and tracer experiments, allowing for the precise tracking of bile acid metabolism in biological systems. Its applications extend to fields such as pharmacokinetics, digestion research, and liver function analysis, enabling scientists to elucidate metabolic pathways with heightened accuracy. -
Stable Isotope
Vatalanib-d4 is a deuterated form of Vatalanib, a potent inhibitor of the vascular endothelial growth factor receptor 2 (VEGFR2/KDR) with an IC50 of 37 nM. The stable isotope labeling of Vatalanib-d4 facilitates quantitative studies in pharmacokinetics, metabolism, and bioavailability. This compound is valuable for research in angiogenesis, cancer therapeutics, and related pathways. -
Stable Isotope
Tivozanib-d6 is a deuterium-labeled form of Tivozanib, a selective inhibitor of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), demonstrating IC50 values of 30 nM, 6.5 nM, and 15 nM, respectively. This reagent is employed in chemical research to track the metabolism and pharmacokinetics of Tivozanib in various biological systems. Its application is particularly relevant in studies focused on tumor growth inhibition and angiogenesis modulation, enhancing understanding of targeted cancer therapies. -
Stable Isotope
Regorafénib N-oxyde-d3(M2) is a deuterium-labeled analog of Regorafénib N-oxyde M2, an active metabolite of the multi-targeted inhibitor Regorafenib. This compound targets key receptors including VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1, exhibiting IC50 values of 13, 4.2, 46, 22, 7, 1.5, and 2.5 nM, respectively. Regorafénib N-oxyde-d3(M2) is primarily utilized in stable isotope labeling studies to trace metabolic pathways and explore pharmacokinetics in research applications. -
Stable Isotope
N-Acetyl-5-hydroxytryptamine-d3 is a deuterium-labeled derivative of N-Acetyl-5-hydroxytryptamine, commonly known as a melatonin precursor. This compound is known for its ability to effectively activate the TrkB receptor, which plays a critical role in neuroprotective and neurotrophic signaling. It is valuable for research applications involving melatonin pathways and receptor activation studies. -
Stable Isotope
Amitriptyline-d3 hydrochloride is a deuterium-labeled derivative of amitriptyline, primarily targeting the serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET). It exhibits Ki values of 3.45 nM and 13.3 nM for human SERT and NET, respectively, and demonstrates weak binding to the dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Additionally, amitriptyline-d3 hydrochloride acts as an agonist for TrkA and TrkB receptors, exhibiting neurotrophic activity and contributing to its antidepressant effects. This stable isotope is valuable for metabolic studies and drug mechanism research. -
Stable Isotope
4-(Trifluoromethyl)aniline-d4 is a deuterium-labeled derivative of 4-(Trifluoromethyl)aniline, known for its specificity as a dual inhibitor of DYRK1A and DYRK1B kinases, with IC50 values of 54.84 nM and 186.40 nM, respectively. This stable isotope is primarily used in metabolic studies and tracing experiments to elucidate biochemical pathways involving DYRK kinases. It serves as a valuable tool in chemical biology and pharmacological research focused on kinase inhibition and the development of therapeutic strategies. -
Stable Isotope
Selpercatinib-d3 is a deuterium-labeled derivative of Selpercatinib, a selective RET kinase inhibitor. It displays potent activity against wild-type RET and its mutants, with IC50 values of 14.0 nM for RET (WT), 24.1 nM for RET (V804M), and 530.7 nM for RET (G810R). This stable isotope is valuable for research applications focused on investigating RET-mediated signaling and potential therapeutic strategies for RET-altered malignancies. -
Stable Isotope
Dexamethasone-4,6α,21,21-d4 is a deuterated derivative of Dexamethasone, functioning as a glucocorticoid receptor agonist. It exhibits potent anti-inflammatory properties, including the modulation of neutrophil and monocyte surface markers such as CD11b and CD18, which are crucial for immune cell activation and migration. This reagent is particularly relevant for research on inflammatory responses, including studies related to COVID-19, as well as investigations into exosome-mediated microRNA regulation in macrophage activation. -
Stable Isotope
Dexamethasone-d5 is a deuterium-labeled analog of the glucocorticoid receptor agonist Dexamethasone. It is known to reduce the expression of CD11b, CD18, and CD62L on neutrophils, as well as CD11b and CD18 on monocytes, thereby modulating immune responses. This stable isotope is particularly valuable in research applications studying the mechanics of inflammation, including the regulation of exosomal microRNA-155 production in lipopolysaccharide-stimulated macrophages, and its efficacy in managing conditions such as COVID-19. -
Stable Isotope
Dexamethasone-d4 is a deuterium-labeled derivative of Dexamethasone, which acts as a potent glucocorticoid receptor agonist. This compound has notable biological activities, including the modulation of immune cell marker expression by decreasing levels of CD11b, CD18, and CD62L on neutrophils, as well as CD11b and CD18 on monocytes. Dexamethasone-d4 is particularly valuable for research applications related to anti-inflammatory responses and the investigation of COVID-19 pathophysiology, as it inhibits exosome production containing inflammatory microRNA-155 during macrophage activation. -
Stable Isotope
Cyclosporin A-d3 is a deuterated form of Cyclosporin A, serving as a stable isotope for research applications. This labeled compound is utilized in pharmacokinetic studies, enabling the tracking and quantification of Cyclosporin A in biological samples. Its unique isotopic signature facilitates accurate analyses of drug metabolism, distribution, and excretion in various biological systems. -
Stable Isotope
Promethazine-d4 hydrochloride is a deuterated form of Promethazine hydrochloride, a first-generation antihistamine that primarily functions as a strong antagonist of the H1 receptor. It also exhibits moderate antagonistic activity at mACh receptors, alongside a moderate affinity for 5-HT2A, 5-HT2C, D2, and α1-adrenergic receptors. This stable isotope is useful for tracing studies, pharmacokinetic research, and metabolite identification in biological samples. -
Stable Isotope
Fexofenadine-d6 Methyl Ester is a stable isotope-labeled derivative of Fexofenadine Methyl Ester. This deuterium-labeled compound is utilized in pharmacokinetic studies and quantitative mass spectrometry applications, facilitating the investigation of drug metabolism and disposition. Its precise isotopic labeling allows for enhanced detection and differentiation in complex biological matrices. -
Stable Isotope
Desloratadine-d4 is a deuterium-labeled analog of Desloratadine, the primary active metabolite of the nonsedating H1-antihistamine Loratadine. As a selective H1-receptor antagonist, Desloratadine-d4 exhibits significant anti-allergic and anti-inflammatory properties. This stable isotope is ideal for pharmacokinetic studies and dynamic research applications involving H1-receptor signaling pathways. -
Stable Isotope
Loratadine-d4 is a deuterated form of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. With an IC50 greater than 32 μM, Loratadine demonstrates significant anti-dengue virus (DENV) activity and can inhibit the immunologic release of inflammatory mediators. This stable isotope is valuable in pharmacokinetic studies and for the development of analytical methods in chemical research. -
Stable Isotope
Betahistine-d3 dihydrochloride is a deuterium-labeled form of Betahistine dihydrochloride, functioning primarily as a histamine H1 receptor agonist and H3 receptor antagonist. This stable isotope is utilized in research focused on rheumatoid arthritis (RA), facilitating studies on histaminergic systems and their implications in inflammatory responses. Its unique labeling allows for enhanced tracking and analysis in various biomedical contexts.
