Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
CDK2-IN-14-d3 is a stable isotope-labeled inhibitor targeting Cyclin-Dependent Kinase 2 (CDK2). This compound exhibits potent and selective inhibition of CDK2, making it a valuable tool in cancer research. It is suitable for studies investigating cell cycle regulation and therapeutic strategies for CDK2-related malignancies. -
Stable Isotope
Palbociclib-d4 is a stable isotope-labeled form of Palbociclib, a selective inhibitor of CDK4 and CDK6, demonstrating IC50 values of 11 and 16 nM respectively. This compound exhibits strong anti-proliferative effects and effectively induces cell cycle arrest in cancer cells. Palbociclib-d4 is primarily utilized in research related to hormone receptor-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma studies. -
Stable Isotope
EthD-d5 bromide is a deuterium-labeled variant of Ethidium bromide, serving as a stable isotope. It acts as an intercalating agent and is widely utilized as a fluorescent nucleic acid stain in molecular biology applications, including agarose gel electrophoresis. This reagent facilitates the visualization and analysis of nucleic acids, enhancing the accuracy of molecular assays. -
Stable Isotope
Fluphenazine-d8 is a deuterium-labeled derivative of fluphenazine, functioning primarily as a dopamine receptor antagonist. It effectively inhibits postsynaptic dopamine-2 receptors in key neural pathways, including the mesolimbic, nigrostriatal, and tuberoinfundibular systems. This reagent is valuable in research areas such as psychosis and diabetic peripheral neuropathy, and it has shown potential in studies related to SARS-CoV-2 inhibition. Fluphenazine-d8 serves as a useful tool for elucidating the pharmacodynamics of dopaminergic activity and its downstream effects. -
Stable Isotope
FOY 251-d4 is a deuterium-labeled derivative of FOY 251, a potent proteinase inhibitor and active metabolite of Camostate. It effectively inhibits SARS-CoV-2 infection in cellular assays, making it a valuable tool for studying viral entry and proteolytic processes. FOY 251-d4 serves as a stable isotope research reagent for exploring protein interactions and mechanisms within virology and pharmacology. -
Stable Isotope
Nirmatrelvir-d6 is a deuterated form of Nirmatrelvir, a potent inhibitor of the SARS-CoV 3C-like protease (3CLPRO). This stable isotope is designed for use in research applications related to COVID-19, allowing researchers to study the pharmacokinetics and metabolic pathways of the original compound. By utilizing Nirmatrelvir-d6, scientists can gain insights into the effects of 3CLPRO inhibition on SARS-CoV-2, contributing to the development of therapeutic strategies against this virus. -
Stable Isotope
DL-Serine-2,3,3-d3 is a stable isotope-labeled form of DL-Serine, a crucial metabolite consisting of both D-Serine and L-Serine. This compound serves as a valuable tool for metabolic and pharmacological studies, particularly in understanding serine metabolism. Additionally, DL-Serine exhibits antiviral activity against the replication of tobacco mosaic virus (TMV), making it relevant for virology research. -
Stable Isotope
L-Lysine-13C6,15N2 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tool in metabolic research and tracer studies, allowing for the examination of amino acid metabolism and kinetics in biological systems. Its applications extend to understanding lysine's role in physiological processes, including calcium absorption and gut health. -
Stable Isotope
L-Lysine-d4 hydrochloride is a deuterium-labeled analog of the essential amino acid L-Lysine, which plays a crucial role in protein synthesis and metabolic functions. As a stable isotope, it serves as a valuable tracer in metabolic studies, particularly in amino acid metabolism and kinetics. Research applications include studying the pharmacokinetics of lysine-related compounds and its implications in health conditions such as herpes treatment and calcium absorption enhancement. -
Stable Isotope
Phenytoin-d10 is a deuterium-labeled derivative of Phenytoin, primarily targeting voltage-gated sodium channels (VGSCs). This compound exhibits significant antiepileptic activity and has been shown to inhibit breast tumor growth and metastasis in murine models. Phenytoin-d10 serves as a valuable tool for research involving drug metabolism, pharmacokinetics, and the investigation of sodium channel function in various biological contexts. -
Stable Isotope
L-Lysine-13C6 dihydrochloride is a stable isotope-labeled derivative of the essential amino acid L-Lysine. This compound plays a crucial role in various biological processes, including the synthesis of connective tissues and carnitine, as well as energy production and immune function. Its applications extend to metabolic studies, isotopic labeling experiments, and research focusing on amino acid metabolism and physiological functions in both human and animal systems. -
Stable Isotope
L-Lysine-13C6 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, targeting metabolic and biological research applications. This compound plays a critical role in protein synthesis, cellular function, and is involved in various physiological processes. Its isotopic labeling allows for precise tracing in metabolic studies, making it a valuable tool for researchers investigating amino acid utilization, metabolism, and related health effects. -
Stable Isotope
L-Lysine-15N2 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, which plays a crucial role in protein synthesis and metabolic processes. This reagent is valuable in biochemical research, particularly in the study of amino acid metabolism, nutritional biochemistry, and the tracking of metabolic pathways using stable isotope labeling techniques. Its applications extend to research on nutritional deficiencies, disease states, and the physiological impacts of lysine supplementation. -
Stable Isotope
L-Lysine-d8 hydrochloride is a stable isotope of the essential amino acid L-lysine. This compound serves as a valuable tool in biochemical and metabolic research applications, particularly in studies involving protein metabolism and amino acid tracking. The deuterium labeling facilitates precise quantification and tracing in various experimental settings, enhancing understanding of metabolic pathways and physiological effects associated with L-lysine supplementation. -
Stable Isotope
L-Lysine-d9 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tool in metabolic studies and isotopic tracing applications. Its role in various biological processes makes it relevant for research related to amino acid metabolism, dietary interventions, and the physiological effects of lysine supplementation in health and disease contexts. -
Stable Isotope
L-Lysine-d3 hydrochloride is a deuterated form of the essential amino acid L-Lysine, which primarily functions as a stable isotope. This compound plays a crucial role in various biological processes, including the synthesis of connective tissues and carnitine, energy metabolism, and supporting immune functions. It is widely utilized in metabolic studies and tracer experiments, facilitating research in nutrition, developmental biology, and related fields. -
Stable Isotope
L-Lysine-13C dihydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tracer in metabolic studies and is significant for research involving amino acid metabolism, cellular transport, and protein synthesis. Its applications include investigating lysine's role in various biological processes and exploring therapeutic potentials for conditions such as herpes, calcium absorption, and diabetes-related disorders. -
Stable Isotope
N-Desmethylclozapine-d8 is a deuterium-labeled analogue of N-Desmethylclozapine, a significant active metabolite of the atypical antipsychotic clozapine. This compound serves as a potent partial agonist at M1 receptors (EC50 = 115 nM), effectively enhancing hippocampal NMDA receptor currents through M1 receptor activation. Additionally, it functions as a δ-opioid agonist, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychiatric disorders. -
Stable Isotope
N-Desmethylclozapine-d8 hydrochloride is a deuterated form of N-Desmethylclozapine hydrochloride, an important active metabolite of the atypical antipsychotic Clozapine. This compound acts as a potent allosteric and partial agonist of M1 receptors (EC50 = 115 nM) and enhances hippocampal N-methyl-D-aspartate (NMDA) receptor currents via M1 receptor activation. Additionally, N-Desmethylclozapine-d8 exhibits δ-opioid agonist activity, making it valuable for research in neuropharmacology and receptor signaling pathways. -
Stable Isotope
Probucol-13C3 is a stable isotope-labeled form of Probucol, a recognized anti-hyperlipidemic agent. It functions by reducing cholesterol levels in the bloodstream through enhanced low-density lipoprotein (LDL) catabolism. This compound is valuable for metabolic studies and can be used in research investigating lipid metabolism and cardiovascular health. -
Stable Isotope
Anthraquinone-d8 is a deuterated form of anthraquinone, serving as a stable isotope for scientific research. This compound is primarily utilized in studies involving organic synthesis and dye formation, providing enhanced accuracy in analytical applications. Its stable isotopic nature aids in tracing pathways and reaction mechanisms in complex biochemical processes. -
Stable Isotope
4-Methylanisole-d3 is a deuterium-labeled derivative of 4-Methylanisole, also known as 4-Methoxytoluene. This stable isotope is primarily utilized in various analytical applications, particularly in the field of mass spectrometry, to enhance the accuracy and sensitivity of detection methods. 4-Methylanisole-d3 is valuable for studying flavor compounds, fragrance profiles, and their metabolic pathways in food and cosmetic research. -
Stable Isotope
L-Lysine-13C6,15N2,d9 dihydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, featuring both deuterium and 13C and 15N isotopes. This compound is utilized in metabolic studies and tracer experiments to elucidate amino acid metabolism and protein synthesis pathways. Its incorporation in research can enhance the understanding of calcium absorption processes, gastrointestinal health, and the management of conditions related to diabetes and herpes. -
Stable Isotope
Phenytoin-15N2,13C is a stable isotope-labeled variant of Phenytoin, which acts primarily as a blocker of voltage-gated sodium channels (VGSCs). This compound demonstrates significant antiepileptic properties and has been shown to inhibit breast tumor growth and metastasis in murine models. It is valuable for research applications involving metabolic tracking and pharmacokinetic studies related to Phenytoin's therapeutic effects and mechanisms of action. -
Stable Isotope
Desmethyl Levofloxacin-d8 is a deuterated form of Desmethyl Levofloxacin, a key metabolite of Levofloxacin. This synthetic fluoroquinolone antibiotic exerts its biological activity by inhibiting bacterial DNA gyrase, thereby disrupting DNA supercoiling and interfering with DNA replication. Desmethyl Levofloxacin-d8 serves as a valuable stable isotope labeled reagent for pharmacokinetic studies and analytical applications in drug metabolism research. -
Stable Isotope
Sulfanilamide-d4 is a stable isotope-labeled derivative of sulfanilamide, specifically designed for quantitative studies. As a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase, sulfanilamide-d4 demonstrates an IC50 of 320 μM. This reagent is utilized in biochemical research to trace metabolic pathways and assess the activity of dihydropteroate synthetase in microbial systems. -
Stable Isotope
Valacyclovir-d8 hydrochloride is a deuterated analog of Valacyclovir hydrochloride, serving as a stable isotope for advanced research applications. This compound exhibits potent antiviral activity against herpes simplex virus type 1 (HSV-1) with an IC50 of 2.9 μg/ml, making it a valuable tool in studying viral infections. Valacyclovir functions as a prodrug of Acyclovir, facilitating studies on pharmacokinetics and metabolism in virology and clinical research contexts. -
Stable Isotope
2-Thiophenecarboxaldehyde-d3 is a deuterium-labeled derivative of 2-Thiophenecarboxaldehyde. This stable isotope is used as an internal standard in analytical chemistry and pharmacokinetic studies. Its primary application lies in the investigation of antibacterial and nematicidal properties, contributing valuable insights to chemical research in microbiology and pest control. -
Stable Isotope
Sarafloxacin-d8 hydrochloride is a deuterium-labeled derivative of the quinolone antibiotic Sarafloxacin. This stable isotope reagent enables investigations into the drug's pharmacokinetics and metabolic pathways. It is widely applicable in tracing studies and mass spectrometry, facilitating enhanced understanding of antibiotic behavior in biological systems. -
Stable Isotope
Nitrofurantoin-13C3 is a stable isotope-labeled form of Nitrofurantoin, a broad-spectrum antimicrobial agent known for its effectiveness against beta-lactamase-producing bacteria. This compound functions as an antibiotic, primarily employed in the study and treatment of urinary tract infections (UTIs), including cystitis and pyelonephritis. The stable isotope labeling allows for enhanced tracking and quantification in pharmacokinetic and metabolic studies. -
Stable Isotope
Moxifloxacin-d3-1 hydrochloride is a deuterium-labeled derivative of Moxifloxacin, an 8-methoxyquinolone antibiotic. This stable isotope serves as a valuable analytical tool in pharmacokinetic studies and metabolic profiling of Moxifloxacin. It is particularly useful in research applications focused on understanding the drug's metabolic pathways, efficacy against bacterial infections, and its role in treating conditions such as acute bacterial sinusitis and community-acquired pneumonia. -
Stable Isotope
Flumequine-13C3 is a stable isotope-labeled variant of flumequine, a quinolone antibiotic known for its ability to inhibit topoisomerase II with an IC50 of 15 μM (3.92 μg/mL). This compound is essential for research involving metabolic studies and drug metabolism, enabling precise tracking and analysis of flumequine's biochemical interactions within biological systems. Its stable isotope label makes it particularly useful in mass spectrometry applications and pharmacokinetic studies. -
Stable Isotope
2-(α-D-Mannopyranosyl)-L-tryptophan-d4 is a stable isotope-labeled derivative of 2-(α-D-Mannopyranosyl)-L-tryptophan, facilitating enhanced analysis in metabolic studies. This compound serves as a valuable tool for tracing metabolic pathways and studying glycoprotein interactions in biochemical research. Its deuterium labeling aids in quantifying and tracking molecules in complex biological systems, making it an essential reagent for researchers in the fields of glycoscience and pharmacology. -
Stable Isotope
Sulfamonomethoxine-d3-1 is a deuterium-labeled derivative of Sulfamonomethoxine, functioning primarily as a stable isotope. This compound serves as an orally active sulfonamide antibiotic utilized in veterinary medicine, exhibiting antibacterial activity. By inhibiting dihydropteroate synthetase, Sulfamonomethoxine-d3-1 effectively disrupts folic acid synthesis, making it a valuable reagent for research applications involving antibiotic activity and metabolic studies. -
Stable Isotope
Moxifloxacin-d3 hydrochloride is a deuterium-labeled derivative of the antibiotic Moxifloxacin hydrochloride, designed for stable isotope applications in research. This compound retains the antimicrobial activity of the original Moxifloxacin, which is effective in treating infections such as acute bacterial sinusitis, exacerbations of chronic bronchitis, and community-acquired pneumonia. Moxifloxacin-d3 hydrochloride is valuable for pharmacokinetic studies and metabolic research involving isotopic tracing. -
Stable Isotope
Ertapenem-d4 is a deuterium-labeled derivative of the broad-spectrum β-lactam antibiotic Ertapenem. This compound exhibits potent antibacterial activity, particularly against a variety of anaerobic bacteria, with a minimum inhibitory concentration (MIC) of 0.12 μg/mL. Ertapenem-d4 is useful in research applications focused on the pharmacokinetics and metabolic pathways of β-lactam antibiotics, as well as studies involving severe bacterial infections in diverse anatomical sites including the skin, lungs, stomach, pelvis, and urinary tract. -
Stable Isotope
Aprepitant-13C2,d2 (Major) is a stable isotope-labeled variant of Aprepitant, a selective and high-affinity antagonist of the neurokinin 1 receptor with a dissociation constant (Kd) of 86 pM. This reagent is primarily utilized in pharmacokinetic studies and metabolic research. The 13C labeling allows for precise tracing and quantification in complex biological systems, facilitating a deeper understanding of Aprepitant's biochemical interactions and tissue distribution. -
Stable Isotope
Tiamulin-d10-1 hydrochloride is a deuterium-labeled derivative of the diterpenic antibiotic Tiamulin. Its primary mechanism targets bacterial protein synthesis, making it crucial in research involving infectious diseases in livestock, particularly in the control of Mycoplasma spp. Tiamulin is commonly utilized in studies of airsacculitis, facilitating enhanced understanding of antibiotic efficacy and resistance mechanisms in veterinary medicine. -
Stable Isotope
Gatifloxacin-d4 hydrochloride is a deuterium-labeled analog of Gatifloxacin, primarily utilized as a stable isotope in chemical and biological research. This reagent is valuable for pharmacokinetic studies, metabolic profiling, and trace analysis in complex biological matrices. Its incorporation of deuterium allows for enhanced detection and quantification in mass spectrometry applications, facilitating the study of drug interactions and metabolic pathways. -
Stable Isotope
(R)-2-Methylbutanoic acid-d3 is a deuterium-labeled derivative of (R)-2-Methylbutanoic acid, serving as a stable isotope used in various research applications. This compound aids in metabolic studies, trace analysis, and isotope labeling experiments, allowing for enhanced sensitivity and specificity in quantitative analysis. Its use in nuclear magnetic resonance (NMR) and mass spectrometry provides valuable tools for probing biochemical pathways and mechanisms. -
Stable Isotope
Sulfisomidin-d4 is a deuterium-labeled derivative of Sulfisomidin, a sulfonamide antibacterial with oral bioavailability. This compound primarily targets bacterial dihydropteroate synthase, inhibiting folate synthesis and demonstrating antibacterial activity. Sulfisomidin-d4 is useful for research applications involving lower urinary tract infections, providing a valuable tool for studying pharmacokinetics and metabolic pathways of sulfonamide antibiotics. -
Stable Isotope
(Rac)-Moxifloxacin-d4 is a deuterium-labeled derivative of (Rac)-Moxifloxacin, an 8-methoxyquinolone antimicrobial. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace and quantify the drug's behavior in biological systems. Its applications extend to investigating the efficacy of antibacterial therapies against pathogens responsible for respiratory infections, such as acute bacterial sinusitis and pneumonia. -
Stable Isotope
Moxifloxacin-d5 is a deuterium-labeled derivative of Moxifloxacin, an 8-methoxyquinolone antibiotic. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the behavior of Moxifloxacin in biological systems. It is particularly relevant for investigations into its action against acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. -
Stable Isotope
Nalidixic Acid-d5 is a deuterium-labeled derivative of nalidixic acid, a quinolone antibiotic that targets DNA gyrase and topoisomerase IV. This compound exhibits bacteriostatic activity at lower concentrations and demonstrates bactericidal effects at higher concentrations against a broad spectrum of gram-positive and gram-negative bacteria. Nalidixic Acid-d5 is utilized in research applications involving antibiotic resistance studies, bacterial DNA replication mechanisms, and pharmacokinetic investigations. -
Stable Isotope
ent-Florfenicol-d3 is a deuterium-labeled analog of the antibiotic Florfenicol, primarily known for its application in veterinary medicine. This compound is indicated for the treatment of bovine respiratory disease and has utility in aquaculture for managing enteric septicemia in fish species. Research has shown that Florfenicol can induce early embryonic death in eggs, with a lethal concentration (LC50) of 1.07 μg/g, making this labeled reagent valuable for pharmacokinetic studies and environmental impact research. -
Stable Isotope
Cefprozil-d4 is a deuterium-labeled analog of Cefprozil, a second-generation cephalosporin antibiotic. This stable isotope exhibits broad-spectrum antibacterial activity and is effective for oral administration. Cefprozil-d4 is suitable for research applications involving the investigation of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections, aiding in the study of therapeutic efficacy and pharmacokinetics. -
Stable Isotope
L-Lactic acid-13C3 is a stable isotope form of L-Lactic acid, labeled with carbon-13. It serves as a valuable tool for investigating lactate metabolism in various biological systems. This compound is particularly useful in metabolic studies, allowing researchers to trace metabolic pathways and analyze lactate dynamics in cellular and tissue samples. -
Stable Isotope
L-Lactic acid-13C3 sodium is a stable isotope of L-Lactic acid that serves as a valuable tool for studying lactate metabolism. This compound enables precise tracking of metabolic pathways and investigation of physiological processes involving lactate. Its applications include metabolic research, isotopic labeling studies, and investigations into energy production and exercise physiology. This reagent is provided at a concentration of 20% w/w in water, facilitating its integration into diverse experimental protocols. -
Stable Isotope
Fenbendazole-d3 is a deuterium-labeled derivative of the anthelmintic agent Fenbendazole, targeting microtubules to destabilize their structure. This compound acts as a HIF-1α agonist, thereby activating the HIF-1α-mediated GLUT1 signaling pathway. Fenbendazole exhibits cell-cycle arrest and induces mitotic cell death, demonstrating significant antitumor activity in xenograft models using wild-type p53. Research applications include studies on cancer biology, parasitology, and mechanisms of cellular stress response. -
Stable Isotope
Meropenem-d6 is the deuterated form of the carbapenem antibiotic Meropenem, which exhibits broad-spectrum antibacterial activity. This stable isotope is particularly effective against susceptible and resistant strains of Neisseria gonorrhoeae, with minimum inhibitory concentration (MIC) values ranging from 0.02 to 0.06 mg/mL, as well as Haemophilus influenzae and Haemophilus ducreyi, with MIC values of 0.03 to 0.12 mg/mL and 0.015 to 0.12 mg/mL, respectively. Meropenem-d6 is valuable for pharmacokinetic studies and metabolic tracing in biological research.
