Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Anandamide-d11 is a deuterium-labeled analog of Anandamide, a known immune modulator in the central nervous system. It primarily targets cannabinoid receptors CB1 and CB2, while also engaging other pathways such as GPR18 and GPR55. This stable isotope is valuable for research applications in pharmacology and biochemistry, particularly in studies investigating endocannabinoid signaling and its role in various physiological processes. -
Stable Isotope
Palmitoyl serinol-d5 is a deuterated analog of N-Palmitoyl serinol, a compound that targets and modulates the endocannabinoid system, specifically resembling N-palmitoyl ethanolamine (PEA). This reagent is known for its significant role in enhancing the epidermal permeability barrier in both healthy and inflamed skin models. It is utilized in research applications focused on skin barrier function and the therapeutic potential of endocannabinoid-related compounds in dermatological studies. -
Stable Isotope
AM404-d4 is a deuterium-labeled analog of AM404, which functions as an endocannabinoid reuptake inhibitor. By blocking the transport of anandamide, AM404 exhibits biological activity with an IC50 in the low micromolar range. Additionally, it demonstrates vasodilatory effects in rat isolated hepatic arteries contracted with phenylephrine, with a pEC50 of 7.4, indicating an EC50 of 0.04 μM. This compound is of particular interest in neuroprotection and cannabinoid research applications. -
Stable Isotope
Olivetol-d9 is a deuterium-labeled derivative of Olivetol, a naturally occurring phenol primarily found in lichens and produced by specific insects. It functions as a competitive inhibitor of cannabinoid receptors CB1 and CB2, thus influencing endocannabinoid signaling pathways. Additionally, Olivetol-d9 has inhibitory effects on the cytochrome P450 enzymes CYP2C19 and CYP2D6, making it a valuable tool in pharmacological research and studies related to cannabinoid biology. -
Stable Isotope
2-Arachidonoylglycerol-d11 is a deuterated form of 2-arachidonoylglycerol, a naturally occurring cannabinoid that acts as an endogenous ligand for cannabinoid receptors in the central nervous system. This stable isotope is useful for tracing and quantifying the metabolism of endocannabinoids in various biological studies. Its applications include pharmacokinetic research and studies of cannabinoid signaling pathways. -
Stable Isotope
O-Arachidonoyl glycidol-d5 is a deuterium-labeled analog of O-Arachidonoyl glycidol, serving as a stable isotope for research applications. This compound functions primarily by inhibiting the hydrolysis of 2-oleoylglycerol (2-OG) with an IC50 of 4.5 μM, impacting lipid signaling pathways. Additionally, O-Arachidonoyl glycidol-d5 inhibits anandamide hydrolysis, demonstrating IC50 values of 19 μM and 12 μM, respectively. This reagent is valuable for studies in lipid metabolism and endocannabinoid signaling. -
Stable Isotope
N-Arachidonyldopamine-d8 is a deuterium-labeled derivative of N-Arachidonyldopamine. This stable isotope is utilized in metabolic studies, allowing for precise tracking of molecular interactions and pathways in biological systems. Its key applications include research in neurobiology and pharmacology, particularly in understanding endocannabinoid signaling and dopamine receptor interactions. -
Stable Isotope
DL-Norepinephrine-d6 hydrochloride is a deuterium-labeled form of DL-Norepinephrine hydrochloride, a racemic catecholamine neurotransmitter. This compound comprises equal parts of the biologically active L-isomer and the inactive D-isomer. DL-Norepinephrine-d6 hydrochloride serves as a stable isotope tracer, facilitating research applications related to neurological disorders, including Parkinson’s disease, by enabling the tracking of neurotransmitter dynamics and metabolism in biological systems. -
Stable Isotope
Inosine-2,8-d2 is a stable isotope-labeled derivative of inosine, an endogenous purine nucleoside derived from adenosine catabolism. This compound exhibits significant biological activities, including anti-inflammatory, antinociceptive, immunomodulatory, and neuroprotective effects. Its role as an agonist for adenosine A1 and A2A receptors makes it valuable for research applications in neurobiology, immunology, and inflammation studies. -
Stable Isotope
Theobromine-d3 is a deuterium-labeled derivative of Theobromine, a methylxanthine naturally occurring in cacao beans. This stable isotope serves as a valuable tool for studying adenosine receptor A1 (AR1) signaling inhibition in research applications. Theobromine-d3 is essential for metabolic tracing, pharmacokinetic studies, and the exploration of purinergic signaling pathways. -
Stable Isotope
Istradefylline-13C,d3 is a stable isotope-labeled version of Istradefylline, a highly potent and selective antagonist of the adenosine A2A receptor. With a Ki value of 2.2 nM, it demonstrates significant efficacy in experimental models of Parkinson's disease. This reagent is essential for studies involving receptor binding and pharmacokinetics, providing insights into the role of adenosine receptors in neurological disorders. -
Stable Isotope
Theobromine-d6 is a deuterium-labeled derivative of theobromine, a methylxanthine compound primarily found in cacao beans. This isotopically enriched reagent can be utilized in studies focusing on adenosine receptor A1 (AR1) signaling inhibition. It is suitable for quantitative analysis in metabolic studies and the investigation of the pharmacokinetics of theobromine and related compounds. -
Stable Isotope
Cytidine-13C9,15N3 is a stable isotope-labeled variant of cytidine, incorporating both carbon-13 and nitrogen-15 isotopes. As a pyrimidine nucleoside, cytidine plays a crucial role in RNA synthesis and acts as a precursor to uridine. This compound is essential for studies investigating neuronal-glial glutamate cycling, as well as its implications on cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function in various biological systems. -
Stable Isotope
Fingolimod-d4 is a stable isotope-labeled form of Fingolimod, a potent sphingosine 1-phosphate (S1P) antagonist. With an IC50 of 0.033 nM, it effectively modulates the activity of K562 and NK cells and serves as a Pak1 activator and immunosuppressant. This reagent is valuable for pharmacokinetic studies, metabolic research, and cellular signaling investigations. -
Stable Isotope
Fingolimod-d4 hydrochloride is a deuterium-labeled form of Fingolimod hydrochloride, a potent sphingosine 1-phosphate (S1P) receptor antagonist. It exhibits high affinity, with an IC50 of 0.033 nM in K562 and NK cells, and is known for its ability to penetrate the blood-brain barrier. This reagent is utilized in research exploring immunosuppressive pathways and the modulation of immune responses, as well as for studying the role of S1P in various biological systems. -
Stable Isotope
Milnacipran-d5 hydrochloride is a deuterated form of Milnacipran hydrochloride, a potent serotonin and norepinephrine reuptake inhibitor. It targets monoamine transporters, exhibiting Ki values of 31 nM for the norepinephrine transporter and 8.5 nM for the serotonin transporter. With notable antidepressant, anxiolytic, and analgesic properties, Milnacipran-d5 hydrochloride is valuable for research on major depressive disorder, anxiety disorders, and neuropathic pain conditions such as fibromyalgia. Additionally, it has been shown to affect behavior in preclinical models, providing insights into its pharmacological mechanisms. -
Stable Isotope
Milnacipran-d10 hydrochloride is a deuterium-labeled form of the serotonin and norepinephrine reuptake inhibitor, Milnacipran hydrochloride. It effectively inhibits monoamine transporters, targeting the norepinephrine and serotonin transporters with reported Ki values of 31 nM and 8.5 nM, respectively. This compound exhibits antidepressant, anxiolytic, and analgesic properties, and has demonstrated efficacy in reducing biting behavior in murine models. Milnacipran-d10 hydrochloride is valuable for research applications focused on major depressive disorder, anxiety disorders, and neuropathic pain syndromes, such as fibromyalgia. -
Stable Isotope
Nicotinamide-d4 is a deuterated form of Nicotinamide, a vital derivative of vitamin B3. This stable isotope is essential for studying NAD+ redox homeostasis and serves as a substrate for various enzymes involved in non-redox reactions. Additionally, Nicotinamide acts as an inhibitor of SIRT1, making Nicotinamide-d4 a valuable tool for investigating metabolic pathways and enzyme activities in cellular research. -
Stable Isotope
Nicotinamide-13C6 is a stable isotope-labeled form of Nicotinamide, also known as vitamin B3. This compound is crucial for maintaining NAD+ redox homeostasis and serves as a substrate for various enzymes involved in non-redox reactions. Additionally, Nicotinamide acts as an inhibitor of SIRT1, making it significant in research focusing on metabolic pathways, aging, and cellular stress responses. Its isotopic labeling allows for precise tracking in metabolic studies and applications in mass spectrometry. -
Stable Isotope
Nicotinamide-15N,13C3 is a stable isotope-labeled form of nicotinamide, featuring both 13C and 15N labels. As a critical derivative of vitamin B3, nicotinamide is integral to cellular physiology, supporting NAD+ redox homeostasis and serving as a substrate for various enzymes involved in non-redox reactions. Additionally, nicotinamide acts as an inhibitor of SIRT1, making it valuable in research applications focused on metabolic regulation and aging. -
Stable Isotope
Ilaprazole-d3 is a deuterium-labeled derivative of Ilaprazole, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic profiling. It allows for the accurate quantification of Ilaprazole in biological samples, facilitating research applications in drug metabolism and pharmacodynamics. -
Stable Isotope
Belotecan-d7 hydrochloride is a deuterium-labeled derivative of Belotecan hydrochloride, a potent Topoisomerase I inhibitor. This stable isotope is utilized in pharmacokinetic studies and metabolic research, providing insights into the mechanism of action and therapeutic efficacy of camptothecin analogs. It is particularly valuable for tracing metabolic pathways and studying drug interactions in various biological systems. -
Stable Isotope
Mitoxantrone-d8 is a deuterium-labeled derivative of Mitoxantrone, a known inhibitor of topoisomerase II. This compound also shows inhibition of protein kinase C (PKC) with an IC50 value of 8.5 μM. Mitoxantrone-d8 is particularly useful in studies involving pharmacokinetics and drug metabolism, providing a stable isotope for quantitative analysis in research applications. -
Stable Isotope
RPR132595A-d3 is a deuterated form of RPR132595A, a prominent active metabolite of Irinotecan (CPT-11). This compound undergoes metabolism via cytochrome P-450 3A4 (CYP3A4) and is ultimately eliminated through the urine. RPR132595A-d3 serves as a valuable stable isotope for studies in drug metabolism and pharmacokinetics, enabling precise tracking and quantification of metabolic pathways involving Irinotecan. -
Stable Isotope
RPR121056-d3 is a deuterated analog of RPR121056, a metabolite of the anticancer drug Irinotecan. It primarily targets and inhibits topoisomerase type I, leading to apoptosis in cancer cells. RPR121056-d3 is utilized in research applications focused on understanding the metabolic pathways and pharmacokinetics of Irinotecan, particularly in the context of colorectal cancer therapy. Additionally, it may also provide insights into the inhibition of acetylcholinesterase (AChE). -
Stable Isotope
1-Hydroxypyrene-d9 is a deuterated form of 1-Hydroxypyrene, serving as a stable isotope used for analytical applications. It functions as a biomarker for exposure to polycyclic aromatic hydrocarbons (PAHs), particularly in urine samples. Additionally, 1-Hydroxypyrene serves as an agonist for the aryl hydrocarbon receptor (AhR), implicating its role in various biological pathways, including renal fibrosis. This compound is valuable for research focused on environmental health and toxicology. -
Stable Isotope
Atenolol-d7 is a deuterium-labeled variant of Atenolol, a cardioselective β1-adrenergic receptor blocker that exhibits a Ki value of 697 nM at the β1-adrenoceptor in guinea pig left ventricle membranes. This stable isotope is instrumental in pharmacokinetic studies and metabolic research related to hypertension and angina pectoris. Its unique properties facilitate the investigation of drug metabolism and disposition in biological systems. -
Stable Isotope
Calcium phosphorylcholine-d9 chloride is a deuterium-labeled derivative of calcium phosphorylcholine chloride, a key phospholipid component found in eukaryotic biofilms. This compound is prevalent in both commensal and pathogenic bacteria that associate with eukaryotic hosts in prokaryotic environments. Additionally, calcium phosphorylcholine chloride displays a diverse array of immunomodulatory properties, making it useful for research in immunology and microbiology. -
Stable Isotope
Metoprolol-d7 hydrochloride is a deuterated form of Metoprolol, a selective β1-adrenoceptor antagonist. This compound exhibits notable anti-inflammatory, antitumor, and anti-angiogenic properties, making it valuable for various biochemical studies. Metoprolol-d7 hydrochloride is instrumental in pharmacokinetic studies and tracer applications due to its stable isotope nature, enabling precise tracking and analysis in metabolic research. -
Stable Isotope
Propranolol-d7 is a stable isotope-labeled form of Propranolol, a nonselective β-adrenergic receptor (βAR) antagonist. It exhibits high affinity for β1AR and β2AR, with inhibition constants (Ki) of 1.8 nM and 0.8 nM, respectively. Propranolol's capability to inhibit [3H]-DHA binding to rat brain membranes, with an IC50 of 12 nM, makes it a valuable tool for researching conditions such as hypertension, myocardial infarction, cardiac arrhythmias, and other cardiovascular disorders. -
Stable Isotope
DL-Norepinephrine-d6 is a deuterium-labeled form of DL-Norepinephrine, a racemic catecholamine neurotransmitter. This compound comprises equal parts of the active L-stereoisomer and the inactive D-stereoisomer. DL-Norepinephrine-d6 serves as a valuable tracer in biochemical studies, including investigations into neurodegenerative diseases such as Parkinson's disease, enabling researchers to study neurotransmitter dynamics and metabolic pathways with enhanced precision. -
Stable Isotope
Propranolol-d7 (ring-d7) is a deuterated analogue of Propranolol hydrochloride, a nonselective β-adrenergic receptor antagonist. It exhibits high affinity for both β1 and β2 adrenergic receptors, with Ki values of 1.8 nM and 0.8 nM, respectively. This compound inhibits [3H]-DHA binding in rat brain membranes with an IC50 of 12 nM, making it a valuable tool for studying cardiovascular conditions such as hypertension, myocardial infarction, and cardiac arrhythmias. Propranolol-d7 (ring-d7) is particularly useful in pharmacokinetic and metabolic studies using mass spectrometry due to its stable isotope labeling. -
Stable Isotope
Medetomidine-13C,d3 hydrochloride is a deuterated derivative of Medetomidine, functioning primarily as a stable isotope. As a potent α2-adrenoceptor agonist with a Ki of 1.08 nM, it exhibits significant sedative and analgesic properties. Its activation of α2-adrenoceptors leads to peripheral vasoconstriction, making it valuable for pharmacological studies aimed at understanding its effects on sedation and pain management in various biological contexts. -
Stable Isotope
Clenbuterol-d9 is a deuterium-labeled derivative of Clenbuterol, a selective β2-adrenergic receptor agonist known for its potent biological activity, with an EC50 of 31.9 nM. This stable isotope serves as a valuable tool for pharmacokinetic studies and metabolic research, enabling precise tracking of drug interactions and bioavailability in various biological systems. Clenbuterol-d9 is instrumental in advancing research on β-adrenergic signaling and its implications in respiratory and metabolic disorders. -
Stable Isotope
Isoxsuprine-d6 hydrochloride is a deuterium-labeled form of Isoxsuprine hydrochloride, a selective beta-adrenergic receptor agonist. It exhibits inhibitory constants (Kis) of 13.65 μM and 3.48 μM for myometrial and placental beta-adrenergic receptors, respectively, and also functions as an NMDA receptor antagonist. This stable isotope variant is valuable for pharmacokinetic studies and metabolic tracing in biological research, facilitating an understanding of drug interactions and mechanisms of action. -
Stable Isotope
Bisoprolol-d5 is a deuterium-labeled derivative of Bisoprolol, a selective and potent β1-adrenergic receptor blocker. This compound predominantly inhibits β1-receptors with minimal β2-receptor activity, making it relevant for research in hypertension, coronary artery disease, and stable ventricular dysfunction. Bisoprolol-d5 serves as a valuable tool in pharmacokinetic studies and metabolic profiling. -
Stable Isotope
Brimonidine-d4 D-tartrate is a stable isotope-labeled form of Brimonidine D-tartrate, featuring deuterium substitution. This compound serves as an important tool for pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution in biological systems. Its incorporation in research applications can enhance the understanding of Brimonidine's mechanisms of action, particularly in the context of its use in the treatment of ocular conditions such as glaucoma. -
Stable Isotope
Acebutolol-d5 is a deuterated form of Acebutolol, specifically designed for use as a stable isotope. This compound is valuable in pharmacokinetic studies and metabolic research, enabling precise tracing of drug metabolism and distribution in biological systems. Its unique labeling makes it an essential tool for researchers investigating the pharmacological effects and metabolism of beta-blockers. -
Stable Isotope
Celiprolol-d9 hydrochloride is a deuterium-labeled derivative of Celiprolol, primarily utilized as a stable isotope. This compound serves as a valuable tool in pharmacokinetic studies, enabling the investigation of metabolic pathways and drug interactions. Researchers can leverage its unique isotopic properties for precise quantification in various biological matrices, making it essential for studies in cardiovascular pharmacology and drug development. -
Stable Isotope
Prazosin-d8 is a deuterium-labeled form of Prazosin, an alpha-adrenergic blocker that exhibits sympatholytic properties. This stable isotope is utilized in pharmacokinetic studies, providing enhanced sensitivity and specificity in metabolic profiling and drug interaction assessments. It plays a crucial role in research applications related to hypertension, anxiety disorders, PTSD, and panic disorder, aiding in the understanding of adrenergic signaling and therapeutic efficacy. -
Stable Isotope
Oxprenolol-d7 hydrochloride is a deuterium-labeled derivative of the β-adrenergic receptor antagonist, Oxprenolol. It exhibits a Ki of 7.10 nM in radioligand binding assays, demonstrating effective inhibition of β-AR activity. This stable isotope is primarily used in pharmacokinetic studies and metabolic research, facilitating investigations into the metabolism and distribution of β-adrenergic antagonists in biological systems. -
Stable Isotope
Sotalol-d6 hydrochloride is a deuterium-labeled derivative of Sotalol hydrochloride, a potent non-selective competitive β-adrenergic receptor blocker. This compound exhibits significant antiarrhythmic activity and is primarily utilized in research focused on pediatric arrhythmias. In addition to blocking β-receptors, Sotalol-d6 also inhibits potassium KCNH2 channels, providing valuable insights into cardiac electrophysiology and potential therapeutic applications. -
Stable Isotope
Brimonidine-d4 is a deuterium-labeled derivative of Brimonidine, a potent agonist of the α2-adrenergic receptor (α2-AR). This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling to trace and quantify Brimonidine in biological systems. Its applications extend to research involving ocular therapies and the modulation of neurotransmitter release through α2-AR pathways. -
Stable Isotope
Formoterol-d6 is a deuterium-labeled derivative of Formoterol, a highly selective and long-acting β2-adrenoceptor agonist. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the behavior of Formoterol in biological systems. Its incorporation into experimental designs aids in understanding drug metabolism and the pharmacological effects associated with β2-adrenoceptor activation. -
Stable Isotope
Octopamine-d4 hydrochloride is a deuterium-labeled derivative of octopamine, a biogenic monoamine related to noradrenaline. It primarily functions as a neurohormone, neuromodulator, and neurotransmitter in invertebrates. This compound has been shown to stimulate alpha2-adrenoceptors in Chinese hamster ovary cells expressing human alpha2-ARs, leading to enhanced glycogenolysis, glycolysis, oxygen uptake, and gluconeogenesis. Octopamine-d4 hydrochloride is utilized in research applications involving metabolic regulation and neurotransmitter signaling pathways. -
Stable Isotope
Phenylephrine-2,4,6-d3 hydrochloride is a stable isotope-labeled form of phenylephrine hydrochloride. It acts as a selective α1-adrenoceptor agonist, exhibiting pKis of 5.86, 4.87, and 4.70 for the α1D, α1B, and α1A receptors, respectively. This compound is utilized in pharmacological research to trace the metabolism and pharmacokinetics of phenylephrine in biological systems, enhancing the understanding of adrenergic signaling pathways. -
Stable Isotope
Yohimbine-13C,d3 is a deuterium and carbon-13 labeled version of Yohimbine, a potent and nonselective antagonist of alpha-2 adrenergic receptors. With an IC50 value of 0.6 μM, Yohimbine exhibits significant biological activity in modulating adrenergic signaling pathways. This stable isotope compound is valuable for research applications in pharmacokinetics, metabolic studies, and tracing within biological systems. -
Stable Isotope
Prazosin-d8 hydrochloride is a deuterium-labeled derivative of Prazosin hydrochloride, an alpha-adrenergic blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research, enabling precise tracking of drug metabolism and distribution. Its labeling with deuterium enhances the accuracy of analytical methods, facilitating investigations into the physiological effects of alpha-adrenergic antagonism. -
Stable Isotope
Bambuterol-d9 hydrochloride is a deuterated form of Bambuterol, a long-acting beta-adrenoceptor agonist (LABA) primarily utilized in asthma management. As a prodrug of terbutaline, it demonstrates significant bronchodilatory effects. This stable isotope compound is valuable for pharmacokinetic studies, enabling researchers to trace metabolic pathways and characterize drug behavior in biological systems. -
Stable Isotope
Terazosin-d8 is a deuterated form of Terazosin, functioning as a competitive and orally active antagonist of the α1-adrenoceptor. This compound plays a crucial role in biological research involving the modulation of vascular tone and bladder relaxation. Terazosin-d8 is particularly valuable for studies related to benign prostatic hyperplasia (BPH) and hypertension, facilitating deeper insights into mechanisms of action and pharmacokinetics through stable isotope labeling.
