Fig. 1 · Structure
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Alectinib-d8
Stable Isotope
Alectinib-d8 is a deuterium-labeled variant of Alectinib, a potent and selective inhibitor of anaplastic lymphoma kinase (ALK). This compound exhibits an IC50 of 1.9 nM and a Kd of 2.4 nM in an ATP-competitive context, further inhibiting ALK F1174L and ALK R1275Q with IC50 values of 1 nM and 3.5 nM, respectively. Alectinib is known for its effective penetration of the central nervous system, making it a valuable tool for research into ALK-driven malignancies and CNS-related drug efficacy studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1256585-15-5 |
| Applications | Stable Isotope |
| Formula | C30H26D8N4O2 |
| Molecular Weight | 490.67 |
| Synonyms | CH5424802-d8; RO5424802-d8; AF802-d8 |
| SMILES | N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6C([2H])([2H])C([2H])([2H])OC([2H])([2H])C6([2H])[2H])=C(C=C4C3=O)CC)C)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.