Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Piperonyl butoxide-d9 is a deuterium-labeled derivative of Piperonyl butoxide, a known pesticide synergist and food additive. This stable isotope is utilized in biochemical research to study metabolic pathways and enhance the understanding of Piperonyl butoxide's biological effects, which include the activation of c-Jun and ATF-2 in mouse hepatocytes. Research has indicated its potential adverse effects on reproduction, development, and behavior in model organisms, as well as its status as a carcinogen in liver studies involving rats and mice. -
Stable Isotope
Cambendazole-d7 is a deuterium-labeled derivative of Cambendazole, serving as a stable isotope. This compound is useful in studies involving pharmacokinetics and metabolic pathways, allowing for precise tracking of Cambendazole in biological systems. Its incorporation into experiments can enhance the understanding of drug action and distribute in biological matrices. -
Stable Isotope
Carbosulfan-d18 is a deuterium-labeled derivative of Carbosulfan, targeting cytochrome P450 enzymes. It exhibits potent inhibition of CYP3A4 while demonstrating moderate inhibition of CYP1A1/2 and CYP2C19 in pooled human liver microsomes. This reagent is valuable for studies exploring the metabolic activation of Carbosulfan, particularly in human liver systems. -
Stable Isotope
Proguanil-d4 is a deuterium-labeled analog of Proguanil, which serves as an antimalarial proagent. Upon administration, Proguanil is metabolized to its active form, Cycloguanil, which exerts its pharmacological effects through the inhibition of dihydrofolate reductase (DHFR). This stable isotope is utilized in research applications including pharmacokinetic studies and metabolic pathway analysis to understand drug actions and interactions. -
Stable Isotope
Pyridaben-d13 is a deuterium-labeled version of Pyridaben, a potent mitochondrial electron transport inhibitor (METI) and acaricide. This compound selectively targets complex I (NADH dehydrogenase), demonstrating an inhibitory efficacy with an IC50 value of 2.4 nM in rat liver and bovine heart mitochondria. Additionally, Pyridaben-d13 significantly affects mitochondrial nitric oxide synthase (mtNOS) function in rat models, making it a valuable reagent for studies on mitochondrial dysfunction and oxidative stress. -
Stable Isotope
Parbendazole-d3 is a deuterium-labeled derivative of Parbendazole, a potent inhibitor of microtubule assembly. This compound disrupts tubulin stability, demonstrating an effective EC50 of 530 nM, and is known for its broad-spectrum anthelmintic activity. Parbendazole-d3 is utilized in research applications aimed at studying microtubule dynamics and developing anthelmintic therapies. -
Stable Isotope
Hexythiazox-d11 is a deuterium-labeled derivative of Hexythiazox, a selective acaricide targeting mites. It exhibits ovicidal, larvicidal, and nymphicidal activities, making it effective for the chemical control of mite populations on cotton, fruits, and vegetables. Hexythiazox demonstrates a favorable safety profile, being non-toxic to mammals while preserving beneficial insect species and natural mite predators. This isotopically labeled compound is valuable for research applications in pesticide efficacy and environmental impact studies. -
Stable Isotope
Methyl Clonazepam-d3 is a deuterium-labeled derivative of Methylclonazepam, a benzodiazepine that exerts anxiolytic effects. This compound is known to inhibit the absorption of 5-hydroxytryptamine by Schistosoma mansoni, demonstrating potential anti-parasitic activity. Methyl Clonazepam derivatives are valuable tools for research focused on schistosomiasis and related disorders, aiding in the exploration of therapeutic interventions. -
Stable Isotope
DL-Methionine-d3 is a stable isotope-labeled form of the essential amino acid DL-Methionine, which contains sulfur and is known for its role in oxidative stress defense. This compound is primarily utilized in research focusing on metabolic studies and isotopic tracing in biological systems. Additionally, DL-Methionine exhibits efficacy against Heterodera rostochiensis in potato plants, making it pertinent for studies in agronomy and plant defense mechanisms. -
Stable Isotope
2,3-Diphosphoglyceric acid-13C3 is a stable isotope-labeled form of 2,3-Diphosphoglyceric acid, an intermediate in the glycolytic pathway. This compound primarily stabilizes the deoxygenated form of hemoglobin through allosteric binding, thereby facilitating oxygen release to tissues. Additionally, 2,3-Diphosphoglyceric acid exhibits antiparasitic activity and is valuable in research related to Alzheimer's disease, contributing to the understanding of metabolic processes and disease mechanisms. -
Stable Isotope
Temephos-d12 is a deuterated form of Temephos, an organophosphate larvicide. It targets the central nervous system of aquatic larvae, including those of mosquitoes, midges, and black flies, by inhibiting cholinesterase activity. This mechanism leads to larval mortality prior to reaching the adult stage, making Temephos-d12 valuable for research on pesticide efficacy and environmental impact studies. -
Stable Isotope
(-)-Fucose-13C-2 is a stable isotope-labeled derivative of (-)-Fucose, a hexose sugar. This compound is instrumental in studying blood group antigen structure, as well as selectin-mediated leukocyte-endothelial adhesion mechanisms. Additionally, (-)-Fucose-13C-2 has applications in examining host-microbe interactions, contributing to research in immunology, glycobiology, and cellular communication. -
Stable Isotope
HCV-IN-49 is a phosphoramidate ester derivative that functions as an inhibitor of Hepatitis C virus (HCV) protease. This compound exhibits notable antiviral activity and is instrumental in the study of HCV replication and pathogenesis. HCV-IN-49 serves as a valuable tool in research applications focused on HCV treatment development and drug resistance mechanisms. -
Stable Isotope
Faldaprevir-d7 is a deuterated analog of Faldaprevir, designed as a stable isotope for research applications. Its primary mechanism involves targeting the NS3 protease of the hepatitis C virus, facilitating studies in viral replication and protease inhibition. This compound is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of drug behavior in biological systems. -
Stable Isotope
Faldaprevir-d6 is a deuterium-labeled analogue of Faldaprevir, a potent inhibitor of the NS3/4A protease in the hepatitis C virus. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for precise tracking of drug metabolism and clearance in biological systems. Its application in research contributes to a deeper understanding of antiviral drug behavior and efficacy. -
Stable Isotope
Darunavir-d9 is a stable isotope-labeled form of Darunavir, a next-generation HIV protease inhibitor. This compound exhibits significant antiviral activity against both wild-type and mutant HIV strains, displaying an IC50 of 0.003 μM and an IC90 of 0.009 μM while maintaining low cytotoxicity. Darunavir-d9 is primarily utilized in biochemical research applications, including drug metabolism studies and pharmacokinetics for advanced HIV research. -
Stable Isotope
Cabotegravir-d5 is a deuterium-labeled derivative of Cabotegravir, primarily used as a stable isotope. Its unique isotopic composition allows for advanced tracking and analysis in metabolic studies and pharmacokinetic research. This reagent serves as a valuable tool for elucidating the mechanisms of action of integrase inhibitors and for studying their pharmacodynamics in various biological systems. -
Stable Isotope
Rilpivirine-d6 is a deuterated form of Rilpivirine, a selective diarylpyrimidine non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV reverse transcriptase. This compound exhibits potent antiviral activity against both wild-type HIV (EC50=0.4 nM) and various mutant strains (EC50=0.1-2.0 nM). Rilpivirine demonstrates a notable genetic barrier to resistance, making it a valuable tool for research in HIV treatment and resistance profiling. Its isotopic labeling aids in pharmacokinetic and metabolic studies, enhancing understanding of drug behavior in biological systems. -
Stable Isotope
Atazanavir-d5 is a deuterium-labeled derivative of Atazanavir, a highly selective inhibitor of HIV-1 protease. This compound serves as a substrate and inhibitor of the cytochrome P450 enzyme CYP3A4, as well as an inhibitor and inducer of P-glycoprotein (P-gp). Additionally, Atazanavir exhibits activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM, making it valuable for research into HIV and coronavirus-related mechanisms. -
Stable Isotope
Indinavir-d6 is a deuterium-labeled analog of the potent HIV protease inhibitor Indinavir. It specifically targets the HIV protease enzyme, inhibiting viral replication and demonstrating favorable oral bioavailability. This stable isotope is utilized in pharmacokinetic studies, metabolic tracing, and the investigation of drug interactions within HIV research. -
Stable Isotope
Raltegravir-d3 potassium is a deuterium-labeled form of Raltegravir, a potent integrase inhibitor utilized in the treatment of HIV infection. This stable isotope serves as a valuable tool for pharmacokinetic studies and drug metabolism research, providing insights into the biological mechanisms of integrase inhibition. Its labeling facilitates the quantification and tracking of Raltegravir in various biological matrices, aiding researchers in understanding its therapeutic effects and metabolic pathways. -
Stable Isotope
Plerixafor-d4 is a deuterated derivative of Plerixafor, a selective antagonist of the CXCR4 receptor with an IC50 of 44 nM. This compound serves as an immunostimulant and is known for its ability to mobilize hematopoietic stem cells (HSCs). Additionally, Plerixafor has demonstrated efficacy in inhibiting HIV-1 and HIV-2 replication, with an EC50 ranging from 1 to 10 nM. Plerixafor-d4 is useful in research applications requiring stable isotopes for tracking and quantification purposes. -
Stable Isotope
Amprenavir-d4 is a deuterated form of Amprenavir, a potent inhibitor of the HIV protease with a Ki value of 0.6 nM. In addition to its antiviral properties, Amprenavir has been identified as a SARS-CoV 3CLpro inhibitor, demonstrating an IC50 of 1.09 μM. This stable isotope is utilized in chemical research for quantitative analysis and metabolic studies of drug metabolism and pharmacokinetics. -
Stable Isotope
Raltegravir-d4 is a deuterated analog of Raltegravir, which functions as a potent inhibitor of HIV integrase (IN). This stable isotope-labeled compound is designed for use in pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Raltegravir in biological systems. Its application is essential for understanding drug metabolism and interaction mechanisms in HIV treatment protocols. -
Stable Isotope
2-Phenylbutyric acid-d5 is a deuterium-labeled derivative of 2-Phenylbutanoic acid, a monocarboxylic acid known for its interaction with various proteins. This stable isotope is utilized in biological research to study malignant lymphoma and HIV-related diseases. Its labeling enables precise tracking and quantification in biochemical assays, making it a valuable tool for understanding metabolic pathways and disease mechanisms. -
Stable Isotope
Pramipexole-d5 dihydrochloride is a deuterated form of Pramipexole dihydrochloride, a selective agonist of the dopamine D2-type receptor that effectively crosses the blood-brain barrier. With binding affinities (Kis) of 2.2 nM for D2-type receptors, alongside 3.9 nM, 0.5 nM, and 1.3 nM for D2, D3, and D4 receptors respectively, it serves as a valuable tool in research. This reagent is primarily utilized in studies related to Parkinson's disease and restless legs syndrome, facilitating analysis of dopaminergic pathways and receptor interactions. -
Stable Isotope
(R)-3-O-Methyldopa-d3 is a deuterated form of the R-enantiomer of 3-O-Methyldopa, which acts as a metabolite of L-DOPA. The compound exerts its biological activity by competitively inhibiting catechol-O-methyltransferase (COMT), thus influencing the pharmacological effects of both L-DOPA and dopamine. This stable isotope is essential for research applications involving metabolic pathways and neurological studies. -
Stable Isotope
Clomipramine-d3 hydrochloride is a deuterium-labeled analog of Clomipramine hydrochloride, primarily acting as an inhibitor of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) with Ki values of 0.14 nM, 54 nM, and 3 nM, respectively. This stable isotope-labeled compound is valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in neuroscience research. Its specificity and potency make it an essential reagent for investigating the pharmacological effects of antidepressants and their mechanisms of action within the central nervous system. -
Stable Isotope
Zuclopenthixol-d4 succinate is a deuterium-labeled derivative of Zuclopenthixol, a thioxanthene compound that functions primarily as a mixed antagonist of dopamine D1 and D2 receptors. This stable isotope is utilized in pharmacokinetic studies and drug metabolism research, enabling precise tracking of the compound's behavior in biological systems. Its unique isotopic labeling enhances the accuracy of analytical methods in various studies related to neurological disorders and the pharmacodynamics of antipsychotic agents. -
Stable Isotope
Azaperone-d4 is a deuterium-labeled variant of Azaperone, which primarily functions as a dopamine antagonist. It exhibits additional antihistaminic and anticholinergic properties, making it a versatile tool in pharmacological studies. This pyridinylpiperazine and butyrophenone neuroleptic agent also demonstrates antiemetic effects, finding utility chiefly as a tranquilizer in veterinary medicine. Its stable isotope labeling provides valuable support for research applications involving drug metabolism and pharmacokinetics. -
Stable Isotope
Propionylpromazine-d6 hydrochloride is a deuterium-labeled derivative of Propionylpromazine hydrochloride, a potent dopamine receptor D2 (DRD2) antagonist. This reagent is primarily utilized in pharmacological research focusing on Parkinson's disease, enabling the study of dopamine signaling pathways and receptor interactions. The stable isotope labeling provides enhanced analytical precision, making it suitable for advanced bioanalytical applications. -
Stable Isotope
Amisulpride-d5 N-Oxide is a deuterium-labeled analog of Amisulpride, functioning as a dopamine D2/D3 receptor antagonist with inhibition constants (Kis) of 2.8 nM and 3.2 nM for human dopamine D2 and D3 receptors, respectively. This stable isotope-labeled compound is essential for research involving pharmacokinetics, biomarker discovery, and labeling in metabolic studies. Its precision and reliability make it suitable for various applications in neuroscientific research and drug development. -
Stable Isotope
Pramipexole-d5 is a deuterium-labeled derivative of Pramipexole, a selective dopamine D2-type receptor agonist that effectively crosses the blood-brain barrier. With binding affinities (Kis) of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for the D2-type, D2, D3, and D4 receptors respectively, Pramipexole-d5 serves as a valuable tool for exploring dopamine receptor interactions. This compound is particularly relevant for research into neurodegenerative disorders such as Parkinson's disease and conditions like restless legs syndrome. -
Stable Isotope
Clomipramine-d3 is a deuterium-labeled derivative of Clomipramine that primarily targets the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), exhibiting inhibition with Ki values of 0.14 nM, 54 nM, and 3 nM, respectively. This stable isotope is valuable for pharmacokinetic studies and metabolic research, enabling the tracking and quantification of Clomipramine in biological samples. Clomipramine-d3 facilitates investigations into its biochemical interactions and the influence of neurotransmitter systems on various physiological processes. -
Stable Isotope
Ropinirole-d14 is a deuterium-labeled derivative of Ropinirole, designed for use in various analytical applications. This stable isotope allows for precise tracking and quantification of Ropinirole in biological systems through advanced techniques such as mass spectrometry. It is particularly useful in pharmacokinetic studies, metabolic profiling, and drug interaction investigations, facilitating deeper insights into Ropinirole's biological activity and efficacy. -
Stable Isotope
Acetophenazine dimaleate-d4 is a deuterium-labeled derivative of Acetophenazine, a phenothiazine-based antipsychotic agent. This compound primarily exerts its effects by selectively blocking dopamine D2 receptors in the central nervous system. Acetophenazine dimaleate-d4 is valuable for studying psychotic disorders, including schizophrenia and anxiety-related depression, providing insights into the pharmacodynamics of antipsychotic treatments. -
Stable Isotope
Pramipexole-d7-1 dihydrochloride is a deuterium-labeled analog of Pramipexole dihydrochloride, a selective agonist of dopamine D2-type receptors. This compound effectively penetrates the blood-brain barrier and exhibits Ki values of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for the D2-type receptor, D2, D3, and D4 receptors, respectively. Pramipexole-d7-1 dihydrochloride is valuable for research on Parkinson's disease and restless legs syndrome, facilitating advanced studies in neuropharmacology and the pharmacokinetics of dopamine receptor interactions. -
Stable Isotope
Ropinirole-d7 hydrochloride is a deuterium-labeled analog of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors. With a Ki value of 29 nM for the D2 receptor, it demonstrates strong biological activity, exhibiting pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is particularly relevant in research focused on Parkinson's disease and neuropharmacology. -
Stable Isotope
(R)-3-O-Methyldopa-d3 hydrochloride is a deuterium-labeled analog of (R)-3-O-Methyldopa, which is the R-enantiomer of 3-O-Methyldopa. This compound acts as a stable isotope and serves as a valuable tool for studying metabolic pathways involving L-DOPA, a precursor to dopamine. 3-O-Methyldopa is known to competitively inhibit the actions of L-DOPA and dopamine, making it useful in research focused on neurotransmitter regulation and related pharmacodynamics. -
Stable Isotope
(rac)-Dobutamine-d6 hydrochloride is a stable isotope-labeled form of racemic Dobutamine hydrochloride, which targets α1-AR, β1-AR, and β2-AR adrenoceptors. This compound primarily functions as a selective β1-AR agonist, exhibiting a relatively weaker effect on α1-AR and β2-AR. Notably, (rac)-Dobutamine-d6 hydrochloride is utilized in research applications focused on cardiovascular studies, particularly for analyzing cardiac output and addressing conditions of hypoperfusion. -
Stable Isotope
Tetrahydrozoline-d4 hydrochloride is a deuterium-labeled form of Tetrahydrozoline hydrochloride, an α-adrenergic agonist that targets α-adrenergic receptors to induce vasoconstriction. This stable isotope is utilized in research applications focusing on nasal and conjunctival congestion. Its unique isotopic labeling allows for enhanced tracking and quantification in various biochemical studies. -
Stable Isotope
5,6-Epoxyeicosatrienoic acid-d11 is a deuterium-labeled analogue of 5,6-Epoxyeicosatrienoic acid (5,6-EET), a compound synthesized from arachidonic acid by cytochrome P450 enzymes. This stable isotope is valuable for studying the biological activities of 5,6-EET, which include modulation of calcium mobilization and hormone secretion in neuroendocrine cells, as well as inhibition of T-type voltage-gated calcium channels (Cav3.1, Cav3.2). Additionally, it functions as a substrate for COX-1 and COX-2, facilitating detailed metabolic studies. 5,6-Epoxyeicosatrienoic acid-d11 aids in quantification and mechanistic investigations through methods such as GC-MS. -
Stable Isotope
Moxonidine-d4 is a deuterium-labeled analogue of Moxonidine, which functions primarily as an imidazoline type 1 receptor (I1-R) agonist. This compound activates I1 receptors and α2 adrenoceptors, modulating the uptake of oxidized low-density lipoprotein. Moxonidine has been shown to effectively reduce atherosclerotic lesions and lower blood pressure, making it a valuable tool for researching hypertension, heart failure, and atherosclerosis. -
Stable Isotope
Mapenterol-d6 hydrochloride is a deuterium-labeled analogue of Mapenterol hydrochloride, functioning as a selective β2-adrenoceptor agonist. This stable isotope is instrumental in pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution. It is valuable in research focusing on respiratory diseases and other therapeutic applications involving β2-adrenergic pathways. -
Stable Isotope
Harmane-d4 is a deuterium-labeled derivative of Harmane, serving as a stable isotope for biochemical research. This compound is useful in studies involving metabolic pathways and can aid in the characterization of Harmane's biological activity. Its application extends to isotopic labeling in pharmacokinetic studies, enabling accurate analyses of drug kinetics and dynamics. -
Stable Isotope
Solabegron-d8 is a deuterium-labeled derivative of Solabegron, a selective β3-adrenergic receptor agonist. It effectively stimulates cAMP accumulation in Chinese hamster ovary cells expressing human β3-adrenergic receptors, exhibiting an EC50 value of 22 nM. This compound is primarily utilized in research focused on the treatment of overactive bladder and irritable bowel syndrome, allowing for the investigation of β3-adrenergic signaling pathways in various biological contexts. -
Stable Isotope
Lofexidine-d4 is a deuterium-labeled derivative of Lofexidine (hydrochloride), a selective α2-adrenergic receptor agonist. This compound is primarily employed in research related to opioid withdrawal by mimicking the activity of Lofexidine in biological assays. The stable isotope labeling enables precise tracking in pharmacokinetic studies and helps in elucidating the pharmacological properties of opioid withdrawal treatments. -
Stable Isotope
Alfuzosin-d6 is a deuterium-labeled derivative of Alfuzosin, a selective and competitive α1-adrenoceptor antagonist. This compound exhibits muscle-relaxing properties in the prostate and bladder neck, thereby facilitating urination. Alfuzosin-d6 is utilized in research related to benign prostatic hyperplasia (BPH) and offers valuable insights into the pharmacokinetics and dynamics of the original Alfuzosin compound. -
Stable Isotope
(rac)-Dobutamine-d4 hydrochloride is a stable isotope-labeled form of the synthetic catecholamine Dobutamine hydrochloride, which primarily targets β1-adrenergic receptors (β1-AR) with lower affinity for α1-adrenergic (α1-AR) and β2-adrenergic receptors (β2-AR). This compound is known for its ability to enhance cardiac output and ameliorate conditions of hypoperfusion. It serves as a valuable tool in pharmacological research, particularly in studies focused on cardiovascular function and receptor activity. -
Stable Isotope
Alfuzosin hydrochloride-d6 is a deuterium-labeled form of Alfuzosin hydrochloride, a selective and competitive antagonist of the α1-adrenoceptor. This compound effectively relaxes smooth muscles in the prostate and bladder neck, facilitating improved urinary flow. Alfuzosin hydrochloride-d6 is primarily used in research applications focused on benign prostatic hyperplasia (BPH) and serves as a valuable tool in pharmacokinetic and metabolic studies.
