Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Thymidine-d4 is a stable isotope-labeled derivative of thymidine, a crucial precursor in deoxyribonucleic acid (DNA) synthesis. Thymidine-d4 serves as a valuable tool for cell synchronization, effectively inhibiting DNA replication and arresting cells at the G1/S transition point. This compound is widely utilized in research applications involving cell cycle analysis and studies of DNA synthesis dynamics. -
Stable Isotope
5-Hydroxymethyl-2'-deoxycytidine-d3 is a deuterium-labeled stable isotope of 5-Hydroxymethyl-2'-deoxycytidine, an oxidation product of 5-methyl-2'-deoxycytidine found in DNA. This compound plays a crucial role in epigenetic studies and can serve as a biomarker for irreversibly damaged cells. Its unique isotopic labeling allows for precise tracking and quantification in biochemical assays and cellular research applications. -
Stable Isotope
Folic acid-d4 is a deuterium-labeled derivative of folic acid, also known as Vitamin B9. This stable isotope is essential for the synthesis and maintenance of new cells, playing a critical role in both DNA and RNA synthesis. Folic acid-d4 is widely utilized in metabolic studies, tracing experiments, and the investigation of folate metabolism in biological systems. -
Stable Isotope
Erythromycin-d3 is a deuterium-labeled derivative of erythromycin, a macrolide antibiotic derived from the actinomycete Streptomyces erythreus. It targets the 50S ribosomal subunit of bacteria, inhibiting RNA-dependent protein synthesis through interference with transpeptidation and translocation processes. This compound demonstrates a broad spectrum of antimicrobial activity, as well as potential antitumor and neuroprotective effects, making it valuable for research applications across microbiology, oncology, and neurobiology. -
Stable Isotope
Metazachlor-d6 is a stable isotope-labeled analog of Metazachlor, a chloroacetamide herbicide. It functions by inhibiting the synthesis of very long chain fatty acids, which disrupts cell division and tissue differentiation in germinating weed seeds. This compound is useful for studying herbicide mechanisms of action, as well as for environmental monitoring and metabolic research related to herbicide fate and behavior in various systems. -
Stable Isotope
Maleic hydrazide-d2 is a deuterium-labeled derivative of maleic hydrazide, a systemic plant growth regulator and herbicide. It functions as an inhibitor of nucleic acid and protein synthesis, making it a valuable tool for studying plant growth mechanisms and herbicide efficacy. This stable isotope variant allows for enhanced tracking and quantification in biochemical research applications. -
Stable Isotope
Folic acid-13C5 is a stable isotope-labeled form of folic acid (Vitamin B9), which is essential for the synthesis and maintenance of new cells, as well as for DNA and RNA synthesis. This compound serves as a valuable tool in metabolic studies, tracer experiments, and nutritional research, allowing for the precise tracking of folate-related pathways and biological processes. The incorporation of the 13C label enables enhanced detection and quantification in various analytical applications, contributing to a better understanding of folate metabolism and its implications in health and disease. -
Stable Isotope
5-Methyl cytosine-13C,15N2 hydrochloride is a stable isotope-labeled derivative of 5-methylcytosine, featuring isotopic labeling with carbon-13 and nitrogen-15. This compound is essential for studying gene regulation, genomic imprinting, and the suppression of transposable elements. Its incorporation into nucleic acids enables advanced research applications, including investigations of epigenetic modifications and translational processes, contributing valuable insights into gene expression dynamics and cellular function. -
Stable Isotope
Uridine triphosphate-13C9,15N2 sodium is a stable isotope-labeled form of uridine triphosphate (UTP) that serves as a key component in nucleic acid synthesis. The incorporation of 13C and 15N isotopes allows for advanced tracking and analysis in metabolic studies and isotopic labeling experiments. This reagent is essential for researchers investigating RNA synthesis and metabolic pathways involving nucleotide usage. -
Stable Isotope
Thymidine-13C is a stable isotope-labeled form of thymidine that serves as a specific precursor for deoxyribonucleic acid (DNA) synthesis. As a potent DNA synthesis inhibitor, it effectively synchronizes cells at the G1/S boundary, halting progression prior to DNA replication. This compound is widely utilized in molecular biology research to study DNA dynamics, cellular processes, and metabolic pathways. -
Stable Isotope
Tempo-d18 is a deuterium-labeled nitroxide radical that serves as a selective scavenger of reactive oxygen species (ROS). It effectively dismutates superoxide through its catalytic cycle, leading to the induction of DNA strand breakage. Additionally, Tempo-d18 acts as an organocatalyst, facilitating the oxidation of primary alcohols to aldehydes. This compound exhibits both mutagenic and antioxidant properties, making it a valuable tool for diverse chemical research applications. -
Stable Isotope
Salbutamol-d3 is a deuterium-labeled derivative of Salbutamol, a short-acting β2-adrenergic receptor agonist. This compound is primarily employed as a stable isotope for metabolic tracing and pharmacokinetic studies. Salbutamol exhibits significant therapeutic effects by relaxing bronchial smooth muscle, making it a valuable tool in research involving asthma and chronic obstructive pulmonary disease. Additionally, it has been identified to promote tumorigenesis in gastric cancer cells via the β2-AR/ERK/EMT pathway, highlighting its utility in oncology research. -
Stable Isotope
Salbutamol-d9 acetate is a deuterium-labeled derivative of Salbutamol, a short-acting β2-adrenergic receptor agonist. This compound is primarily utilized as a stable isotope for research applications, specifically in studying its effects on bronchial smooth muscle relaxation and the β2-adrenergic receptor pathways. Salbutamol has also been implicated in promoting tumorigenesis in gastric cancer cells via the β2-AR/ERK/EMT signaling cascade, making it relevant for cancer research as well as respiratory studies. -
Stable Isotope
Salbutamol-d9 is a deuterium-labeled derivative of Salbutamol, a short-acting β2-adrenergic receptor agonist. It is primarily utilized as a stable isotope in biological research, allowing for the precise tracking of Salbutamol's pharmacokinetics and metabolism. Salbutamol is known for its ability to relax bronchial smooth muscle and is widely studied in the context of asthma and chronic obstructive pulmonary disease, as well as its role in promoting tumorigenesis in gastric cancer cells via the β2-AR/ERK/EMT signaling pathway. -
Stable Isotope
Propoxur-d3 is the deuterated form of Propoxur, a reversible and competitive acetylcholinesterase (AChE) inhibitor. It crosses the blood-brain barrier and exerts neurotoxic effects by inhibiting AChE activity, leading to increased acetylcholine levels and resultant neurological dysfunction. Additionally, Propoxur-d3 promotes the expression of matrix metalloproteinase-2 (MMP-2) and enhances tumor cell migration and invasion through the generation of intracellular reactive oxygen species (ROS) and the activation of the ERK/Nrf2 signaling pathway. This compound has applications in neurotoxicity studies and cancer research, as well as in assessing pesticide effects in ecological studies. -
Stable Isotope
Salbutamol-d4 is a deuterated form of the beta-2 adrenergic receptor agonist Salbutamol, designed for stable isotope applications in biochemical research. This compound has been shown to promote tumorigenesis in gastric cancer cells via the β2-AR/ERK/EMT signaling pathway. In addition, Salbutamol-d4 is utilized in studies investigating bronchospasms associated with asthma and chronic obstructive pulmonary disease (COPD), allowing for precise tracking of biological processes and metabolic pathways. -
Stable Isotope
Propoxur-d7 is the deuterium-labeled analog of Propoxur, a reversible and competitive inhibitor of acetylcholinesterase (AChE). This compound exhibits significant neurotoxic effects by inhibiting AChE activity, leading to increased levels of acetylcholine and subsequent neurological dysfunction. Propoxur-d7 also enhances tumor cell migration and invasion through the promotion of matrix metalloproteinase-2 (MMP-2) expression, driven by reactive oxygen species (ROS) generation and activation of the ERK/Nrf2 signaling pathway. Additionally, Propoxur serves as a carbamate insecticide effective against a variety of pests in turf, forestry, and household settings. -
Stable Isotope
Sitagliptin-d6 is a deuterium-labeled derivative of Sitagliptin, a selective DPP-4 inhibitor that demonstrates an IC50 of 19 nM. By inhibiting the degradation of incretins such as GLP-1 and GIP, Sitagliptin-d6 promotes increased levels of active glucagon-like peptides, thereby enhancing insulin secretion in a glucose-dependent manner. Additionally, it can stimulate GLP-1 secretion from intestinal L cells independently of DPP-4 inhibition, engaging the cAMP/PKA and ERK1/2 signaling pathways. This reagent is valuable for research on type 1 and type 2 diabetes, as well as the protective effects on pancreatic islet grafts. -
Stable Isotope
Emodin-d4 is a deuterium-labeled derivative of emodin, an anthraquinone compound recognized for its interactions with viral spike proteins. It effectively inhibits the engagement of the SARS-CoV spike protein with angiotensin-converting enzyme 2 (ACE2), demonstrating antiviral properties. Emodin also exhibits significant anti-inflammatory and anticancer effects, alongside selective inhibition of 11β-HSD1 with IC50 values of 186 nM for human and 86 nM for mouse enzymes. This reagent is valuable for studies involving metabolic disorders and cellular signaling pathways, particularly in obesity-related research. -
Stable Isotope
Pirfenidone-d5 is a deuterium-labeled derivative of pirfenidone, primarily utilized as a stable isotope in chemical research. This compound exhibits antifibrotic properties by reducing the production of CCL2 and CCL12 in fibrocyte cells. Additionally, pirfenidone-d5 demonstrates a growth-inhibitory effect and lowers TGF-β2 protein levels in human glioma cell lines, while also possessing anti-inflammatory activities. It is a valuable tool for studying fibrotic disease mechanisms and evaluating therapeutic strategies in cancer and inflammation research. -
Stable Isotope
Hydrochlorothiazide-13C6 is a stable isotope-labeled form of Hydrochlorothiazide (HCTZ), a thiazide diuretic that primarily targets the TGF-β/Smad signaling pathway. It exhibits direct vascular relaxant properties through the activation of calcium-activated potassium (KCA) channels. Hydrochlorothiazide-13C6 is utilized in various research applications, including studies on cardiac function improvement, fibrosis reduction, and antihypertensive effects in cardiovascular research. -
Stable Isotope
Hydrochlorothiazid-d2 is the deuterated form of Hydrochlorothiazide, a thiazide diuretic known for its role in inhibiting the transforming growth factor-beta (TGF-β)/Smad signaling pathway. This compound exhibits direct vascular relaxation by activating calcium-activated potassium channels, contributing to its antihypertensive properties. Hydrochlorothiazid-d2 is valuable in research applications involving the study of cardiovascular function, fibrosis reduction, and the overall effects of diuretics on systemic blood pressure regulation. -
Stable Isotope
Hydrochlorothiazid-13C,d2 is a stable isotope-labeled form of Hydrochlorothiazide (HCTZ), a thiazide diuretic that functions by inhibiting the TGF-β/Smad signaling pathway. This compound exhibits direct vascular relaxant effects through the activation of calcium-activated potassium channels. Hydrochlorothiazide is primarily utilized in research to improve cardiac function, reduce fibrosis, and exhibit antihypertensive properties, making it a valuable tool for studies on cardiovascular health and hypertension management. -
Stable Isotope
Hydrochlorothiazide-15N2,13C,d2 is a stable isotope-labeled derivative of hydrochlorothiazide, incorporating 15N and deuterium for enhanced tracking in metabolic studies. As a thiazide diuretic, hydrochlorothiazide inhibits the TGF-β/Smad signaling pathway, which plays a crucial role in cardiovascular remodeling. This compound exhibits direct vascular relaxation by activating calcium-activated potassium channels, thereby improving cardiac function, reducing fibrosis, and delivering antihypertensive effects. It is ideal for research applications focusing on cardiovascular health and the mechanisms of diuretic therapy. -
Stable Isotope
2-Oleoylglycerol-d5 is a deuterium-labeled derivative of 2-Oleoylglycerol, a known agonist of GPR119. It exhibits significant biological activity by activating human GPR119 with an EC50 of 2.5 μM in COS-7 cells, enhancing macrophage inflammatory responses and promoting fibrosis through the GPR119/TAK1/NF-κB/TGF-β1 signaling cascade. Additionally, this compound stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol-d5 is particularly useful for studying mechanisms underlying non-alcoholic steatohepatitis (NASH). -
Stable Isotope
Hippuric acid-13C6 is a stable isotope-labeled form of hippuric acid, primarily utilized in metabolic studies and tracing experiments. This compound acts as an orally active metabolite that is generated by intestinal microorganisms from the metabolism of polyphenols and benzoic acid. Hippuric acid-13C6 plays a role in decreasing NRF2 and MMP9, leading to reactive oxygen species (ROS) accumulation, and activates TGFβ/SMAD signaling pathways. It is relevant for research applications in hyperuricemia, colitis, and cardiovascular disease. -
Stable Isotope
(±)-Nornicotine-d4 is a deuterium-labeled analog of (±)-Nornicotine, a significant metabolite of nicotine. It acts as a partial agonist at nicotinic acetylcholine receptors (nAChRs), particularly those containing α7 and α6 subunits, influencing various biological pathways. This compound has been shown to disrupt β-catenin and ZO-1 interactions while inducing F-actin depolymerization. (±)-Nornicotine-d4 is valuable for research focused on atherosclerosis, Alzheimer's disease, and schizophrenia, providing insights into nicotine's metabolic effects and related neurological conditions. -
Stable Isotope
Nefopam-d3 hydrochloride is a deuterium-labeled derivative of Nefopam hydrochloride, a centrally-acting non-opioid analgesic. This compound is primarily utilized for pain relief in moderate to severe cases. In research applications, Nefopam hydrochloride modulates β-catenin protein levels in mesenchymal cells, providing insights into pain mechanisms and potential therapeutic pathways. -
Stable Isotope
Toxoflavin-13C4 is a stable isotope-labeled derivative of Toxoflavin, which serves as an antagonist of the transcription factor 4 (TCF4)/β-catenin complex. This compound exhibits significant antitumor activity and functions as an inhibitor of the lysine demethylase KDM4A. In addition to its antineoplastic properties, Toxoflavin is recognized for its antibiotic effects, making it valuable for diverse biological research applications. -
Stable Isotope
Nefopam-d4 hydrochloride is a deuterium-labeled form of Nefopam hydrochloride, which is a centrally acting, non-opioid analgesic agent. This compound is utilized for the relief of moderate to severe pain and has been shown to specifically target β-catenin protein levels in mesenchymal cells both in vitro and in vivo. Nefopam-d4 hydrochloride serves as a valuable tool for mechanistic studies and pharmacokinetic investigations related to pain management. -
Stable Isotope
N-Desmethylnefopam-d5 is a deuterium-labeled derivative of N-Desmethylnefopam, the primary metabolite of the analgesic Nefopam. This compound acts as a centrally-acting, non-opioid analgesic, effectively alleviating moderate to severe pain. Its primary mechanism involves the modulation of β-catenin protein levels in mesenchymal cells, making it a valuable tool for researching pain mechanisms and the pharmacokinetics of analgesic drugs. -
Stable Isotope
Sulindac sulfide-d3 is a deuterium-labeled derivative of Sulindac sulfide, primarily known for its role as a noncompetitive inhibitor of γ-secretase. This compound exhibits an IC50 of 20.2 μM for inhibiting γ42-secretase activity, making it a valuable tool in the study of Alzheimer’s disease and related pathologies. Applications include investigations into the biochemical pathways involved in amyloid precursor protein processing and the modulation of signaling pathways associated with γ-secretase activity. -
Stable Isotope
2-Iodoacetamide-d4 is a deuterated form of the alkylating agent 2-Iodoacetamide, targeting cysteine residues in proteins. This reagent is widely utilized in proteomics for the specific alkylation of cysteine, facilitating improved identification and quantification of proteins in complex samples. Its stable isotope labeling enhances the accuracy of mass spectrometry analysis, making it an essential tool in protein characterization studies. -
Stable Isotope
Cyclophosphamide-d4 is a deuterium-labeled derivative of Cyclophosphamide, a synthetic alkylating agent of the nitrogen mustards class. It exhibits significant antineoplastic activity and immunosuppressive properties, making it valuable in cancer therapy and autoimmune disease research. As a stable isotope, Cyclophosphamide-d4 is utilized in metabolic studies and pharmacokinetic assessment to track drug behavior and metabolism in biological contexts. -
Stable Isotope
Ifosfamide-d4 is a deuterium-labeled derivative of Ifosfamide, an alkylating chemotherapeutic agent. It exhibits potent antitumor activity against various malignancies, facilitating studies on the pharmacokinetics and metabolism of Ifosfamide. This stable isotope is valuable for research applications in cancer therapy, drug development, and metabolic studies involving alkylating agents. -
Stable Isotope
Methyl methanesulfonate-d3 is a deuterium-labeled analog of methyl methanesulfonate, serving as a stable isotope. As an alkylating agent, it effectively transfers methyl groups and induces DNA damage, making it a valuable tool in the study of mutagenesis and DNA repair mechanisms. This reagent is widely utilized in biochemical and life science research for investigating cellular responses to DNA-altering agents. -
Stable Isotope
Thio-TEPA-d12 is a deuterated form of Thio-TEPA, a potent DNA alkylating agent known for its antitumor properties. This stable isotope is utilized in chemical research to trace and quantify the mechanism of action of Thio-TEPA in cancer therapy. Its application extends to studies on DNA interactions and the development of therapeutic strategies targeting DNA repair pathways. -
Stable Isotope
Hexamethylphosphoramide-d18 is a deuterated form of Hexamethylphosphoramide, acting as a stable isotope for analytical research. This compound serves as a polar aprotic solvent and flame retardant while participating in metabolic processes, specifically undergoing cytochrome P-450-mediated N-demethylation to produce formaldehyde. Hexamethylphosphoramide-d18 is utilized in studies investigating DNA-protein crosslinking and its implications in carcinogenicity, particularly in relation to nasal tumors and reproductive toxicity. It provides valuable insights for researchers examining chemical toxicity and metabolic pathways. -
Stable Isotope
Cyclophosphamide-d8 is a deuterium-labeled analog of cyclophosphamide, a synthetic alkylating agent classified as a nitrogen mustard. It exerts antineoplastic activity through DNA cross-linking, leading to inhibited cell division. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the metabolic pathways of cyclophosphamide and understand its therapeutic effects and side effects. -
Stable Isotope
1-Linoleoyl Glycerol-d5 is a deuterium-labeled derivative of 1-Linoleoyl Glycerol, functioning primarily as a stable isotope. This compound inhibits lipoprotein-associated phospholipase A2 (LpPLA2) and serves as a precursor for the synthesis of various functional lipids, including phospholipids. Additionally, 1-Linoleoyl Glycerol-d5 has been shown to reduce inflammation associated with Apolipoprotein CIII, evidenced by a decrease in interleukin-6 (IL-6) levels. This reagent is valuable for understanding lipid metabolism and inflammation in biological research. -
Stable Isotope
Lipoxin A4-d5 is the deuterium-labeled form of Lipoxin A4, a naturally occurring eicosanoid derived from lipoxygenase. This compound exhibits significant pro-resolving and anti-inflammatory properties, effectively inhibiting the proliferation of human epidermal keratinocytes and the production of inflammatory cytokines and chemokines through the ERK1/2 and NF-kB pathways. Lipoxin A4 also reduces IL-8 release mediated by serum amyloid A (SAA), demonstrating an IC50 value of 25.74 nM. Lipoxin A4-d5 serves as a valuable tool in research aimed at understanding inflammation resolution and related signaling pathways. -
Stable Isotope
Balsalazide-d3 is a deuterium-labeled form of Balsalazide, a prodrug that converts to mesalamine in the colon. This compound demonstrates significant anti-inflammatory properties, particularly in the treatment of colitis, and has been shown to exert anticancer effects through the modulation of the IL-6/STAT3 signaling pathway. Balsalazide-d3 is valuable in research applications focused on inflammatory bowel diseases and cancer biology, facilitating studies on drug metabolism and therapeutic efficacy. -
Stable Isotope
N-Acetyl-D-glucosamine-d3 is a deuterium-labeled derivative of the monosaccharide N-Acetyl-D-glucosamine. This compound serves as a stable isotope for various biological applications, exhibiting significant anti-tumor and anti-inflammatory activities. It has been identified as a bacterial metabolite in Escherichia coli and is known to induce yeast-mycelial conversion in Candida albicans. Additionally, N-Acetyl-D-glucosamine has demonstrated the ability to enhance cartilage healing in rabbit models, making it a valuable tool for research in cellular metabolism and regenerative medicine. -
Stable Isotope
Manidipine-d4 is a deuterated form of Manidipine, a calcium channel antagonist with oral bioavailability. It exerts hypotensive effects and modulates the expression of cytokines, such as IL-1β and IL-6. This reagent is applicable in the investigation of cardiovascular conditions, including hypertension and myocardial ischemia-reperfusion injury, as well as in renal pathologies and epilepsy research. -
Stable Isotope
(±)-Lisofylline-d4 is a deuterated form of the racemic compound (±)-Lisofylline, known for its ability to inhibit phosphatidic acid and free fatty acid generation. This compound is effective in blocking the release of pro-inflammatory cytokines during oxidative tissue injury, particularly in scenarios involving cancer chemotherapy and experimental sepsis. It is a valuable reagent for research in Type 1 diabetes, aiding in the understanding of inflammatory pathways and lipid metabolism. -
Stable Isotope
Tacrolimus-13C,d2 is a stable isotope-labeled form of Tacrolimus, a macrocyclic lactone that targets FK506 binding protein (FKBP). This compound forms a complex that inhibits calcineurin phosphatase activity, thereby blocking T-lymphocyte signal transduction and interleukin-2 (IL-2) transcription. Its potent immunosuppressive properties make it valuable for research in immunology and transplantation studies. -
Stable Isotope
D-erythro-Sphingosine-d7 is a deuterium-labeled derivative of D-erythro-Sphingosine, functioning as a stable isotope marker in chemical research. This compound serves as a potent activator of p32-kinase with an EC50 of 8 μM and has demonstrated the ability to inhibit protein kinase C (PKC). Additionally, D-erythro-Sphingosine-d7 acts as an activator of protein phosphatase 2A (PP2A), making it valuable for studies investigating signaling pathways involved in cell growth and cancer research. -
Stable Isotope
Fenvalerate-d5 is a deuterium-labeled derivative of Fenvalerate, a potent inhibitor of protein phosphatase 2B (calcineurin) with an IC50 of 2-4 nM for PP2B-Aα. This chemical has applications in research involving signal transduction and calcium-dependent pathways. Additionally, Fenvalerate serves as a pyrethroid ester insecticide and acaricide, making it valuable in studies related to pest management and toxicology. -
Stable Isotope
Trimyristin-d15 is a deuterium-labeled derivative of Trimyristin, a naturally occurring compound extracted from Myristica fragrans. This reagent effectively inhibits acetylcholinesterase (AChE), as well as acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata, with IC50 values of 0.11 mM, 0.16 mM, and 0.18 mM, respectively. Trimyristin-d15 serves as a valuable tool for biochemical research and enzyme activity studies, particularly in exploring the mechanisms of neurotoxicity and molluscicidal action. -
Stable Isotope
Methyl syringate-d6 is a deuterated form of Methyl syringate, known for its selective agonism of TRPA1 channels. This compound plays a crucial role in regulating food intake and gastric emptying via TRPA1-mediated pathways. Methyl syringate-d6 serves as a valuable probe in studies of its antimicrobial properties, particularly regarding its effectiveness against bacteria and fungi, as well as its potential applications in cancer prevention and suppression of hypoxia-induced inflammation. Additionally, it is used as a chemical marker in the characterization of Asphodel monofloral honey.
