Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
Propionylpromazine-d6 hydrochloride is a deuterium-labeled derivative of Propionylpromazine hydrochloride, a potent dopamine receptor D2 (DRD2) antagonist. This reagent is primarily utilized in pharmacological research focusing on Parkinson's disease, enabling the study of dopamine signaling pathways and receptor interactions. The stable isotope labeling provides enhanced analytical precision, making it suitable for advanced bioanalytical applications. -
Stable Isotope
Amisulpride-d5 N-Oxide is a deuterium-labeled analog of Amisulpride, functioning as a dopamine D2/D3 receptor antagonist with inhibition constants (Kis) of 2.8 nM and 3.2 nM for human dopamine D2 and D3 receptors, respectively. This stable isotope-labeled compound is essential for research involving pharmacokinetics, biomarker discovery, and labeling in metabolic studies. Its precision and reliability make it suitable for various applications in neuroscientific research and drug development. -
Stable Isotope
Pramipexole-d5 is a deuterium-labeled derivative of Pramipexole, a selective dopamine D2-type receptor agonist that effectively crosses the blood-brain barrier. With binding affinities (Kis) of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for the D2-type, D2, D3, and D4 receptors respectively, Pramipexole-d5 serves as a valuable tool for exploring dopamine receptor interactions. This compound is particularly relevant for research into neurodegenerative disorders such as Parkinson's disease and conditions like restless legs syndrome. -
Stable Isotope
Clomipramine-d3 is a deuterium-labeled derivative of Clomipramine that primarily targets the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), exhibiting inhibition with Ki values of 0.14 nM, 54 nM, and 3 nM, respectively. This stable isotope is valuable for pharmacokinetic studies and metabolic research, enabling the tracking and quantification of Clomipramine in biological samples. Clomipramine-d3 facilitates investigations into its biochemical interactions and the influence of neurotransmitter systems on various physiological processes. -
Stable Isotope
Ropinirole-d14 is a deuterium-labeled derivative of Ropinirole, designed for use in various analytical applications. This stable isotope allows for precise tracking and quantification of Ropinirole in biological systems through advanced techniques such as mass spectrometry. It is particularly useful in pharmacokinetic studies, metabolic profiling, and drug interaction investigations, facilitating deeper insights into Ropinirole's biological activity and efficacy. -
Stable Isotope
Acetophenazine dimaleate-d4 is a deuterium-labeled derivative of Acetophenazine, a phenothiazine-based antipsychotic agent. This compound primarily exerts its effects by selectively blocking dopamine D2 receptors in the central nervous system. Acetophenazine dimaleate-d4 is valuable for studying psychotic disorders, including schizophrenia and anxiety-related depression, providing insights into the pharmacodynamics of antipsychotic treatments. -
Stable Isotope
Pramipexole-d7-1 dihydrochloride is a deuterium-labeled analog of Pramipexole dihydrochloride, a selective agonist of dopamine D2-type receptors. This compound effectively penetrates the blood-brain barrier and exhibits Ki values of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for the D2-type receptor, D2, D3, and D4 receptors, respectively. Pramipexole-d7-1 dihydrochloride is valuable for research on Parkinson's disease and restless legs syndrome, facilitating advanced studies in neuropharmacology and the pharmacokinetics of dopamine receptor interactions. -
Stable Isotope
Ropinirole-d7 hydrochloride is a deuterium-labeled analog of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors. With a Ki value of 29 nM for the D2 receptor, it demonstrates strong biological activity, exhibiting pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is particularly relevant in research focused on Parkinson's disease and neuropharmacology. -
Stable Isotope
(R)-3-O-Methyldopa-d3 hydrochloride is a deuterium-labeled analog of (R)-3-O-Methyldopa, which is the R-enantiomer of 3-O-Methyldopa. This compound acts as a stable isotope and serves as a valuable tool for studying metabolic pathways involving L-DOPA, a precursor to dopamine. 3-O-Methyldopa is known to competitively inhibit the actions of L-DOPA and dopamine, making it useful in research focused on neurotransmitter regulation and related pharmacodynamics. -
Stable Isotope
(rac)-Dobutamine-d6 hydrochloride is a stable isotope-labeled form of racemic Dobutamine hydrochloride, which targets α1-AR, β1-AR, and β2-AR adrenoceptors. This compound primarily functions as a selective β1-AR agonist, exhibiting a relatively weaker effect on α1-AR and β2-AR. Notably, (rac)-Dobutamine-d6 hydrochloride is utilized in research applications focused on cardiovascular studies, particularly for analyzing cardiac output and addressing conditions of hypoperfusion. -
Stable Isotope
Tetrahydrozoline-d4 hydrochloride is a deuterium-labeled form of Tetrahydrozoline hydrochloride, an α-adrenergic agonist that targets α-adrenergic receptors to induce vasoconstriction. This stable isotope is utilized in research applications focusing on nasal and conjunctival congestion. Its unique isotopic labeling allows for enhanced tracking and quantification in various biochemical studies. -
Stable Isotope
5,6-Epoxyeicosatrienoic acid-d11 is a deuterium-labeled analogue of 5,6-Epoxyeicosatrienoic acid (5,6-EET), a compound synthesized from arachidonic acid by cytochrome P450 enzymes. This stable isotope is valuable for studying the biological activities of 5,6-EET, which include modulation of calcium mobilization and hormone secretion in neuroendocrine cells, as well as inhibition of T-type voltage-gated calcium channels (Cav3.1, Cav3.2). Additionally, it functions as a substrate for COX-1 and COX-2, facilitating detailed metabolic studies. 5,6-Epoxyeicosatrienoic acid-d11 aids in quantification and mechanistic investigations through methods such as GC-MS. -
Stable Isotope
Moxonidine-d4 is a deuterium-labeled analogue of Moxonidine, which functions primarily as an imidazoline type 1 receptor (I1-R) agonist. This compound activates I1 receptors and α2 adrenoceptors, modulating the uptake of oxidized low-density lipoprotein. Moxonidine has been shown to effectively reduce atherosclerotic lesions and lower blood pressure, making it a valuable tool for researching hypertension, heart failure, and atherosclerosis. -
Stable Isotope
Mapenterol-d6 hydrochloride is a deuterium-labeled analogue of Mapenterol hydrochloride, functioning as a selective β2-adrenoceptor agonist. This stable isotope is instrumental in pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution. It is valuable in research focusing on respiratory diseases and other therapeutic applications involving β2-adrenergic pathways. -
Stable Isotope
Harmane-d4 is a deuterium-labeled derivative of Harmane, serving as a stable isotope for biochemical research. This compound is useful in studies involving metabolic pathways and can aid in the characterization of Harmane's biological activity. Its application extends to isotopic labeling in pharmacokinetic studies, enabling accurate analyses of drug kinetics and dynamics. -
Stable Isotope
Solabegron-d8 is a deuterium-labeled derivative of Solabegron, a selective β3-adrenergic receptor agonist. It effectively stimulates cAMP accumulation in Chinese hamster ovary cells expressing human β3-adrenergic receptors, exhibiting an EC50 value of 22 nM. This compound is primarily utilized in research focused on the treatment of overactive bladder and irritable bowel syndrome, allowing for the investigation of β3-adrenergic signaling pathways in various biological contexts. -
Stable Isotope
Lofexidine-d4 is a deuterium-labeled derivative of Lofexidine (hydrochloride), a selective α2-adrenergic receptor agonist. This compound is primarily employed in research related to opioid withdrawal by mimicking the activity of Lofexidine in biological assays. The stable isotope labeling enables precise tracking in pharmacokinetic studies and helps in elucidating the pharmacological properties of opioid withdrawal treatments. -
Stable Isotope
Alfuzosin-d6 is a deuterium-labeled derivative of Alfuzosin, a selective and competitive α1-adrenoceptor antagonist. This compound exhibits muscle-relaxing properties in the prostate and bladder neck, thereby facilitating urination. Alfuzosin-d6 is utilized in research related to benign prostatic hyperplasia (BPH) and offers valuable insights into the pharmacokinetics and dynamics of the original Alfuzosin compound. -
Stable Isotope
(rac)-Dobutamine-d4 hydrochloride is a stable isotope-labeled form of the synthetic catecholamine Dobutamine hydrochloride, which primarily targets β1-adrenergic receptors (β1-AR) with lower affinity for α1-adrenergic (α1-AR) and β2-adrenergic receptors (β2-AR). This compound is known for its ability to enhance cardiac output and ameliorate conditions of hypoperfusion. It serves as a valuable tool in pharmacological research, particularly in studies focused on cardiovascular function and receptor activity. -
Stable Isotope
Alfuzosin hydrochloride-d6 is a deuterium-labeled form of Alfuzosin hydrochloride, a selective and competitive antagonist of the α1-adrenoceptor. This compound effectively relaxes smooth muscles in the prostate and bladder neck, facilitating improved urinary flow. Alfuzosin hydrochloride-d6 is primarily used in research applications focused on benign prostatic hyperplasia (BPH) and serves as a valuable tool in pharmacokinetic and metabolic studies. -
Stable Isotope
Phentolamine-d4 hydrochloride is a deuterated form of Phentolamine hydrochloride, a reversible and non-selective inhibitor of α1 and α2 adrenergic receptors. This compound is utilized primarily for its vasodilatory effects, which reduce peripheral vascular resistance. Phentolamine-d4 hydrochloride is valuable in research applications related to pheochromocytoma-induced hypertension, heart failure, and erectile dysfunction, providing insights into adrenergic receptor modulation in these conditions. -
Stable Isotope
Mabuterol-d9 hydrochloride is a deuterium-labeled form of Mabuterol hydrochloride, targeting the beta-2 adrenergic receptor (ADRB2) as a selective agonist. This compound exhibits the ability to inhibit cellular proliferation and reduce PDGF-BB-induced increases in intracellular calcium levels. Additionally, Mabuterol hydrochloride downregulates the expression of key proteins such as Drp-1, cyclin D1, and PCNA, while promoting the expression of Mfn-2. This reagent is valuable for research involving cellular signaling, proliferation, and metabolic regulation. -
Stable Isotope
Mirabegron-d5 is a deuterated derivative of Mirabegron, a selective β3-adrenoceptor agonist with an EC50 of 22.4 nM. This stable isotope-labelled compound is instrumental for researchers investigating metabolic pathways and pharmacokinetics involving β3-adrenoceptor modulation. Mirabegron-d5 facilitates the study of drug metabolism and distribution in biological systems, enhancing the understanding of therapeutic strategies targeting bladder function and adipose tissue regulation. -
Stable Isotope
Silodosin-d4 is a deuterium-labeled form of Silodosin, a potent and selective α1A-adrenergic receptor (α1A-AR) blocker. This compound demonstrates a high affinity for the α1A-AR with a Ki value of 0.036 nM, while showing significantly lower binding to α1B-AR and α1D-AR, with Ki values of 21 nM and 2.0 nM, respectively. Silodosin-d4 can be utilized in research focused on lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), allowing for in-depth studies on receptor dynamics and pharmacokinetics. -
Stable Isotope
Ractopamine-d3 (hydrochloride) is a deuterated form of the potent β-adrenergic receptor (βAR) agonist, Ractopamine hydrochloride. With a Kd value of approximately 25 nM for pig β1AR and β2AR, this compound is known to promote muscle mass development, limit fat deposition, reduce feed consumption, and enhance protein synthesis in swine. It serves as a valuable tool in research focused on improving production efficiency and increasing lean tissue growth in agricultural settings. -
Stable Isotope
(rac)-Nebivolol-d4 is a stable isotope-labeled form of the racemic compound Nebivolol, which selectively targets the β1-adrenergic receptor with an IC50 of 0.8 nM. This reagent is valuable for pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Nebivolol in biological systems. Its stable isotope labeling facilitates investigations into drug interactions and receptor dynamics, offering insights into cardiovascular pharmacology. -
Stable Isotope
Droxidopa-13C6 is a stable isotope-labeled form of Droxidopa, a potent orally active precursor to norepinephrine. This compound is primarily utilized in research focused on neurogenic orthostatic hypotension (nOH) and may also provide insights into alternative therapies for attention deficit hyperactivity disorder (ADHD). By enhancing blood pressure and improving standing ability, Droxidopa-13C6 serves as a valuable tool for investigating the physiological effects of norepinephrine-related pathways in neurovascular health. -
Stable Isotope
(Rac)-Nebivolol-d4 hydrochloride is a stable isotope-labeled analog of racemic Nebivolol, which serves as a selective β1-adrenergic receptor inhibitor with an IC50 of 0.8 nM. This reagent is primarily utilized in pharmacokinetic studies and metabolic profiling, offering insights into drug metabolism and receptor interactions in various biological systems. Its application in research facilitates a deeper understanding of adrenergic signaling pathways and cardiovascular pharmacotherapy. -
Stable Isotope
Acepromazine-d6 (maleate) is a deuterium-labeled derivative of Acepromazine, a phenothiazine tranquilizer that acts primarily as an alpha-adrenoceptor antagonist. This stable isotope is valuable for metabolic studies and pharmacokinetic research, allowing for tracking and quantification of Acepromazine metabolism in various biological systems. Its unique labeling enables enhanced sensitivity in analytic techniques, making it an essential tool for researchers studying psychopharmacology and related disciplines. -
Stable Isotope
Romifidine-d4 hydrochloride is a deuterated form of Romifidine hydrochloride, serving as a stable isotope used in various chemical research applications. This compound is primarily utilized to study pharmacokinetics, metabolic pathways, and mechanism of action in pharmacological research. Its isotopic labeling enhances the accuracy of tracer studies, making it a valuable tool for elucidating the behavior of drugs in biological systems. -
Stable Isotope
Tamsulosin-d4 is a deuterium-labeled analog of Tamsulosin, a selective antagonist of the α1-adrenergic receptor. This compound is primarily utilized in the study of benign prostatic hyperplasia and offers insights into its pharmacological effects. Additionally, Tamsulosin has been shown to mitigate abdominal aortic aneurysm growth in preclinical models, making it a valuable reagent for cardiovascular research. -
Stable Isotope
Valsartan-d8 is a deuterated form of Valsartan, an angiotensin II receptor antagonist. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the pharmacodynamic and pharmacokinetic profiles of Valsartan in biological systems. Its applications extend to investigations involving hypertension and heart failure, providing valuable insights into the drug's effects and mechanisms of action. -
Stable Isotope
Candesartan-d4 is a deuterium-labeled version of Candesartan, a potent angiotensin II AT1 receptor blocker and PPAR-γ agonist. This stable isotope enables precise pharmacokinetic studies and metabolic profiling of Candesartan's antihypertensive effects. Research applications include investigations into hypertension, chronic heart failure, and traumatic brain injury, providing valuable insights into cardiovascular and neurological conditions. -
Stable Isotope
Olmesartan-d4 is a deuterium-labeled derivative of Olmesartan, functioning as an angiotensin II receptor (AT1R) antagonist. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling to trace its activity and distribution in biological systems. Olmesartan-d4 aids researchers in understanding the therapeutic effects and mechanisms of action associated with blood pressure regulation. -
Stable Isotope
Olmesartan-d6 is the deuterated form of Olmesartan, an angiotensin II receptor (AT1R) antagonist. This stable isotope serves as a valuable tool in pharmacokinetic studies and drug metabolism research. Its use allows for the precise tracking of Olmesartan in biological systems, facilitating a better understanding of its pharmacological properties and therapeutic effects in the management of hypertension. -
Stable Isotope
Irbesartan-d4 is a deuterated form of Irbesartan, a selective angiotensin II type 1 (AT1) receptor blocker. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research, enabling accurate tracing of Irbesartan metabolism and distribution within biological systems. The compound is particularly relevant in investigating conditions such as hypertension, heart failure, and diabetic nephropathy. -
Stable Isotope
Candesartan-d5 is a deuterated form of Candesartan, an angiotensin II receptor antagonist. With an IC50 of 0.26 nM, it effectively inhibits the angiotensin II type 1 receptor, playing a crucial role in the regulation of blood pressure and fluid balance. This stable isotope is valuable for pharmacokinetic studies and research involving drug metabolism and receptor binding kinetics. -
Stable Isotope
Valsartan-d3 is a deuterated derivative of Valsartan, an angiotensin II receptor antagonist. This stable isotope is primarily used in pharmacokinetic studies and metabolic research to trace the pharmacodynamics of Valsartan in biological systems. Its application is significant in understanding the mechanisms of action related to hypertension and heart failure therapies. -
Stable Isotope
Eprosartan-d3 is a deuterium-labeled variant of Eprosartan, a selective and competitive angiotensin II receptor antagonist. Eprosartan exhibits potent antihypertensive activity by binding to angiotensin II receptors with IC50 values of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively. This stable isotope is primarily utilized in biochemical research to study receptor interactions and pharmacokinetic properties of Eprosartan in various biological systems. -
Stable Isotope
Losartan-d3 Carboxylic Acid is a deuterium-labeled derivative of Losartan, which serves as an angiotensin II receptor antagonist. It inhibits the binding of angiotensin II to AT1 receptors with an IC50 of 20 nM, making it valuable in cardiovascular research. This stable isotope is particularly useful for pharmacokinetic studies, enabling accurate tracking and quantification of Losartan in biological systems. -
Stable Isotope
Losartan-d2 is a deuterated form of Losartan, an angiotensin II receptor antagonist. It competitively inhibits the binding of angiotensin II to the AT1 receptor with an IC50 value of 20 nM. This stable isotope is useful for research applications in pharmacokinetics, drug metabolism studies, and receptor binding assays, facilitating the investigation of Losartan's biological activity in various experimental contexts. -
Stable Isotope
Losartan-d9 is a deuterated form of Losartan, which serves as an angiotensin II receptor antagonist. It effectively competes with angiotensin II for binding to AT1 receptors, demonstrating an IC50 value of 20 nM. This stable isotope is valuable in pharmacokinetic studies and metabolic research, providing insights into drug metabolism and pharmacodynamics. -
Stable Isotope
Olmesartan medoxomil-d6 is a deuterium-labeled derivative of olmesartan medoxomil, a selective angiotensin AT1 receptor inhibitor. This compound demonstrates an IC50 of 66.2 μM, indicating its efficacy in modulating blood pressure and cardiovascular responses. Olmesartan medoxomil-d6 is primarily used in pharmacokinetic studies and metabolic research to trace the pharmacological properties and disposition of olmesartan in biological systems. -
Stable Isotope
Sparsentan-d5 is a deuterated form of Sparsentan, a potent dual antagonist of angiotensin II and endothelin A receptors with inhibition constants (Kis) of 0.8 nM and 9.3 nM, respectively. This stable isotope-labeled reagent is suitable for pharmacokinetic studies, enabling precise tracking and quantification in biological systems. Its unique properties make it an invaluable tool in the exploration of receptor biology and the development of therapeutics targeting cardiovascular and renal diseases. -
Stable Isotope
2-Phenylphenol-d5 is a stable isotope-labeled variant of 2-Phenylphenol, featuring five deuterium atoms. This compound is utilized primarily in analytical chemistry and mass spectrometry for tracing and quantifying organic compounds. Its incorporation of deuterium enhances the sensitivity and accuracy of assays in research applications, including environmental monitoring and pharmaceutical studies. -
Stable Isotope
2-Arachidonoylglycerol-d8 is a deuterated analog of 2-Arachidonoylglycerol, a natural endocannabinoid that acts as a ligand for cannabinoid receptors in the central nervous system. This stable isotope is utilized in biochemical and pharmacological research to study cannabinoid signaling and interactions. Its application includes mass spectrometry-based analysis, enabling precise quantification of endocannabinoid levels in biological samples for further investigation of their physiological roles. -
Stable Isotope
2-Arachidonoylglycerol-d5 is a deuterium-labeled analogue of 2-Arachidonoylglycerol, a naturally occurring endogenous cannabinoid in the central nervous system. This stable isotope is instrumental in studying the pharmacokinetics and metabolic pathways of cannabinoid compounds. It is widely used in biochemical research to elucidate the role of cannabinoids in physiological and pathological processes. -
Stable Isotope
Linoleoyl ethanolamide-d4 is a deuterated analog of Linoleoyl ethanolamide, targeting cannabinoid receptors type-1 (CB1) and type-2 (CB2). This compound exhibits weak binding affinity, with inhibition constants (Kis) of 10 μM and 25 μM for CB1 and CB2, respectively. It is utilized in biochemical research to investigate cannabinoid receptor dynamics and efficacy in functional assays. Additionally, Linoleoyl ethanolamide-d4 serves as a useful tool in studies exploring fatty acid ethanolamides and their biological effects. -
Stable Isotope
β-Caryophyllene-d2 is a deuterium-labeled form of β-Caryophyllene, a compound known for its role as a CB2 receptor agonist. This stable isotope serves as a valuable tool in chemical research, enabling the tracing and quantification of β-Caryophyllene in biological systems. Its applications include studying cannabinoid signaling pathways and investigating the therapeutic potential of CB2 receptor modulation. -
Stable Isotope
Eicosapentaenoyl ethanolamide-d4 is a deuterium-labeled analogue of Eicosapentaenoyl ethanolamide, targeting cannabinoid receptors CB1 and CB2. This compound exhibits significant biological activity as a metabolic signal and is involved in modulating lifespan extension related to dietary restriction. Research applications include studies on the effects of Eicosapentaenoyl ethanolamide on lifespan dynamics in wild-type models and TOR pathway mutants, contributing to the understanding of metabolic and signaling pathways in physiology.
