Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Cimetidine-d3 is a deuterated form of Cimetidine, a potent inverse agonist targeting the histamine H2 receptor with a Ki of 0.6 μM. This stable isotope is utilized in various research applications, including the study of anti-cancer and anti-inflammatory mechanisms. The incorporation of deuterium enhances its stability and allows for improved analytical tracking in pharmacokinetic studies. -
Stable Isotope
Desloratadine-d9 is a deuterium-labeled derivative of Desloratadine, a selective H1-receptor antagonist. This compound exhibits anti-allergic and anti-inflammatory properties and is the primary metabolite of Loratadine. Desloratadine-d9 serves as a valuable tool in pharmacokinetic studies and metabolic research, aiding in the investigation of drug interactions and the pharmacological profile of antihistamines. -
Stable Isotope
Carebastine-d5 Methyl Ester is a deuterium-labeled derivative of Carebastine, the active metabolite of Ebastine and a potent histamine H1 receptor antagonist. This compound exhibits significant biological activity by inhibiting VEGF-induced proliferation, migration, and angiogenesis in human umbilical vein endothelial cells (HUVEC) and human pulmonary artery endothelial cells (HPAEC) in a dose-dependent manner. It also demonstrates the ability to suppress the expression of macrophage migration inhibitory factor, making it a valuable tool for research in inflammation and angiogenesis. -
Stable Isotope
(E/Z)-Triprolidine-d8 hydrochloride is a deuterium-labeled analog of (E/Z)-Triprolidine hydrochloride. This stable isotope can be utilized in various biological and pharmacological studies, serving as a valuable tool for metabolic tracing and pharmacokinetic research. Its unique isotopic labeling allows for enhanced detection and analysis in mass spectrometry applications, facilitating deeper insights into drug metabolism and behavior in biological systems. -
Stable Isotope
Carebastine-d5 is the deuterium-labeled derivative of Carebastine, a potent histamine H1 receptor antagonist. This stable isotope is utilized in research to explore the pharmacokinetics and metabolic pathways of Carebastine and its effects on various biological systems. Carebastine demonstrates significant inhibition of VEGF-induced proliferation, migration, and angiogenesis in human umbilical vein endothelial cells (HUVEC) and human pulmonary artery endothelial cells (HPAEC), while also suppressing the expression of macrophage migration inhibitory factor. -
Stable Isotope
Nizatidine-d3 is a deuterated analog of Nizatidine, a potent and orally active antagonist of the histamine H2 receptor. This stable isotope is primarily used in research applications related to gastric acid secretion and ulcer management in the stomach and intestines. By inhibiting histamine activity, Nizatidine-d3 provides valuable insights into mechanisms of gastric ulcer prevention and healing in various animal models. -
Stable Isotope
Azelastine-d3 is a deuterium-labeled form of Azelastine, a potent and selective histamine H1 antagonist. This stable isotope variant is useful in pharmacokinetic studies and can aid in understanding the metabolism of Azelastine. Research applications include investigations into allergic rhinitis, asthma, diabetic hyperlipidemia, and the effects on viral infections such as SARS-CoV-2. -
Stable Isotope
Asenapine-13C,d3 is a stable isotope-labeled form of Asenapine, a novel atypical antipsychotic. This compound acts primarily as an antagonist of serotonin, dopamine, adrenoceptors, and histamine receptors, demonstrating a range of pKi values indicative of strong binding affinity. Asenapine-13C,d3 is valuable for pharmacokinetic studies and metabolic research related to schizophrenia and bipolar disorder, providing insights into drug behavior in biological systems. -
Stable Isotope
Benztropine-d3 mesylate is a deuterium-labeled form of the centrally acting anticholinergic agent, Benztropine mesylate. This compound is primarily utilized in Parkinson's disease research and exhibits anti-histaminic properties alongside its function as a dopamine reuptake inhibitor. Additionally, Benztropine mesylate acts as an allosteric antagonist at the human D2 dopamine receptor and demonstrates effects against cancer stem cells (CSCs), making it valuable for studies in both neuropharmacology and oncology. -
Stable Isotope
Mirtazapine-d4 hydrochloride is a deuterated analog of Mirtazapine, functioning as a noradrenergic and specific serotonergic antidepressant (NaSSA) agent. This compound exhibits potent antagonistic properties at 5-HT2, 5-HT3, histamine H1, and α2-adrenoceptors, with pKi values of 8.05, 8.1, 9.3, and 6.95, respectively. Mirtazapine-d4 hydrochloride is valuable for research applications involving the study of depression and the pharmacological characterization of related receptors. -
Stable Isotope
Lafutidine-d10 is a deuterium-labeled derivative of Lafutidine, a histamine H2-receptor antagonist (H2RA) known for its gastric mucosal protective effects. This stable isotope is utilized in pharmacokinetic studies and metabolic research involving Lafutidine, particularly in the context of gastroesophageal reflux disease (GERD). Its unique labeling allows for precise tracking and quantification in complex biological systems, enhancing the understanding of H2RA pharmacodynamics and pharmacokinetics. -
Isotope-Labeled Compounds
Pitolisant-d5 hydrochloride is a deuterium-labeled analog of Pitolisant hydrochloride, functioning primarily as a selective nonimidazole inverse agonist at the human histamine H3 receptor (Ki=0.16 nM). This compound enables researchers to study the pharmacokinetics and metabolism of Pitolisant in biological systems. Its isotopic labeling provides a valuable tool for various applications in drug development, including receptor binding studies and metabolic pathway investigation. -
Stable Isotope
Desloratadine-3,3,5,5-d4 is a deuterium-labeled analog of Desloratadine, the major metabolite of the nonsedating H1-antihistamine Loratadine. As a selective H1-receptor antagonist, Desloratadine exhibits anti-allergic and anti-inflammatory properties, making it valuable in research related to allergy and inflammation. The stable isotope labeling enables enhanced tracking and detection in various biochemical studies, contributing to a better understanding of H1-antihistamine mechanisms. -
Stable Isotope
Fexofenadine-d10 hydrochloride is a deuterium-labeled derivative of Fexofenadine hydrochloride, a potent H1 receptor antagonist. This stable isotope is primarily utilized in pharmacokinetic studies and drug metabolism research, allowing for enhanced tracking of drug distribution and action in biological systems. It plays a critical role in understanding the pharmacological properties of anti-allergic agents used in the treatment of conditions such as seasonal allergic rhinitis and chronic idiopathic urticaria. -
Stable Isotope
Fexofenadine-d10 is a deuterium-labeled analogue of Fexofenadine, primarily utilized as a stable isotope for pharmacokinetic studies. This compound aids in the quantitative analysis of drug metabolism and disposition, providing insights into the bioavailability of Fexofenadine in various biological matrices. Its applications extend to drug interaction studies and the investigation of antihistaminic efficacy in clinical and preclinical research settings. -
Stable Isotope
Famotidine-13C3 is a stable isotope-labeled derivative of Famotidine, a competitive histamine H2-receptor antagonist. It primarily functions by inhibiting gastric secretion, making it valuable for studying gastric physiology and pharmacology. Famotidine-13C3 is utilized in metabolic tracing and kinetic studies, aiding research in drug metabolism and receptor binding mechanisms. -
Stable Isotope
Ketotifen-13C,d3 is a deuterium-labeled derivative of Ketotifen, functioning as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic research, enabling precise tracking of drug metabolism and distribution in biological systems. Its application enhances the understanding of Ketotifen's biological pathways and interactions in various therapeutic contexts. -
Stable Isotope
Hydroxyzine-d8 dihydrochloride is a deuterium-labeled derivative of hydroxyzine, a benzodiazepine antihistamine. It functions as an oral histamine H1-receptor and serotonin antagonist, exhibiting anxiolytic properties. This compound is valuable for research applications focused on generalized anxiety disorder and other related disorders, enabling the study of histaminergic and serotonergic systems in anxiety modulation. -
Stable Isotope
Azelastine-d4 hydrochloride is a deuterated form of Azelastine hydrochloride, designed as a stable isotope reagent for analytical applications. This compound serves as a valuable internal standard in pharmacokinetic studies and isotopic labeling experiments, enabling precise quantification in biological matrices. Its use enhances the understanding of drug metabolism and pharmacodynamics in research contexts. -
Stable Isotope
Mirtazapine-d4 is a deuterium-labeled derivative of Mirtazapine, a potent noradrenergic and specific serotonergic antidepressant (NaSSA). It functions primarily as an antagonist of the 5-HT2, 5-HT3, histamine H1 receptors, and α2-adrenoceptors, with pKi values of 8.05, 8.1, 9.3, and 6.95, respectively. This stable isotope is useful for pharmacokinetic studies, metabolic profiling, and elucidating the mechanisms of action of antidepressant therapies in research settings. -
Isotope-Labeled Compounds
Alimemazine-d6 hydrochloride is a deuterated derivative of Alimemazine, a phenothiazine compound. This reagent functions primarily as a partial agonist at the histamine H1 receptor (H1R) and serves as an antagonist to hemagglutinin (HA) receptors. Alimemazine-d6 exhibits notable biological activities, including antipruritic, antiserotonin, antispasmodic, and antiemetic properties. It is valuable for research applications involving the study of receptor interactions, pharmacokinetics, and metabolic pathways of phenothiazine derivatives. -
Stable Isotope
Fenspiride-d5 is a deuterium-labeled derivative of Fenspiride, an orally active non-steroidal anti-inflammatory agent. It functions primarily as an H1-histamine receptor antagonist and exhibits inhibitory activity against phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4), and phosphodiesterase 5 (PDE5), with -log IC50 values of 3.44, 4.16, and approximately 3.8, respectively. This reagent is valuable for investigating respiratory diseases and understanding the pharmacodynamics of its parent compound in biochemical research. -
Stable Isotope
Olopatadine-d6 is a deuterated form of Olopatadine, a selective antagonist of the histamine H1 receptor and mast cell stabilizer. This compound effectively inhibits the release of pro-inflammatory mediators from human conjunctival mast cells in response to immunological stimulation. Olopatadine-d6 serves as a valuable tool for research on allergic conjunctivitis and related allergic disorders. -
Stable Isotope
Hydroxyzine-d4 dihydrochloride is a deuterated form of Hydroxyzine dihydrochloride, a benzodiazepine antihistamine. This compound acts primarily as a histamine H1-receptor and serotonin antagonist, demonstrating significant anxiolytic effects. It is utilized in research related to generalized anxiety disorder, allowing for the study of pharmacokinetics and the efficacy of antihistaminic therapies in a stable isotope context. -
Stable Isotope
Ebastine-d5 is a deuterium-labeled derivative of Ebastine, a second-generation histamine H1 receptor antagonist. It is utilized in research to study the pharmacokinetics and metabolic pathways of Ebastine, particularly in the context of allergic rhinitis and chronic idiopathic urticaria. This stable isotope provides a valuable tool for investigating the dynamics of histamine receptor interactions and drug efficacy in various biological systems. -
Stable Isotope
(E/Z)-Chlorprothixene-d6 hydrochloride is a deuterium-labeled derivative of (E/Z)-Chlorprothixene hydrochloride, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic research, allowing for enhanced tracking and quantification in various biological systems. Its unique isotopic signature facilitates the investigation of drug metabolism and distribution in vivo, making it valuable for both preclinical and clinical studies. -
Stable Isotope
Zotepine-d6 is a deuterium-labeled derivative of Zotepine, a potent antipsychotic agent that acts as an antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. This stable isotope is valuable for pharmacokinetic studies and metabolic research, aiding in the elucidation of the drug's mechanisms of action and its effects on neurotransmitter systems. Zotepine-d6 is useful in exploring the compound's antidepressive and anxiolytic properties in various experimental setups. -
Stable Isotope
Lodoxamide-15N2,d2 is a stable isotope-labeled derivative of Lodoxamide, featuring deuterium and nitrogen-15 isotopes. This antiallergic compound functions primarily as a mast-cell stabilizer and is utilized in research pertaining to asthma and allergic conjunctivitis. The isotopic labeling enhances its utility in pharmacokinetic studies and metabolic research, allowing for precise tracking and analysis of its biological pathways and interactions. -
Stable Isotope
Ranitidine-d6 is a deuterium-labeled form of Ranitidine, a selective and orally active antagonist of the histamine H2-receptor, primarily involved in the inhibition of gastric acid secretion. This compound effectively antagonizes histamine-induced cardiovascular responses in isolated guinea pig atria and modulates uterine activity in rat models, showcasing pA2 values of 7.2 and 6.95, respectively. Additionally, Ranitidine has demonstrated potential in inhibiting breast tumor progression in murine studies, making it valuable for pharmacological research and cancer biology applications. -
Stable Isotope
Chlorpheniramine-d4 maleate is a deuterium-labeled derivative of Chlorpheniramine, functioning as a stable isotope. This compound is used in pharmacokinetic studies and drug metabolism research to trace metabolic pathways and quantify drug levels in biological samples. Its utility in analytical chemistry makes it an essential tool for the development and validation of therapeutic compounds. -
Stable Isotope
Famotidine-13C,d3 is a stable isotope-labeled derivative of Famotidine, a competitive antagonist of the histamine H2-receptor. This compound primarily functions to inhibit gastric acid secretion, making it valuable for gastrointestinal research. It is widely used in studies focused on histamine receptor activity, pharmacokinetics, and metabolic pathways. -
Stable Isotope
Fenspiride-d5 hydrochloride is a deuterium-labeled derivative of Fenspiride hydrochloride, functioning as an α-adrenergic and H1 histamine receptor antagonist. This stable isotope is instrumental in pharmacokinetic studies and metabolic research, allowing for the tracking of drug metabolism and distribution in biological systems. Its unique labeling enhances the understanding of receptor interactions and pharmacological profiles in various experimental settings. -
Stable Isotope
Ketotifen-d3 is a deuterium-labeled analog of Ketotifen, a noncompetitive antagonist of the histamine 1 (H1) receptor and a mast cell stabilizer. This compound exhibits biochemical activity that includes the inhibition of 6-phosphogluconate dehydrogenase (PGD) in vitro, as well as antiviral effects against SARS-CoV-2 and Influenza virus. Ketotifen-d3 is utilized in research applications pertaining to autoimmune encephalomyelitis (EAE) and the prevention of asthma attacks. -
Stable Isotope
Bilastine-d4 is a deuterium-labeled derivative of Bilastine, recognized as a potent oral histamine H1-receptor antagonist. This stable isotope is valuable for pharmacokinetic studies and metabolic research involving allergic rhinitis and urticaria. Additionally, Bilastine has demonstrated efficacy in improving diabetic nephropathy in murine models, while ensuring safety for central nervous system functions. -
Stable Isotope
Chlorpheniramine-d6 is a deuterium-labeled form of Chlorpheniramine, an H1 antihistamine. This stable isotope is extensively utilized in pharmacokinetic studies and metabolic research related to allergic diseases. Chlorpheniramine-d6 can aid in elucidating the pharmacodynamics and pharmacokinetics of antihistaminic therapies in various experimental settings. -
Stable Isotope
Ranitidine-d6 hydrochloride is a deuterium-labeled variant of the histamine H2-receptor antagonist, Ranitidine hydrochloride. This compound selectively inhibits gastric acid secretion by blocking H2 receptors, demonstrating notable effectiveness in antagonizing histamine-induced effects in various tissues. Ranitidine-d6 hydrochloride is utilized in pharmacokinetic studies and metabolic research, offering insights into drug disposition and mechanisms of action in biological systems. Its application extends to investigations of gastric physiology and related therapeutic areas. -
Stable Isotope
Famotidine-d4 is a deuterium-labeled derivative of Famotidine, which functions as a competitive antagonist of histamine H2-receptors. Its primary biological activity involves the inhibition of gastric acid secretion, making it a valuable tool in gastrointestinal research. Famotidine-d4 is particularly useful for studies involving pharmacokinetics and metabolism, enabling precise tracking of Famotidine's behavior in biological systems. -
Stable Isotope
Loratadine-d4-1 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral H1-histamine receptors. With an IC50 value exceeding 32 μM, Loratadine exhibits significant biological activity, including anti-dengue virus (DENV) effects and the inhibition of immunologic release of inflammatory mediators. This stable isotope reagent is valuable for mechanistic studies, pharmacokinetic evaluations, and research applications in allergy and inflammatory response investigations. -
Stable Isotope
Cyclizine-d3 is a deuterium-labeled derivative of Cyclizine, a piperazine-based compound that functions as a selective antagonist of the histamine H1 receptor. This stable isotope is valuable for pharmacokinetic studies and metabolic research, particularly in investigating the effects of Cyclizine on nausea, vomiting, and dizziness. Its unique isotopic signature allows for precise tracking in biological systems. -
Stable Isotope
Bilastine-d6 is a deuterium-labeled form of Bilastine, a selective antagonist of the histamine H1 receptor. This reagent is primarily utilized in pharmacokinetic studies and metabolic research to trace the behavior of Bilastine in biological systems. Its isotopic labeling aids in enhancing the accuracy of quantification and understanding of drug metabolism and distribution in various experimental conditions. -
Stable Isotope
Cinitapride-d5 is a deuterium-labeled derivative of Cinitapride, primarily utilized as a stable isotope standard in analytical chemistry. Its distinctive isotopic labeling allows for enhanced sensitivity and accuracy in mass spectrometry applications, facilitating the study of metabolic processes and pharmacokinetics. This reagent is essential for researchers aiming to investigate the pharmacological profiles and interactions of Cinitapride in biological systems. -
Stable Isotope
Pitolisant-d6 is a deuterium-labeled derivative of Pitolisant, which acts as a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). This stable isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research, allowing for in-depth analysis of drug metabolism and interaction with the H3 receptor. It is an essential tool for researchers investigating sleep disorders and cognitive function modulation. -
Stable Isotope
Olopatadine-d3 hydrochloride is a stable isotope derivative of Olopatadine hydrochloride, a potent histamine H1 receptor antagonist. It exhibits significant activity in inhibiting allergic responses, particularly in the treatment of allergic conjunctivitis. This deuterated form is utilized in various research applications, including pharmacokinetic studies and metabolic fate investigations of Olopatadine in biological systems. -
Stable Isotope
Mianserin-d3 hydrochloride is a deuterium-labeled derivative of Mianserin, primarily acting as an H1 receptor antagonist. This compound demonstrates key biological activities by activating κ-opioid receptors and octopamine receptors and is involved in enhancing ERK1/2 and CREB phosphorylation. Mianserin has significant implications in research applications related to neurological disorders, including depression and epilepsy, as well as in studies assessing its effects on social behavior and electroconvulsive thresholds. -
Stable Isotope
Asenapine-d3,13C is a stable isotope-labeled form of Asenapine, an atypical antipsychotic that acts as an antagonist at various serotonin, adrenoceptor, dopamine, and histamine receptors. This compound is valuable for studies investigating the pharmacokinetics and metabolism of Asenapine, particularly in the context of schizophrenia and bipolar disorder research. Its unique isotopic labeling allows for precise tracking and analysis in biochemical assays and in vivo studies. -
Stable Isotope
Crizotinib-d5 is a deuterium-labeled form of Crizotinib, a selective and potent inhibitor of the anaplastic lymphoma kinase (ALK) and c-Met targets. With IC50 values of 20 nM and 8 nM, respectively, Crizotinib-d5 effectively inhibits tyrosine phosphorylation of both NPM-ALK and c-Met in cellular assays, demonstrating anticancer activity. This compound is utilized in research applications to study its role in tumor growth inhibition and the mechanistic pathways involved in ALK- and c-Met-mediated signaling. -
Stable Isotope
Decanoic acid-13C is a stable isotope of Decanoic acid, a medium-chain fatty acid derived from coconut oil. It acts as a non-competitive inhibitor of AMPA receptors, demonstrating antiseizure activity in preclinical models. Additionally, Decanoic acid has been shown to reduce tyrosinase activity and inhibit melanosome maturation. It suppresses c-Met phosphorylation and induces apoptosis in hepatocellular carcinoma cells by inhibiting oncogenic protein expression, making it a valuable reagent for studies in mTORC1 signaling, epilepsy, and cancer research. -
Stable Isotope
Crizotinib-d8 is a deuterated analog of Crizotinib, functioning as an ATP-competitive inhibitor of ALK and c-Met. This compound exhibits potent biological activity, with IC50 values of 20 nM and 8 nM, respectively, and effectively inhibits tyrosine phosphorylation of NPM-ALK and c-Met in cellular assays. Additionally, Crizotinib-d8 serves as an inhibitor of ROS1. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research involving Crizotinib to enhance understanding of its therapeutic mechanisms. -
Stable Isotope
Acalabrutinib-d4 is a deuterated derivative of Acalabrutinib, an orally active and irreversible second-generation Bruton Tyrosine Kinase (BTK) inhibitor. This stable isotope labeled compound serves as a valuable tool for studying BTK inhibition in biological systems. Additionally, Acalabrutinib-d4 features an alkyne group, facilitating its use as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its applications extend to exploring therapeutic potential and pharmacokinetic properties in research settings.
