Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Ornidazole-d5 is a deuterium-labeled derivative of Ornidazole, a nitroimidazole compound. This reagent exhibits anti-trichomonad properties and demonstrates in vitro activity against various anaerobic bacteria. Additionally, Ornidazole inhibits the Sonic hedgehog (Shh) signaling pathway and displays antitumor effects, making it a valuable tool for research in cancer biology and conditions such as Crohn's disease. -
Stable Isotope
Succinic anhydride-13C2 is a stable isotope-labeled form of succinic anhydride. This cyclic anhydride serves as a versatile linker for antibody-drug conjugates (ADCs), facilitating the attachment of proagents to amine or hydroxy groups on targeting polypeptides. Its application in labeling and tracing metabolic pathways makes it suitable for biochemical research, particularly in studying drug delivery systems and protein interactions. -
Stable Isotope
Succinic anhydride-d4 is a deuterium-labeled variant of succinic anhydride, a cyclic anhydride frequently utilized in chemical synthesis. This stable isotope serves as a valuable tool in the development of antibody-drug conjugates (ADCs), as it facilitates the conjugation of proagents to amine or hydroxy groups within targeting polypeptides. Its unique isotopic properties allow for enhanced tracking and characterization in various biological studies and applications. -
Stable Isotope
N-butyryl-L-Homoserine lactone-d5 is a deuterium-labeled version of N-butyrate-L-homoserine lactone, serving as a stable isotope for research applications. This compound is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). N-butyryl-L-homoserine lactone exhibits antibacterial properties and interferes with quorum sensing, thereby inhibiting biofilm formation in Pseudomonas aeruginosa. Its ability to block bacterial communication makes it a valuable tool in studies focusing on bacterial pathogenesis and biofilm-related infections. -
Stable Isotope
Nateglinide-d5 is a deuterium-labeled derivative of Nateglinide, an insulinotropic agent that functions as a DPP IV inhibitor. This compound enhances insulin secretion by inhibiting ATP-sensitive K+ channels in pancreatic β-cells, making it an important tool for studying type 2 diabetes mellitus. Nateglinide-d5 is valuable in metabolic research and can aid in pharmacokinetic studies involving deuterated compounds. -
Stable Isotope
Trelagliptin-13C,d3 is a stable isotope-labeled derivative of Trelagliptin, a highly selective DPP-4 inhibitor with an IC50 value of 4 nM. This compound is utilized in research applications aimed at understanding the pharmacokinetics and pharmacodynamics of glycemic control in type 2 diabetes mellitus (T2DM). Its deuterated form allows for precise tracking in metabolic studies, facilitating deeper insights into the therapeutic effects of DPP-4 inhibition. -
Stable Isotope
5-Hydroxy saxagliptin-13C,d2-2 hydrochloride is a stable isotope-labeled form of 5-Hydroxy saxagliptin hydrochloride, a potent and selective DPP-4 inhibitor. This active metabolite of Saxagliptin demonstrates Ki values of 2.6 nM in human enzymes and 2.9 nM in cynomolgus monkeys, highlighting its efficacy in inhibiting DPP-4 activity. It is valuable for research applications focusing on type 2 diabetes mellitus, enabling detailed metabolic studies and pharmacokinetic assessments. -
Stable Isotope
(rel)-Saxagliptin-13C,d2 TFA is a stable isotope-labeled analogue of Saxagliptin, designed for use in metabolic studies and pharmacokinetic research. This compound serves as a valuable tool for tracing metabolic pathways and understanding the pharmacological behavior of Saxagliptin in biological systems. It facilitates the investigation of its biological effects and interactions, contributing to a more comprehensive understanding of diabetes treatment efficacy. -
Stable Isotope
Vardenafil-d4 is a deuterium-labeled variant of Vardenafil, designed for metabolic and pharmacokinetic studies. This stable isotope can be utilized as an internal standard in mass spectrometry analysis, providing accuracy in quantifying Vardenafil and its metabolites in biological samples. Its application supports research in cardiovascular pharmacology, specifically in the assessment of phosphodiesterase type 5 inhibitors. -
Stable Isotope
Cis-Tadalafil-d3 is a stable isotope-labeled form of cis-Tadalafil, designed for enhanced analytical applications. This compound retains the biological activity of its non-labeled counterpart, facilitating studies related to pharmacokinetics, metabolism, and drug interaction. By utilizing cis-Tadalafil-d3, researchers can achieve improved sensitivity and specificity in mass spectrometry and other analytical techniques. -
Stable Isotope
Doxofylline-d4 is a deuterium-labeled derivative of Doxofylline, which functions primarily as an antagonist of the adenosine A1 receptor while also inhibiting phosphodiesterase IV. This reagent is valuable for studying pharmacokinetics and metabolic pathways in research involving adenosine receptor modulation and phosphodiesterase activity. Its stable isotope labeling allows for enhanced detection and quantification in various analytical applications. -
Stable Isotope
Ibudilast-d3 is a deuterated form of Ibudilast, a cyclic AMP phosphodiesterase (PDE) inhibitor. This stable isotope contributes to research on asthma by inhibiting tracheal smooth muscle contractility and exhibiting platelet anti-aggregatory effects. Additionally, Ibudilast-d3 shows potential as a neuroprotective agent, with applications in studies related to neurotoxicity in activated microglia and anti-dementia research. -
Stable Isotope
Propentofylline-d6 is a deuterium-labeled derivative of Propentofylline, which primarily acts as an adenosine uptake inhibitor and a phosphodiesterase activity blocker. This compound exhibits neuroprotective, antiproliferative, and anti-inflammatory properties, making it valuable in research related to cognitive enhancement and the treatment of dementia, including Alzheimer's and vascular dementia. Propentofylline-d6 is a stable isotope that facilitates in vivo studies and tracer applications in metabolic and pharmacokinetic research. -
Stable Isotope
Homo Sildenafil-d5 is a deuterium-labeled analog of Homo Sildenafil, targeting phosphodiesterase enzymes. This stable isotope variant retains the biochemical properties of its parent compound, making it useful in pharmacokinetic studies and metabolic research. Its application extends to elucidating the pharmacodynamics of phosphodiesterase inhibitors and tracking drug metabolism in vivo. -
Stable Isotope
Avanafil-d4 is a deuterium-labeled analog of Avanafil, serving as a stable isotope for biomedical research. This compound can be utilized in pharmacokinetic studies, enabling precise tracking and quantification in various biological systems. Its isotopic labeling enhances the accuracy of mass spectrometry analyses and facilitates investigations into the pharmacodynamics of Avanafil and its metabolites. -
Stable Isotope
Lisinopril-d5 is the deuterated form of Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research to track drug metabolism and interactions in various biological systems. Lisinopril is clinically used to manage hypertension, congestive heart failure, and to prevent further heart attack complications. -
Stable Isotope
Ramiprilat-d5 is a deuterium-labeled form of Ramiprilat, the active metabolite of Ramipril, which functions as a potent angiotensin-converting enzyme (ACE) inhibitor, exhibiting a Ki value of 7 pM. This stable isotope is useful for pharmacokinetic and metabolic studies of Ramiprilat and its mechanisms of action in regulating blood pressure and heart failure. Its unique labeling allows for enhanced tracking and differentiation in complex biological systems, facilitating research in cardiovascular pharmacology. -
Stable Isotope
Benazeprilat-d5 is a deuterated analog of Benazeprilat, serving as a stable isotope for various biochemical studies. This compound is primarily used in pharmacokinetic and metabolic research, allowing for precise tracking of drug absorption, distribution, metabolism, and excretion in biological systems. It facilitates the assessment of pharmacological interactions and the evaluation of therapeutic effects in associated studies. -
Stable Isotope
Ramiprilat-d3 (Mixture of Diastereomers) is a deuterium-labeled form of Ramiprilat, designed as a stable isotope. It functions primarily to trace metabolic pathways and pharmacokinetics in biological systems. This reagent is particularly useful in the study of angiotensin-converting enzyme (ACE) inhibition and its implications in cardiovascular research. -
Stable Isotope
Quinapril-d5 is a deuterium-labeled derivative of Quinapril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is utilized in pharmacokinetic studies and metabolic profiling to trace drug metabolism and dynamics in biological systems. Its incorporation into research facilitates accurate quantification and analysis of Quinapril's pharmacological effects and distribution in vivo. -
Stable Isotope
Perindoprilat-d4 is a deuterium-labeled form of Perindoprilat, a potent inhibitor of angiotensin-converting enzyme (ACE). This stable isotope enables precise pharmacokinetic studies and metabolic profiling of Perindoprilat and its derivatives. Perindoprilat-d4 is utilized in research involving cardiovascular pharmacology, hypertension, and drug metabolism to enhance analytical accuracy in tracer studies. -
Stable Isotope
Delapril-d3 hydrochloride is a deuterium-labeled derivative of Delapril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is used in metabolic studies and pharmacokinetic research to trace drug distribution and metabolism within biological systems. Its application facilitates a deeper understanding of ACE inhibition and its effects on cardiovascular health. -
Stable Isotope
Captopril-d3 is a deuterium-labeled derivative of Captopril, a well-characterized competitive angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM. This stable isotope is utilized in the study of hypertension and congestive heart failure. Additionally, Captopril has been identified as an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), exhibiting an IC50 of 7.9 μM, making it valuable in antibiotic resistance research. -
Isotope-Labeled Compounds
Guanosine-13C10,15N5 is an isotope-labeled compound featuring carbon-13 and nitrogen-15 isotopes within its structure. This purine nucleoside, consisting of guanine linked to a ribofuranose ring via a β-N9-glycosidic bond, serves as a valuable tool for metabolic studies. Guanosine is known for its antiviral properties, particularly against herpes simplex virus (HSV), and is useful in research applications involving nucleic acid synthesis and signal transduction pathways. -
Stable Isotope
Adipic acid-d4 is a deuterium-labeled derivative of adipic acid (hexanedioic acid) primarily used as a stable isotope in research applications. This compound exhibits low toxicity and is valued for its role as a food additive and gelling agent. Additionally, adipic acid is involved in the synthesis of various industrial materials, including lubricants, artificial resins, and plastics, making it relevant for studies in both biochemical and materials science fields. -
Stable Isotope
Adipic acid-13C6 is a stable isotope-labeled form of hexanedioic acid. This compound serves as a valuable tool in metabolic studies and tracer experiments due to its stable carbon isotope labeling. Adipic acid is recognized for its minimal toxicity and offers broad applications, including as a food additive and gelling agent, as well as in the synthesis of lubricants and plastics. Its unique isotopic properties make it suitable for applications in both biochemical and environmental research. -
Stable Isotope
Adipic acid-d8 is a deuterium-labeled variant of adipic acid (hexanedioic acid), serving as a stable isotope for research applications. This compound exhibits anti-HSV-1 activity and possesses low toxicity, making it suitable for various biological studies. Adipic acid-d8 can be utilized in the synthesis of lubricants, artificial resins, and plastics, as well as in food additive applications, thereby supporting investigations in both chemical and pharmaceutical research. -
Stable Isotope
Adipic acid-13C is a stable isotope-labeled form of adipic acid (hexanedioic acid) that serves as a valuable tracer in metabolic studies. This compound exhibits anti-HSV-1 activity and is recognized for its low toxicity, making it suitable for various applications, including food additives and gelling agents. Additionally, adipic acid-13C is utilized in the synthesis of lubricants, artificial resins, and plastics, facilitating research in biochemistry and materials science. -
Stable Isotope
Adipic acid-d10 is a stable isotope-labeled derivative of adipic acid (hexanedioic acid), serving as a valuable tool in chemical research. This compound maintains its anti-HSV-1 activity and low toxicity profile, making it suitable for various biological studies. Additionally, adipic acid-d10 can be utilized in synthetic applications for lubricants, artificial resins, and plastics, facilitating research in polymer chemistry and materials science. -
Stable Isotope
Levamisole-d5 hydrochloride is a deuterium-labeled analog of Levamisole hydrochloride, a synthetic imidazothiazole derivative. This compound acts as an anthelmintic and immunomodulator, exhibiting significant biological activity against various targets. Research applications include the study of its immunomodulatory effects and antiviral properties, particularly against herpes simplex virus (HSV). -
Stable Isotope
Penciclovir-d4 is a deuterium-labeled derivative of Penciclovir, primarily targeting the herpes simplex virus (HSV). This stable isotope enables precise tracking and analysis in various biological studies. Penciclovir has demonstrated significant antiviral activity against HSV types 1 and 2, with reported IC50 values ranging from 0.04 to 1.8 μg/mL and 0.06 to 4.4 μg/mL, respectively. It is suitable for research applications focused on viral pathogenesis and therapeutic development. -
Stable Isotope
3-Indoleacetonitrile-d4 is a deuterated derivative of 3-Indoleacetonitrile, functioning as a stable isotope. This compound exhibits significant antiviral activity, particularly against a range of influenza A viruses, HSV-1, and VSV in vitro. Notably, it reduces lung virus titers and mitigates lung lesions in vivo, while also promoting an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile-d4 serves as a valuable tool in research aimed at understanding and combating viral infections, including COVID-19, HSV-1, and VSV. -
Stable Isotope
Famciclovir-d4 is a deuterated form of the antiviral agent Famciclovir, which acts as a guanine analogue. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research involving Famciclovir. Its unique labeling allows for enhanced tracking and analysis of drug metabolism and distribution in biological systems, contributing to a deeper understanding of herpesvirus infections and their treatment. -
Stable Isotope
Trifluridine-13C,15N2 is a stable isotope-labeled form of Trifluridine, which functions as an irreversible inhibitor of thymidylate synthase, leading to inhibition of DNA synthesis. This compound exhibits antiviral activity against herpes simplex virus (HSV) infections and possesses anti-orthopoxvirus properties. Trifluridine-13C,15N2 is utilized in research applications involving metabolic studies and the tracking of nucleic acid synthesis in cellular processes. -
Stable Isotope
Adipic acid-13C2 is a stable isotope-labeled derivative of adipic acid (hexanedioic acid), incorporating two carbon-13 atoms. This compound is utilized primarily in metabolic studies and tracer experiments due to its stable isotope labeling, allowing for improved analysis in biological systems. Adipic acid exhibits low toxicity and demonstrates potential applications as a food additive and gelling agent, while also serving as a precursor in the synthesis of lubricants, artificial resins, and plastics. -
Stable Isotope
Adipic acid-d44-1 is a deuterium-labeled derivative of adipic acid, primarily serving as a stable isotope reagent. This compound enables precise tracking and quantification in metabolic studies and chemical syntheses. Adipic acid exhibits low toxicity and is commonly utilized as a food additive, gelling agent, and in the production of lubricants, artificial resins, and plastics. Its stable isotope form facilitates advanced analytical techniques in various research applications. -
Stable Isotope
N6-Methyladenosine-d3 is a deuterated stable isotope of N6-Methyladenosine, a key internal modification in messenger RNA (mRNA) across higher eukaryotes. This modification plays a significant role in various biological processes, including gene expression regulation and RNA stability. N6-Methyladenosine-d3 can also interact with viral RNAs, demonstrating potential antiviral activities. Its applications include studies in RNA biology and epitranscriptomics, enabling researchers to explore the dynamics and functions of RNA modifications in cellular processes. -
Stable Isotope
DL-Pyroglutamic acid-d5 is a deuterium-labeled form of DL-Pyroglutamic acid, serving as a stable isotope. It is used in various analytical techniques, including nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, to trace metabolic pathways and study amino acid metabolism. This reagent is valuable for researchers investigating biochemical processes involving pyroglutamic acid and its derivatives. -
Stable Isotope
Coumarin-d4 is a deuterium-labeled analog of Coumarin, a compound recognized for its diverse biological activities. This stable isotope is utilized in pharmacological research to trace metabolic pathways and enhance analytical sensitivity. Coumarin exhibits significant anticancer, anti-inflammatory, and antiviral properties, making this labeled variant particularly valuable for studies involving its mechanism of action and therapeutic potential. -
Stable Isotope
Oseltamivir acid-d3 is a deuterium-labeled derivative of Oseltamivir acid, which serves as the active metabolite of Oseltamivir phosphate. This compound acts as a highly selective inhibitor of influenza virus neuraminidase, exhibiting an IC50 of 2 nM against both influenza A and B viruses. While its ability to cross the blood-brain barrier is limited under normal physiological conditions, penetration is notably increased during inflammatory states, making it a valuable reagent for studying antiviral mechanisms and neuroinflammation in research applications. -
Stable Isotope
Palmitoylethanolamide-d4 is a deuterated analog of Palmitoylethanolamide, a naturally occurring fatty acid amide. This stable isotope is utilized in research to study the pharmacokinetics and biological effects of Palmitoylethanolamide. Key applications include investigations into its role in modulating inflammation and its potential therapeutic effects in respiratory viral infections. -
Stable Isotope
Oseltamivir-d5 is a deuterated derivative of Oseltamivir, a neuraminidase inhibitor that targets the influenza virus. It exhibits potent antiviral activity against various strains of influenza, including A/H3N2, A/H1N2, A/H1N1, and B, with mean IC50 values of 0.67, 0.9, 1.34, and 13 nM, respectively. This stable isotope-labeled compound is valuable for pharmacokinetic studies and research applications focusing on influenza virus dynamics and drug metabolism. -
Stable Isotope
Palmitoylethanolamide-d5 is a deuterated stable isotope of Palmitoylethanolamide, an endogenous compound known for its role in modulating inflammation and pain. Its biological activity includes potential antiviral effects, particularly in preventing respiratory tract infections. This compound is valuable for research applications involving metabolic studies and the investigation of lipid signaling pathways. -
Stable Isotope
L-Norleucine-d9 is the deuterium-labeled variant of L-Norleucine, a non-proteinogenic amino acid that specifically impacts protein synthesis in skeletal muscle. This stable isotope is valuable for studying metabolic pathways and post-translational modifications in protein research. Additionally, L-Norleucine exhibits antiviral activity, making it applicable in virology studies and therapeutic research. -
Stable Isotope
Baloxavir-d1 is a deuterium-labeled derivative of Baloxavir, a first-in-class, potent, and selective cap-dependent endonuclease inhibitor targeting the polymerase PA subunit of influenza A and B viruses. This reagent functions to inhibit viral RNA transcription and replication, demonstrating significant antiviral activity. Baloxavir-d1 is valuable in biological research, particularly in studies focused on influenza virus mechanisms and the development of antiviral therapies. -
Stable Isotope
N-Acetylneuraminic acid-13C-1 is a stable isotope-labeled form of N-Acetylneuraminic acid, which serves as a key sialic acid component in glycoproteins and glycolipids. This compound is instrumental in metabolic studies and tracing pathways in carbohydrate metabolism. It is widely used in research to explore cell signaling, immune response, and interactions involving sialic acids in various biological contexts. -
Stable Isotope
N-Acetylneuraminic acid-13C-2 is a stable isotope-labeled form of N-Acetylneuraminic acid, designated for use in metabolic and biochemical research. This compound serves as a valuable tracer in studies of sialic acid metabolism and its role in cellular processes. Its incorporation into biomolecules allows for advanced imaging and analysis, contributing to a deeper understanding of glycan dynamics in various biological systems. -
Stable Isotope
N-Acetylneuraminic acid-13C is a stable isotope-labeled form of N-Acetylneuraminic acid, which serves as a crucial component of glycoproteins and glycolipids. This compound is primarily utilized in metabolic studies and tracing experiments to investigate sialic acid's role in cellular interactions and signaling. The incorporation of the 13C label allows for precise tracking of this biomolecule in various biological systems, facilitating further research in cell biology, immunology, and microbiology. -
Stable Isotope
Oseltamivir-13C,d3 phosphate is a stable isotope-labeled form of Oseltamivir phosphate, a potent neuraminidase inhibitor. It effectively targets the influenza virus, making it useful for both treatment and prophylaxis of influenza A and B. This compound is valuable for research applications requiring isotopic labeling in pharmacokinetics and metabolic studies. -
Stable Isotope
N-Desethyl amodiaquine-d5 is a deuterium-labeled analog of N-Desethyl amodiaquine, the principal active metabolite of Amodiaquine. This compound exhibits significant antiparasitic activity, with IC50 values of 97 nM against V1/S strains and 25 nM against 3D7 strains. It is utilized in studies focused on the pharmacokinetics and dynamics of antimalarial therapies, making it an essential tool for researchers in malaria treatment and related fields.
