Fig. 1 · Structure
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Apatinib-d8 free base
Stable Isotope
Apatinib-d8 free base is a deuterium-labeled form of Apatinib, a potent orally bioavailable tyrosine kinase inhibitor that primarily targets VEGFR-2 with an IC50 of 1 nM. This compound exhibits significant anti-angiogenic activity and is integral to research focused on advanced or metastatic gastric cancer. Additionally, Apatinib-d8 inhibits Ret, c-Kit, and c-Src with IC50 values of 13 nM, 429 nM, and 530 nM, respectively, and effectively obstructs the phosphorylation of VEGFR-2, c-Kit, and PDGFRβ, making it a valuable tool for cancer biology studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2468771-43-7 |
| Applications | Stable Isotope |
| Formula | C24H15D8N5O |
| Molecular Weight | 405.52 |
| Synonyms | YN968D1-d8 free base |
| SMILES | O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H])C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.