Catalog No.
Product Name
Application
Product Information
Citations
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HIV/EV-A71 Inhibitor
AL-470 is a potent antiviral compound targeting HIV-1, HIV-2, and EV-A71, exhibiting EC50 values of 0.27 µM, 0.63 µM, and 0.35 µM, respectively. This compound demonstrates significant inhibition of viral replication and is suitable for studies focused on HIV and enterovirus A71 infections. AL-470 serves as a valuable tool for researchers investigating antiviral mechanisms and therapeutic strategies against these viral pathogens. -
Antiviral Agent
γ-Carboline is a bioactive compound primarily functioning as an antiviral agent. It exhibits significant antiviral activity against Bovine Viral Diarrhea Virus (BVDV) with an EC50 of 2.0 μM. Additionally, derivatives of γ-Carboline have demonstrated antibacterial, antifungal, and antitumor properties, making it a valuable tool for various research applications in virology and broader therapeutic studies. -
NS2B-NS3 Protease Inhibitor
NS2B/NS3-IN-3 is a potent inhibitor of the Flavivirus NS2B-NS3 protease, which plays a critical role in viral polyprotein processing. This compound demonstrates significant antiviral activity, making it a valuable tool for research investigating Flavivirus infections and potential therapeutic strategies. Applications include studies on protease inhibition mechanisms and the development of antiviral drugs targeting flavivirus-related diseases. -
Psoralen Derivative, Viral Inactivator
Aminomethyltrioxsalen hydrochloride is a psoralen derivative that acts as a viral inactivator through nucleic acid intercalation. It effectively penetrates intact cells, allowing it to react with nucleic acid secondary structures in vivo while preserving the integrity of natural nucleoprotein tissues. Upon exposure to UV-A radiation, it crosslinks pyrimidine residues in viral nucleic acids, leading to inactivation of viruses. This reagent is valuable for research applications related to viral infections, including studies on dengue virus. -
Flavivirus NS2B-NS3 Inhibitor
NS2B/NS3-IN-3 hydrochloride is a potent inhibitor of the Flavivirus NS2B-NS3 protease, crucial for the viral replication cycle. This compound selectively disrupts the protease activity, demonstrating significant antiviral efficacy. It serves as a valuable tool for research applications focused on understanding Flavivirus pathogenesis and developing new antiviral therapies. -
DENV Inhibitor
(-)-JNJ-A07 is a potent and selective inhibitor of Dengue Virus (DENV) with an EC50 value of 31 nM. It demonstrates significant antiviral activity, making it a valuable tool for research in virology and the study of DENV pathogenesis. This compound is suitable for investigations into potential therapeutic strategies for dengue fever and other flavivirus-related diseases. -
Yellow Fever Virus Inhibitor
RCB16007 is a selective inhibitor of the Yellow Fever Virus (YFV). It demonstrates effective antiviral activity against the West Nile virus, with an EC50 value of 7.9 μM and a CC50 of 17 μM. This compound serves as a valuable tool for studies related to flavivirus infections and can aid in the development of therapeutics targeting RNA viruses. -
δ-Opioid Receptor Antagonist/DENV Inhibitor
SDM25N hydrochloride is a potent δ-opioid receptor antagonist that also serves as an effective inhibitor of the dengue virus (DENV). It specifically targets the viral NS4B protein, significantly limiting genomic RNA replication. This compound presents valuable opportunities for research on antiviral strategies and the role of δ-opioid receptors in viral pathogenesis. -
NS5 RdRp/NS2B-NS3pro Inhibitor
LabMol-301 is a potent inhibitor of both NS5 RNA-dependent RNA polymerase (RdRp) and NS2B-NS3 protease, with IC50 values of 0.8 μM and 7.4 μM, respectively. This reagent demonstrates cytoprotective properties by effectively preventing cell death induced by the Zika virus (ZIKV). LabMol-301 is valuable for research applications focusing on antiviral drug development and the mechanistic study of flavivirus pathogenesis. -
Anti-virus Agent
XA-E is a purified compound derived from a methanol-ethyl acetate extract of A. keiskei, targeting viral replication. This compound exhibits potent anti-Zika virus activity, with an IC50 value of 22.0 µM. XA-E is suitable for research applications focusing on antiviral drug development and the mechanistic study of flavivirus infections. -
STT3A-mediated Mega Protein Complex Assembly Inhibitor
NSC-323241 is an STT3A-mediated mega protein complex assembly inhibitor that effectively disrupts the endoplasmic reticulum (ER) mega complex essential for dengue virus (DENV) and Zika virus (ZIKV) infection. By targeting the interaction between the STT3A subcomplex, viral nonstructural proteins (e.g., NS2B, NS3), and host translocon proteins, NSC-323241 impedes the establishment of the viral replication microenvironment. This compound is valuable for investigating the mechanisms of flavivirus infections, including dengue fever and Zika virus. -
Flavivirus inhibitor
Flaviviruses-IN-1 is a potent inhibitor of various viruses within the Flaviviridae family, acting primarily by modulating the host cell immune response to viral infection. This compound has demonstrated significant efficacy in preventing viral replication and infection, making it a valuable tool in virology research. Flaviviruses-IN-1 was identified through high-throughput screening as a promising candidate for therapeutic development against flavivirus infections, offering new avenues for intervention in related diseases. -
Flaviviru Inhibitor
TYT-1 is a sulfonamide-thiourea compound that targets flavivirus replication. It demonstrates potent inhibitory activity against West Nile virus, with a 50% effective concentration of 0.7 µM, effectively blocking a post-entry, pre-assembly step in the viral life cycle. This compound is valuable for research applications focused on understanding flavivirus pathogenesis and developing antiviral strategies. -
Rna Virus Inhibitor
Galidesivir dihydrochloride is a broad-spectrum RNA virus inhibitor targeting various RNA viruses, including Ebola and yellow fever viruses. This compound exhibits potent antiviral activity against tick-borne encephalitis virus (TBEV) and inhibits the proliferation of several other medically significant flaviviruses. Its efficacy makes Galidesivir a valuable tool for research applications focused on viral pathogenesis and antiviral drug development. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-1 is a non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating an IC50 of 1.8 μM. This compound also effectively inhibits the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 is capable of inhibiting ZIKV replication and reducing virus-induced cytopathic effects, making it a valuable tool for research focused on ZIKV infection and associated viral pathogenesis. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-2 is an orally active, non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating IC50 values of 0.04 μM for the wild-type and 3.1 μM for the I156T mutant strains. This compound exhibits broad-spectrum activity against flaviviruses, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus serotype 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-2 effectively inhibits ZIKV replication and mitigates virus-induced cytopathic effects, making it a valuable tool for research on ZIKV infection and the study of flavivirus-related diseases. -
HIV/HBV Inhibitor
Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of Emtricitabine triphosphate, a phosphorylated metabolite of Emtricitabine. This compound functions as a nucleoside reverse transcriptase inhibitor, effectively targeting both HIV and HBV. Emtricitabine triphosphate tetrasodium salt is utilized in research applications focused on antiviral drug development and the mechanisms of viral replication. -
HIV Inhibitor
(S)-Tenofovir is an S-enantiomer of Tenofovir, functioning primarily as a nucleotide reverse transcriptase inhibitor. This compound demonstrates significant biological activity against HIV and is also relevant in the treatment of chronic Hepatitis B (HBV). It is commonly utilized in research applications focused on antiviral therapies and the mechanistic study of retroviral infections. -
Antiviral Agent
Helioxanthin is an antiviral agent with demonstrated in vitro activity, exhibiting an effective concentration (EC50) of 1 μM against hepatitis B virus (HBV). Additionally, Helioxanthin shows efficacy against flaviviruses, making it a valuable compound in antiviral research. It is suitable for studies focusing on the development of treatments for viral infections. -
HIV/HBV Inhibitor
L-Fd4A is an adenine derivative that inhibits both human immunodeficiency virus (HIV) and hepatitis B virus (HBV) with effective concentrations (EC50) of 1.5 μM and 1.7 μM, respectively. This compound demonstrates promising antiviral activity while exhibiting low cytotoxicity, making it suitable for research applications in studying HIV and HBV inhibition mechanisms. -
anti-HBV/HIV-1 Agent
Periglaucine A is a hasubanane-type alkaloid that targets anti-HBV and anti-HIV-1 activity. It effectively inhibits the secretion of HBV surface antigen (HBsAg) in Hep G2.2.15 cells, demonstrating its potential as a therapeutic agent against hepatitis B virus. Additionally, Periglaucine A exhibits anti-HIV-1 efficacy in C8166 cells, with an EC50 value of 204 μM, making it a valuable compound for research in viral infections. -
Fungicide
Bromuconazole is a triazole fungicide that targets fungal cells and demonstrates effective crop protection. In addition to its primary function, it exhibits cytotoxic properties against various cancer cell lines by inducing G0/G1 cell cycle arrest, inhibiting DNA synthesis, and triggering apoptosis through the activation of caspase-3. Bromuconazole also enhances reactive oxygen species production, influences mitochondrial function, and disrupts MAPK signaling pathways, thereby impairing the stress response in human trophoblast and endometrial cells. This reagent is suitable for research applications in glioma, colon cancer, reproductive health, and cardiac dysfunction studies. -
Antiplasmodial Agent
19,20-Epoxycytochalasin C is a cytochalasin derivative derived from the fungal species Nemania sp. This compound demonstrates significant in vitro antiplasmodial activity, making it a valuable tool for malaria research. Additionally, it exhibits phytotoxic properties, further expanding its potential applications in studying plant interactions and responses. -
Antiparasitic Agent
Sporogen AO-1 is a fungal metabolite derived from Aspergillus oryzae, functioning as an antiparasitic agent. It exhibits potent antimalarial activity, specifically targeting Plasmodium falciparum, with an IC50 value of 1.53 μM. Additionally, Sporogen AO-1 demonstrates certain levels of cytotoxicity, making it a valuable compound for research in parasitic diseases and potential therapeutic applications. -
Nematode Growth Inhibitor
5-(4-Methoxyphenyl)oxazole is a nematode growth inhibitor that targets Caenorhabditis elegans, effectively interfering with hatching and growth processes. This compound, derived from fungal culture broth, exhibits potential in studying nematode biology and assessing the efficacy of nematicidal agents. Its application in research provides valuable insights into nematode management and development. -
Antimalarial Agent
Asperaculane B is a fungal metabolite that targets Plasmodium falciparum, exhibiting a significant antimalarial activity with an IC50 of 7.89 µM. This compound effectively inhibits the development of asexual stages of P. falciparum, showing an IC50 of 3 µM, while demonstrating low cytotoxicity to human cells. Asperaculane B serves as a valuable resource for research into malaria therapies and the mechanisms of Plasmodium transmission. -
FREP1 Inhibitor
P-orlandin is a specific inhibitor of FREP1, a protein that mediates the binding of Plasmodium gametocytes and ookinetes. This fungal metabolite demonstrates potent activity in blocking Plasmodium falciparum infections in mosquito vectors, making it a valuable tool for research in malaria transmission and vector control studies. Its unique mode of action offers insights into potential strategies for disrupting the lifecycle of malaria parasites. -
Antimalarial Drug
Chevalone C is a meroterpenoid fungal metabolite that exhibits potent antimalarial activity, demonstrating an IC50 value of 25.00 μg/mL. In addition to its antimalarial properties, Chevalone C displays anti-proliferative effects against various cancer cell lines, including colon HCT116, liver HepG2, and melanoma A375. This compound is useful for research applications in the study of malaria and cancer therapeutics. -
Non-Antibacterial Macrolide Agent
Glasmacinal is a non-antibacterial macrolide agent that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity, making it a valuable tool for researchers studying inflammation-related processes. This compound can be utilized in various biological research applications, including the exploration of immune response modulation and the development of novel therapeutic strategies. -
Antifolate Agent, Antibacterial Agent
11-Oxahomoaminopterin is an antifolate agent that inhibits dihydrofolate reductase, targeting bacterial and tumor cell proliferation. This compound exhibits significant antibacterial activity against Lactobacillus casei, demonstrating potential applications in antimicrobial and antitumor research. Its ability to interfere with folate metabolism makes it a valuable tool for studying various biological systems. -
Antibacterial Agent
Antibacterial Agent 330 is an antibacterial compound that operates by inducing reactive oxygen species (ROS) accumulation and forming supramolecular complexes through DNA intercalation, which inhibits DNA replication. This agent disrupts bacterial metabolism by inhibiting lactate dehydrogenase (LDH) and promotes cell lysis, resulting in the leakage of intracellular contents and bacterial cell death. Antibacterial Agent 330 demonstrates significant antibacterial activity and enhances wound healing in both Galleria mellonella larval and murine models, making it a valuable tool for researching bacterial infections. -
Antifungal Agent
Fluoxastrobin is an antifungal agent that targets NAD-dependent epimerase/dehydratase, inhibiting electron transport and reducing ATP production, which effectively controls foliar diseases in tea plants. This compound induces oxidative stress by elevating reactive oxygen species (ROS) levels and lipid peroxidation, leading to DNA damage and apoptosis. Additionally, Fluoxastrobin exhibits high acute toxicity to Danio rerio embryos and larvae, making it a valuable tool in research related to tea foliar diseases, including tea red leaf spot and tea gray leaf spot. -
Macropinocytosis inhibitor
Virapinib is a potent macropinocytosis inhibitor that demonstrates significant antiviral activity. It effectively inhibits viral entry of a broad range of viruses, including SARS-CoV-2, monkeypox virus, tick-borne encephalitis virus, and Ebola pseudotyped vesicular stomatitis virus, while also enhancing Dengue Virus infection. By obstructing macropinocytosis, Virapinib reduces syncytium formation in SARS-CoV-2-infected cells and hinders the cellular entry of SARS-CoV-2 variants. This compound is valuable for research focused on viral pathogenesis and therapeutic evaluations related to COVID-19 and other viral infections. -
SAR Inducer
3-Acetonyl-3-hydroxyoxindole functions as a potent systemic acquired resistance (SAR) inducer in plants. This compound has demonstrated the ability to enhance resistance in tobacco plants against the tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole also elevates levels of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation, and phenylalanine ammonia-lyase activity, making it a valuable tool for studying plant immune responses. -
TMV Inhibitor
TMV-IN-12 is a potent inhibitor of tobacco mosaic virus (TMV), targeting the aggregation and self-assembly of TMV capsid protein (TMV-CP) with a dissociation constant (Kd) of 0.142 μM. This compound effectively disrupts TMV particle formation, thereby preventing the infection of tobacco plants. Additionally, TMV-IN-12 exhibits antifungal properties, making it a valuable reagent for studying viral and fungal interactions in plant biology and for developing strategies to combat TMV-related diseases. -
Flaviviruse Inhibitor
Flaviviruses-IN-3 is a potent inhibitor specifically targeting flaviviruses. This compound demonstrates significant activity by reducing West Nile virus (WNV) protease activity, achieving an impressive inhibition rate of 54%. Flaviviruses-IN-3 is applicable for research into therapeutic strategies against flavivirus-related diseases and contributes to the understanding of viral protease functions. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-5 is an allosteric inhibitor targeting the NS2B/NS3 protease of Dengue Virus Serotype 2 (DENV2) and Zika Virus (ZIKV). It demonstrates effective inhibitory activity with IC50 values of 0.67 µM against ZIKV and 4.38 µM against DENV2 NS2B/NS3 proteases. This compound presents significant potential for research applications in virology, specifically in the development of antiviral therapies targeting these flavivirus proteases. -
MTase Inhibitor
NSC 288387 is a pan-flavivirus methyltransferase (MTase) inhibitor that targets the S-adenosylmethionine (SAM) binding pocket. It demonstrates significant antiviral activity, inhibiting Zika virus (ZIKV) replication with an IC50 of 0.2 μM. This compound is useful in research applications focused on flavivirus infections and the mechanisms of viral replication. -
Flaviviruses Inhibitor
Flaviviruses-IN-2 is a potent inhibitor targeting flavivirus proteases, particularly effective against the West Nile virus (WNV). This compound significantly reduces WNV protease activity, achieving an inhibition level of 56%. Flaviviruses-IN-2 is primarily utilized in research applications focused on understanding flaviviral pathogenesis and developing antiviral therapeutics. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-4 is an allosteric inhibitor targeting the NS2B/NS3 protease of dengue virus serotype 2 (DENV2) and Zika virus (ZIKV). It demonstrates IC50 values of 0.69 µM for DENV2 and 1.04 µM for ZIKV proteases, highlighting its potent enzymatic inhibition. This compound serves as a valuable tool in antiviral research, particularly for elucidating mechanisms of viral replication and developing therapeutic strategies against flavivirus infections. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-6 is an allosteric inhibitor targeting the NS2B/NS3 protease of Dengue virus (DENV) and Zika virus (ZIKV). It exhibits IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively. This compound is valuable for research applications focused on developing antiviral therapies and understanding the enzymatic mechanisms of flavivirus proteases. -
HIV-1 Protease Inhibitor
(Rac)-PD 135390 is a potent HIV-1 protease inhibitor, exhibiting an IC50 of 2 nM. This dipeptide is instrumental in antiviral research, providing insights into HIV-1 protease activity and potential therapeutic interventions. Its efficacy in inhibiting viral replication makes it a valuable tool for studying HIV pathogenesis and drug resistance. -
DENV2 Inhibitor
YKL-04-085 is a potent inhibitor of dengue virus serotype 2 (DENV2) translation, demonstrating an IC90 of 0.555 μM. This compound specifically targets viral translation mechanisms, making it a valuable tool for research on DENV2 pathogenesis and antiviral drug development. Additionally, YKL-04-085 shows no kinase activity, allowing for more targeted investigations into its antiviral efficacy. -
IRF3 Activator
KIN1400 is a potent IRF3 activator that stimulates the expression of IRF3-dependent antiviral genes, including RIG-I, MDA5, IFIT1, and Mx1, as well as IFN-β production. This compound effectively inhibits the replication of West Nile Virus (WNV) and Dengue Virus (DV), both of which are mosquito-borne flaviviruses, as well as Hepatitis C Virus (HCV). KIN1400 activates innate antiviral immunity via the MAVS-IRF3 signaling pathway, making it a valuable tool for research focused on antiviral responses and immune modulation. -
HCV/HIV Inhibitor
C5A is a microbicidal peptide that targets and inhibits both hepatitis C virus (HCV) and human immunodeficiency virus (HIV). By disrupting the membrane integrity of the HIV virion and affecting the conical capsid core that encases the viral genome, C5A significantly reduces the infectivity of a wide range of HIV isolates in various primary target cells in vitro. Additionally, studies have demonstrated that C5A offers protective effects in mice against vaginal and rectal challenges with HIV, highlighting its potential utility in antiviral research applications. -
COVID-19 Inhibitor
RBT-9 is a COVID-19 inhibitor that targets viral replication and inflammation pathways. It has demonstrated efficacy in preventing the progression to severe COVID-19 and associated organ failure. Furthermore, RBT-9 exhibits antiviral activity against various enveloped viruses, including influenza, hepatitis C virus (HCV), dengue, and yellow fever, making it a valuable tool for research in viral pathogenesis and therapeutic intervention. -
Antibacterial Agent
HSGN-218 is an antibacterial agent that demonstrates potent efficacy against various strains of Clostridium difficile, exhibiting minimum inhibitory concentration (MIC) values between 0.007 μM and 0.07 μM. Despite its low permeability across Caco-2 cells, HSGN-218 is a valuable tool for investigating bacterial growth inhibition and exploring therapeutic options for C. difficile infections in research applications. -
Bacterial Inhibitor
Pyrroxamycin is a novel antibiotic with a primary mechanism targeting Gram-positive bacteria and dermatophytes. Derived from the fermentation of Streptomyces, it exhibits potent antibacterial activity. This compound has potential applications in pharmaceutical research for the development of new antimicrobials, particularly against resistant bacterial strains. Detailed analysis of its chemical structure was performed using X-ray crystallography and 13C NMR spectroscopy, elucidating its physicochemical properties and enhancing its utility in microbiological studies. -
Antibacterial Agent
Antibacterial Agent 39 is a potent antibacterial compound that demonstrates synergistic effects by significantly lowering the minimum inhibitory concentration (MIC) of Ceftazidime. This compound exhibits strong antibacterial activity against various Gram-negative bacteria, making it a valuable tool for research focused on combating antibiotic resistance and enhancing the efficacy of existing antibiotics. Its application in microbiological studies can provide insights into the mechanisms of action and interactions between different antibacterial agents. -
Quorum Sensing Inhibitor
Aculene D is a quorum sensing inhibitor derived from fungal metabolites that targets the signaling mechanisms in bacteria. It effectively reduces violacein production in Chromobacterium violaceum CV026 cultures induced by N-hexanoyl-L-homoserine lactone (C6-HSL) at sub-inhibitory concentrations. This compound is valuable for research exploring bacterial communication and the modulation of biofilm formation, with potential applications in combating antibiotic resistance and developing new antimicrobial strategies.
