Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
LL-BM123α is a bacterial inhibitor derived from Nocardia sp., with a primary mechanism of action targeting Gram-negative bacteria. This compound demonstrates moderate antimicrobial activity, making it a valuable tool in research focused on bacterial infections and antibiotic resistance. LL-BM123α can be utilized in studies aimed at understanding the efficacy of novel antibiotics and developing strategies for overcoming bacterial resistance. -
Antibiotic
Actagardin is a tetracyclic lantibiotic that effectively targets Gram-positive bacteria by inhibiting peptidoglycan synthesis. This compound is characterized by its unique macrocyclic structure, formed through thioether bridges. Actagardin is utilized in research for its antibiotic properties, providing insights into bacterial resistance mechanisms and potential therapeutic applications. -
Cephalosporin Antibiotic
Cephradine sodium is a broad-spectrum cephalosporin antibiotic that demonstrates efficacy against both gram-positive and gram-negative bacteria, including penicillinase-producing strains. Its primary mechanism involves disrupting bacterial cell wall synthesis, leading to cell lysis and death. This reagent is utilized extensively in research focusing on genitourinary, gastrointestinal, and respiratory tract infections, as well as infections of the skin and soft tissues. Additionally, Cephradine sodium has been shown to inhibit TOPK, providing a potential therapeutic avenue for managing solar-ultraviolet induced skin inflammation. -
Antibiotic
PTZ601 is an antibiotic that targets gram-positive bacteria, effectively inhibiting strains such as Vancomycin-resistant Enterococcus faecium (VREF) and Methicillin-resistant Staphylococcus aureus (MRSA). This compound demonstrates significant antimicrobial activity in infected mouse models, making it a valuable tool for research in bacterial resistance and therapeutic development. Its application in preclinical studies may provide insights into potential treatments for resistant bacterial infections. -
Tetracycline Antibiotic
Demeclocycline calcium is a tetracycline antibiotic that primarily inhibits protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl tRNA. This compound exhibits a broad spectrum of antibacterial activity, making it useful in the treatment of various bacterial infections. Demeclocycline calcium is frequently utilized in research applications to study bacterial resistance and protein synthesis mechanisms. -
Antibiotic
Teicoplanin A2-3 is an antibiotic that primarily targets Gram-positive bacteria, including both aerobic and anaerobic strains. It exhibits potent antibacterial activity by inhibiting cell wall synthesis, making it effective in treating various infections caused by susceptible microorganisms. This reagent is valuable for research applications focused on antibiotic resistance, microbial pathogenesis, and the development of novel antibacterial therapies. -
Antibiotic
Malioxamycin is an antibiotic that targets Gram-negative bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls. This mechanism disrupts bacterial cell wall integrity, leading to the formation of spheroplasts and subsequently causing cell lysis. Malioxamycin is applicable in research related to antibiotic resistance and bacterial cell wall biology. -
Antibiotic
Desotamide is a cyclic hexapeptide antibiotic that targets bacterial cell membrane integrity. It demonstrates potent activity against Staphylococcus aureus, Streptococcus pneumoniae, and methicillin-resistant Staphylococcus epidermidis (MRSE), with minimum inhibitory concentrations of 16, 12.5, and 32 μg/mL, respectively. This compound is useful for research applications related to antibiotic activity and resistance mechanisms in pathogenic bacteria. -
Antibiotic
Teicoplanin A3-1 is a glycopeptide antibiotic that targets Gram-positive bacteria. It is a degradation product of teicoplanins A2-1 to 5, showcasing broad-spectrum antibacterial activity. This compound is pivotal in research applications involving the effectiveness of glycopeptide antibiotics against resistant bacterial strains. -
Antibacterial, Biofilm Formation Inhibitor
Majoranaquinone is a potent antibacterial agent that targets various bacterial strains, demonstrating significant inhibitory effects against four Staphylococcus species, one Moraxella species, and one Enterococcus species. Additionally, it exhibits substantial efflux pump inhibitory activity in Escherichia coli ATCC 25922. Majoranaquinone also effectively inhibits biofilm formation in both E. coli ATCC 25922 and E. coli K-12 AG100, making it a valuable reagent for research applications focused on combating bacterial infections and biofilm-related challenges. -
Antibiotic
Antibacterial agent 159 is a broad-spectrum antibiotic that targets bacterial infections. It exhibits efficacy against impetigo and Clostridium difficile infections (CDI), demonstrating complete absence of recurrence for CDI while preserving the integrity of beneficial gut microbiota. This compound is valuable for research applications focusing on antibiotic resistance and the management of C. difficile-associated diseases. -
Antibiotic Peptide
BMAP-28 is an antibiotic peptide that acts as an inducer of the mitochondrial permeability transition pore. It triggers cell death by promoting the opening of this pore, making it a valuable tool for studying microbial infections and cancer mechanisms. Researchers can utilize BMAP-28 to explore its potential therapeutic applications and the underlying processes involved in cell apoptosis. -
Antibacterial Metabolite
Monomethylsulochrin is a potent antibacterial metabolite derived from the endophytic fungus Aspergillus fumigatus, isolated from the leaves of Albizia lucidior. This compound demonstrates significant antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 31.25 μg/mL. Monomethylsulochrin serves as a valuable tool for research applications focused on exploring novel antimicrobial agents and mechanisms of bacterial resistance. -
Bacterial Inhibitor
Lauryl-LF 11 is an N-terminally acylated analogue of LF11 that acts as a bacterial inhibitor. This peptide demonstrates significant antibacterial activity, making it a valuable tool for research in microbiology and infectious diseases. It can be utilized in studies focused on the mechanisms of bacterial resistance and the development of novel antimicrobial agents. -
Antibacterial Agent
FK-041 is an orally active cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to exert its antibacterial effects. It demonstrates broad-spectrum activity against a variety of pathogens, including both Gram-positive and Gram-negative bacteria as well as anaerobes. Additionally, FK-041 shows efficacy against certain drug-resistant strains, such as penicillin-resistant Streptococcus pneumoniae. This reagent is valuable for research focused on infectious diseases and the development of new antibacterial therapies. -
Bacterial Inhibitor
Citreamicin alpha is a potent bacterial inhibitor demonstrated to exhibit significant antimicrobial activity against a range of Gram-positive cocci. In vitro studies reveal that MIC values for Staphylococci range from 0.12-4.0 μg/ml, and for Streptococcus pyogenes, they range from 0.03-0.12 μg/ml. While Citreamicin alpha shows superior efficacy compared to ampicillin, amoxicillin, and ceftriaxone, it exhibits comparable effects to vancomycin. Its effectiveness against various strains makes it a valuable reagent for research in antibiotic development and resistance studies. -
Antibiotic
CK0683A is a novel biaminourea antibiotic that targets bacterial plaque formation. Demonstrating significant antiplaque effects, this compound has shown efficacy in experimental mouse models of dental disease. In a 12-week study, CK0683A was evaluated in beagles for its potential to reduce plaque and gingivitis while assessing safety and staining potential. The canine model is relevant, as the onset and progression of periodontal disease in dogs parallels that in humans, making CK0683A a promising candidate for further research in periodontal treatment. -
Antibiotic
Aztreonam (lysine) is a monocyclic beta-lactam antibiotic that specifically targets penicillin-binding protein 3 (PBP-3). It exhibits potent activity against Gram-negative aerobic bacteria, making it an important reagent for studies involving bacterial resistance and the development of antimicrobial therapies. This compound is particularly relevant in research focused on combating infections caused by resistant strains and understanding the mechanisms of beta-lactam antibiotics. -
Antibiotic/Antimicrobial Peptide
Aurein 2.4 is an antibiotic antimicrobial peptide that primarily targets Gram-positive bacteria. It exhibits potent antibacterial activity, making it a valuable reagent for research focused on antimicrobial resistance and the development of novel antibacterial therapies. Its unique mechanism of disrupting bacterial membranes positions Aurein 2.4 as a relevant tool in studies investigating the efficacy of peptide-based antibiotics. -
Antibiotic
Cefmenoxime is a semisynthetic cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. This compound is primarily applied in microbiological research and antibiotic susceptibility studies. -
Antibiotic
N-Formylfortimicin A is an aminoglycoside antibiotic that targets bacterial ribosomes to inhibit protein synthesis. It demonstrates broad-spectrum antibacterial activity, effectively inhibiting both Gram-positive and Gram-negative bacteria, such as Escherichia coli with a minimum inhibitory concentration (MIC) of 12.5-50 μg/mL. This compound is a promising candidate for research focused on bacterial infections and related diseases. -
Antibiotic
Arbekacin is an aminoglycoside antibiotic that targets bacterial protein synthesis, inhibiting the growth of both Gram-positive and Gram-negative bacteria. It demonstrates broad-spectrum antimicrobial activity, making it a valuable tool in the study of bacterial infections and resistance mechanisms. Arbekacin is utilized in research applications aimed at understanding antibiotic efficacy and developing new therapeutic strategies. -
Recombinant Bacterial Clones Chromogenic Substrate
X-GalNAc is a chromogenic substrate that specifically targets N-acetyl-β-galactosidase. This reagent is utilized in molecular biology to detect the presence of cloned DNA inserts in bacterial colonies cultured on agar plates. The enzymatic hydrolysis of X-GalNAc results in a distinct color change, facilitating easy identification of recombinant bacterial clones in various genetic research applications. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
Antibacterial Agent
ANS ammonium is a potent antibacterial agent that also serves as a textile dye. It functions as a fluorescence probe, enabling the detection of various biological interactions. Additionally, ANS ammonium is known to inhibit the binding of triiodothyronine to thyroxine binding globulin, making it useful in radioimmunoassays for triiodothyronine analysis. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Antibiotic Agent
Polyketomycin is a tetracyclic quinone glycoside antibiotic derived from Streptomyces sp. or Streptomyces diastatochromogenes, targeting Gram-positive bacteria with a minimal inhibitory concentration (MIC) of less than 0.2 µg/mL. This compound exhibits notable antibacterial, anticancer, and antimalarial activities, making it a valuable tool in microbiological and pharmacological research. Its diverse biological applications support investigations in antibiotic efficacy, cancer treatment, and antimalarial drug development. -
Antitumor Antibiotic
Sandramycin is a cyclic depsipeptide antibiotic with a primary mechanism of action as an antitumor agent. It exhibits potent DNA intercalation and binding, functioning effectively as a cytotoxin in antibody-drug conjugates (ADCs). Sandramycin demonstrates significant activity against Gram-positive bacteria and is recognized for its strong antitumor efficacy, making it a valuable reagent for cancer research and the development of targeted therapies. -
Dengue Protease Inhibitor
Carbonic anhydrase inhibitor 16 is a potent dengue protease inhibitor that targets human carbonic anhydrases I and II, exhibiting inhibitory constants (Ki) of 28.5 nM and 2.2 nM, respectively. This compound demonstrates significant biological activity in hindering dengue virus replication by disrupting protease function. It may be utilized in research applications aimed at elucidating mechanisms of dengue virus pathogenesis and developing antiviral therapeutics. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
Nucleoside Antibiotic
Dealanylascamycin is a nucleoside antibiotic that functions as a carbonic anhydrase (CA) inhibitor, exhibiting Ki values of 167, 65.2, 234, and 143 nM for human CA isoforms I, II, IV, and IX, respectively. This compound demonstrates broad-spectrum antibacterial activity, notably effective against pathogens such as Xanthomonas citri with a minimum inhibitory concentration (MIC) of 0.4 μg/mL. Additionally, Dealanylascamycin displays significant cytotoxicity, making it a substance of interest for various biological research applications, particularly in the study of antimicrobial effects and CA inhibition. -
HIV Inhibitor
ZL0580 is an HIV inhibitor that functions by selectively binding to the BD1 domain of BRD4, leading to epigenetic suppression of the virus. This compound effectively inhibits Tat transactivation and transcription elongation while promoting a repressive chromatin structure at the HIV promoter. ZL0580 is valuable for research applications focused on HIV therapies and the mechanisms of viral transcription regulation. -
HIV-1 LRA
UMB-136 is a bromodomain inhibitor targeting HIV-1 latency. It serves as a promising latency-reversing agent (LRA) for the eradication of HIV-1, effectively reactivating the virus in various cell models. UMB-136 enhances HIV-1 transcription and promotes viral production by facilitating the release of P-TEFb, thereby contributing to research in HIV treatment strategies. -
FgGpmk1 Inhibitor
FgGpmk1-IN-1 is a selective inhibitor of the Fusarium graminearum mitogen-activated protein kinase (FgGpmk1), exhibiting an EC50 value of 3.46 μg/mL. This compound is valuable for investigating the biological role of FgGpmk1 in fungal pathogenesis and offers potential applications in the study of plant-fungal interactions. Researchers can utilize FgGpmk1-IN-1 to explore therapeutic strategies against Fusarium-related diseases. -
Heterocyclic Compound
Indazole, a heterocyclic aromatic compound, exhibits significant biological activity through its diverse derivatives. These derivatives are known for their anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal, and antitumor properties. Indazole and its derivatives are valuable tools for research into cancer, neurological disorders, cardiovascular diseases, and gastrointestinal diseases, highlighting their potential in various therapeutic applications. -
Antibiotic
Luisol A is an anthraquinone antibiotic analog derived from an aromatic tetraol, recognized as a major metabolite of Streptomyces, a marine actinomycete. This compound exhibits significant antibacterial activity, making it a valuable tool in the study of antibiotic mechanisms and resistance. Its application in research aids in the exploration of novel antimicrobial agents and their effects on various bacterial strains. -
Bacterial Inhibitor
Aniline-MPB-amino-C3-PBD is a cytotoxic agent targeting bacterial cells through minor-groove binding of DNA. This sequence-selective compound serves as an effective payload for antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy. Its antimicrobial properties make it a valuable tool for research in bacterial inhibition and related applications. -
Antibiotic
Agrochelin is an alkaloid antibiotic with cytotoxic properties, derived from the fermentation of marine Agrobacterium species. This compound exhibits significant cytotoxic activity against various tumor cell lines, making it a valuable tool in cancer research. Agrochelin's mechanism of action may provide insights into antibiotic efficacy and the development of novel therapeutic strategies for oncological applications. -
Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Phytoestrogen
3,7-Dihydroxyflavone is a flavonoid phytoestrogen that modulates estrogen receptors, making it a valuable compound for research in hormonal signaling pathways. It serves as an inhibitor of the human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase, demonstrating redox inhibitory activity with IC50 values of 0.6 μM and 6.0 μM, respectively. Additionally, 3,7-Dihydroxyflavone exhibits fluorescence properties, acting as a binding substrate for human serum albumin with specific excitation and emission wavelengths, rendering it useful for biochemical assays and studies related to protein binding interactions. -
Bacterial Metabolite
12-Tridecenoic acid is a bacterial metabolite that plays a crucial role in the regulation of lipid metabolism. It promotes the expression of acetyl-CoA carboxylase α (ACC) while inhibiting carnitine palmitoyltransferase 1A (CPT1A), contributing to the development of hepatic steatosis. This compound is relevant for research in metabolic diseases and cellular lipid regulation. -
Antibacterial Agent
Metioprim is a competitive inhibitor of bacterial dihydrofolate reductase (DHFR), targeting critical pathways in bacterial folate metabolism. It exhibits potent antibacterial activity against anaerobic bacteria and demonstrates synergistic effects when combined with DDS against E. coli and various mycobacterial strains. This reagent is valuable for antibacterial research and development, particularly in studies focused on antibiotic resistance and the efficacy of combination therapies. -
Antibacterial Agent
AR-102 is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus. It demonstrates competitive inhibition of the F98Y mutant dihydrofolate reductase (DHFR) with a Ki value of 0.22 nM. Structural studies have characterized AR-102 as forming a ternary complex with NADPH in both wild-type and TMP-resistant F98Y mutant S. aureus DHFR, making it a valuable compound for research on antibacterial resistance mechanisms. -
Antibiotic
Cefempidone is a third-generation cephalosporin antibiotic that targets penicillin-binding proteins, leading to the inhibition of bacterial cell wall synthesis. This mechanism results in effective antibacterial activity against a range of gram-positive and gram-negative bacteria. Cefempidone is primarily utilized in research applications involving the study of bacterial resistance and the development of new therapeutic strategies against bacterial infections. -
Antibiotic
Cefamandole lithium is a second-generation broad-spectrum cephalosporin antibiotic that exerts its antibacterial activity by inhibiting bacterial cell wall synthesis. This compound is effective against a variety of Gram-positive and Gram-negative bacteria. Upon metabolism, cefamandole lithium releases free N-methylthiotetrazole (NMTT), which may result in low prothrombinemia, highlighting its importance in biochemical and pharmacological research applications. -
Antibiotic
Resorcinomycin A is an antibiotic primarily targeting mycobacterial species, demonstrating potent anti-mycobacterial activity. This compound exhibits weaker activity against mycoplasma, making it a valuable reagent for research applications focused on mycobacterial infections and mechanisms of action within this class of pathogens. -
Antitumor Antibiotic
IB-96212 is an antitumor antibiotic derived from the marine bacterium Micromonospora sp. It primarily targets cancer cells, demonstrating potent activity against the P-388 leukemia cell line. Additionally, IB-96212 exhibits antimicrobial properties against Micrococcus luteus, making it a valuable compound for various research applications in cancer and microbiology studies. -
Anti-Candidal Agent
Callophycin A is a natural metabolite derived from red seaweed, demonstrating strong antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 62.5–250 mg/L. This compound effectively diminishes fungal load in models of vaginal candidiasis and is associated with reduced inflammatory responses and modulation of immune molecules. Callophycin A is valuable for research applications focusing on antifungal therapies and the immune responses associated withCandida infections. -
Antibiotic
A-83016F is an antibiotic compound with activity derived from an unidentified actinomycete designated A83016. This compound exhibits weak antimicrobial properties and is primarily used for research applications exploring antibiotic efficacy and microbial resistance mechanisms. Further investigation of A-83016F may provide insights into its potential therapeutic applications and bacteriologic interactions. -
Antibiotic
TS 155-2 is an antibiotic that acts as an analogue of Bafilomycin, functioning primarily through the inhibition of V-ATPase activity. This enzyme is critical for various cellular processes and has been associated with a range of diseases, including osteopetrosis, male infertility, and renal acidosis. TS 155-2 is valuable for research applications focusing on antimicrobial effects and the physiological roles of V-ATPase in disease contexts.
