Catalog No.
Product Name
Application
Product Information
Citations
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Compound Antibiotic
Piperacillin mixture with tazobactam (8:1) is a β-lactam antibiotic and β-lactamase inhibitor combination. This compound exhibits broad-spectrum antibacterial activity against various pathogens, effectively targeting most Gram-positive bacteria as well as Gram-negative aerobic and anaerobic bacteria, including those that produce β-lactamase. It is commonly utilized in research applications for studying bacterial resistance mechanisms and evaluating the efficacy of antibiotic combinations. -
Bacterial Inhibitor
BMS-247243 is a β-lactam antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA). It exhibits significant antibacterial activity, making it a valuable tool for research into bacterial resistance mechanisms and the development of new antimicrobial therapies. BMS-247243 is particularly relevant for studies focused on treating infections caused by resistant bacterial strains. -
Anthracyclic Antibiotic
Aranciamycin A is an anthracyclic antibiotic derived from the Streptomyces genus. It exhibits significant antibacterial activity against Mycobacterium bovis and Bacillus subtilis, with minimum inhibitory concentration (MIC) values of 30 µM and 7.5 µM, respectively. This compound is suitable for research applications involving the assessment of antibiotic efficacy and the exploration of bacterial resistance mechanisms. -
Antibiotic
4"-Isovalerylspiramycin III is an antibiotic that primarily targets bacterial protein synthesis. As the main active component of Shengjimycin, it exhibits potent antibacterial activity, making it a valuable tool in microbiological research. Its efficacy in inhibiting bacterial growth allows for applications in investigating antibiotic resistance mechanisms and developing new therapeutic strategies against bacterial infections. -
Bacterial Inhibitor, Translation Inhibitor
Sancycline hydrochloride is a bacterial inhibitor that functions by reversibly binding to the 30S ribosomal subunit, thereby inhibiting protein translation. It effectively blocks the entry of aminoacyl-tRNA into the ribosomal A site, similar to other tetracycline derivatives. This semi-synthetic tetracycline, characterized by its four linearly fused six-membered rings and four stereocenters, is primarily utilized in research focusing on bacterial protein synthesis and the development of antibacterial agents. -
Antibiotic
Chrysomycin B is an antibiotic derived from a Streptomyces strain, primarily functioning as a topoisomerase II inhibitor. It exhibits significant biological activity by inducing DNA damage in the A549 human lung adenocarcinoma cell line and effectively suppresses tumor growth in murine models. This compound is useful for research applications focused on cancer therapeutics and mechanisms of antibiotic action. -
Antibiotic
A-692345 is a naphthyridone antibiotic that targets bacterial cell processes. It demonstrates significant antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 8 µg/mL. This compound is suitable for use in antimicrobial research and studies aimed at understanding bacterial resistance mechanisms. -
Antibiotic
Manumycin B is an antibiotic that also demonstrates notable antitumor activity. It functions as an inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 15 mM. This compound is valuable for research in cancer biology and neuropharmacology, providing insights into therapeutic strategies for cancer treatment and neurodegenerative disorders. -
InhA Inhibitor/Antibiotic
Pyridomycin is a selective inhibitor of InhA, an essential enzyme in Mycobacterium tuberculosis, providing a targeted approach in combating this pathogen. As an antibiotic derived from the metabolites of Dactylosporangium fulvum, Pyridomycin exhibits low cytotoxicity while effectively impeding the growth of Mycobacterium tuberculosis. Its application is significant in the study and treatment of bacterial infections, particularly tuberculosis, making it a valuable reagent for research in infectious disease mechanisms and antibiotic development. -
Antitumor Antibiotic
Saptomycin D is an antitumor antibiotic that targets various cancer cell lines and exhibits potent cytotoxicity. Isolated from the Streptomyces sp. HP530 strain, Saptomycin D demonstrates robust inhibitory effects against Gram-positive bacteria and limited activity against some Gram-negative bacteria and yeasts. This compound is particularly relevant for research applications in oncology, offering potential insights into tumor suppression mechanisms and treatment development. -
Anti-bacterial Agent
Antibiotic A-33853 is an antibacterial agent derived from a Streptomyces strain. It exhibits potent antimicrobial activity against Staphylococcus aureus and Mycoplasma gallisepticum, with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively. This compound is valuable for research in microbiology and antibiotic susceptibility studies. -
Antibiotic
Nocardicin A is a beta-lactam antibiotic targeting bacterial cell wall synthesis. It exhibits moderate antibacterial activity against a wide range of Gram-negative bacteria, including Proteus and Pseudomonas, while demonstrating no inhibitory effects on Staphylococcus, Mycobacterium, fungi, and yeast. This compound is useful in research applications focused on bacterial resistance and the mechanisms of antibiotic action. -
Antibiotic
PKUMDL-LTQ-301 is a HipA toxin inhibitor that disrupts bacterial persistence by targeting the HipA protein in Escherichia coli. This compound has demonstrated significant reduction in bacterial survival rates in both in vitro and in vivo models, making it a valuable tool for antibiotic research. PKUMDL-LTQ-301's efficacy is supported by specific KD and EC50 values, underscoring its potential in studies focused on overcoming antibiotic resistance and developing novel antibacterial therapies. -
Antibiotic
Pacidamycin I is a nucleoside peptide antibiotic that selectively targets Pseudomonas aeruginosa. It exhibits potent antibacterial activity, making it a valuable tool for research focused on combating antibiotic-resistant infections. Pacidamycin I is particularly useful in studies of microbial physiology and antibiotic development pathways. -
Antibiotic
Lavanducyanin is an antibiotic that targets microbial cell membranes, disrupting their integrity and functionality. This compound demonstrates significant antimicrobial activity, making it a valuable tool in the study of infections. Additionally, its potential as an adjuvant in cancer research presents opportunities for further exploration in therapeutic applications. -
Antibiotic
Celastramycin A is an antibiotic derived from Streptomyces MaB-QuH-8, known for its significant antimicrobial activity against a variety of gram-negative bacteria and mycobacteria, with minimum inhibitory concentrations (MICs) ranging from 0.05 to 3.1 μg/ml. This compound exhibits immunosuppressive effects, evidenced by its ability to modulate immune responses in ex vivo Drosophila and human models, demonstrating an IC50 of 0.008 μg/ml through the immune deficiency pathway and inhibiting TNF-α signaling. Additionally, Celastramycin A effectively reduces IL-8 production in human umbilical vein endothelial cells (HUEVCs), with an IC50 of 0.06 μg/ml, making it a valuable tool for research in microbial resistance and immune modulation. -
Antibiotic
Fumaramidmycin is an antibiotic derived from Streptomyces kurssanovii NR-7GG1, primarily targeting bacterial cell processes. It exhibits significant antimicrobial activity against a broad spectrum of both Gram-positive and Gram-negative bacteria. This compound is valuable for research applications focused on the mechanisms of antibiotic resistance and the development of novel antimicrobial therapies. -
Antibiotic
CK0492B is a novel biaminourea antibiotic that targets bacterial plaque formation. Demonstrating significant antiplaque properties in vitro, it has also shown efficacy in reducing dental disease symptoms in an experimental mouse model. A 12-week study conducted in beagles highlighted its effectiveness in decreasing plaque and gingivitis while assessing its safety profile. The selection of canine subjects is informed by the similarities in periodontal disease onset and progression between dogs and humans, with chlorhexidine acetate serving as a positive control for comparison. -
Antibacterial Agent
GE 2270A is an antibacterial agent that inhibits protein synthesis in gram-positive bacteria and anaerobes. This compound effectively targets bacterial ribosomes, leading to a reduction in bacterial proliferation. GE 2270A is primarily utilized in research exploring bacterial infections and antimicrobial treatments. -
Antitumor Antibiotic
1-Hydroxyauramycin B is an anthracycline antibiotic with a primary mechanism of action as an antitumor agent. It exhibits significant activity against Gram-positive bacteria and demonstrates effectiveness in inhibiting tumor cell proliferation. This compound is utilized in cancer research and investigations aimed at understanding its therapeutic potential in oncological applications. -
Antibiotic
Lavendofuseomycin is a macrolide pentaene antibiotic that exerts its antibacterial activity by inhibiting protein synthesis in susceptible bacteria. This compound is valuable for research applications focused on antibacterial mechanisms and the development of novel antimicrobial agents. Its unique structure and mode of action make it a significant tool for investigating antibiotic resistance and exploring therapeutic options. -
Antibiotic
Paromamine is an antibiotic that targets ribosomal RNA (rRNA) components, inhibiting bacterial protein synthesis. This compound exhibits potent antibacterial activity, making it valuable for research into bacterial resistance mechanisms and antibiotic efficacy. Its role in elucidating the interactions between antibiotics and ribosomes contributes to the development of new therapeutic strategies against infectious diseases. -
β-Lactam Antibiotic
Temocillin is a semisynthetic β-lactam antibiotic that functions primarily through its inhibition of bacterial cell wall synthesis. This 6-alpha-methoxy penicillin derivative exhibits a broad spectrum of activity against most aerobic Gram-negative bacteria. It is particularly valuable in research settings focused on antibiotic resistance, bacterial pathogenesis, and the development of novel therapeutic strategies against Gram-negative infections. -
Bacterial Metabolite
Carbazomycin B is a bacterial metabolite isolated from Streptomyces, exhibiting potent antifungal and antibacterial properties. It primarily functions by inhibiting 5-lipoxygenase (5-LO) activity, demonstrating an IC50 value of 1.5 µM in extracts from RBL-1 cells. This compound is valuable for research in microbiology and pharmacology, particularly in studying inflammatory responses and developing antimicrobial therapies. -
Lincosamide Antibiotic
Pirlimycin is a lincosamide antibiotic that targets Gram-positive bacteria. Its primary mechanism involves the inhibition of bacterial protein synthesis through binding to the 50S ribosomal subunit. This action disrupts the translation process, providing effective antimicrobial activity. Pirlimycin is commonly used in research to explore antibacterial mechanisms and resistance in bacterial infections. -
Antibiotic
Flurithromycin functions as a broad-spectrum antibiotic by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. This compound exhibits significant antimicrobial activity against various gram-positive and some gram-negative bacteria. Flurithromycin is utilized in research applications focused on understanding bacterial infections and developing new therapeutic strategies. -
Fluoroquinolones Antibiotic
Norfloxacin (nicotinate) is a fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV, inhibiting their activity and preventing bacterial cell replication. This compound demonstrates significant antibacterial activity and has been utilized in veterinary medicine, particularly in animal husbandry and aquaculture. At elevated concentrations, norfloxacin nicotinate can also stimulate the innate immune response, making it a valuable tool for exploring immune modulation in research applications. -
Antibiotic
Cycloviracin B2 is an antibiotic with potent antiviral activity, primarily targeting herpes simplex virus type 1 (HSV-1). It exhibits strong inhibitory effects, making it a valuable tool for research into antiviral therapies and the mechanisms of viral infections. This compound is essential for studies focused on HSV-1 and other related viral pathogens. -
Lipophilic Antibiotic
Lysolipin I is a lipophilic antibiotic derived from Streptomyces violaceoniger, targeting bacterial cell membranes. It exhibits effective antibacterial activity against both Gram-positive and Gram-negative bacteria, making it a valuable tool for research in microbiology and antibiotic resistance studies. Its unique mechanism of action and broad-spectrum efficacy position it as a significant compound for exploring new therapeutic strategies against bacterial infections. -
Antibiotic
Loloatin B 10 is an antibiotic with significant antibacterial activity against gram-positive, antibiotic-resistant human pathogens. This compound targets bacterial cell viability and growth, making it a valuable tool for research applications focused on antibiotic resistance and developing new antimicrobial agents. Its efficacy against resistant strains highlights its potential in advancing therapeutic strategies in infectious disease management. -
Antibiotic/Antimicrobial Peptide
Aurein 2.3 is an antibiotic antimicrobial peptide targeting bacterial ATPases, primarily inhibiting E. coli ATPase activity. This compound demonstrates significant antibacterial activity, effectively suppressing cell growth in susceptible bacterial strains. Aurein 2.3 serves as a valuable tool in microbiological studies and the development of new antimicrobial therapies. -
Antibiotic
O-Deacetylravidomycin is an antibiotic derived from Streptomyces, functioning as a microbial metabolite. It demonstrates light-dependent antibacterial and anticancer properties, making it suitable for research applications in microbial resistance and cancer therapy studies. -
Antibiotic
Gramicidin B is a nonribosomal peptide antibiotic that exerts its action by forming ion-permeable channels in bacterial membranes. This mechanism disrupts osmotic balance, leading to cell death. Gramicidin B is widely used in research to study bacterial resistance, membrane dynamics, and the molecular mechanisms of antibiotic action. Its effectiveness against a range of Gram-positive bacteria makes it a valuable tool in microbiological investigations. -
Beta-Lactam Antibiotic
Faropenem is a potent beta-lactam antibiotic with oral bioavailability. It exhibits broad-spectrum antimicrobial activity against a variety of gram-positive and gram-negative bacteria, including both aerobes and anaerobes. Notably, Faropenem is resistant to hydrolysis by most beta-lactamases, including extended-spectrum and AmpC varieties. It has been developed as an oral proagent, faropenem medoxomil, for the investigation of respiratory tract infections and related conditions. -
Antitumor Antibiotic
Respinomycin A2 is an anthracycline antibiotic known for its mechanism as an antitumor agent. It exhibits notable biological activity by inducing differentiation in leukemic K-562 cells, demonstrating potential in leukemia research and treatment. This compound may be utilized in studying the mechanisms of cancer differentiation and developing new therapeutic strategies against leukemia. -
Antibiotic
Althiomycin is a thiazole antibiotic derived from polyketide synthesis, primarily targeting Gram-positive bacteria. It exhibits potent antibacterial activity against strains such as Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes, with minimum inhibitory concentrations (MICs) of 25 μg/mL, 25 μg/mL, and 3.1 μg/mL, respectively. Additionally, Althiomycin inhibits protein synthesis in Escherichia coli at concentrations of 1 and 10 μg/mL, though it does not affect protein synthesis in isolated rabbit reticulocytes at 100 μg/mL. This compound is useful in antibiotic research and studies related to bacterial resistance mechanisms. -
Antitumor Antibiotic
4-Methylaeruginoic acid is an antitumor antibiotic that selectively targets various human tumor cell lines. This compound demonstrates significant cytotoxic activity, making it a valuable agent for cancer research. It is utilized in studies investigating mechanisms of tumor cell inhibition and potential therapeutic applications in oncology. -
Beta-lactamase Antibiotic
Ritipenem acoxil is an oral-active beta-lactamase antibiotic designed to inhibit bacterial cell wall synthesis. It demonstrates significant activity against various bacterial strains, making it a valuable tool in the study of bacterial pneumonia. This compound serves as a critical reagent for researchers investigating antibiotic resistance and the mechanisms of bacterial infections. -
Antibiotic
Chartreusin sodium is an antibiotic targeting specific Gram-positive bacteria and mycobacteria. It exhibits inhibitory activity against pathogens, including Micrococcus flavus and Staphylococcus aureus phage. This compound is valuable for research focused on antibiotic resistance and the mechanisms of bacterial infection. -
Antibiotic
Helvecardin A is a glycopeptide antibiotic that targets and disrupts cell wall synthesis in bacteria. It demonstrates potent activity against both aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). This compound serves as a valuable tool for research focused on antibiotic resistance and the mechanisms underlying Gram-positive bacterial infections. -
Antibiotic
Aurantiogliocladin is a weak antibiotic that primarily targets Staphylococcus epidermidis, exhibiting minimal activity against Staphylococcus aureus. This compound has shown the ability to inhibit biofilm formation, making it a valuable tool for studying bacterial adhesion and resistance mechanisms. Its selective properties may facilitate research into antibiotic efficacy and the development of strategies to combat biofilm-related infections. -
Antibiotic Inhibitor
Levorin A0 is an aromatic polyene antibiotic known for its potent antifungal properties. It primarily acts by disrupting the integrity of fungal cell membranes, leading to cell death. This compound is essential for research focused on antifungal drug development and understanding membrane-targeting mechanisms in fungal pathogens. Its efficacy against a range of fungi makes it a valuable tool in both in vitro and in vivo studies. -
Antibiotic
Clavicoronic acid is an inhibitor of reverse transcriptases from avian myeloblastosis virus and Moloney murine leukemia virus, exhibiting Ki values of 130 µM and 68 µM, respectively. This compound effectively inhibits the replication of vesicular stomatitis virus by disrupting its RNA-directed RNA polymerase activity. Notably, Clavicoronic acid demonstrates no cytotoxic effects, making it a valuable tool for research applications focused on viral replication mechanisms and antiviral drug development. -
Bacterial Inhibitor
Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology. -
Antibiotic Peptide
Aurein 1.1 is an antibiotic peptide derived from the skin of the Australian Bell Frog (Litoria raniformis). It demonstrates potent antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria. This peptide is valuable for research applications in the field of antimicrobial resistance and the development of new therapeutic agents targeting bacterial infections. -
Antitumor Antibiotic
Clecarmycin C is an antitumor antibiotic that exhibits significant cytotoxic properties against various tumor cell lines. Its potent antitumor activity makes it a valuable tool in cancer research. Additionally, Clecarmycin C demonstrates antimicrobial activity, providing further potential for exploration in various biological applications. -
Antibiotic
Prumycin is an antifungal antibiotic that targets Pseudoperonospora cubensis, the causative agent of cucumber powdery mildew. It effectively inhibits spore germination, demonstrating significant activity against the pathogen without triggering plant defense gene expression. This characteristic makes Prumycin a valuable tool for studying antifungal mechanisms and developing crop protection strategies in agricultural research. -
Antibiotic
Milbemycin α10 is a macrolide antibiotic that targets glutamate-gated chloride channels in nematodes and arthropods. It exhibits potent insecticidal activity, effectively controlling a variety of agricultural pests, including larvae and other harmful insects. This compound is valuable for research in agricultural biotechnology and pest management. -
Antibiotic
Saroaspidin A is an antibiotic derived from Hypericum japonicum thunb, targeting bacterial pathogens. This compound exhibits significant antibacterial activity, making it valuable for research focused on combating bacterial infections. Its unique mechanism may provide insight into novel therapeutic strategies in antibiotic development. -
Fluoroquinolone Antibiotic
Binfloxacin is a fluoroquinolone antibiotic that primarily targets bacterial DNA gyrase and topoisomerase IV, thereby inhibiting bacterial DNA replication. It demonstrates effective antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Due to its minimal interference with the metabolism of theophylline, Binfloxacin is considered a safer option for combination therapies in studies involving bacterial infections and other drugs metabolized by CYP450 1A2.
