Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial Agent
3-Hydroxyglabrol is an antibacterial agent derived from Glycyrrhiza glabra L. var. typica. It demonstrates significant inhibitory activity against Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a minimum inhibitory concentration (MIC) of 6.25 mcg/mL. This compound is valuable for research focused on infections caused by these bacterial strains, contributing to the development of potential therapeutic strategies. -
Bacterial Inhibitor
Propioxatin B is a tricyclic sesquiterpenoid compound that acts as a bacterial inhibitor. This compound demonstrates significant anti-tuberculosis activity, exhibiting effectiveness against various drug-resistant Mycobacterium tuberculosis strains. In silico docking studies indicate that Propioxatin B binds with bacterial DNA gyrase, suggesting a targeted mechanism of action and potential safety in in vivo applications. -
Antibacterial Agent
Dunnianol is a natural sesqui-neolignan that acts as an antibacterial agent. It demonstrates moderate antibacterial activity against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA). This compound is valuable for research applications focused on antimicrobial resistance and the development of new antibacterial therapies. -
Antibacterial
Methyl isocostate is a natural compound with demonstrated antibacterial activity, isolated from the plant Globba schomburgkii. This compound is of interest for its potential applications in antimicrobial research and the development of new antibacterial agents. Its unique properties make it a valuable reagent in studies aimed at understanding bacterial resistance and screening for effective antibacterial pharmaceuticals. -
Bacterial Inhibitor
Drimentine A is a terpenylated diketopiperazine that acts as a bacterial inhibitor, originally isolated from Actinomycete bacteria. It exhibits significant antibacterial activity, making it a valuable tool in microbiological studies. This compound is primarily utilized in research involving bacterial pathogenesis and the development of antimicrobial agents. Unlike its analogs Drimentine B and C, Drimentine A does not possess anticancer activity. -
Antibacterial Agent
Dodicin is an antibacterial agent that exhibits broad-spectrum antimicrobial activity. It targets bacterial cell membranes, disrupting their integrity and leading to cell death. This reagent is suitable for use in various research applications, including microbiological studies and disinfectant efficacy evaluations. -
Antibacterial Agent
DC-159a is an 8-methoxyfluoroquinolone that functions as a broad-spectrum antibacterial agent. This compound demonstrates significant antimicrobial activity against various Gram-positive pathogens, including Peptostreptococcus, Clostridium difficile, and Bacteroides fragilis, with minimum inhibitory concentration (MIC90) values of 0.5, 4, and 2 μg/mL, respectively. DC-159a is suitable for research applications focused on antibacterial resistance and infection treatment. -
Antibacterial
NR-NO2 is an innovative antibacterial agent that acts by producing reactive nitrogen species, thereby disrupting bacterial cell function. Its bioactivity involves the inhibition of bacterial growth, making it suitable for research applications in the development of new antibacterial therapies. Additionally, NR-NO2 offers potential in imaging-based guidance due to its unique targeting capabilities, enhancing its use in both antitumor and antibacterial research contexts. -
Antibacterial/anticancer Agent
1-Hydroxy-3,5-dimethoxyxanthone, a xanthone derivative, serves as an effective antibacterial and anticancer agent. Isolated from Lomatogonium rotatum, this compound demonstrates inhibitory effects on the growth of Pseudomonas aeruginosa and Escherichia coli, achieving a minimum inhibitory concentration (MIC) of 640 μg/mL. Additionally, 1-Hydroxy-3,5-dimethoxyxanthone shows significant anticancer activity against various cancer types, including cervical, breast, melanoma, liver, and gastric cancers, making it a valuable tool for biological research and therapeutic development. -
Lipopeptide Antibiotic
Friulimicin D is a lipopeptide antibiotic derived from the actinomycete Actinoplanes friuliensis. It demonstrates significant antibacterial activity against a range of Gram-positive bacteria. Research applications include the study of bacterial resistance mechanisms and the potential development of novel antimicrobial therapies. -
Antibacterial Agent
4-Ethyloctane is a potent antibacterial agent targeting bacterial infections. Demonstrating strong activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 0.04 mg/mL, it serves as a valuable compound for the study of antibacterial properties and mechanisms. Researchers can utilize 4-Ethyloctane in investigations aimed at understanding bacterial resistance and the development of potential therapeutic applications. -
Antibacterial Agent
8-Hydroxy-9,10-diisobutyryloxythymol is a natural monoterpenoid that functions as an antibacterial agent. It demonstrates significant activity against various bacterial strains, including Staphylococcus aureus, Shigella flexneri, and Salmonella paratyphi-B, with minimal inhibitory concentration (MIC) values of 6.25 μg/mL. This compound is valuable for research in antimicrobial efficacy and the development of new antibacterial therapies. -
Antibacterial Agent
Antibacterial Agent 108 is a potent antibacterial compound targeting bacterial pathogens. It exhibits a minimum inhibitory concentration (MIC) of 3 μM against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic-resistant strains. This compound is suitable for research applications in studying bacterial infections and developing new antibacterial therapies. -
Antibacterial Agent
Altromycin A is a natural antibacterial agent classified as a Pluramycin analog. It demonstrates significant activity against a range of bacterial strains, making it a valuable tool for studying bacterial infections and developing new antimicrobial strategies. Its mechanism of action involves interference with protein synthesis, which is critical for bacterial growth and survival. Research applications include antibiotic susceptibility testing and the investigation of resistance mechanisms. -
Antibacterial Agent
YXL-13 is a potent inhibitor of Pseudomonas aeruginosa (PAO1) with an IC50 value of 3.686 μM. This compound effectively targets the quorum sensing (QS) system, leading to inhibition of virulence factors and biofilm formation, thereby reducing both pathogenicity and antibiotic resistance. YXL-13 is suitable for research applications focused on the development of antibacterial strategies against PAO1 infections. -
Antibacterial Agent
11-Keto fusidic acid is an antibacterial agent that demonstrates potent activity against Staphylococcus aureus, exhibiting a minimal inhibitory concentration (MIC) of 0.078 μg/mL. Its effectiveness makes it a valuable compound for research focused on microbial infections and the development of novel antibacterial therapies. This compound can aid in the exploration of resistance mechanisms and therapeutic strategies in bacterial pathogenesis. -
antibacterial
Emeguisin A is a depsidone that exhibits notable antibacterial activity. It has been shown to inhibit cell viability in human colon carcinoma (HCT-116) cells by approximately 87.06%. This compound is valuable for research applications focused on developing antibacterial agents and studying the effects of natural products on cancer cell lines. -
Anti-Bacterial Agent
Saframycin F is an anti-bacterial agent primarily targeting Gram-positive bacteria. It demonstrates potent inhibitory activity against mouse lymphocyte L-1210, with an ID50 of 0.59 μM. This compound is useful in research applications focused on antibacterial activity and immune response modulation. -
Antibacterial Agent
Antibacterial Agent 321 is a lipophilic compound that targets bacterial cell membranes, inducing structural disruption. This agent exhibits phototoxic effects against both Staphylococcus aureus and Escherichia coli, demonstrating significant antibacterial activity. Antibacterial Agent 321 is suitable for research applications focusing on bacterial infection mechanisms and therapeutic interventions. -
Antibacterial Agent
Antibacterial Agent 198 is a potent antibacterial compound targeting gram-positive bacteria, specifically Staphylococcus aureus and various Enterococcus strains. This reagent exhibits significant antibacterial activity, making it a valuable tool for research focused on bacterial resistance and infection control mechanisms. Its application in microbiological studies provides insights into the efficacy of antibacterial agents and contributes to the development of new therapeutic strategies. -
Asperlicin
Asperlicin D is an metabolite derived from the Aspergillus alliaceus strain (ATCC 20656), primarily involved in the regulation of fungal biosynthesis. It exhibits antifungal and antibacterial activities through inhibition of various biological pathways. Due to its potential therapeutic properties, Asperlicin D is of interest in studies related to natural product chemistry and antimicrobial drug development. -
Fungicide
Bromuconazole is a triazole fungicide that targets fungal cells and demonstrates effective crop protection. In addition to its primary function, it exhibits cytotoxic properties against various cancer cell lines by inducing G0/G1 cell cycle arrest, inhibiting DNA synthesis, and triggering apoptosis through the activation of caspase-3. Bromuconazole also enhances reactive oxygen species production, influences mitochondrial function, and disrupts MAPK signaling pathways, thereby impairing the stress response in human trophoblast and endometrial cells. This reagent is suitable for research applications in glioma, colon cancer, reproductive health, and cardiac dysfunction studies. -
Antiplasmodial Agent
19,20-Epoxycytochalasin C is a cytochalasin derivative derived from the fungal species Nemania sp. This compound demonstrates significant in vitro antiplasmodial activity, making it a valuable tool for malaria research. Additionally, it exhibits phytotoxic properties, further expanding its potential applications in studying plant interactions and responses. -
Antiparasitic Agent
Sporogen AO-1 is a fungal metabolite derived from Aspergillus oryzae, functioning as an antiparasitic agent. It exhibits potent antimalarial activity, specifically targeting Plasmodium falciparum, with an IC50 value of 1.53 μM. Additionally, Sporogen AO-1 demonstrates certain levels of cytotoxicity, making it a valuable compound for research in parasitic diseases and potential therapeutic applications. -
Nematode Growth Inhibitor
5-(4-Methoxyphenyl)oxazole is a nematode growth inhibitor that targets Caenorhabditis elegans, effectively interfering with hatching and growth processes. This compound, derived from fungal culture broth, exhibits potential in studying nematode biology and assessing the efficacy of nematicidal agents. Its application in research provides valuable insights into nematode management and development. -
Antimalarial Agent
Asperaculane B is a fungal metabolite that targets Plasmodium falciparum, exhibiting a significant antimalarial activity with an IC50 of 7.89 µM. This compound effectively inhibits the development of asexual stages of P. falciparum, showing an IC50 of 3 µM, while demonstrating low cytotoxicity to human cells. Asperaculane B serves as a valuable resource for research into malaria therapies and the mechanisms of Plasmodium transmission. -
FREP1 Inhibitor
P-orlandin is a specific inhibitor of FREP1, a protein that mediates the binding of Plasmodium gametocytes and ookinetes. This fungal metabolite demonstrates potent activity in blocking Plasmodium falciparum infections in mosquito vectors, making it a valuable tool for research in malaria transmission and vector control studies. Its unique mode of action offers insights into potential strategies for disrupting the lifecycle of malaria parasites. -
Antimalarial Drug
Chevalone C is a meroterpenoid fungal metabolite that exhibits potent antimalarial activity, demonstrating an IC50 value of 25.00 μg/mL. In addition to its antimalarial properties, Chevalone C displays anti-proliferative effects against various cancer cell lines, including colon HCT116, liver HepG2, and melanoma A375. This compound is useful for research applications in the study of malaria and cancer therapeutics. -
Non-Antibacterial Macrolide Agent
Glasmacinal is a non-antibacterial macrolide agent that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity, making it a valuable tool for researchers studying inflammation-related processes. This compound can be utilized in various biological research applications, including the exploration of immune response modulation and the development of novel therapeutic strategies. -
HIV Inhibitor Prodrug
HIV-IN-13 prodrug is designed as a prodrug of an HIV inhibitor, engaging specifically with viral components upon conversion. In the presence of glutathione (GSH), this compound exhibits significant antiviral activity, demonstrating EC50 values of 10 μM and 8.2 μM against HIV-1 at concentrations of 1 mM and 2 mM GSH, respectively. This prodrug serves as a valuable tool for research focused on HIV infection and therapeutic development. -
HIV Substrate
Fluorescent HIV Substrate is specifically designed to facilitate the study of HIV protease activity. This highly sensitive substrate emits fluorescence upon cleavage by the HIV protease, enabling real-time monitoring of enzymatic activity. It serves as an essential tool in HIV research, helping to evaluate protease inhibitors and advance therapeutic strategies against HIV infection. -
HIV-1 Inhibitor
NB-64 is an orally active inhibitor of HIV-1 that targets viral replication. Its significant antiviral activity makes it a valuable tool for research into HIV infections and the development of therapeutic strategies. This compound contributes to a better understanding of HIV pathogenesis and potential treatment options. -
HIV Inhibitor
PNU-142721 is a reverse transcriptase inhibitor that targets HIV by effectively inhibiting various type I variants. This compound serves as a valuable tool in HIV research, particularly in the study of viral replication and resistance mechanisms. Its dual function as a PXR agonist further enhances its relevance in investigating drug metabolism and therapeutic strategies against HIV. -
HIV Integrase Inhibitor
Lepetegravir is a potent HIV integrase inhibitor that exerts its antiviral effects by blocking the integration of viral DNA into the host genome. With an EC50 value of 0.98 nM in MT-4 cells, it demonstrates strong efficacy in suppressing HIV replication. Lepetegravir is applicable in research aimed at understanding HIV pathogenesis and developing antiretroviral therapies. -
Anti-HIV Agent
NYAD-13 is an anti-HIV agent that demonstrates antiviral activity against HIV-1 IIIB. While it shows potential in inhibiting viral replication, it is important to note that it also exhibits significant cytotoxicity. This compound may be useful in research focused on understanding the mechanisms of HIV infection and evaluating antiviral strategies. -
HIV-1 Integrase Inhibitor
Integracin B is a potent inhibitor targeting HIV-1 integrase through a dimeric alkyl aromatic structure. It effectively inhibits both the coupled and strand transfer activities of the integrase, making it a valuable tool for studying HIV-1 replication and integration processes. This compound is suitable for research applications focused on antiviral drug development and the mechanistic understanding of integrase-mediated viral entry. -
Control of Anti-HIV Agent
Marsdenoside F is a polyoxygenated pregnane glycoside derived from the stems of Marsdenia tenacissima, primarily targeting anti-HIV applications. In biological assays, Marsdenoside F demonstrated negligible cytotoxicity toward A549 and MCF-7 cell lines, as well as a lack of significant anti-HIV activity. Its properties make it a candidate for further research in the context of HIV treatment and cell line studies. -
HIV Inhibitor
HIV-1 Inhibitor-9 is a potent inhibitor targeting HIV-1, effectively inhibiting both wild-type and various non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant strains at low nanomolar concentrations. This compound demonstrates significant antiviral activity, making it a valuable tool for research into HIV treatment and drug resistance mechanisms. Its efficacy against resistant strains supports its potential use in therapeutic studies and drug development efforts aimed at combating HIV-1 infection. -
HIV Inhibitor
Tripterifordin is a potent inhibitor of HIV replication, specifically targeting H9 lymphocyte cells. It demonstrates significant anti-HIV activity with an EC50 value of 3100 nM. This compound is valuable for research applications aimed at understanding HIV pathogenesis and developing therapeutic strategies against HIV infection. -
HIV Inhibitor
UK-88947 hydrochloride is a potent HIV protease inhibitor, primarily targeting HIV-1 replication. It effectively disrupts the early stages of the viral life cycle when administered to cells prior to infection. Additionally, UK-88947 hydrochloride inhibits viral protease activity during infection, thereby significantly impacting viral replication. This compound is valuable for research focused on developing therapeutic strategies against HIV. -
HIV Inhibitor
(D-Ala)-Peptide T is an octapeptide that acts as an HIV inhibitor by targeting the HIV-1 envelope glycoprotein gp120. This compound has been shown to release chemokines and protect against neuronal death induced by gp120. It is a valuable reagent for research into infectious diseases and neurological disorders, particularly AIDS-related dementia. -
Anti-HIV Agent
KP-1461 is a nucleoside derivative that acts as an anti-HIV agent by inducing lethal mutations in the viral genome. This compound has significant potential for research applications focused on HIV infection and the development of novel antiviral strategies. It is valuable for studies aimed at understanding the mechanisms of viral resistance and the efficacy of mutation-inducing therapies. -
HIV-1 Inhibitor
HIV-1 Inhibitor-29 is a potent inhibitor targeting the HIV-1 virus, demonstrating an EC50 of 2.18 μM against the HIV-1 IIIB strain. This compound exhibits significant anti-resistance properties against the F227L/V106A mutant strain, with an EC50 of 0.974 μM, while maintaining low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 Inhibitor-29 is a valuable tool for research focused on AIDS and HIV-1 therapeutic development. -
HIV-1 TAR RNA Binder
WRNA10 is a potent HIV-1 TAR RNA binder that exhibits an IC50 of 10 µM, demonstrating its efficacy in inhibiting interactions with the TAR RNA structure. With a CC50 value of 40 µM, WRNA10 serves as a valuable tool for studying HIV-1 RNA functionalities and therapeutic approaches targeting HIV-1 infections. Its precise binding affinity and biological activity make it suitable for research applications in virology and antiviral drug development. -
HIV-1 Inhibitor
NNRT-IN-1 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor targeting HIV-1. This compound demonstrates significant anti-resistance efficacy, effectively inhibiting wild-type HIV-1 as well as five mutant strains, with EC50 values in the nanomolar range. Additionally, NNRT-IN-1 exhibits favorable pharmacokinetic properties, making it a valuable tool for research applications in HIV therapeutics. -
HIV Inhibitor
(+)-Carbovir is a nucleoside analog specifically designed to inhibit human immunodeficiency virus type 1 (HIV-1). Its enhanced chemical and metabolic stability contributes to its antiviral efficacy. This compound serves as a valuable tool in AIDS research, facilitating studies aimed at understanding and combating HIV infection. -
HIV-1 RT Inhibitor
Tivirapine is a non-nucleoside inhibitor targeting HIV-1 reverse transcriptase (RT), demonstrating potent antiviral activity with an EC50 value of 4 nM. This compound effectively inhibits the Y181C mutant of HIV-1 RT, offering a valuable tool for studying drug resistance mechanisms and evaluating therapeutic strategies against HIV-1 infection. Its application is relevant in both basic research and development of novel antiviral therapies. -
HIV-1 Inhibitor
HIV-1 inhibitor-64 (Compound 7c) is a potent antagonist targeting HIV-1, demonstrating effective inhibition of both wild-type and resistant mutants, specifically E138K/Q148K and G140S/Q148R, with EC50 values of 62.5 nM and 11.3 nM, respectively. This compound exhibits significant antiviral activity, making it a valuable tool for AIDS research and studies focused on HIV-1 resistance mechanisms. -
HIV
(Threo)-Indinavir is a potent protease inhibitor targeting HIV-1, crucial for the management of HIV/AIDS. By obstructing the viral protease activity, (threo)-Indinavir effectively disrupts viral replication. This compound is commonly utilized as part of highly active antiretroviral therapy (HAART) for the suppression of HIV viral load in infected individuals. -
HIV-1 Inhibitor
HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1 with an EC50 of 1.9 nM, demonstrating potent antiviral activity. This compound exhibits minimal interaction with cytochrome P450 enzymes, with IC50 values of 5.16 μM for CYP2C9 and 4.51 μM for CYP2C19, indicating its favorable profile for therapeutic applications. Notably, HIV-1 inhibitor-40 shows no significant acute toxicity in vivo, making it a promising candidate for further research in HIV treatment.
