Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
Aurachin D is an antibiotic that primarily targets Gram-positive bacteria and certain fungi. It functions by inhibiting NADH oxidation in beef heart submitochondrial particles, which disrupts cellular respiration and energy production. This compound is valuable for research applications focused on understanding bacterial and fungal resistance mechanisms as well as exploring metabolic pathways. -
Antifungal Antibiotic/Complex III Inhibitor
Myxothiazol is an antifungal antibiotic that acts as an inhibitor of mitochondrial electron transport chain complex III (bc1 complex). It demonstrates potent antifungal activity against various yeasts and fungi, exhibiting effective growth inhibition at concentrations ranging from 0.01 to 3 μg/ml. This compound is valuable for research applications focused on mitochondrial function and the mechanisms of antifungal resistance. -
Antibiotic Fungicide
Validamycin A acts as an antibiotic fungicide primarily targeting fungal pathogens. Isolated from Streptomyces hygroscopicus var. limoneus, it exhibits significant inhibitory effects against Aspergillus flavus, with a minimum inhibitory concentration (MIC) of 1 µg/mL. Additionally, Validamycin A demonstrates potent inhibition of trehalase in Rhizoctonia solani, with an IC50 value of 72 µM. It also functions as a reversible inhibitor of tyrosinase, exhibiting a Ki value of 5.893 mM, making it a valuable reagent for agricultural and biochemical research applications. -
Antitumor Antibiotic
Peplomycin sulfate is an antitumor antibiotic that acts by inducing DNA strand breaks, thereby promoting apoptosis in cancer cells. It exhibits significant antitumor activity while displaying relatively low pulmonary toxicity. Additionally, Peplomycin sulfate has been shown to induce various skin abnormalities and can lead to pulmonary fibrosis. This compound is valuable for research applications related to cancer, pulmonary fibrosis, and other associated diseases. -
Anti-tumour Antibiotic
Boanmycin is an anti-tumor antibiotic that exerts its biological activity by inducing cellular senescence and apoptosis in cancer cells. This compound is primarily utilized in research to explore mechanisms of tumor suppression and to assess its potential therapeutic applications in oncology. Its ability to promote programmed cell death makes it a valuable tool for studying cancer biology and developing novel treatment strategies. -
Antibiotic
4-Epianhydrotetracycline hydrochloride is an antibiotic that serves as a significant intermediate in tetracycline synthesis. It demonstrates cytotoxic effects and induces apoptosis in zebrafish embryos, highlighting its potential for developmental toxicology studies. Furthermore, it exhibits antimicrobial activity against Shewanella, Escherichia coli, and Pseudomonas aeruginosa, with minimum inhibitory concentrations of 2 mg/L, 1 mg/L, and 64 mg/L, respectively, indicating its utility in microbial resistance research. -
Antibiotic
Deoxynybomycin is an antibiotic that acts as an inhibitor of DNA gyrase and Topoisomerase I. It demonstrates significant antibacterial activity against Staphylococcus aureus and induces the expression of p21/WAF1. Additionally, Deoxynybomycin exhibits cytotoxic effects and promotes apoptosis in various cancer cell lines, including Saos-2, TMK-1, and THP-1, making it a valuable tool for research in antimicrobial and cancer biology. -
Anti-tumour Antibiotic
Boanmycin hydrochloride is an anti-tumor antibiotic that exhibits significant cytotoxic effects against various cancer cell lines. It functions by inducing cellular senescence and apoptosis, making it a valuable tool for studying mechanisms of tumor progression and resistance. This compound is useful in cancer research and can aid in the development of therapeutic strategies targeting malignant cells. -
Antibiotic
Undecylprodigiosin hydrochloride is an antibiotic derived from the prodiginine class of compounds. It exhibits potent antimicrobial activity and selectively induces apoptosis in human breast carcinoma cells through a p53-independent mechanism. Additionally, this compound demonstrates immunosuppressive and anticancer properties, making it a valuable tool for research in cancer therapy and microbial studies. -
Antitumor Antibiotic
Antibiotic DC 81 is a potent antitumor antibiotic derived from Streptomyces species, classified as a pyrrolo[2,1-c][1,4]benzodiazepine (PBD). It functions primarily as an inhibitor of nucleic acid synthesis by recognizing and binding to specific DNA sequences, resulting in the formation of a labile covalent adduct. This ability to interact with DNA makes Antibiotic DC 81 valuable for research in cancer biology and the development of novel therapeutic agents targeting DNA. -
Antibiotic
FSL-1 is a bacterial-derived agonist of toll-like receptor 2/6 (TLR2/6). It exhibits immunostimulatory activity that enhances resistance against experimental Herpes Simplex Virus Type 2 (HSV-2) infection. This compound is valuable for research applications focused on innate immunity and the development of therapeutic strategies for viral infections. -
Antibiotic
TAN-420E (Dihydroherbimycin A) is an antibiotic derived from the fermentation of Streptomyces hygroscopicus. This compound demonstrates significant cytotoxicity against P-388 and KB cancer cell lines, highlighting its potential as an anti-cancer agent. In addition, TAN-420E effectively scavenges DPPH free radicals, with an IC50 value of 1.3 μM, indicating its potential antioxidant properties. Research applications include investigations into its antimicrobial and anticancer effects. -
Glycylcycline Antibiotic
Tigecycline hydrate is a glycylcycline antibiotic characterized by its broad-spectrum antibacterial activity. It exhibits significant inhibitory effects against various bacterial strains, with a mean inhibitory concentration (MIC) of approximately 125 ng/mL for E. coli (MG1655 strain). In addition, it displays MIC50 and MIC90 values of 1 mg/L and 2 mg/L, respectively, for Acinetobacter baumannii. This compound is valuable for research applications related to antibiotic efficacy and resistance studies. -
Antibiotic
Rifaquizinone is a hybrid antibiotic that combines the mechanisms of Rifamycin and Quinolone. It effectively inhibits wild-type Staphylococcus aureus RNA polymerase, exhibiting an IC50 value of 34 nM. Rifaquizinone demonstrates potent antibacterial activity against S. aureus infections, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.5 μg/mL across 300 clinical isolates of staphylococci and streptococci, making it a valuable tool for antibiotic research and investigation into resistance mechanisms. -
Antibiotic
Erythromycin (aspartate) is a macrolide antibiotic that exerts its effects by binding to the 50S ribosomal subunit of bacteria, inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity, making it an important tool in microbiological research. Additionally, erythromycin aspartate has shown potential antitumor and neuroprotective properties, expanding its applications in various fields of biomedical research. -
Antibiotic
Alatrofloxacin is a fluoronaphthyridone antibiotic that serves as a proagent of Trovafloxacin. Its primary mechanism involves the inhibition of DNA synthesis in pathogenic organisms, resulting in effective antimicrobial activity. In addition to its antibacterial properties, Alatrofloxacin also exhibits immunosuppressive effects, making it relevant for research applications in studying immune responses and infectious diseases. -
Antibiotic
Ficellomycin is a nitrogen-containing bicyclic antibiotic targeting Gram-positive bacteria, including multidrug-resistant Staphylococcus aureus. It exerts its biological activity by inducing the formation of defective 34S DNA fragments that disrupt the semi-conservative DNA replication process. These fragments are unable to integrate into larger DNA segments, ultimately hindering the assembly of a complete bacterial chromosome. Ficellomycin is valuable for research on bacterial diseases and antibiotic resistance mechanisms. -
Tetracycline derivatives of antibiotic
Sarecycline is a narrow-spectrum tetracycline derivative antibiotic that primarily targets bacterial protein synthesis by interfering with tRNA accommodation and stabilizing mRNA binding to the 70S ribosome. It exhibits significant anti-inflammatory activity and effectively inhibits the growth of Gram-positive bacteria, including various strains of keratobacterium acnes. Sarecycline is suitable for research applications focused on understanding moderate to severe acne and its underlying mechanisms. -
Fluoroquinolone Antibiotic
PD 124816 is an orally active fluoroquinolone antibiotic that inhibits DNA gyrase (topoisomerase IV), providing broad-spectrum antibacterial activity. It demonstrates efficacy against both Gram-positive and Gram-negative bacteria, with a minimum inhibitory concentration (MIC₉₀) of ≤ 0.06 μg/mL and an MIC₉₀ of 1 μg/mL for anaerobic bacteria such as Peptostreptococcus fragi. Additionally, PD 124816 exhibits complete bactericidal effectiveness in a mouse model of Mycobacterium leprae infection. This compound is valuable for research involving mixed infections and antibiotic resistance mechanisms. -
Antitumor Antibiotic
Esperamicin A1 is a highly potent antitumor antibiotic derived from Actinomadura verrucosospora. It exhibits significant cytotoxic activity, making it valuable for cancer research applications. In addition to its antitumor properties, Esperamicin A1 functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This allows for versatile applications in bioconjugation and molecular imaging studies. -
Antibiotic
Ibezapolstat hydrochloride is a novel, orally active inhibitor of DNA polymerase IIIC (pol IIIC) with a Ki of 0.325 μM specific to the enzyme from Clostridium difficile. This compound exhibits antibiotic activity and is primarily utilized in research focused on Clostridium difficile infections (CDI). Its unique mechanism makes it a valuable tool for studying CDI and developing potential therapeutic strategies. -
Antibiotic
Alatrofloxacin mesylate is a broad-spectrum antibiotic that targets and inhibits bacterial growth. It demonstrates significant hydrophilicity in aqueous solutions, facilitating the formation of stable suspensions. Understanding its degradation products, which can become hydrophobic upon exposure, is essential for maintaining long-term stability, as this affects particle aggregation. Additionally, variations in surface tension characteristics under different lighting conditions can influence the physical and chemical properties of Alatrofloxacin mesylate, making it a valuable candidate for research into antibiotic efficacy and stability. -
Antibiotics
4-Demethoxy-7,9-di-epi-daunorubicin is an anthracycline antibiotic that targets DNA by intercalating into the double helix, forming stable complexes with calf thymus DNA. Its primary activity includes the inhibition of prokaryotic nucleic acid polymerases, such as E. coli DNA polymerase I and RNA polymerase. This compound is particularly useful in cancer research and investigations into bacterial infections, providing insights into therapeutic mechanisms and potential treatment strategies. -
Antibiotic
Erythromycin A dihydrate is a macrolide antibiotic that targets the bacterial 50S ribosomal subunit, effectively inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. It possesses a broad spectrum of antimicrobial activity and is commonly used in microbiological research. Additionally, Erythromycin A dihydrate has demonstrated antitumor and neuroprotective effects, making it valuable for diverse applications in biological research. -
Antibiotic
Erythromycin stearate is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, leading to the inhibition of RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. It exhibits a broad spectrum of antimicrobial activity against various gram-positive and some gram-negative bacteria. In addition to its antibacterial properties, erythromycin stearate has been investigated for its potential antitumor and neuroprotective effects, making it suitable for diverse research applications in microbiology and cancer studies. -
Antibiotic
Eponemycin is an antibiotic with significant antitumor properties, targeting cancer cell proliferation. It demonstrates potent cytotoxicity against various cancer cell lines including B16-F10, L1210, P388, and HCT-116, with IC50 values of 0.0017, 0.01, 0.031, and 0.0097 µg/mL, respectively. Additionally, Eponemycin effectively inhibits DNA synthesis in the B16-F10 cell line, exhibiting an IC50 of 0.1 µg/mL, thereby demonstrating its utility in cancer research applications focused on DNA replication and cell viability. -
Antitumor Antibiotic
2-Hydroxyaclacinomycin A is an anthracycline antibiotic that exerts its antitumor effects through the inhibition of RNA and DNA synthesis. It demonstrates potent cytotoxic activity against leukemia L-1210 cells, with IC50 values of 0.10 μg/mL and 0.95 μg/mL for RNA and DNA synthesis, respectively. This compound is valuable for research focused on cancer therapeutics and the cellular mechanisms of anthracycline antibiotics. -
Antitumor Antibiotic
1-Hydroxyoxaunomycin is an antitumor antibiotic that targets cellular proliferation. It effectively inhibits U210 cell growth, demonstrating IC50 values of 0.0005 μg/mL for cell growth, 1.00 μg/mL for DNA synthesis, and 0.76 μg/mL for RNA synthesis. This compound is primarily utilized in cancer research to explore mechanisms of action related to nucleic acid synthesis and cellular function. -
Antibiotic
Erythromycin glutamate is a macrolide antibiotic that primarily targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis by blocking transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacterial pathogens. In addition to its antibiotic properties, erythromycin glutamate has shown potential antitumor and neuroprotective effects, making it valuable for diverse research applications in microbiology, oncology, and neurobiology. -
AntibioticAgent
GSK299423 is an antibiotic agent primarily targeting DNA gyrase. It exhibits potent inhibition of supercoiling in Staphylococcus aureus with an IC50 of 14 nM and in Escherichia coli with an IC50 of 100 nM. This compound is suitable for research applications focused on antibacterial mechanisms and the evaluation of DNA-targeting therapies. -
Antibiotic
Viquidacin is an antibiotic that primarily targets topoisomerase IV and DNA gyrase. It demonstrates significant antibacterial activity against gram-positive bacteria, particularly Staphylococcus aureus, by inhibiting supercoiling, decatenation, and relaxation processes. Viquidacin also exhibits activity against Escherichia coli and shows a minimum inhibitory concentration (MIC) range of 2-128 mg/L against wild-type and mutant strains of S. aureus, making it a valuable reagent for antibacterial research applications. -
Antibiotic
Erythromycin hydrochloride is a macrolide antibiotic that acts as a protein synthesis inhibitor, targeting bacterial ribosomes. It demonstrates broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, making it effective in treating various bacterial infections, including respiratory and skin infections. Additionally, erythromycin hydrochloride has been implicated in the inhibition of mammalian mRNA splicing, indicating potential roles in research related to gene expression and cellular function. This compound is widely utilized in biomedical research for its antibacterial properties and mechanisms. -
Antitumor Antibiotic
Herbimycin B is an ansamycin antibiotic targeting Src family tyrosine kinases. It exhibits significant antitumor activity by inhibiting cell proliferation in various cancer cell lines, including HeLa and Ehrlich cells. Additionally, Herbimycin B demonstrates a herbicidal effect on both monocotyledons and dicotyledons and can inhibit the tobacco mosaic virus (TMV), making it relevant for studies in plant pathology and cancer research. -
Antibiotic
Methicillin is a narrow-spectrum β-lactam antibiotic that targets and inhibits penicillin-binding proteins (PBPs). Its efficacy is primarily observed against Staphylococcus aureus and Staphylococcus epidermidis strains that exhibit resistance to other penicillins. Methicillin is utilized in research investigating various conditions, including skin infections, osteomyelitis, and endocarditis. -
Antibiotic
Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis. Effective against Staphylococcus aureus and Staphylococcus epidermidis, particularly strains resistant to other penicillins, it is utilized in researching conditions such as skin infections, osteomyelitis, and endocarditis. -
Angucycline Antibiotic
Urdamycin A is an angucycline antibiotic derived from Streptomyces fradiae. Notably, it functions as an orange pH indicator, shifting to ultramarine blue at pH 7.7. Urdamycin A exhibits significant anticancer activity, showing IC50 values of 2.4 μg/mL in proliferation assays and 0.55 μg/mL in stem cell assays. This compound is relevant for research applications in cancer biology and antibiotic activity studies. -
Antibiotic
Fenbendazole is an orally active benzimidazole compound that primarily targets tubulin, acting as a microtubule destabilizing agent. It exhibits a broad antiparasitic activity by disrupting microtubule equilibrium in helminths. Additionally, fenbendazole is known for its anti-proliferative effects, inducing apoptosis and causing cell-cycle arrest in various cancer models. Its antitumor properties have been demonstrated in mice xenografted with wild-type p53, making it a valuable reagent for exploring mechanisms of cancer therapy. -
Antibiotic
Nalidixic acid is a quinolone antibiotic that primarily targets DNA gyrase and topoisomerase IV, interfering with bacterial DNA replication. It exhibits a bacteriostatic effect at lower concentrations and becomes bactericidal at higher concentrations. Nalidixic acid is effective against both gram-positive and gram-negative bacteria, making it valuable for studies involving bacterial infections and resistance mechanisms in microorganisms. -
Antibiotic
Secnidazole is an orally active azole antibiotic that primarily targets bacterial quorum sensing (QS) mechanisms. By inhibiting acylhomoserine lactones, Secnidazole attenuates the virulence of Pseudomonas aeruginosa and exhibits antimicrobial activity against a range of anaerobic Gram-negative and Gram-positive bacteria. This reagent is valuable for research applications related to diseases such as amoebiasis, giardiasis, and bacterial vaginitis, facilitating studies on their pathogenesis and treatment. -
Sulfonamide Antibiotic
Sulfadiazine is a sulfonamide antibiotic that inhibits bacterial folic acid synthesis by competitively antagonizing para-aminobenzoic acid (PABA). It exhibits antimalarial properties and is primarily utilized in research involving toxoplasmosis. Sulfadiazine's mechanism of action makes it a valuable tool for studying sulfamethoxazole efficacy and the interplay of antibiotics in parasitic infections. -
Antibiotic
Sulfameter, a sulfonamide antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria. Its long-acting formulation makes it suitable for research applications targeting bacterial infections, particularly in respiratory and urinary tracts. This compound serves as a valuable tool in the study of antibiotic efficacy and resistance mechanisms in various pathogens. -
Sulfathiazole Antibiotic
Sulfamethizole is a sulfathiazole antibiotic that inhibits the synthesis of folic acid and thymine, thereby affecting bacterial growth. It demonstrates antibacterial activity against Escherichia coli in urinary tract infections, though it is ineffective against sulII gene-positive strains. This compound is valuable for research into the mechanisms of urinary tract infections and the bioluminescence of Photobacterium phosphoreum. -
Sulfonamide Antibiotic
Sulfamethoxazole is a sulfonamide antibiotic that exerts its antibacterial effect by inhibiting bacterial folate metabolism. It achieves this by competitively interfering with 4-Aminobenzoic acid (PABA) at the active site of dihydropteroate synthetase and dihydropteroate reductase. This compound is primarily utilized in the research of urinary tract infections (UTIs), prostatitis, and bronchitis, making it a valuable tool for studying antibiotic resistance and bacterial infections. -
Antibiotic
Sulfanilamide is a potent sulfonamide antibiotic that primarily targets bacterial growth by inhibiting dihydropteroate synthase. This compound demonstrates significant biological activity against various pathogens, including inhibition of the lymphogranuloma venereum virus. Additionally, sulfanilamide acts as a carbonic anhydrase inhibitor, making it useful in a range of biochemical research applications, particularly in studies involving antibiotic resistance and enzyme dynamics. -
Antibacterial Antibiotic
Tebipenem pivoxil is an orally active antibacterial antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis. Its efficacy against a range of pathogenic bacteria makes it a valuable tool for research applications in microbiology and pharmacology, particularly in studying antibiotic resistance mechanisms and developing new therapeutic strategies. -
Cephalosporin Antibiotic
Cephalexin is a semisynthetic cephalosporin antibiotic known for its broad-spectrum activity against numerous gram-positive and gram-negative bacteria. It functions primarily by inhibiting penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis. This compound is widely utilized in research related to bacterial infections, including pneumonia, streptococcal throat infections, and bacterial endocarditis. Its oral bioavailability and efficacy make it a valuable tool in microbiological studies. -
Antibiotic
Amoxicillin is a beta-lactam antibiotic that targets bacterial cell wall synthesis. It exerts its antimicrobial activity by inhibiting the peptidoglycan biosynthesis necessary for cell wall formation, leading to impaired cell growth and division. Amoxicillin is widely used in various research applications to study bacterial infections and resistance mechanisms. -
Aminoglycoside Antibiotic
Amikacin hydrate is an aminoglycoside antibiotic that serves as a semisynthetic analog of kanamycin. It exhibits bactericidal activity by binding to the 30S and 50S ribosomal subunits in bacteria, ultimately inhibiting protein synthesis. This reagent is particularly effective against a wide range of Gram-negative bacteria, including strains resistant to gentamicin and tobramycin, as well as infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin hydrate is commonly utilized in research focused on combating antibiotic-resistant infections and studying mechanisms of antibiotic action. -
Antibiotic
Bacitracin Zinc is a complex of Bacitracin and zinc ions, functioning primarily as an antibiotic with bactericidal activity. This polypeptide antibiotic is effective in causing damage to bacterial DNA and deoxyribose, making it a valuable agent in combating microbial infections. Additionally, Bacitracin Zinc has been shown to enhance gut microbiota composition in broiler and beef cattle, contributing to improved overall health and growth performance in livestock research applications. -
Antibiotic
Carbenicillin disodium is a broad-spectrum semi-synthetic penicillin antibiotic targeting gram-negative bacteria. It exerts its antibacterial activity by inhibiting cell wall synthesis, making it effective in various microbiological applications. Due to its low toxicity, it is also suitable for use in plant tissue research.
