Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Bacterial Metabolite
12-Tridecenoic acid is a bacterial metabolite that plays a crucial role in the regulation of lipid metabolism. It promotes the expression of acetyl-CoA carboxylase α (ACC) while inhibiting carnitine palmitoyltransferase 1A (CPT1A), contributing to the development of hepatic steatosis. This compound is relevant for research in metabolic diseases and cellular lipid regulation. -
Antibacterial Agent
Metioprim is a competitive inhibitor of bacterial dihydrofolate reductase (DHFR), targeting critical pathways in bacterial folate metabolism. It exhibits potent antibacterial activity against anaerobic bacteria and demonstrates synergistic effects when combined with DDS against E. coli and various mycobacterial strains. This reagent is valuable for antibacterial research and development, particularly in studies focused on antibiotic resistance and the efficacy of combination therapies. -
Antibacterial Agent
AR-102 is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus. It demonstrates competitive inhibition of the F98Y mutant dihydrofolate reductase (DHFR) with a Ki value of 0.22 nM. Structural studies have characterized AR-102 as forming a ternary complex with NADPH in both wild-type and TMP-resistant F98Y mutant S. aureus DHFR, making it a valuable compound for research on antibacterial resistance mechanisms. -
Antifolate Agent, Antibacterial Agent
11-Oxahomoaminopterin is an antifolate agent that inhibits dihydrofolate reductase, targeting bacterial and tumor cell proliferation. This compound exhibits significant antibacterial activity against Lactobacillus casei, demonstrating potential applications in antimicrobial and antitumor research. Its ability to interfere with folate metabolism makes it a valuable tool for studying various biological systems. -
Antibacterial Agent
Antibacterial Agent 330 is an antibacterial compound that operates by inducing reactive oxygen species (ROS) accumulation and forming supramolecular complexes through DNA intercalation, which inhibits DNA replication. This agent disrupts bacterial metabolism by inhibiting lactate dehydrogenase (LDH) and promotes cell lysis, resulting in the leakage of intracellular contents and bacterial cell death. Antibacterial Agent 330 demonstrates significant antibacterial activity and enhances wound healing in both Galleria mellonella larval and murine models, making it a valuable tool for researching bacterial infections. -
Antibacterial Agent
10-Decarbamoyloxy-9-dehydromitomycin B is a derivative of mitomycin with notable antibacterial properties. This compound exhibits significant antibacterial and antitumor activities, making it a valuable tool for research in infectious diseases and cancer treatment. Its mechanism of action involves DNA crosslinking, leading to inhibition of replication and cell division, thereby providing insights into therapeutic potential and resistance mechanisms. -
Antibacterial Agents
Sulfachloropyridazine sodium is a sulfonamide antibiotic that exerts its antibacterial activity through the inhibition of bacterial folic acid synthesis. This compound is effective against a range of Gram-positive and Gram-negative bacteria, making it useful for research in antibiotic efficacy and resistance mechanisms. Its application includes studying bacterial growth inhibition and exploring the therapeutic potential in various infectious diseases. -
Bacterial Inhibitor
FR-202306 is a bacterial inhibitor that targets peptide deformylase, an enzyme crucial for bacterial protein synthesis. This compound displays significant antibacterial activity against Staphylococcus aureus by effectively inhibiting its peptide deformylase activity. FR-202306 is valuable for research applications focused on developing antibacterial agents and exploring mechanisms of bacterial resistance. -
Bacterial Inhibitor
LF11 is a peptide that functions as a bacterial inhibitor by disrupting microbial cell membrane integrity. It exhibits potent antibacterial activity, making it a valuable tool for research focused on combating bacterial infections and studying antimicrobial mechanisms. Its application is particularly relevant in the development of new therapies and understanding resistance in pathogenic bacteria. -
Antibacterial Agent
Antibacterial Agent 105 is a phenanthrolinic analog of quinolones that targets bacterial cell functions, demonstrating significant antibacterial activity against Mycobacterium tuberculosis with an MIC90 of 2.64 μM. This compound also exhibits broad-spectrum antibacterial efficacy against various bacterial species, including MIC90 values of 11.18 μM for M. smegmatis and M. aurum, 0.70 μM for M. marinum, 1.40 μM for BCG, 44.70 μM for Enterobacter aerogenes, and 22.35 μM for Staphylococcus aureus. Its diverse activity profile makes it a valuable tool for research in antimicrobial resistance and therapeutic interventions. -
Bacterial Inhibitor
Rifametane is a novel 3-azamethyl-rifamycin that acts as a bacterial inhibitor. It exhibits a pharmacokinetic profile that surpasses that of rifampin, demonstrating higher peak serum concentrations in healthy volunteers. This compound is primarily used in research focused on antibacterial activity and the evaluation of new therapeutic strategies against resistant bacterial strains. -
Anti-metastatic Antibacterial Agent
ADG-2e is a potent antibacterial agent with demonstrated minimum inhibitory concentrations (MICs) of 16, 4, 2, and 2 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B. subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. Additionally, ADG-2e exhibits anti-metastatic properties in breast cancer cell lines, making it a valuable tool for research in both infection control and cancer metastasis studies. -
Bacterial Inhibitor
BMS-247243 is a β-lactam antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA). It exhibits significant antibacterial activity, making it a valuable tool for research into bacterial resistance mechanisms and the development of new antimicrobial therapies. BMS-247243 is particularly relevant for studies focused on treating infections caused by resistant bacterial strains. -
Bacterial Inhibitor, Translation Inhibitor
Sancycline hydrochloride is a bacterial inhibitor that functions by reversibly binding to the 30S ribosomal subunit, thereby inhibiting protein translation. It effectively blocks the entry of aminoacyl-tRNA into the ribosomal A site, similar to other tetracycline derivatives. This semi-synthetic tetracycline, characterized by its four linearly fused six-membered rings and four stereocenters, is primarily utilized in research focusing on bacterial protein synthesis and the development of antibacterial agents. -
Anti-bacterial Agent
Antibiotic A-33853 is an antibacterial agent derived from a Streptomyces strain. It exhibits potent antimicrobial activity against Staphylococcus aureus and Mycoplasma gallisepticum, with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively. This compound is valuable for research in microbiology and antibiotic susceptibility studies. -
Antibacterial Agent
GE 2270A is an antibacterial agent that inhibits protein synthesis in gram-positive bacteria and anaerobes. This compound effectively targets bacterial ribosomes, leading to a reduction in bacterial proliferation. GE 2270A is primarily utilized in research exploring bacterial infections and antimicrobial treatments. -
Bacterial Metabolite
Carbazomycin B is a bacterial metabolite isolated from Streptomyces, exhibiting potent antifungal and antibacterial properties. It primarily functions by inhibiting 5-lipoxygenase (5-LO) activity, demonstrating an IC50 value of 1.5 µM in extracts from RBL-1 cells. This compound is valuable for research in microbiology and pharmacology, particularly in studying inflammatory responses and developing antimicrobial therapies. -
Bacterial Inhibitor
Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology. -
Bacterial Inhibitor
Pivmecillinam is an orally active prodrug of mecillinam, functioning primarily as a bacterial inhibitor. It exhibits potent activity against various gram-negative bacteria by interfering with the synthesis of bacterial cell walls. Pivmecillinam is utilized in research to investigate mechanisms of antibiotic resistance and the efficacy of beta-lactam antibiotics. -
Bacterial Inhibitor
Altromycin F is an anthraquinone-derived antibiotic that functions as a bacterial inhibitor by targeting and disrupting bacterial cell function. This compound exhibits significant antibacterial activity specifically against Gram-positive bacteria, including Streptococcus and Staphylococcus, with a microbial inhibitory concentration (MIC) ranging from 0.2 to 3.12 μg/mL. Altromycin F is valuable for research applications focused on understanding bacterial resistance and developing new antibacterial strategies. -
Bacterial Inhibitor
Cefoselis hydrochloride is a fourth-generation cephalosporin and a β-lactam antibiotic that targets bacterial cell wall synthesis. It demonstrates potent antibacterial activity against a broad spectrum of both Gram-positive and Gram-negative bacteria. Furthermore, cefoselis hydrochloride effectively penetrates the blood-brain barrier, making it a valuable compound for research applications in infectious diseases and central nervous system infections. -
Antibacterial Agent
O-Demethylpaulomycin A is an antibiotic that exhibits potent antibacterial activity, specifically targeting Gram-positive bacteria. This compound is particularly effective against Staphylococcus aureus, making it a valuable reagent for research applications focused on bacterial infections and antibiotic resistance. Its mechanism of action may provide insights into new therapeutic strategies for combating resistant bacterial strains. -
Antibacterial Agent
Sulopenem sodium is a parenteral penem antibiotic that exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. This compound is particularly relevant for the treatment of urinary tract infections and intra-abdominal infections, offering a therapeutic option in complex infectious diseases. However, it is ineffective against Pseudomonas aeruginosa and Xanthomonas maltophilia. -
Antibacterial Agent
(Rac)-LY193239 is a racemic variant of LY193239, a higher-lactam pyrazolidinone with potent antibacterial properties. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into bacterial infections. Its mechanism as an antibacterial agent allows for investigations into therapeutic applications and the development of new antibiotics. -
Antibacterial
CGP 31608 is a semisynthetic penem derivative that exhibits potent antibacterial activity. Its structural modifications confer resistance to various significant beta-lactamases, including mutationally derepressed chromosomal enzymes. CGP 31608 is suitable for research applications focused on bacterial infections and the mechanisms of antibiotic resistance. -
Antibacterial Agent
Antibacterial Agent 128 is an innovative siderophore analog-Ciprofloxacin conjugate featuring a cleavable linker. This compound exhibits potent antibacterial activity against Pseudomonas aeruginosa, with minimum inhibitory concentration (MIC) values ranging from 0.25 to 64 μg/mL, and against Burkholderia pseudomallei, with MIC values between 1 and 32 μg/mL. Antibacterial Agent 128 is suitable for research applications focused on combating bacterial infections and studying antibiotic resistance mechanisms. -
Bacterial Inhibitor
KKL-40 is a small molecule inhibitor that targets the trans-transcription process in bacteria. It exhibits effective antibacterial activity against methicillin-sensitive and -resistant Staphylococcus aureus, as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 demonstrates a synergistic effect with the human antimicrobial peptide LL-37 against S. aureus, while showing no synergy with commonly used antibiotics such as daptomycin, kanamycin, or erythromycin. Notably, KKL-40 selectively inhibits trans-transcription without toxicity to HeLa cells, making it a valuable tool for research in bacterial genetics and antibiotic resistance. -
Antibacterial Agent
Clindamycin palmitate is an antibacterial agent that undergoes rapid hydrolysis in vivo, converting to the active form, clindamycin, which effectively targets bacterial infections. This prodrug is primarily used in research to study antibiotic efficacy and mechanisms of action. Its application extends to exploring resistance patterns and enhancing the understanding of bacterial pathogenesis. -
Antibacterial Agent
Kocurin is a thiazolyl cyclic-peptide antibiotic that primarily targets bacterial protein biosynthesis during the translation phase. It exhibits strong antibacterial activity against Gram-positive bacteria, making it a valuable reagent for research into antimicrobial resistance and the mechanisms of bacterial translation. Kocurin shows no activity against fungi or Gram-negative bacteria, highlighting its selective antibacterial profile. -
Antibacterial Agent
Cryptosporiopsin is a potent antibacterial agent derived from Cryptosporiopsis sp. and Sporormia affinis. This compound exhibits significant antibacterial activity against a variety of fungi, including basidiomycetes, algal fungi, ascomycetes, and hemiplegia fungi responsible for wood rot. Additionally, Cryptosporiopsin has been shown to inhibit the spore germination of Phytophthora species affecting potatoes, and demonstrates activity against both gram-positive and gram-negative bacteria, making it valuable for antibacterial research applications. -
Antibacterial Agent
Ticarcillin monosodium is a semisynthetic, extended-spectrum carboxypenicillin with notable antibacterial activity targeting gram-positive cocci, such as streptococci and staphylococci, as well as a broad range of gram-negative organisms, including Pseudomonas aeruginosa. This compound is utilized in research related to lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections. Its diverse spectrum of activity makes it a valuable tool for studying various infectious diseases. -
Antibacterial Agent
Gepotidacin hydrochloride is a novel antibacterial agent that inhibits bacterial type II topoisomerases. By interfering with DNA replication and repair processes, it exhibits potent activity against a range of Gram-negative and Gram-positive bacteria. This compound is primarily utilized in research focused on bacterial infections and the development of new antibacterial therapies. -
Bacterial Inhibitor
Norfloxacin hydrochloride is a broad-spectrum antibacterial agent that targets and inhibits DNA gyrase, thus interfering with bacterial DNA replication and repair. It exhibits activity against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable reagent for microbiological research and the study of bacterial resistance mechanisms. This compound is utilized in the investigation of bacterial infections and the development of new antimicrobial therapies. -
Antibacterial Agent
Antibacterial Agent 285 is a cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits potent antibacterial activity against gram-negative bacteria, with minimum inhibitory concentrations (MICs) of 0.125-0.5 µg/mL for carbapenem-resistant Acinetobacter baumannii, 0.125-0.5 µg/mL for Klebsiella pneumoniae, and 0.125-2 µg/mL for Pseudomonas aeruginosa. This compound is suitable for research applications related to bacterial infections, including complicated urinary tract infections and kidney infections. -
Anti-Bacterial Agent
Elaiomycin is an anti-bacterial agent that exhibits activity against Gram-positive bacteria as well as certain anaerobic bacteria. Additionally, it demonstrates efficacy against the protists Eimeria tenella and Eimeria acervulina. This compound is valuable for research applications focused on bacterial infections and parasitic control. -
Antibacterial Agent
4'-Acetyl-chrysomycin A, an analog of chrysomycin A, primarily targets bacterial cellular processes. This compound exhibits significant antibacterial activity, making it a valuable tool for antimicrobial research. Its applications include the study of antibacterial mechanisms and potential therapeutic development against bacterial infections. -
Anti-bacterial Agent
S-2,3-Dicarboxyaziridine is an antibacterial agent derived from metabolites isolated from Streptomyces species. It exhibits significant antibacterial activity, making it an important compound for research focused on microbial infections and antibiotic development. This reagent can facilitate investigations into the efficacy and mechanisms of new antibacterial therapies. -
Bacterial Inhibitor
Ceforanide (lysine) is a second-generation cephalosporin that functions as a bacterial inhibitor by interfering with bacterial cell wall synthesis. It exhibits a broad spectrum of in vitro antibacterial activity against various Gram-positive and Gram-negative bacteria. Ceforanide is primarily utilized in microbiological research to study bacterial resistance and the effects of cephalosporins on different bacterial strains. -
Antibacterial Agent
Chitotriose is a chitooligosaccharide derived from chitosan obtained from crab shells. It exhibits antibacterial activity specifically against Salmonella species. This compound is valuable for research applications in studying antimicrobial mechanisms and the development of antibacterial agents. -
Bacterial Inhibitor
Deoxypheganomycin D is a specific antimycobacterial agent that demonstrates selective inhibition of Mycobacterium 607 growth without cross-resistance to other antibiotics. At a concentration of 28 μM, it significantly reduces bacterial proliferation while showing minimal impact on DNA, RNA, or protein synthesis pathways. Notably, at 7 μM, Deoxypheganomycin D interferes with leucine influx and alters efflux dynamics, suggesting its action may involve interactions with the cell membrane and distinct mycobacterial lipid components. This reagent is valuable for researchers studying mycobacterial resistance mechanisms and developing alternative treatment strategies. -
Bacterial Quorum-sensing Molecule
N-3-Hydroxydecanoyl-DL-homoserine lactone is a bacterial quorum-sensing molecule that primarily targets the transcription factor SdiA. It activates SdiA with an EC50 value of 0.6 µM, enabling the detection of N-acyl homoserine lactones (AHLs) in bacterial systems. This compound is particularly relevant for research into the regulation of gene expression in Salmonella enterica and other bacteria, providing insights into quorum sensing mechanisms and potential therapeutic strategies against bacterial infections. -
Antibacterial Agent
Cefditoren Pivoxil hydrochloride is a third-generation oral cephalosporin antibiotic with broad-spectrum antibacterial activity, particularly effective against Gram-negative and Gram-positive bacteria. Its enhanced stability against various β-lactamases makes it a valuable tool in studying infectious diseases. Research applications include investigating acute exacerbations of chronic bronchitis, community-acquired pneumonia, streptococcal pharyngitis/tonsillitis, and uncomplicated skin and skin structure infections. -
Bacterial Inhibitor
Lysostaphin targets the bacterial cell wall, acting as an antistaphylococcal agent. This enzyme exhibits the activities of glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase, leading to effective inhibition of Staphylococcus species. Due to its specific enzymatic action, lysostaphin is valuable in research focused on bacterial resistance, pathogen biology, and the development of antimicrobial therapeutics. -
Antibacterial Agent
Moxifloxacin is an 8-methoxyquinolone antibiotic that functions through the inhibition of bacterial DNA gyrase and topoisomerase IV. It effectively targets a variety of Gram-positive and Gram-negative bacteria, making it useful in the treatment of conditions such as acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. This compound is valuable for research involving antimicrobial resistance and bacterial infections in clinical microbiology studies. -
Bacterial Inhibitor
Cefotaxime is a third-generation cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria and is notably stable against β-lactamase enzymes. This compound is widely used in microbiological research and clinical settings for the treatment and study of bacterial infections. -
Bacterial Inhibitor
Gastric mucin is a glycoprotein that acts as a bacterial inhibitor, particularly effective against Helicobacter pylori infection. It exhibits natural antibiotic properties and scavenges hydroxyl radicals, contributing to its protective role in the gastrointestinal tract. Gastric mucin plays a critical role in safeguarding against acid, proteases, and pathogenic microorganisms, while also providing defense against mechanical trauma. This functionality makes it a valuable reagent for research focused on gastrointestinal health and microbiome interactions. -
Bacterial Inhibitor
Mecillinam, a β-lactam antibiotic, primarily targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins in gram-negative organisms. It demonstrates a broad spectrum of antibacterial activity, making it valuable in studying bacterial infections and resistance mechanisms. Researchers often utilize Mecillinam for its effectiveness against various pathogenic strains, aiding in the development of therapeutic strategies and understanding bacterial physiology. -
Antibacterial Agent
Zosurabalpin is a polypeptide antibiotic that targets the LPS transporter complex (LptB2FGC), effectively inhibiting the transport of lipopolysaccharides (LPS). This mechanism leads to the accumulation of endotoxins within cells, demonstrating significant antibacterial activity against Carbapenem-resistant Acinetobacter baumannii (CRAB). Zosurabalpin serves as a valuable tool for research in antibiotic resistance and bacterial infection mechanisms. -
Bacterial Inhibitor
Cecropin A is a linear antimicrobial polypeptide composed of 37 residues that exhibits potent antibacterial activity. Additionally, it demonstrates anticancer and anti-inflammatory properties, making it a valuable tool for research in infectious diseases, cancer therapy, and inflammatory response studies. Its ability to disrupt bacterial membranes can be leveraged in the development of novel antimicrobial agents.
