Antibacterial Agent 105 is a phenanthrolinic analog of quinolones that targets bacterial cell functions, demonstrating significant antibacterial activity against Mycobacterium tuberculosis with an MIC90 of 2.64 μM. This compound also exhibits broad-spectrum antibacterial efficacy against various bacterial species, including MIC90 values of 11.18 μM for M. smegmatis and M. aurum, 0.70 μM for M. marinum, 1.40 μM for BCG, 44.70 μM for Enterobacter aerogenes, and 22.35 μM for Staphylococcus aureus. Its diverse activity profile makes it a valuable tool for research in antimicrobial resistance and therapeutic interventions.
Antibacterial Agent 105 is a phenanthrolinic analog of quinolones that targets bacterial cell functions, demonstrating significant antibacterial activity against Mycobacterium tuberculosis with an MIC90 of 2.64 μM. This compound also exhibits broad-spectrum antibacterial efficacy against various bacterial species, including MIC90 values of 11.18 μM for M. smegmatis and M. aurum, 0.70 μM for M. marinum, 1.40 μM for BCG, 44.70 μM for Enterobacter aerogenes, and 22.35 μM for Staphylococcus aureus. Its diverse activity profile makes it a valuable tool for research in antimicrobial resistance and therapeutic interventions.
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