β-lactamase

Cat. No.

A46332

CAS No.

2938989-90-1

Avibactam sodium hydrate

Synonyms: NXL-104 hydrate

Avibactam sodium hydrate is a reversible non-β-lactam β-lactamase inhibitor that specifically targets β-lactamase enzymes TEM-1 and CTX-M-15, demonstrating IC50 values of 8 nM and 5 nM, respectively. This compound is crucial for enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. Its use in research applications includes investigations into antibiotic resistance mechanisms and the development of combination therapies to overcome β-lactamase-mediated resistance.

Cat. No.

A46416

CAS No.

61177-45-5

Clavulanate potassium

Clavulanate potassium is a potent β-lactamase inhibitor that enhances the effectiveness of β-lactam antibiotics by inhibiting bacterial enzyme activity. It is primarily used in research to study antimicrobial resistance mechanisms and to evaluate the synergy of antibiotic combinations. Clavulanate potassium is essential in elucidating bacterial adaptations and informing therapeutic strategies against resistant organisms.

Cat. No.

A46421

CAS No.

61177-44-4

Clavulanate lithium

Clavulanate lithium is a potent β-lactamase inhibitor that enhances the efficacy of β-lactam antibiotics by inhibiting bacterial enzymes responsible for antibiotic resistance. Its ability to combat antibiotic resistance makes it invaluable in research focused on understanding and overcoming treatment failures caused by resistant pathogens. Clavulanate lithium is commonly used in studies investigating the mechanisms of resistance and in the development of novel therapeutics.

Cat. No.

A46530

CAS No.

69388-79-0

Sulbactam pivoxil

Synonyms: Pivsulbactam; CP 47904

Sulbactam pivoxil is a prodrug of Sulbactam, functioning primarily as a β-lactamase inhibitor. It demonstrates significant antibacterial activity by overcoming resistance mechanisms associated with β-lactam antibiotics. This compound is characterized by enhanced absorption compared to Sulbactam, leading to elevated serum concentrations following oral administration, making it a valuable tool for research on antibiotic resistance and evaluation of combination therapies.

Cat. No.

A46633

CAS No.

9012-26-4

Cephalosporinase,bacillus

Cephalosporinase, bacillus is an enzyme that functions as a β-lactamase, inactivating and degrading the activity of cephalosporin antibiotics. This enzyme is essential for research on antibiotic resistance mechanisms in bacteria, as it allows the study of the efficacy of cephalosporins against resistant strains. It is useful in developing strategies to combat bacterial infections and improve antibiotic therapies.

Cat. No.

A46695

CAS No.

2114651-20-4

β-Lactamase-IN-2

Synonyms: EX-A4764; UUN51204

β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings.

Cat. No.

A46753

CAS No.

1379594-98-5

Enmetazobactam iodide

Synonyms: AAI101 iodide

Enmetazobactam iodide is an extended-spectrum β-lactamase inhibitor that targets various β-lactamase enzymes produced by resistant Gram-negative bacteria. This compound effectively enhances the efficacy of β-lactam antibiotics, making it a valuable tool in combating antibiotic resistance. Research applications include studying antibiotic resistance mechanisms and developing novel therapeutic strategies against multidrug-resistant infections.

Cat. No.

A46760

CAS No.

2832966-95-5

MB076

MB076 is a heterocyclic triazole that acts as an inhibitor of Class C Acinetobacter-derived cephalosporinases (ADCs), displaying improved plasma stability. This compound efficiently inhibits seven β-lactamase variants with Ki values less than 1 μM, offering potential in combating antibiotic resistance. Additionally, MB076 demonstrates synergistic effects when combined with various cephalosporins, effectively restoring susceptibility in pBCSK(-) strains. This makes it a valuable reagent for research related to antibiotic resistance mechanisms and β-lactamase inhibition.

Cat. No.

A47220

CAS No.

87238-52-6

Ritipenem acoxil

Synonyms: FCE 22891; RIPM-AC; Ritipenem acetoxymethyl ester

Ritipenem acoxil is an oral-active beta-lactamase antibiotic designed to inhibit bacterial cell wall synthesis. It demonstrates significant activity against various bacterial strains, making it a valuable tool in the study of bacterial pneumonia. This compound serves as a critical reagent for researchers investigating antibiotic resistance and the mechanisms of bacterial infections.

Cat. No.

A47525

CAS No.

414858-51-8

AM-112

AM-112 is a potent β-lactamase inhibitor that targets class A, C, and D β-lactamase enzymes, demonstrating IC50 values as low as 0.0002 μg/mL. Its mechanism involves the inhibition of PBP2, a penicillin-binding protein in E. coli, thereby protecting Ceftazidime from enzymatic hydrolysis and enhancing its antibacterial activity against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability, making it a valuable tool for research into bacterial infections.

Cat. No.

A47843

CAS No.

102507-71-1

Tigemonam

Tigemonam is a monobactam antibiotic that targets β-lactamase enzymes, demonstrating a Ki of 0.86 μM against Enterobacter cloacae P99 and 50.8 μM against Escherichia coli TEM-1. It binds to penicillin-binding proteins 1a, 3, and 4, effectively inhibiting bacterial cell wall synthesis and exhibiting bactericidal activity against a range of aerobic gram-negative bacteria, including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam is resistant to hydrolysis by multiple β-lactamases and has been shown to reduce bacterial load in systemic and localized infections in rodent models. This compound is valuable for research into gram-negative bacterial infections, particularly acute pyelonephritis, lung infections, and thigh muscle infections.

Cat. No.

A47864

CAS No.

2244235-49-0

Taniborbactam hydrochloride

Synonyms: VNRX-5133 hydrochloride

Taniborbactam hydrochloride is a reversible and selective β-lactamase inhibitor that targets various β-lactamase enzymes, demonstrating IC50 values ranging from 8 to 530 nM, with specific IC50s of 30 nM for KPC-2, 32 nM for AmpC, 42 nM for OXA-48, and 20 nM for VIM-2. This compound is effective against Gram-negative bacteria, making it a valuable tool in the study of antibiotic resistance mechanisms and the development of novel antibacterial strategies. Researchers can utilize Taniborbactam hydrochloride in investigations aimed at enhancing the efficacy of β-lactam antibiotics.

Cat. No.

A47883

CAS No.

2170848-99-2

Xeruborbactam disodium

Xeruborbactam disodium is a potent beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with exceptional efficacy. This ultra-broad-spectrum compound operates at nanomolar concentrations, rendering it a valuable tool in combating antibiotic resistance. It is suitable for research applications aimed at understanding beta-lactamase mechanisms and developing new therapeutic strategies against resistant bacterial strains.

Cat. No.

A47955

CAS No.

2410688-61-6

Pilabactam sodium

Synonyms: ANT3310 sodium

Pilabactam sodium is a potent serine β-lactamase inhibitor that demonstrates broad-spectrum activity, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase enzymes. This compound enhances the efficacy of β-lactam antibiotics against strains of Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium is essential for research aimed at understanding and overcoming bacterial infections, particularly those caused by resistant pathogens.

Cat. No.

A48010

CAS No.

228579-27-9

Cymal-6

Synonyms: Cyclohexyl-hexyl-β-D-maltoside

Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a potent inhibitor of TEM-1 β-lactamase, exhibiting a Ki value of 40.05 µM. This compound serves as a glycosidic surfactant, facilitating various biochemical applications. Its inhibitory properties make it valuable for research focused on antibiotic resistance and enzyme activity modulation.

Cat. No.

A48029

CAS No.

1842397-36-7

Ledaborbactam

Synonyms: VNRX-5236

Ledaborbactam is a β-lactamase inhibitor that targets various β-lactamase enzymes, enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. This compound is instrumental in research focused on combating bacterial infections, especially those caused by multidrug-resistant organisms. Its ability to inhibit β-lactamases makes it a valuable tool for investigating and developing novel therapeutic approaches in infectious disease treatment.

Cat. No.

A48071

CAS No.

2365454-12-0

Funobactam

Synonyms: XNW4107

Funobactam is a β-lactamase inhibitor that targets bacterial enzymes responsible for antibiotic resistance. This compound exhibits potent activity against various β-lactamases, making it a valuable tool in the study of antibiotic mechanisms and the development of novel antimicrobial agents. Funobactam is particularly useful in research applications focused on overcoming bacterial resistance to β-lactam antibiotics.

Cat. No.

A48150

CAS No.

2058151-78-1

MK-3402

MK-3402 is a potent metallo-β-lactamase inhibitor that exhibits IC50 values of 0.53 nM, 0.25 nM, and 0.169 nM against enzymes IMP-1, NDM-1, and VIM-1, respectively. This compound enhances the efficacy of beta-lactam antibiotics and is valuable in bacterial research, particularly in studies focused on combating antibiotic resistance. MK-3402's strong inhibitory properties make it a critical tool for investigating metallo-β-lactamase-mediated resistance mechanisms.

Cat. No.

A48228

CAS No.

2580120-08-5

BLI-489 hydrate

BLI-489 hydrate is a penem β-lactamase inhibitor that effectively targets class A, class C, and certain class D β-lactamases. This compound demonstrates notable biological activity when used in combination with Piperacillin, showing efficacy against murine infections caused by pathogens expressing extended-spectrum β-lactamases, AmpC β-lactamases, and class D β-lactamases. BLI-489 hydrate is a valuable reagent for research into antibiotic resistance and the development of combination therapies.

Cat. No.

A48241

CAS No.

1804915-68-1

WCK-4234

WCK-4234 is a potent β-lactamase inhibitor that effectively targets class A, C, and D β-lactamases. While lacking direct antibacterial activity, WCK-4234 enhances the efficacy of carbapenems such as imipenem and meropenem against Enterobacteriaceae possessing OXA-48/OXA-181 or KPC enzymes, as well as those exhibiting combinations of impermeability and AmpC or ESBL activity. This compound is particularly noteworthy for its ability to overcome resistance conferred by OXA-type carbapenemases, making it valuable for research in antibiotic resistance mechanisms.

Cat. No.

A48309

CAS No.

1452459-52-7

FPI-1523 sodium

FPI-1523 sodium is a potent β-lactamase inhibitor targeting CTX-M-15 and OXA-48, with dissociation constants (Kd) of 4 nM and 34 nM, respectively. Additionally, it inhibits penicillin-binding protein 2 (PBP2) with an IC50 of 3.2 μM. FPI-1523 sodium demonstrates significant antimicrobial activity, making it a valuable reagent in the study of antibiotic resistance and the development of novel antimicrobial therapies.

Cat. No.

A48356

CAS No.

1087784-71-1

Metallo β-lactamase ligand 1

Metallo β-lactamase ligand 1 is an established class B β-lactamase inhibitor that targets metallo-β-lactamases, enzymes responsible for antibiotic resistance. This compound exhibits significant antibacterial activity, making it a useful tool in combating infections caused by β-lactamase-producing bacteria. It is particularly valuable in research focused on developing new antimicrobial strategies and understanding the mechanism of β-lactamase-mediated resistance.

Cat. No.

A48362

CAS No.

112714-99-5

Sodium new houttuyfonate

Synonyms: SNH

Sodium new houttuyfonate is a partially reversible inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1), exhibiting an IC50 value of 14.2 μM. This compound also demonstrates inhibitory activity against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate has potential applications in restoring the antibacterial efficacy of Meropenem against antibiotic-resistant E. coli strains harboring the blaNDM-1 gene, making it a valuable tool in combating multidrug-resistant infections.

Cat. No.

A48376

CAS No.

73335-78-1

Brobactam sodium

Brobactam sodium is a potent synthetic β-lactamase inhibitor that effectively targets various β-lactamase enzymes. This compound exhibits broad-spectrum antibacterial activity, making it a valuable tool for enhancing the efficacy of β-lactam antibiotics. Brobactam sodium is primarily utilized in research applications aimed at understanding antibiotic resistance mechanisms and developing new therapeutic strategies against resistant bacterial strains.

Cat. No.

A48446

CAS No.

1452459-50-5

FPI-1523

FPI-1523 is a potent β-lactamase inhibitor targeting CTX-M-15 and OXA-48, exhibiting dissociation constants (Kd) of 4 nM and 34 nM, respectively. Additionally, it inhibits penicillin-binding protein 2 (PBP2) with an IC50 of 3.2 μM. FPI-1523 demonstrates significant antimicrobial activity, making it a valuable reagent for research in antibiotic resistance and bacterial infection studies.