Catalog No.
Product Name
Application
Product Information
Citations
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Beta-Lactamase Inhibitor
β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings. -
β-lactamase Inhibitor
Enmetazobactam iodide is an extended-spectrum β-lactamase inhibitor that targets various β-lactamase enzymes produced by resistant Gram-negative bacteria. This compound effectively enhances the efficacy of β-lactam antibiotics, making it a valuable tool in combating antibiotic resistance. Research applications include studying antibiotic resistance mechanisms and developing novel therapeutic strategies against multidrug-resistant infections. -
β-lactamase inhibitor
ETX0282 is a β-lactamase inhibitor that functions as an orally active prodrug, converted in the liver to its active form, ETX1317. This compound demonstrates excellent stability during intestinal absorption and enhances the efficacy of antibiotics, like Cefpodoxime Proxetil, in reducing bacterial load in models of neutropenic infections. ETX0282 is useful for research focused on combating infections caused by drug-resistant Gram-negative bacteria. -
Beta-lactamase
CENTA is a colorimetric substrate specifically designed for the detection of beta-lactamase activity. Upon hydrolysis by beta-lactamases, CENTA undergoes a color change from light yellow to chrome yellow, facilitating quantification via colorimetric detection at 405 nm. This property makes CENTA an effective tool for studying β-lactamase function and assessing antibiotic resistance mechanisms in microbial research. -
β-Lactamase
β-Lactamase is an enzyme produced by various bacteria that hydrolyzes β-lactam antibiotics, thereby contributing to antibiotic resistance. This enzyme plays a critical role in bacterial survival against β-lactam treatments, making it a key target for research in antimicrobial resistance. It is utilized in the study of antibiotic efficacy and the development of β-lactamase inhibitors for overcoming resistance mechanisms in pathogenic bacteria. -
Beta-lactamase Inhibitor
Doxazosin impurity 12 is identified as a CTX-M β-lactamase inhibitor, exhibiting a Ki value of 0.7 mM against the CTX-M enzyme. This compound is valuable for research applications aimed at overcoming antibiotic resistance mediated by β-lactamases, particularly in the study of bacterial infections and the development of novel antimicrobial strategies. -
Metallo-β-Lactamase Inhibitor
Metallo-β-lactamase-IN-14 is a potent inhibitor of metallo-β-lactamases, specifically targeting VIM-1 and VIM-2 enzymes. This compound demonstrates significant antibacterial activity against Gram-negative bacteria, including Pseudomonas aeruginosa. It is a valuable tool for research applications aimed at combating resistance in clinical pathogens. -
Metallo-β-Lactamase Inhibitor
Metallo-β-lactamase-IN-13 is a potent inhibitor of metallo-β-lactamases, targeting enzymes that confer resistance in Gram-negative bacteria. This compound demonstrates significant antibacterial activity against Pseudomonas aeruginosa, making it an important tool for research into combating antibiotic resistance. Its broad-spectrum activity against various metallo-β-lactamases supports investigations into novel therapeutic strategies for treating resistant bacterial infections. -
β-lactamase II Inhibitor
N-Cbz-D-Cysteine is a potent inhibitor of β-lactamase II with a Ki value of 20.1 µM. This compound can be utilized in the study of antibiotic resistance mechanisms and the development of novel β-lactamase inhibitors. N-Cbz-D-Cysteine's biological activity makes it a valuable reagent in research focusing on antimicrobial strategies and enzymatic inhibition. -
β-lactamase II Inhibitor
N-Cbz-L-Cysteine is a potent inhibitor of β-lactamase II, demonstrating a Ki value of 97 µM. This compound is useful in biochemical research aimed at overcoming antibiotic resistance by targeting β-lactamase enzymes. N-Cbz-L-Cysteine may be employed in studies exploring the inhibition of β-lactamase-mediated antibiotic degradation and enhancing the efficacy of β-lactam antibiotics. -
Beta-lactamase Inhibitor
Xeruborbactam isoboxil is a novel beta-lactamase inhibitor that effectively targets and inhibits the activity of various beta-lactamases. Its primary mechanism involves the binding to the active site of these enzymes, preserving the efficacy of beta-lactam antibiotics. This compound is particularly valuable in combating antibiotic resistance and is utilized in research focused on understanding and overcoming beta-lactam resistance in bacterial infections. -
β-lactamase Inhibitor
GT-055 is a potent β-lactamase inhibitor that demonstrates broad-spectrum activity against a variety of β-lactamase enzymes. This compound effectively enhances the efficacy of β-lactam antibiotics by preventing their hydrolysis, making it a valuable tool in combating antibiotic resistance. GT-055 is suitable for research applications focused on understanding β-lactamase mechanisms and developing new therapeutic strategies. -
Metallo-β-lactamases (MBLs) Inhibitor
epi-D-Captopril is a stereoisomer of Captopril that serves as an inhibitor of metallo-β-lactamases (MBLs). It demonstrates inhibitory activity with IC50 values against NDM-1, IMP-1, and VIM-2 of 64 μM, 173 μM, and 5.5 μM, respectively. This reagent is useful for research applications focused on understanding and addressing drug-resistant bacterial infections associated with MBLs. -
Beta-lactamase Inhibitor
ANT431 is a metallo-β-lactamase inhibitor that enhances the efficacy of beta-lactam antibiotics, particularly Meropenem. This compound is designed for applications in combating antibiotic resistance by restoring the effectiveness of β-lactam antibiotics in bacterial infections, specifically in models involving Escherichia coli. Its potential utility in therapeutic contexts makes it a valuable reagent for microbiological and pharmacological research. -
β-lactamase Inhibitor
Izumenolide is a potent β-lactamase inhibitor derived from the strain Micromonospora chalcea subsp. izumensis. It exhibits significant inhibitory activity against certain β-lactamases, with an IC50 value of 0.01 μg/mL specifically for TEM-2 β-lactamase. This compound is valuable for research applications focused on antibiotic resistance and the development of new therapeutic strategies targeting bacterial infections. -
Serine β-Lactamase Inhibitor
Pilabactam is a potent covalent inhibitor of serine β-lactamases, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase types. This compound significantly enhances the efficacy of β-lactam antibiotics against challenging pathogens such as Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam is valuable in research focused on bacterial infections and antibiotic resistance mechanisms. -
β-lactamase Inhibitor
β-Lactamase-IN-5 is a potent β-lactamase inhibitor that serves to enhance the efficacy of β-lactam antibiotics against resistant bacterial strains. Its primary mechanism involves the inhibition of β-lactamase enzymes, which are responsible for antibiotic resistance. This compound is valuable for research applications aimed at understanding and combating bacterial infections, particularly those caused by multidrug-resistant pathogens. -
β-Lactamase
ETX1317 is a potent β-lactamase inhibitor designed to restore the antibacterial efficacy of various β-lactam antibiotics, including third-generation cephalosporins like Cefpodoxime. This reagent is ideal for investigating bacterial resistance mechanisms and enhancing the therapeutic effectiveness of β-lactam therapies in research settings focused on bacterial infections. -
β-lactamase Inhibitor
CB-618 is a β-lactamase inhibitor that reversibly covalently interacts with Ambler class A, C, and select class D serine β-lactamases. While it exhibits limited antibacterial activity on its own, CB-618 notably enhances the effectiveness of Meropenem against enzyme-producing Enterobacteriaceae. This compound is a valuable tool for research focused on combating drug-resistant bacterial strains. -
β-Lactamase Inhibitor
LN-1-255 sodium is a β-lactamase inhibitor designed to effectively combat resistance in bacteria. It exhibits a broad-spectrum inhibitory effect on type D carbapenemases, demonstrating an IC50 of 3 nM against OXA-48, while also showing strong activity against OXA-23 and OXA-24/40. The compound enhances the efficacy of carbapenem antibiotics through a synergistic mechanism. LN-1-255 sodium is a valuable tool for researching the challenges posed by carbapenem-hydrolyzing class D β-lactamases (CHDLs) in bacterial resistance. -
Beta-lactamase Inhibitor
Relebactam sodium is a potent and selective β-lactamase inhibitor that functions to inhibit the enzymatic breakdown of β-lactam antibiotics. By binding to a diverse range of β-lactamases, Relebactam sodium enhances the effectiveness of these antibiotics and delays the emergence of bacterial resistance. This compound is particularly valuable in research focusing on combating complex bacterial infections and improving antibiotic therapeutic options. -
Beta-lactamase Inhibitor
Ent-Avibactam sodium is a β-lactamase inhibitor designed to combat a wide range of bacterial infections. It effectively inhibits Ambler A and C type β-lactamases produced by Enterobacteriaceae, enhancing the efficacy of β-lactam antibiotics like Cefazidime. With an IC50 value significantly lower than other commonly used β-lactamase inhibitors, ent-Avibactam sodium demonstrates superior potency against TEM-1 and P99 enzymes, making it a valuable tool for bacterial resistance research and antibiotic development. -
Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-8 is a potent reversible and competitive inhibitor of metallo-β-lactamases (MβLs), exhibiting IC50 values of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM against L1, ImiS, IMP-1, and VIM-2 respectively. This compound demonstrates significant antibacterial activity, making it a valuable tool for studying β-lactam resistance mechanisms in bacterial pathogens. Its ability to inhibit a broad spectrum of MβLs highlights its potential for research applications in antimicrobial resistance and drug development. -
β-lactamase/PBP Inhibitor
FPI-1465 is a dual inhibitor targeting serine β-lactamases and penicillin-binding proteins (PBPs). This compound effectively inhibits PBP2 with an IC50 value of 1.0 µg/mL, demonstrating significant activity against β-lactamase enzymes CTX-M-15 and OXA-48, with Kd values of 0.011 µM and 5.3 µM, respectively. FPI-1465 is suitable for research applications focused on antibiotic resistance and the modulation of β-lactam antibiotic efficacy. -
Beta-lactamase Inhibitor
Xeruborbactam is a potent boronic acid beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with high efficacy. Demonstrating activity in the nanomolar range, it serves as an ultra-broad-spectrum agent in combating antibiotic resistance. Xeruborbactam is valuable for research applications focused on understanding beta-lactamase activity and developing novel antimicrobial strategies. -
VIM-Type Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-7 is a specific inhibitor of VIM-type metallo-β-lactamases, demonstrating potent inhibition with IC50 values of 0.019 μM for VIM-2, 13.64 μM for VIM-1, and 0.38 μM for VIM-5. This compound enhances the antibacterial efficacy of Meropenem against Gram-negative bacterial strains, making it a valuable tool in combating antibiotic resistance in microbial research. Its application is crucial for studies focused on understanding and overcoming metallo-β-lactamase mediated resistance mechanisms. -
β-lactamase Inhibitor
β-Lactamase-IN-4 is a potent β-lactamase inhibitor that targets β-lactamase enzymes, effectively enhancing the efficacy of β-lactam antibiotics. This compound is critical for research applications focused on combating bacterial infections caused by β-lactamase-producing microorganisms. Its use may contribute to the development of novel therapeutic strategies against resistant bacterial strains. -
VIM-Type Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-6 is a potent inhibitor of VIM-type metallo-β-lactamases, demonstrating IC50 values of 0.56 μM for VIM-2, 29.50 μM for VIM-1, and 5.78 μM for VIM-5. This compound exhibits significant antibacterial synergy with Meropenem against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa strains that produce VIM-2 metallo-β-lactamase. It serves as a valuable research tool for exploring resistance mechanisms in bacterial pathogens and for developing novel therapeutic strategies. -
β-lactamase Inhibitor
FPI-1602 is a β-lactamase inhibitor that enhances the efficacy of β-lactam antibiotics. It exhibits significant antimicrobial activity against pathogens such as Pseudomonas aeruginosa, Escherichia coli, and Enterobacter spp. This compound is valuable for research applications aimed at overcoming antibiotic resistance mediated by β-lactamase enzymes. -
β-lactamase Inhibitor
Brobactam is a potent synthetic β-lactamase inhibitor designed to combat antibiotic resistance by inhibiting β-lactamase enzymes. It exhibits broad-spectrum antibacterial activity, making it valuable in the study and treatment of β-lactamase-mediated resistance in various bacterial infections. Research applications include the evaluation of combination therapies and the development of novel antibacterial agents. -
β-Lactamase Inhibitor
KSP-1007 is a bicyclic boronate compound functioning as a broad-spectrum β-lactamase inhibitor. It effectively targets class A, B, C, and D β-lactamases, including serine-type and metallo-type enzymes such as NDM, VIM, and IMP, in addition to Acinetobacter baumannii OXA-type enzymes. KSP-1007 enhances the antibacterial activity of Meropenem, decreasing its minimum inhibitory concentration (MIC) against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. This reagent is suitable for research on bacterial infections and antibiotic resistance mechanisms. -
β-Lactamase Inhibitor
Ledaborbactam etzadroxil is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes. It is designed to provide enhanced protection for β-lactam antibiotics from hydrolysis by these enzymes, thereby improving their efficacy. This compound is particularly relevant in research applications focused on combating antibiotic resistance and expanding the therapeutic options for bacterial infections. -
β-lactamase Inhibitor
β-Lactamase-IN-8 is a potent β-lactamase inhibitor with a broad-spectrum profile, utilizing a cyclic boronate structure to enhance oral bioavailability. It effectively inhibits various β-lactamases, making it a valuable tool for studying antibacterial resistance mechanisms and developing new therapeutic strategies against resistant bacterial strains. Researchers can utilize β-Lactamase-IN-8 for investigating the efficacy of β-lactam antibiotics in microbial infections. -
Metallo-β-lactamase Inhibitor
β-Lactamase-IN-7 is a potent inhibitor of VIM-type metallo-β-lactamases, exhibiting inhibition constants (Ki) of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. This compound demonstrates effective inhibition against Klebsiella pneumoniae, making it valuable for studies focused on antibiotic resistance and the development of novel therapeutic strategies against resistant bacterial infections. Its role in characterizing metallo-β-lactamase activity positions it as an important tool in chemical biology research.
