β-lactamase

Cat. No.

A11299

CAS No.

1192500-31-4

Avibactam

Synonyms: NXL-104 free acid

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.

Cat. No.

A11648

CAS No.

68373-14-8

Sulbactam

Sulbactam is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.

Cat. No.

A11651

CAS No.

69388-84-7

Sulbactam sodium

Synonyms: CP45899 sodium

Sulbactam sodium is a competitive, irreversible beta-lactamase inhibitor, primarily targeting beta-lactamases in bacterial pathogens. It exhibits significant antimicrobial activity against multidrug-resistant Acinetobacter calcoaceticus–Acinetobacter baumannii (Acb) complex, making it a valuable compound for research into antibiotic resistance. This reagent is useful for studying mechanisms of resistance and developing novel therapeutic strategies in the fight against MDR infections.

Cat. No.

A12384

CAS No.

58001-44-8

Clavulanic acid

Clavulanic acid is a mechanism-based β-lactamase inhibitorcombined with penicillin group antibiotics to overcome certain types of antibiotic resistance.

Cat. No.

A13801

CAS No.

1467157-21-6

Durlobactam sodium

Durlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate.

Cat. No.

A14053

CAS No.

89786-04-9

Tazobactam

Synonyms: CL-298741; YTR-830H

Tazobactam is a potent β-lactamase inhibitor that enhances the effectiveness of β-lactam antibiotics by preventing the hydrolysis of the β-lactam ring. This compound exhibits significant antibacterial activity, making it a valuable tool in the study of bacterial resistance mechanisms. Tazobactam is particularly useful in research related to pneumonia and other infections caused by β-lactamase-producing pathogens.

Cat. No.

A16437

CAS No.

58-71-9

Cephalothin sodium

Synonyms: Cefalotin

Cephalothin sodium is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.

Cat. No.

A16739

CAS No.

89785-84-2

Tazobactam sodium

Tazobactam sodium is a beta-lactamase inhibitor that enhances the efficacy of beta-lactam antibiotics by preventing the breakdown of their molecular structure. It is commonly used in combination with ceftolozane to extend its antimicrobial activity against extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and certain Bacteroides species. This compound is valuable in research applications focused on combating antibiotic resistance and studying the mechanisms of beta-lactamase enzymes.

Cat. No.

A17306

CAS No.

1192491-61-4

Avibactam sodium

Synonyms: NXL-104

Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.

Cat. No.

A17914

CAS No.

72558-82-8

Ceftazidime

Synonyms: GR20263

Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.

Cat. No.

A18341

CAS No.

1001404-83-6

AAI101

Synonyms: Enmetazobactam

AAI-101, also known as Enmetazobactam, is a beta lactamase inhibitor potentially for the treatment of multi-drug resistant gram-negative bacterial infections.

Cat. No.

A18722

CAS No.

1436861-97-0

Zidebactam

Synonyms: WCK-5107

Zidebactam (WCK-5107) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL.

Cat. No.

A18824

CAS No.

1613268-23-7

VNRX-5133

VNRX-5133 is a cyclic boronate β-lactamase inhibitor.

Cat. No.

A19471

CAS No.

1452458-86-4

Nacubactam

Synonyms: OP0595 free acid; OP 0595

Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases.

Cat. No.

A20232

CAS No.

1613267-49-4

Taniborbactam

Taniborbactam is a potent inhibitor of β-lactamase, with IC50s of

Cat. No.

A20638

CAS No.

1360457-46-0

Vaborbactam

Synonyms: RPX7009

Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

Cat. No.

A20726

CAS No.

102209-75-6

BRL-42715

BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .

Cat. No.

A20784

CAS No.

1075237-97-6

beta-lactamase-IN-1

beta-lactamase-IN-1 targets Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.

Cat. No.

A21071

CAS No.

1174018-99-5

Relebactam

Synonyms: MK-7655

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes.

Cat. No.

A21896

CAS No.

1706777-46-9

Zidebactam sodium salt

Synonyms: WCK-5107 sodium salt; WCK5107

Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL.

Cat. No.

A22051

CAS No.

120788-07-0

Sulopenem

Synonyms: CP-70429

Sulopenem (CP-70429) is an orally active, potent inhibitor of beta-lactamase. Sulopenem is a parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria.

Cat. No.

A27404

CAS No.

11048-15-0

Kalafungin

Synonyms: Kalamycin; U-19718

Kalafungin is a β-lactamase inhibitor derived from marine Streptomyces, exhibiting an IC50 value of 225.37 μM. This compound demonstrates potent antimicrobial activity against a range of pathogenic fungi, yeasts, and protozoa, as well as significant effects on gram-positive bacteria like Staphylococcus aureus. Additionally, Kalafungin shows moderate activity against select gram-negative bacteria, making it a valuable tool for research in antibiotic resistance and microbial pathogenesis.

Cat. No.

A32138

CAS No.

1417737-65-5

Metallo-β-lactamase-IN-5

Metallo-β-lactamase-IN-5 is a potent inhibitor of metallo-β-lactamases (MBLs), specifically targeting NDM-1 and VIM-1 enzymes. This compound demonstrates significant biological activity with an IC50 of 45 μg/mL against human umbilical vein endothelial cells (HUVECs). Additionally, the combination of Metallo-β-lactamase-IN-5 with Imipenem leads to synergistic antimicrobial effects, making it a valuable reagent for research into antibiotic resistance and potential therapeutic strategies.

Cat. No.

A35352

CAS No.

4155-82-2

RDR 02308

RDR 02308 is a β-lactamase inhibitor that targets the TLR4-MyD88 signaling pathway. This compound effectively inhibits the activity of full-length β-lactamase, providing a valuable tool for studies related to antibiotic resistance. Its mechanism of action makes it suitable for research applications focused on bacterial infections and the development of novel therapeutic strategies.

Cat. No.

A46317

CAS No.

41906-86-9

Nitrocefin

Nitrocefin is a chromogenic substrate specifically targeting β-lactamase enzymes. It displays a characteristic color shift from yellow to red upon hydrolysis of the β-lactam ring, enabling visual quantification of β-lactamase activity. This reagent is widely utilized in studies of enzyme inhibition and the development of β-lactamase-resistant antibiotics.