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Catalog No.
Product Name
Application
Product Information
Citations
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Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 3 is a selective inhibitor of chitin synthase, exhibiting an IC50 value of 0.16 mM. This compound demonstrates significant antifungal activity, with a minimum inhibitory concentration (MIC) of 1 µg/mL against Candida albicans. It is primarily utilized in research applications focusing on antifungal drug development and the study of chitin biosynthesis pathways in pathogenic fungi. -
Fungal Inhibitor
Antifungal Agent 16 is a potent fungal inhibitor, demonstrating significant antifungal activity compared to established agents such as ciprofloxacin and fluconazole. This compound is ideal for research aimed at exploring new antifungal therapies and addressing drug resistance in fungal pathogens. Its robust efficacy makes it a valuable tool in the investigation of fungal infections and therapeutics. -
Fungal Inhibitor
Antifungal agent 12 is a fluconazole-based compound that functions as a fungal inhibitor by disrupting fungal cell membrane synthesis. It demonstrates significant antifungal activity, making it suitable for research applications focused on fungal infections and resistance mechanisms. This compound can be utilized in studies aimed at developing new antifungal therapies. -
Fungal Inhibitor
3,5-Dimethyl-4-phenylisoxazole acts as a fungal inhibitor by disrupting fungal cell function. This heterocyclic compound demonstrates significant anti-fungal activity, making it a valuable tool for research in mycology and infectious disease studies. Additionally, it has shown promise in anti-inflammatory and anti-bacterial applications, indicating its potential for broader biological research. Its ability to modulate immune responses further highlights its versatility in various scientific investigations. -
Fungal Inhibitor
Fumigaclavine A is a clavine alkaloid that acts as a fungal inhibitor targeting Aspergillus species. This mycotoxin, produced by Aspergillus fumigatus, is significant in studies related to fungal contamination and plant disease management. Research applications include investigating the pathogenicity of A. fumigatus and assessing the efficacy of antifungal agents in various environments. -
Fungal Inhibitor
(-)-Zonarol is a potent antifungal agent that targets and inhibits fungal growth. This compound exhibits diverse translational potential in research applications, particularly in the study of fungal infections and resistance mechanisms. As an isomer of Zonarol and related to the natural product (-)-Yahazunol, (-)-Zonarol provides valuable insights into fungal biology and therapeutic strategies. -
Germination Self-inhibitor
Methyl (Z)-ferulate is a natural germination self-inhibitor primarily derived from the leaves of Tetragonia tetragonoides. It effectively blocks germination in rust fungi by reversibly inhibiting the degradation of the germination pore plug through modulation of existing enzyme activity. In addition to its antifungal properties, Methyl (Z)-ferulate exhibits antioxidant activity, demonstrating significant scavenging capabilities against DPPH and ABTS+ radicals. This compound is valuable for research applications focused on plant defense mechanisms and antioxidant strategies. -
C. albicans Nmt Inhibitor
SC-58272 is a potent and selective inhibitor of N-myristoyltransferase (Nmt) in Candida albicans, exhibiting an IC50 of 56 nM against the strain B311. This compound demonstrates a 250-fold selectivity for the fungal enzyme when compared to the human counterpart. SC-58272 is valuable for research applications involving fungal pathogenesis and the study of myristoylation processes in C. albicans. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 2 selectively targets chitin synthase, demonstrating potent inhibitory effects with an IC50 of 0.09 mM and a Ki of 0.12 mM. This compound exhibits significant antimicrobial activity in vitro and can enhance the effects of fluconazole and polyoxin B, making it a valuable tool for investigating chitin biosynthesis and potential applications in antifungal research. -
Succinate Dehydrogenase Inhibitor
Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens. -
SDH Inhibitor/Antifungal Agent
SDH-IN-13 (Compound 5IIIh) is an inhibitor of succinate dehydrogenase (SDH) with an IC50 of 13.7 μg/mL. This compound exhibits antifungal activity, making it a valuable tool in the study of fungal pathogens and mitochondrial function. Its selective targeting of SDH positions it as a promising candidate for further research in antifungal therapies. -
SDH Inhibitor
SDH-IN-4 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.28 μg/mL. This compound demonstrates potent antifungal activity, specifically against Rhizoctonia solani, with an EC50 value of 0.23 μg/mL. SDH-IN-4 is primarily utilized in research applications involving fungal pathogen studies and metabolic pathway analysis. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 6 is a potent inhibitor of chitin synthase (CHS) with an IC50 value of 0.21 mM. This compound exhibits broad-spectrum antifungal activity against drug-resistant fungi, making it a valuable tool in the study of fungal infections. It is applicable in research focused on understanding fungal pathogenesis and developing antifungal therapies. -
Fungal Inhibitor
Antifungal Agent 68 is a potent inhibitor targeting fungal ergosterol biosynthesis, with demonstrated efficacy against Candida species and Cryptococcus gattii. This compound likely exerts its antifungal effects by inhibiting lanosterol 14α-demethylase (CYP51), wherein its imidazole ring interacts with the heme group of the enzyme. It serves as a valuable tool for research into fungal infections and the development of novel antifungal therapies. -
β-1,3-Glucan Inhibitor
Ibrexafungerp phosphate is a selective inhibitor of β-1,3-glucan synthesis, exhibiting notable antifungal activity. This compound is primarily utilized in research related to fungal pathogens, particularly for investigating infections caused by Candida and Aspergillus species. Its mechanism of action disrupts the integrity of the fungal cell wall, making it a valuable tool for exploring antifungal therapies. -
Ole1p Inhibitor
N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is an inhibitor of Ole1p desaturase, an important enzyme in the biosynthesis of unsaturated fatty acids. This compound exhibits antifungal activity, making it a valuable tool for research in antifungal drug development and lipid metabolism studies. It is suitable for investigating the mechanisms of fungal resistance and characterizing lipid profiles in various biological systems. -
Fungal Inhibitor
Antifungal agent 13 is a potent fungal inhibitor specifically targeting Sclerotinia sclerotiorum, exhibiting an effective concentration (EC50) of 1.25 mg/L. This compound demonstrates significant antifungal activity, making it a valuable tool for research into fungal pathogenesis and susceptibility. Its application includes studies aimed at understanding fungal resistance mechanisms and the development of novel antifungal therapies. -
Fungal Inhibitor
Diethofencarb is a fungicide that exhibits potent activity against Botrytis cinerea and Benzimidazole-resistant strains of Botrytis species. It functions primarily as an antifungal agent in agricultural applications, demonstrating efficacy in managing fungal pathogens in crops. Researchers may utilize Diethofencarb for studies related to fungal resistance mechanisms and the development of sustainable pest management strategies. -
Fungal Inhibitor
Antifungal agent 11 targets fungal organisms by inhibiting key metabolic processes, demonstrating significant antifungal activity. This compound is valuable in research applications aimed at understanding fungal behavior and developing new antifungal treatments. Its efficacy against various fungal strains makes it an essential tool for studying fungal infections and resistance mechanisms. -
CHS Inhibitor
Chitin Synthase Inhibitor 10 is a potent chitin synthase inhibitor, demonstrating an IC50 value of 0.11 mM. This compound exhibits significant antifungal activity, particularly against drug-resistant fungal strains such as Candida albicans and Cryptococcus neoformans. Chitin Synthase Inhibitor 10 is useful in the study of invasive fungal infections (IFIs), providing valuable insights into potential therapeutic strategies. -
Gamma-Glutamyl Transferase Inhibitor
Gamma-Glutamyl Transferase-IN-2 is a potent inhibitor of gamma-glutamyl transferase, a key enzyme involved in amino acid metabolism. This β-carboline 1-hydrazide compound demonstrates significant antifungal and antibacterial activities through its mechanism, which leads to the accumulation of reactive oxygen species, disruption of cell membranes, and alteration of histone acetylation patterns. Gamma-Glutamyl Transferase-IN-2 is valuable for research focused on understanding oxidative stress, cellular integrity, and epigenetic regulation in various biological systems. -
SDH Inhibitor
SDH-IN-6 is a potent inhibitor of succinate dehydrogenase (SDH). This compound demonstrates significant antifungal activity against Valsa mali, exhibiting an EC50 value of 1.77 mg/L. It is a valuable research tool for investigating the role of SDH in fungal metabolism and potential therapeutic approaches for treating fungal infections. -
Cholesterol Biosynthesis Inhibitor
Agistatin B is a mycotoxin derived from fungal sources that serves as a cholesterol biosynthesis inhibitor. This compound effectively disrupts the biosynthetic pathway of cholesterol, making it a valuable tool for studying lipid metabolism and related disorders. Its inhibition of cholesterol synthesis positions Agistatin B as an important reagent for research in areas such as cardiovascular disease and metabolic regulation. -
Synthesis Dextran Inhibitor
MK-5204 is an orally active inhibitor of β-1,3-glucan synthesis, targeting the pathways involved in fungal cell wall formation. Its primary mechanism disrupts the synthesis of glucans, which are essential for fungal structural integrity. This compound serves as a valuable tool in antifungal research and development, enabling the study of fungal pathogenesis and the evaluation of novel therapeutic strategies. MK-5204 is particularly useful in elucidating the role of glucans in fungal virulence and resistance mechanisms. -
Fungal Inhibitor
Fusapyrone is a broad-spectrum antifungal metabolite that targets fungal growth by inhibiting specific pathways in various fungal species. Initially isolated from Fusarium species, it demonstrates significant efficacy against ochratoxin-producing strains of Aspergillus section Nigri, making it valuable in the control of postharvest crop diseases. Its application in agricultural research allows for the exploration of novel antifungal strategies to enhance crop quality and safety. -
Fungal Inhibitor
Oxaziclomefone is a broad-spectrum fungicide that inhibits the growth of several plant pathogenic fungi. It exhibits significant antifungal activity, making it an effective agent in the control of various crop diseases. Oxaziclomefone is utilized in agricultural applications to safeguard crops, enhancing both yield and quality. -
Succinate Dehydrogenase Inhibitor
SDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways. -
Fungal Inhibitor
2,2-Dibromopropanoic acid is a dibromo derivative of propionic acid, functioning as a potent fungal inhibitor. This compound exhibits significant mold-inhibitory properties and is widely utilized in various research applications concerning food preservation and microbial control. Its role as a chemical intermediate further enhances its utility in synthetic chemistry and biochemistry studies. -
1,3-β-glucan Synthase Inhibitor
Arborcandin A is a potent inhibitor of 1,3-β-glucan synthase, serving as an effective antifungal antibiotic. It demonstrates significant antifungal activity with IC50 values of 0.25 μg/mL against Candida albicans and 0.05 μg/mL against Aspergillus fumigatus. Arborcandin A also exhibits a minimum inhibitory concentration (MIC) of 4-8 μg/mL against various Candida species, making it a valuable tool for research in fungal pathogenesis and treatment. -
Fungal Inhibitor
Fungicide4 is a potent fungal inhibitor targeting Phytophthora infestans. It exhibits significant activity against this strain, demonstrating its efficacy in controlling fungal outbreaks. This compound is valuable for research applications focused on plant pathology and the development of antifungal strategies. -
Chitin Synthesis Inhibitor
Cyclopent-4-ene-1,3-dione is a potent chitin synthesis inhibitor with significant antifungal activity against human pathogenic Candida species, exhibiting an IC50 in the range of 1-2 μM. Found in certain feijoa cultivars, this compound demonstrates strong antifungal bioactivity. It serves as a valuable tool for research focused on fungal infections and the mechanisms of antifungal resistance. -
Fungal Inhibitor
Chloracetophos is a potent fungal inhibitor that targets cell processes critical for fungal growth and survival. It exhibits significant antifungal activity, making it a valuable tool for research in mycology and agricultural applications. Its effectiveness in inhibiting fungal pathogens supports studies aimed at understanding fungal resistance mechanisms and developing new antifungal strategies. -
Antimicrobial Inhibitor
Antibacterial Agent 101 (Compd 7f) is an antimicrobial inhibitor targeting both bacterial and fungal pathogens. With minimum inhibitory concentration (MIC) values ranging from 4 to 32 µg/mL, it demonstrates potent antibacterial and antifungal activity. This compound is suitable for research applications focused on developing new antimicrobial therapies. -
Chitin Deacetylase Inhibitor
CDA-IN-1 is a potent inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal activity. This compound effectively suppresses fungal growth by inhibiting fungal CDA activity, stimulating the plant immune response, and promoting the accumulation of reactive oxygen species (ROS). At a concentration of 100 μM, CDA-IN-1 achieves inhibition rates of 86.9% and 74.5% against the chitin deacetylases PxCDA1 and PxCDA2 of Pseudoperonospora xanthii, respectively. CDA-IN-1 is a valuable tool for research into plant fungal disease control, particularly in studies focused on diseases such as cucurbit powdery mildew and tomato gray mold. -
Fungal Inhibitor
Oxadixyl is a fungicide that targets fungal growth by inhibiting key cellular processes. It demonstrates significant biological activity in the presence of fungi, making it useful for evaluating its effects on microbial populations during processes such as malic fermentation in winemaking. This compound is valuable for researchers investigating antifungal treatments and their implications in fermentation science. -
CYP51 Inhibitor
CYP51-IN-19 is a potent inhibitor of cytochrome P450 51 (CYP51), a critical enzyme involved in sterol biosynthesis in fungi. This compound induces the generation of reactive oxygen species (ROS), leading to significant fungicidal activity. It is primarily utilized in antifungal research and the development of therapeutic agents targeting fungal infections. -
Fungal Inhibitor
Antifungal agent 59 is a potent fungal inhibitor with minimum inhibitory concentration (MIC) values ranging from 0.01 to 1 μg/mL. This compound effectively disrupts the formation of fungal biofilms, making it a valuable tool for research in mycology and fungal pathogenesis. Its favorable safety profile further supports its application in studying antifungal mechanisms and therapeutic approaches. -
Fungal Inhibitor
Fludazonium chloride is a potent antifungal agent that targets a range of fungal pathogens. It exhibits strong inhibitory activity against both superficial and systemic fungal infections, making it suitable for therapeutic applications in mycoses treatment and prevention. This compound can be utilized in research to further understand antifungal mechanisms and develop new treatments. -
Microbial Inhibitor
Antifungal agent 38 is a heterocyclic disulfide that acts as a potent microbial inhibitor. Its primary mechanism involves inducing hyphal shrinkage and disrupting the integrity of the plasma membrane, leading to cellular damage and leakage of intracellular contents. This compound is valuable for research applications focused on antifungal and antibacterial activities, offering insights into cell membrane dynamics and potential therapeutic approaches against microbial infections. -
Antifungal Agent/HIV-1 Inhibitor
Amphotericin B methyl ester hydrochloride is a derivative of the polyene antibiotic amphotericin B, functioning primarily as an antifungal agent. This compound exhibits potent antifungal activity by binding to cholesterol in fungal cell membranes, leading to cell death. Additionally, it disrupts HIV-1 particle production and significantly inhibits HIV-1 replication, making it valuable for research in antifungal therapies and HIV treatment studies. -
Serine Palmitoyltransferase Inhibitor
Lipoxamycin is a potent serine palmitoyltransferase inhibitor, exhibiting an IC50 of 21 nM. This compound demonstrates significant antifungal activity, making it a valuable tool for studying lipid metabolism and sphingolipid biosynthesis. Lipoxamycin is applicable in research focused on fungal infections and potential avenues for therapeutic interventions targeting lipid-related pathways. -
SDH Iinhibitor
SDH-IN-5 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 3.293 μM. It exhibits significant antifungal activity, achieving an EC50 of 0.046 μg/mL against Rhizoctonia solani. In agricultural applications, SDH-IN-5 effectively inhibits the growth of R. solani in rice leaves, showcasing substantial protective and curative efficacies against this pathogen. -
Tau Aggregation Inhibitor
Nimbin is a potent tau aggregation inhibitor derived from the limonoid class of compounds found in Azadirachta. It is shown to enhance cell viability while effectively inhibiting the envelope protein of the dengue virus. Additionally, Nimbin exhibits a range of biological activities, including anti-inflammatory, antifungal, antihistamine, antiseptic, antioxidant, anticancer, and antiviral properties. This diverse activity profile makes Nimbin a valuable reagent for research in neurodegenerative diseases and viral infections. -
Fungal Inhibitor
2,4′-Dichloroacetanilide is a fungistatic agent that inhibits the growth of fungi by targeting key cellular processes. It demonstrates significant antifungal activity against Trichosporon asteroides, with a minimum inhibitory concentration (MIC) of 6.25 μg/mL. This compound is valuable for research applications involving fungal pathogenesis and the development of antifungal therapies. -
Fungal Inhibitor
Cyclo(Pro-dArg) is a potent chitinase inhibitor, primarily targeting fungal cell wall integrity. It effectively disrupts cell separation in Saccharomyces cerevisiae while having no significant impact on its overall growth. Additionally, Cyclo(Pro-dArg) inhibits the morphological transition of Candida albicans from yeast to filamentous forms, making it valuable for research in fungal biology and antifungal drug development. -
Fungal Inhibitor
4-Chlorosalicylic acid is a potent fungal inhibitor that functions primarily by inhibiting monophenolase and diphenolase activities, demonstrating IC50 values of 1.89 mM and 1.10 mM, respectively. It exhibits significant antimicrobial properties, displaying an MIC of 250 μg/mL and an MBC of 500 μg/mL against E. coli. This compound is useful in research applications focused on elucidating mechanisms of fungal and bacterial inhibition. -
Fungal Inhibitor
(E)-Coniferyl alcohol is a fungal inhibitor that acts as an intermediate in the biosynthetic pathways of eugenol, stilbenoids, and coumarin. This compound demonstrates potent activity against fungal species, making it valuable for studies focused on fungal growth inhibition. Its applications span research on plant defense mechanisms and the development of antifungal agents. -
BoNT A Inhibitor
Chaetochromin A is a fungal metabolite that acts as an inhibitor of botulinum neurotoxin serotype A (BoNT A). With an IC50 value of 24.6 μM, it demonstrates significant inhibitory effects, making it a valuable tool for research into neurotoxicology and the mechanistic pathways of neurotoxin action. Its role in understanding BoNT A interactions provides insights for potential therapeutic applications. -
Fungal Inhibitor
Isopyrazam serves as a potent fungal inhibitor, demonstrating significant efficacy against various plant pathogenic fungi. Its mechanism of action enhances disease resistance in crops, making it a valuable tool in agricultural research focused on plant protection and disease management. The use of Isopyrazam can lead to improved crop yield and quality, highlighting its potential applications in agro-biological studies. -
Mpro Inhibitor/Anti-Coronaviral Agent
Polycarpine hydrochloride is a potent inhibitor of the main protease (Mpro) with an IC50 of 30 nM, making it a valuable anti-coronaviral agent. This compound, derived from Polycarpa aurata, exhibits significant antiviral properties, demonstrating effectiveness against SARS-CoV-2 Mpro and PEDV Mpro, with IC50 values of 30.0 nM and 0.12 μM respectively. It also possesses antifungal activity, positioning it as a versatile tool for research in virology and infectious diseases.
