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MK-5204

Catalog No.: A28108
Synthesis Dextran Inhibitor
MK-5204 is an orally active inhibitor of β-1,3-glucan synthesis, targeting the pathways involved in fungal cell wall formation. Its primary mechanism disrupts the synthesis of glucans, which are essential for fungal structural integrity. This compound serves as a valuable tool in antifungal research and development, enabling the study of fungal pathogenesis and the evaluation of novel therapeutic strategies. MK-5204 is particularly useful in elucidating the role of glucans in fungal virulence and resistance mechanisms.
MK-5204 1207751-75-4 Synthesis Dextran Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMK-5204 is an orally active inhibitor of β-1,3-glucan synthesis, targeting the pathways involved in fungal cell wall formation. Its primary mechanism disrupts the synthesis of glucans, which are essential for fungal structural integrity. This compound serves as a valuable tool in antifungal research and development, enabling the study of fungal pathogenesis and the evaluation of novel therapeutic strategies. MK-5204 is particularly useful in elucidating the role of glucans in fungal virulence and resistance mechanisms.
Product Information
Catalog NumA28108
FormulaC40H65N5O5
Molecular Weight695.97
CAS Number1207751-75-4
SMILESC[C@@]12[C@@](CC3)([H])[C@@](C[C@](N4C(C(N)=O)=NC=N4)([H])[C@@H]1OC[C@](C)(N)C(C)(C)C)(COC2)C([C@@]3([H])[C@]5(CC[C@]6(C)[C@H](C)C(C)C)C)=CC[C@]5([C@@H]6C(O)=O)C
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Microbiology > Antifection > Fungal