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SDH-IN-8

Catalog No.: A28116
Succinate Dehydrogenase Inhibitor
SDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways.
SDH-IN-8 2757173-77-4 Succinate Dehydrogenase Inhibitor
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways.
Product Information
Catalog NumA28116
FormulaC18H14Cl3F4N3O
Molecular Weight470.68
CAS Number2757173-77-4
SMILESO=C(C1=C(F)N(C)N=C1C(F)F)N(C2CC2)C/C(C3=CC=C(Cl)C=C3F)=C(Cl)\Cl
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Microbiology > Antifection > Fungal
Metabolism > Succinate Dehydrogenase (SDH)