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Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial, Biofilm Formation Inhibitor
Majoranaquinone is a potent antibacterial agent that targets various bacterial strains, demonstrating significant inhibitory effects against four Staphylococcus species, one Moraxella species, and one Enterococcus species. Additionally, it exhibits substantial efflux pump inhibitory activity in Escherichia coli ATCC 25922. Majoranaquinone also effectively inhibits biofilm formation in both E. coli ATCC 25922 and E. coli K-12 AG100, making it a valuable reagent for research applications focused on combating bacterial infections and biofilm-related challenges. -
Bacterial Inhibitor
Lauryl-LF 11 is an N-terminally acylated analogue of LF11 that acts as a bacterial inhibitor. This peptide demonstrates significant antibacterial activity, making it a valuable tool for research in microbiology and infectious diseases. It can be utilized in studies focused on the mechanisms of bacterial resistance and the development of novel antimicrobial agents. -
Bacterial Inhibitor
Citreamicin alpha is a potent bacterial inhibitor demonstrated to exhibit significant antimicrobial activity against a range of Gram-positive cocci. In vitro studies reveal that MIC values for Staphylococci range from 0.12-4.0 μg/ml, and for Streptococcus pyogenes, they range from 0.03-0.12 μg/ml. While Citreamicin alpha shows superior efficacy compared to ampicillin, amoxicillin, and ceftriaxone, it exhibits comparable effects to vancomycin. Its effectiveness against various strains makes it a valuable reagent for research in antibiotic development and resistance studies. -
Beta-Lactamase Inhibitor
β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings. -
β-lactamase Inhibitor
Enmetazobactam iodide is an extended-spectrum β-lactamase inhibitor that targets various β-lactamase enzymes produced by resistant Gram-negative bacteria. This compound effectively enhances the efficacy of β-lactam antibiotics, making it a valuable tool in combating antibiotic resistance. Research applications include studying antibiotic resistance mechanisms and developing novel therapeutic strategies against multidrug-resistant infections. -
Bacterial Inhibitor
MT0703 is an aminothiazolyl glycyl cephalosporin that targets bacterial pathogens, exhibiting potent anti-Pseudomonas activity. This compound is studied for its potential in understanding bacterial resistance mechanisms and developing novel therapeutic strategies. Its structure, featuring a 1,5-dihydroxy-4-pyridone-2-carbonyl group, enhances its efficacy against a range of bacterial infections. -
ATPase/Bacterial Inhibitor
Dihydronovobiocin is a bacterial inhibitor that targets ATPase activity by binding to the GyrB subunit of DNA gyrase. This compound is useful for investigating the interactions between coumarin antibiotics, such as Novobiocin, Chlorobiocin, and Coumermycin, and their effects on DNA gyrase function. Dihydronovobiocin also has potential applications in the study of bacterial infections, facilitating research into the mechanisms of antibiotic action and resistance. -
Bacterial Inhibitor
(4-Aminobenzyl)phosphonic acid is a bioactive compound that acts as a bacterial inhibitor. It exhibits notable antibacterial and potential anticancer activities, making it useful in various research applications, particularly in the synthesis of new compounds aimed at inhibiting bacterial growth. Its unique structural properties enable effective interaction with biological targets, facilitating the exploration of novel therapeutic strategies. -
Bacterial Inhibitor
MGB-BP-3 is a bacterial inhibitor that targets multi-resistant Gram-positive pathogens. This antibiotic exhibits potent activity across a variety of clinically relevant bacterial strains, making it a valuable tool for studies focused on combating antibiotic resistance. Its broad-spectrum efficacy supports research applications in antibiotic development and microbiology. -
Bacterial Inhibitor
Gramicidin C is a polypeptide antibiotic with a primary mechanism of action as a bacterial inhibitor. It disrupts bacterial cell membrane function, resulting in increased permeability that leads to cell lysis. This compound is widely utilized in microbiology research to study bacterial resistance mechanisms and to investigate antibiotic efficacy against various gram-positive and gram-negative bacteria. -
Bacterial Inhibitor
Anhydroerythromycin A is a bacterial inhibitor derived from the degradation of the macrolide antibiotic erythromycin. It exhibits antimicrobial activity against Staphylococcus aureus and Bacillus cereus, with minimum inhibitory concentrations of 12.5 µg/ml and 6.25 µg/ml, respectively. Additionally, Anhydroerythromycin A inhibits steroid 6β-hydroxylase activity linked to the cytochrome P450 isoform CYP3A in human liver microsomes, making it a valuable tool for studying bacterial resistance and metabolic pathways. -
Bacterial Inhibitor
Cefsulodin is a bacterial inhibitor primarily targeting Pseudomonas aeruginosa. It exhibits potent antimicrobial activity against penicillin-susceptible and gentamicin-sensitive strains, demonstrating effectiveness comparable to gentamicin and debendazole. However, Cefsulodin's efficacy is reduced against penicillin-resistant strains of P. aeruginosa, particularly those also resistant to gentamicin. The compound shows a similar minimum inhibitory concentration for P. aeruginosa maltofila when compared to penicillin, gentamicin, and debendazole, while Pseudomonas cepacia strains typically present moderate resistance to Cefsulodin. Its applications include evaluating bacterial resistance mechanisms and antibiotic efficacy in clinical microbiology. -
Parasite Inhibitor
Asimilobine is an aporphine isoquinoline alkaloid derived from Magnolia obovata. This compound acts as a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist, making it a valuable reagent for studying neurotransmitter pathways. Asimilobine exhibits significant antimalarial and anti-cancer activities, highlighting its potential applications in parasitology and oncology research. -
Bacterial Inhibitor
Ampicillin is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent in microbiological research and antibiotic susceptibility testing. Ampicillin is commonly used to study bacterial resistance mechanisms and is also employed in molecular biology for the selection of recombinant plasmids in cloning applications. -
SPT Inhibitor
Myriocin is a potent serine palmitoyltransferase (SPT) inhibitor derived from various fungal species such as Myriococcum albomyces, Isaria sinclairi, and Mycelia sterilia. By inhibiting SPT, Myriocin plays a crucial role in the disruption of de novo sphingolipid synthesis. It has demonstrated significant antiviral activity, effectively suppressing the replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL. This compound is valuable for research into sphingolipid metabolism and hepatitis C virus infection mechanisms. -
SARS-CoV-2 Inhibitor
TFMU-ADPr is a selective reporter substrate that targets the SARS-CoV-2 Macro1 protein, displaying an IC50 of 0.59 μM. This compound emits fluorescence at 502 nm (or 495 nm) upon enzymatic hydrolysis by Poly(ADP-ribose) Glycohydrolase (PARG) and ADP-ribosylhydrolase 3. TFMU-ADPr binds to the ADPr-binding site of Macro1, providing a robust method for assessing the activity of poly(ADP-ribose) hydrolases. Its applications extend to evaluating small-molecule inhibitors under in vitro conditions, investigating ADP-ribosyl catabolic enzyme mechanisms, and detecting PAR hydrolase activity in whole-cell lysates, making it a valuable tool for COVID-19-related research. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
SARS-CoV Inhibitor
Direct Violet 1 is an azo dye that functions as an inhibitor of the spike protein-ACE2 interaction in SARS-CoV-2, exhibiting IC50 values ranging from 1.47 to 2.63 μM. This compound serves as a valuable tool for investigating viral entry mechanisms and studying protein-protein interactions related to SARS-CoV-2. Its application may extend to antiviral research and the development of therapeutic strategies targeting COVID-19. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Dengue Protease Inhibitor
Carbonic anhydrase inhibitor 16 is a potent dengue protease inhibitor that targets human carbonic anhydrases I and II, exhibiting inhibitory constants (Ki) of 28.5 nM and 2.2 nM, respectively. This compound demonstrates significant biological activity in hindering dengue virus replication by disrupting protease function. It may be utilized in research applications aimed at elucidating mechanisms of dengue virus pathogenesis and developing antiviral therapeutics. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
HIV Inhibitor
ZL0580 is an HIV inhibitor that functions by selectively binding to the BD1 domain of BRD4, leading to epigenetic suppression of the virus. This compound effectively inhibits Tat transactivation and transcription elongation while promoting a repressive chromatin structure at the HIV promoter. ZL0580 is valuable for research applications focused on HIV therapies and the mechanisms of viral transcription regulation. -
FgGpmk1 Inhibitor
FgGpmk1-IN-1 is a selective inhibitor of the Fusarium graminearum mitogen-activated protein kinase (FgGpmk1), exhibiting an EC50 value of 3.46 μg/mL. This compound is valuable for investigating the biological role of FgGpmk1 in fungal pathogenesis and offers potential applications in the study of plant-fungal interactions. Researchers can utilize FgGpmk1-IN-1 to explore therapeutic strategies against Fusarium-related diseases. -
Bacterial Inhibitor
Aniline-MPB-amino-C3-PBD is a cytotoxic agent targeting bacterial cells through minor-groove binding of DNA. This sequence-selective compound serves as an effective payload for antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy. Its antimicrobial properties make it a valuable tool for research in bacterial inhibition and related applications. -
Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Bacterial Inhibitor
FR-202306 is a bacterial inhibitor that targets peptide deformylase, an enzyme crucial for bacterial protein synthesis. This compound displays significant antibacterial activity against Staphylococcus aureus by effectively inhibiting its peptide deformylase activity. FR-202306 is valuable for research applications focused on developing antibacterial agents and exploring mechanisms of bacterial resistance. -
Bacterial Inhibitor
LF11 is a peptide that functions as a bacterial inhibitor by disrupting microbial cell membrane integrity. It exhibits potent antibacterial activity, making it a valuable tool for research focused on combating bacterial infections and studying antimicrobial mechanisms. Its application is particularly relevant in the development of new therapies and understanding resistance in pathogenic bacteria. -
Bacterial Inhibitor
Rifametane is a novel 3-azamethyl-rifamycin that acts as a bacterial inhibitor. It exhibits a pharmacokinetic profile that surpasses that of rifampin, demonstrating higher peak serum concentrations in healthy volunteers. This compound is primarily used in research focused on antibacterial activity and the evaluation of new therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
BMS-247243 is a β-lactam antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA). It exhibits significant antibacterial activity, making it a valuable tool for research into bacterial resistance mechanisms and the development of new antimicrobial therapies. BMS-247243 is particularly relevant for studies focused on treating infections caused by resistant bacterial strains. -
Bacterial Inhibitor, Translation Inhibitor
Sancycline hydrochloride is a bacterial inhibitor that functions by reversibly binding to the 30S ribosomal subunit, thereby inhibiting protein translation. It effectively blocks the entry of aminoacyl-tRNA into the ribosomal A site, similar to other tetracycline derivatives. This semi-synthetic tetracycline, characterized by its four linearly fused six-membered rings and four stereocenters, is primarily utilized in research focusing on bacterial protein synthesis and the development of antibacterial agents. -
InhA Inhibitor/Antibiotic
Pyridomycin is a selective inhibitor of InhA, an essential enzyme in Mycobacterium tuberculosis, providing a targeted approach in combating this pathogen. As an antibiotic derived from the metabolites of Dactylosporangium fulvum, Pyridomycin exhibits low cytotoxicity while effectively impeding the growth of Mycobacterium tuberculosis. Its application is significant in the study and treatment of bacterial infections, particularly tuberculosis, making it a valuable reagent for research in infectious disease mechanisms and antibiotic development. -
Antibiotic Inhibitor
Levorin A0 is an aromatic polyene antibiotic known for its potent antifungal properties. It primarily acts by disrupting the integrity of fungal cell membranes, leading to cell death. This compound is essential for research focused on antifungal drug development and understanding membrane-targeting mechanisms in fungal pathogens. Its efficacy against a range of fungi makes it a valuable tool in both in vitro and in vivo studies. -
Bacterial Inhibitor
Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology. -
Bacterial Inhibitor
Pivmecillinam is an orally active prodrug of mecillinam, functioning primarily as a bacterial inhibitor. It exhibits potent activity against various gram-negative bacteria by interfering with the synthesis of bacterial cell walls. Pivmecillinam is utilized in research to investigate mechanisms of antibiotic resistance and the efficacy of beta-lactam antibiotics. -
Bacterial Inhibitor
Altromycin F is an anthraquinone-derived antibiotic that functions as a bacterial inhibitor by targeting and disrupting bacterial cell function. This compound exhibits significant antibacterial activity specifically against Gram-positive bacteria, including Streptococcus and Staphylococcus, with a microbial inhibitory concentration (MIC) ranging from 0.2 to 3.12 μg/mL. Altromycin F is valuable for research applications focused on understanding bacterial resistance and developing new antibacterial strategies. -
Bacterial Inhibitor
Cefoselis hydrochloride is a fourth-generation cephalosporin and a β-lactam antibiotic that targets bacterial cell wall synthesis. It demonstrates potent antibacterial activity against a broad spectrum of both Gram-positive and Gram-negative bacteria. Furthermore, cefoselis hydrochloride effectively penetrates the blood-brain barrier, making it a valuable compound for research applications in infectious diseases and central nervous system infections. -
Bacterial Inhibitor
KKL-40 is a small molecule inhibitor that targets the trans-transcription process in bacteria. It exhibits effective antibacterial activity against methicillin-sensitive and -resistant Staphylococcus aureus, as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 demonstrates a synergistic effect with the human antimicrobial peptide LL-37 against S. aureus, while showing no synergy with commonly used antibiotics such as daptomycin, kanamycin, or erythromycin. Notably, KKL-40 selectively inhibits trans-transcription without toxicity to HeLa cells, making it a valuable tool for research in bacterial genetics and antibiotic resistance. -
Parasite Inhibitor
Clindamycin B is a derivative of Clindamycin, primarily targeting parasitic infections. It exhibits potent inhibitory activity against various protozoa, making it useful in research related to parasitic diseases. Clindamycin B is valuable for studying mechanisms of action in parasite biology and evaluating therapeutic strategies for parasitic infections. -
β-lactamase Inhibitor
AM-112 is a potent β-lactamase inhibitor that targets class A, C, and D β-lactamase enzymes, demonstrating IC50 values as low as 0.0002 μg/mL. Its mechanism involves the inhibition of PBP2, a penicillin-binding protein in E. coli, thereby protecting Ceftazidime from enzymatic hydrolysis and enhancing its antibacterial activity against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability, making it a valuable tool for research into bacterial infections. -
Bacterial Inhibitor
Norfloxacin hydrochloride is a broad-spectrum antibacterial agent that targets and inhibits DNA gyrase, thus interfering with bacterial DNA replication and repair. It exhibits activity against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable reagent for microbiological research and the study of bacterial resistance mechanisms. This compound is utilized in the investigation of bacterial infections and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Ceforanide (lysine) is a second-generation cephalosporin that functions as a bacterial inhibitor by interfering with bacterial cell wall synthesis. It exhibits a broad spectrum of in vitro antibacterial activity against various Gram-positive and Gram-negative bacteria. Ceforanide is primarily utilized in microbiological research to study bacterial resistance and the effects of cephalosporins on different bacterial strains. -
Bacterial Inhibitor
Deoxypheganomycin D is a specific antimycobacterial agent that demonstrates selective inhibition of Mycobacterium 607 growth without cross-resistance to other antibiotics. At a concentration of 28 μM, it significantly reduces bacterial proliferation while showing minimal impact on DNA, RNA, or protein synthesis pathways. Notably, at 7 μM, Deoxypheganomycin D interferes with leucine influx and alters efflux dynamics, suggesting its action may involve interactions with the cell membrane and distinct mycobacterial lipid components. This reagent is valuable for researchers studying mycobacterial resistance mechanisms and developing alternative treatment strategies. -
Bacterial Inhibitor
Lysostaphin targets the bacterial cell wall, acting as an antistaphylococcal agent. This enzyme exhibits the activities of glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase, leading to effective inhibition of Staphylococcus species. Due to its specific enzymatic action, lysostaphin is valuable in research focused on bacterial resistance, pathogen biology, and the development of antimicrobial therapeutics. -
Bacterial Inhibitor
Cefotaxime is a third-generation cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria and is notably stable against β-lactamase enzymes. This compound is widely used in microbiological research and clinical settings for the treatment and study of bacterial infections. -
Bacterial Inhibitor
Gastric mucin is a glycoprotein that acts as a bacterial inhibitor, particularly effective against Helicobacter pylori infection. It exhibits natural antibiotic properties and scavenges hydroxyl radicals, contributing to its protective role in the gastrointestinal tract. Gastric mucin plays a critical role in safeguarding against acid, proteases, and pathogenic microorganisms, while also providing defense against mechanical trauma. This functionality makes it a valuable reagent for research focused on gastrointestinal health and microbiome interactions. -
Beta-lactamase Inhibitor
Avibactam sodium hydrate is a reversible non-β-lactam β-lactamase inhibitor that specifically targets β-lactamase enzymes TEM-1 and CTX-M-15, demonstrating IC50 values of 8 nM and 5 nM, respectively. This compound is crucial for enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. Its use in research applications includes investigations into antibiotic resistance mechanisms and the development of combination therapies to overcome β-lactamase-mediated resistance. -
Bacterial Inhibitor
Mecillinam, a β-lactam antibiotic, primarily targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins in gram-negative organisms. It demonstrates a broad spectrum of antibacterial activity, making it valuable in studying bacterial infections and resistance mechanisms. Researchers often utilize Mecillinam for its effectiveness against various pathogenic strains, aiding in the development of therapeutic strategies and understanding bacterial physiology. -
Bacterial Inhibitor
Cecropin A is a linear antimicrobial polypeptide composed of 37 residues that exhibits potent antibacterial activity. Additionally, it demonstrates anticancer and anti-inflammatory properties, making it a valuable tool for research in infectious diseases, cancer therapy, and inflammatory response studies. Its ability to disrupt bacterial membranes can be leveraged in the development of novel antimicrobial agents. -
Parasite Inhibitor
Milbemycin oxime is an orally active macrolide that serves as a potent inhibitor of parasite activity. This compound, a mixture of oxime derivatives related to milbemycin A4 and A3, selectively binds to glutamate-gated chloride channels, leading to paralysis and death of various intestinal nematodes and lung/heart worms. It is widely utilized in research focused on antiparasitic drug development and mechanisms of parasitic resistance. -
Bacterial Biofilm Formation Inhibitor
Ethyl acetoacetate is an ester compound that acts as an inhibitor of bacterial biofilm formation. Its unique chemical structure facilitates its role in impairing the ability of bacteria to adhere and form protective biofilms, making it a valuable research tool in studying microbial resistance and infection control. This reagent is useful in various biological applications, particularly in investigations aimed at understanding bacterial behavior and developing new antimicrobial strategies.
