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Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
MGB-BP-3 is a bacterial inhibitor that targets multi-resistant Gram-positive pathogens. This antibiotic exhibits potent activity across a variety of clinically relevant bacterial strains, making it a valuable tool for studies focused on combating antibiotic resistance. Its broad-spectrum efficacy supports research applications in antibiotic development and microbiology. -
Bacterial Inhibitor
Gramicidin C is a polypeptide antibiotic with a primary mechanism of action as a bacterial inhibitor. It disrupts bacterial cell membrane function, resulting in increased permeability that leads to cell lysis. This compound is widely utilized in microbiology research to study bacterial resistance mechanisms and to investigate antibiotic efficacy against various gram-positive and gram-negative bacteria. -
Bacterial Inhibitor
Anhydroerythromycin A is a bacterial inhibitor derived from the degradation of the macrolide antibiotic erythromycin. It exhibits antimicrobial activity against Staphylococcus aureus and Bacillus cereus, with minimum inhibitory concentrations of 12.5 µg/ml and 6.25 µg/ml, respectively. Additionally, Anhydroerythromycin A inhibits steroid 6β-hydroxylase activity linked to the cytochrome P450 isoform CYP3A in human liver microsomes, making it a valuable tool for studying bacterial resistance and metabolic pathways. -
Bacterial Inhibitor
Cefsulodin is a bacterial inhibitor primarily targeting Pseudomonas aeruginosa. It exhibits potent antimicrobial activity against penicillin-susceptible and gentamicin-sensitive strains, demonstrating effectiveness comparable to gentamicin and debendazole. However, Cefsulodin's efficacy is reduced against penicillin-resistant strains of P. aeruginosa, particularly those also resistant to gentamicin. The compound shows a similar minimum inhibitory concentration for P. aeruginosa maltofila when compared to penicillin, gentamicin, and debendazole, while Pseudomonas cepacia strains typically present moderate resistance to Cefsulodin. Its applications include evaluating bacterial resistance mechanisms and antibiotic efficacy in clinical microbiology. -
Parasite Inhibitor
Asimilobine is an aporphine isoquinoline alkaloid derived from Magnolia obovata. This compound acts as a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist, making it a valuable reagent for studying neurotransmitter pathways. Asimilobine exhibits significant antimalarial and anti-cancer activities, highlighting its potential applications in parasitology and oncology research. -
Bacterial Inhibitor
Ampicillin is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent in microbiological research and antibiotic susceptibility testing. Ampicillin is commonly used to study bacterial resistance mechanisms and is also employed in molecular biology for the selection of recombinant plasmids in cloning applications. -
SPT Inhibitor
Myriocin is a potent serine palmitoyltransferase (SPT) inhibitor derived from various fungal species such as Myriococcum albomyces, Isaria sinclairi, and Mycelia sterilia. By inhibiting SPT, Myriocin plays a crucial role in the disruption of de novo sphingolipid synthesis. It has demonstrated significant antiviral activity, effectively suppressing the replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL. This compound is valuable for research into sphingolipid metabolism and hepatitis C virus infection mechanisms. -
Bacterial Inhibitor
Acorafloxacin hydrochloride is a broad-spectrum fluoroquinolone antibacterial agent that targets bacterial DNA gyrase and topoisomerase IV. It exhibits potent activity against a range of Gram-positive bacteria, with a mean MIC90 value of 0.12 mg/L. This compound is particularly relevant for research on acute bacterial skin infections and community-acquired pneumonia, as well as the investigation of methicillin-resistant Staphylococcus aureus (MRSA) infections. -
Bacterial Inhibitor
Targeting the bacterial sliding clamp peptide 46 is a short peptide designed to inhibit the bacterial sliding clamp (SC). By interfering with SC-dependent DNA synthesis, this peptide serves as a valuable tool for studying bacterial replication mechanisms and developing novel antibacterial strategies. Its application in research underscores its potential utility in exploring bacterial growth and resistance pathways. -
β-lactamase Inhibitor
Pralurbactam is a potent β-lactamase inhibitor that enhances the antibacterial efficacy of Imipenem against Mycobacterium abscessus. Its ability to reduce pulmonary bacterial load in neutropenic mice highlights its potential as a significant therapeutic agent. This compound is valuable in research focused on infections caused by Mycobacterium abscessus complex, as well as strains of Escherichia coli and Klebsiella pneumoniae. -
Bacterial Inhibitor
Cephabacin M6 is a 7-methoxydesacetylcephalosporin that acts as a bacterial inhibitor. It is isolated from the culture filtrate of Xanthomonas lactamica and exhibits significant antibacterial activity against various bacterial strains. This compound is useful in microbiological research for studying antibiotic mechanisms and resistance patterns in bacteria. -
Bacterial Inhibitor
Lascufloxacin hydrochloride is a potent antibacterial compound that targets bacterial DNA gyrase and topoisomerase IV, exhibiting broad-spectrum activity against diverse clinical isolates. It demonstrates robust efficacy against Gram-positive bacteria, outperforming other quinolone derivatives. Notably, Lascufloxacin hydrochloride shows incomplete cross-resistance to certain quinolone-resistant strains, making it a valuable candidate for further investigation. Its ability to inhibit both wild-type and mutated target enzymes underscores its potential in tackling resistant bacterial infections in research settings. -
Bacterial Inhibitor
Antibacterial Agent 63 is a conjugate of aztreonam and a siderophore mimetic, designed to inhibit gram-negative bacteria. This compound exhibits a significant antibacterial activity by targeting bacterial cell wall synthesis, providing a mechanism that enhances its effectiveness against resistant strains. It is suitable for research applications aimed at studying bacterial infections and antibiotic resistance mechanisms. -
Bacterial Inhibitor
DA-7867 is an antibacterial compound that targets a broad spectrum of bacterial strains, including those that are drug-resistant. This amide analog of Tedizolid demonstrates significant antibacterial activity against key clinically relevant pathogens, highlighting the potential of tetrazoles in the discovery of novel antibacterial agents. Its efficacy makes DA-7867 a valuable tool for research into bacterial infections and antibiotic resistance. -
Bacterial Inhibitor
Ro 24-6392 is an ester-linked co-drug that combines Ciprofloxacin and Desacetylcefotaxime, targeting inhibition of bacterial growth. It demonstrates potent antibacterial activity against a range of aerobic bacteria in vitro, making it a valuable tool for microbiological research and studies focused on bacterial resistance mechanisms. This compound can be utilized in the development of novel antibacterial therapies and for evaluating bacterial susceptibility to co-drug formulations. -
Bacterial Inhibitor
Apalcillin is a bacterial inhibitor designed to target and disrupt the activity of various gram-negative bacteria, particularly those that produce β-lactamase. In combination with Ro 48-1220, a β-lactamase inhibitor, Apalcillin exhibits broad-spectrum activity, effectively inhibiting strains such as Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with minimum inhibitory concentrations as low as 11 μg/mL. This combination also shows significant effectiveness against Pseudomonas aeruginosa and Stenotrophomonas maltophilia at even lower MICs (0.25 to 4 μg/mL). However, its efficacy against certain gram-positive organisms remains limited, making it a valuable tool for research on β-lactamase resistance. -
Bacterial Inhibitor
Phenyl(9H-purin-6-yl)amine is an antibacterial compound that targets bacterial growth by inhibiting various cellular processes. This reagent exhibits significant antibacterial activity and is useful in the development of novel antibacterial agents. Its potential inhibitory effects make it a valuable tool for medical research focused on combating bacterial infections. -
Bacterial Inhibitor
Radicinol is a bacterial inhibitor derived from the metabolite of Cochliobolus lunata. It demonstrates potent antimicrobial activity, particularly against various strains of bacteria, making it a valuable tool for research in microbiology and drug development. Radicinol can be utilized to study bacterial resistance mechanisms and assess the efficacy of new antibacterial agents. -
Bacterial Inhibitor
Trimethylsilyl-L-(+)-rhamnose acts as a bacterial inhibitor through its structural similarity to natural rhamnose, playing a crucial role in the study of bacterial cell wall composition. This modified sugar is utilized to investigate the biological functions associated with bacterial growth, providing insights into mechanisms of resistance. Researchers can leverage Trimethylsilyl-L-(+)-rhamnose to enhance understanding of bacterial physiology and the implications for antibiotic development. -
Bacterial Inhibitor
Urechistachykinin II is a tachykinin-related peptide (TRP) derived from echiuroid worms, primarily targeting bacterial pathogens. This compound exhibits significant antimicrobial activity while demonstrating a lack of hemolytic effect, making it a valuable tool in the study of bacterial inhibition. Its unique properties may support research in microbial resistance and novel antimicrobial strategies. -
Bacterial Inhibitor
1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine (21:0 PC) functions as a surfactant with notable antibacterial properties. It exhibits efficacy by acting in mucus to inhibit the dissemination of pathogens. Additionally, 1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine contributes to the stability of biofilms, supporting the overall health of associated organisms. This compound is applicable in studies focused on bacterial inhibition and biofilm dynamics. -
β-lactamase Inhibitor
rel-Avibactam sodium is a potent β-lactamase inhibitor designed to combat bacterial resistance. It demonstrates broad-spectrum antibacterial activity, particularly against Enterobacteriaceae that produce Ambler A and C types of β-lactamases. When used in combination with Cefazidime, rel-Avibactam sodium exhibits significant inhibitory effects and offers enhanced efficiency compared to traditional β-lactamase inhibitors, as indicated by its low IC50 values against TEM-1 and P99 enzymes. This compound is essential for research into antibiotic resistance and the development of novel antibacterial therapies. -
Bacterial Inhibitor
Antibacterial Agent 240 (compound 62-7c) is a bacterial inhibitor specifically designed to target multidrug-resistant (MDR) strains of Methicillin-resistant Staphylococcus aureus (MRSA). This compound demonstrates significant antibacterial efficacy, as evidenced by its potent anti-infection activity in preclinical mouse models of pneumonia and wound infections caused by MRSA. Its favorable biosafety profile further supports its potential use in therapeutic applications against resistant bacterial infections. -
Bacterial Penicillin-binding Protein (PBPs) Inhibitor
J-114870 is an inhibitor of bacterial penicillin-binding proteins (PBPs), demonstrating significant efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci (MRCoNS). This compound is valuable for research applications focused on bacterial infections, particularly in understanding resistance mechanisms and developing new therapeutic strategies. -
Bacterial Inhibitor
Antistaphylococcal agent 2 is a bacterial inhibitor targeting Staphylococcus species. It exhibits potent antimicrobial activity, making it effective in combating staphylococcal infections. This compound is primarily utilized in research applications aimed at understanding and developing therapies for bacterial resistance and infection control. -
Bacterial Inhibitor
Antibacterial agent 31 is a bacterial inhibitor that demonstrates significant antibacterial activity against rice bacterial leaf streak. This compound is essential for research applications focused on plant pathology and the development of disease-resistant agricultural practices. Its mechanism of action provides insights into bacterial resistance mechanisms and potential strategies for crop protection. -
Bacterial Inhibitor
Antibacterial agent 249 is a bacterial inhibitor that exhibits broad-spectrum antimicrobial properties. It effectively inhibits the growth of various pathogens including Aspergillus niger, Bacillus subtilis, Pseudomonas albicans, Escherichia coli, and Staphylococcus aureus. Additionally, it displays anti-inflammatory activity in vitro, highlighting its potential applications in the treatment of bacterial infections. -
Bacterial Inhibitor
Kipukasin D is a natural nucleoside derived from Aspergillus versicolor, exhibiting potent antibacterial activity. It operates primarily as a bacterial inhibitor, making it valuable for research involving bacterial infections and microbial resistance mechanisms. This compound is useful for studies in pharmacology, microbiology, and drug development focused on identifying new antimicrobial agents. -
Bacterial Inhibitor
Antistaphylococcal agent 3 is a bacterial inhibitor that targets Staphylococcus species, disrupting their growth and proliferation. This compound exhibits potent antimicrobial activity, making it suitable for research applications focused on bacterial infection models and therapeutic development. Its efficacy against resistant strains renders it valuable for studies aimed at understanding staphylococcal pathogenesis and developing novel antibacterial strategies. -
Bacterial Inhibitor
DS-8587 is a novel fluoroquinolone designed as a bacterial inhibitor, demonstrating significant antibacterial activity against amoxicillin-resistant Bacillus strains. Its minimum inhibitory concentration (MIC) values outperform those of ciprofloxacin and levofloxacin, while exhibiting reduced susceptibility to efflux pump-mediated resistance mechanisms such as adeA/adeB/adeC and abeM. Additionally, DS-8587 has a lower single-step mutation frequency compared to ciprofloxacin, positioning it as a promising therapeutic candidate for the treatment of amoxicillin-resistant Bacillus infections. -
Bacterial Inhibitor
Urechistachykinin I is a tachykinin-related peptide derived from echiuroid worms, primarily targeting bacterial pathogens. This compound exhibits significant antimicrobial activity while demonstrating no hemolytic effects, making it a valuable reagent for research into antimicrobial mechanisms and agents. Its unique properties make it suitable for studies investigating bacterial inhibition in various biological contexts. -
β-lactamase Inhibitor
Taniborbactam hydrochloride is a reversible and selective β-lactamase inhibitor that targets various β-lactamase enzymes, demonstrating IC50 values ranging from 8 to 530 nM, with specific IC50s of 30 nM for KPC-2, 32 nM for AmpC, 42 nM for OXA-48, and 20 nM for VIM-2. This compound is effective against Gram-negative bacteria, making it a valuable tool in the study of antibiotic resistance mechanisms and the development of novel antibacterial strategies. Researchers can utilize Taniborbactam hydrochloride in investigations aimed at enhancing the efficacy of β-lactam antibiotics. -
Bacterial Inhibitor
(Z)-Ligustilide acts as a bacterial inhibitor with demonstrated antimicrobial and antifungal properties. Extracted from Ligusticum chuanxiong Hort, it has shown an average antifungal score of 5.6. This compound inhibits the expression of FATP5 and DGAT, thereby reducing fatty acid uptake and esterification, positioning it as a potential therapeutic agent for nonalcoholic fatty liver disease (NAFLD). Additionally, (Z)-Ligustilide is involved in reactivating ERα and exhibits epigenetic regulatory functions, making it relevant for research into tamoxifen-resistant breast cancer. -
LAL Inhibitor
Lalistat 1 is a selective and competitive inhibitor of lysosomal acid lipase (LAL), demonstrating an IC50 of 68 nM against purified human LAL. It also inhibits immunoglobulin A1 protease (IgA1P) from Haemophilus influenzae while exhibiting minimal effects on other serine hydrolases such as trypsin and β-lactamase. This compound is valuable for investigating Niemann-Pick type C (NPC) disease and related metabolic disorders. -
Beta-lactamase Inhibitor
Xeruborbactam disodium is a potent beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with exceptional efficacy. This ultra-broad-spectrum compound operates at nanomolar concentrations, rendering it a valuable tool in combating antibiotic resistance. It is suitable for research applications aimed at understanding beta-lactamase mechanisms and developing new therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
Roseoflavin is a bacterial inhibitor, functioning as an antimetabolite analog of riboflavin and flavin mononucleotide. This natural pigment, originally extracted from Streptomyces davawensis, exhibits potent antimicrobial properties. It is commonly utilized in research applications aimed at studying bacterial metabolism and the mechanisms of antibiotic resistance. -
Bacterial Inhibitor
Poly-L-lysine hydrochloride is a cationic polymer that functions as a bacterial inhibitor by enhancing cell adhesion through electrostatic interactions with negatively charged cell membranes. It promotes liquid-liquid phase separation (LLPS) at low concentrations while inhibiting LLPS at elevated concentrations, making it a versatile tool for cell culture applications. This reagent is particularly useful in studies involving bacterial attachment mechanisms and cell substrate interactions. -
Bacterial Riboflavin Riboswitches Inhibitor
Ribocil-C is a potent inhibitor of bacterial riboflavin riboswitches, targeting their regulatory mechanism to disrupt riboflavin biosynthesis. This compound exhibits a high degree of selectivity and is valuable for studying riboswitch function and its role in bacterial gene regulation. Ribocil-C is applicable in research focusing on microbial metabolism and the development of antibacterial strategies. -
Bacterial Inhibitor
Lymecycline is a tetracycline derivative known for its mechanism as a bacterial inhibitor. It exhibits broad-spectrum antibacterial activity, making it effective against a variety of bacterial infections. Additionally, Lymecycline possesses anti-inflammatory properties, which may be beneficial in treating conditions where inflammation plays a significant role. Its applications in research include studying bacterial resistance mechanisms and exploring its therapeutic potential in inflammatory diseases. -
Bacterial Inhibitor
Procyanidin A2 is a flavonoid with documented antibacterial properties. It exhibits significant antimicrobial activity, making it a valuable compound for research into bacterial inhibition and potential therapeutic applications. Additionally, Procyanidin A2 possesses antioxidant and anti-inflammatory effects, further supporting its relevance in studies focused on cancer and inflammatory diseases. -
Bacterial Inhibitor
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis that primarily targets bacterial pathogens. It exhibits significant anti-inflammatory and antimicrobial properties, demonstrating potent efficacy against Mycobacterium aurum and Mycobacterium bovis BCG. This compound is valuable for research focused on osteoclast differentiation, survival, and function as well as the development of novel antibacterial therapies. -
Bacterial Inhibitor
Acetylalkannin is an isohexenylnaphthazarin pigment derived from Arnebia euchroma, primarily known for its bacterial inhibitory properties. This compound exhibits significant antimicrobial and cytotoxic activities, making it valuable for research in antibacterial drug development and cell viability studies. Its unique structure and biological efficacy provide a useful tool for investigating microbial interactions and potential therapeutic applications. -
Serine β-Lactamase Inhibitor
Pilabactam sodium is a potent serine β-lactamase inhibitor that demonstrates broad-spectrum activity, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase enzymes. This compound enhances the efficacy of β-lactam antibiotics against strains of Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium is essential for research aimed at understanding and overcoming bacterial infections, particularly those caused by resistant pathogens. -
Bacterial Inhibitor
4-Hydroxycoumarin is a versatile coumarin derivative that acts as a bacterial inhibitor. It demonstrates both electrophilic and nucleophilic properties, making it a valuable scaffold in organic synthesis. This compound exhibits significant biological activities, including anti-inflammatory, antibacterial, and anti-tumor effects, and has been utilized in research focusing on HIV protease and tyrosine kinase inhibition. Its multifaceted applications make it an important reagent in chemical and biological research. -
Bacterial Inhibitor
Furanone C-30 is a potent quorum sensing inhibitor that targets bacterial communication systems. It effectively disrupts biofilm formation in Streptococcus mutans, including its luxS mutant strain. This compound is valuable for research applications focused on bacterial pathogenesis and biofilm-related studies, providing insights into microbial interactions and potential therapeutic strategies against bacterial infections. -
SCD Inhibitor
Elemicin is a potent inhibitor of Stearoyl-CoA Desaturase 1 (SCD1), acting through metabolic activation. This compound exhibits a range of biological activities, including anti-influenza, antimicrobial, antioxidant, and antiviral effects. Its mechanism and diverse applications make Elemicin a valuable reagent for research in metabolic studies and infectious disease treatment. Caution is advised, as Elemicin and its reactive metabolite, 1′-Hydroxyelemicin, may induce hepatotoxicity. -
Bacterial Inhibitor/Anti-inflammatory Agent
Cyclo(L-Pro-L-Val) is a peptide-based compound that functions as a bacterial inhibitor and anti-inflammatory agent. It exhibits antimicrobial activity against plant pathogens, such as R. fascians, and demonstrates significant inhibition of critical signaling molecules like IKKα, IKKβ, NF-κB, iNOS, and COX-2, contributing to its anti-inflammatory properties. This compound is valuable for research applications in developing biopesticides and investigating inflammation-related diseases. -
TEM-1 β-Lactamase Inhibitor
Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a potent inhibitor of TEM-1 β-lactamase, exhibiting a Ki value of 40.05 µM. This compound serves as a glycosidic surfactant, facilitating various biochemical applications. Its inhibitory properties make it valuable for research focused on antibiotic resistance and enzyme activity modulation. -
Beta-Lactamase Inhibitor
Ledaborbactam is a β-lactamase inhibitor that targets various β-lactamase enzymes, enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. This compound is instrumental in research focused on combating bacterial infections, especially those caused by multidrug-resistant organisms. Its ability to inhibit β-lactamases makes it a valuable tool for investigating and developing novel therapeutic approaches in infectious disease treatment. -
Bacterial Inhibitor
N-Acetyltyramine is a quorum-sensing inhibitor (QSI) produced by Vibrio alginolyticus M3-10. It effectively inhibits the quorum-sensing processes of Chromobacterium violaceum ATCC 12472, showing promise in modulating bacterial communication. Additionally, N-acetyltyramine has demonstrated the potential to reverse resistance in Doxorubicin-resistant leukemia P388 cells, making it a valuable tool for studying antibiotic resistance and leukemic cell sensitivity.
