Fig. 1 · Structure
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BACE1-IN-12
BACE1 Inhibitor
BACE1-IN-12 is a potent inhibitor of Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), exhibiting an IC50 of 8.9 µM. This compound demonstrates selective inhibition of butyrylcholinesterase (BuChE) with an IC50 of 3.2 µM and possesses antioxidant activity with an IC50 of 10.2 μM, as assessed by the DPPH assay. BACE1-IN-12 may serve as a potentially valuable agent in Alzheimer's disease research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2479315-19-8 |
| Applications | BACE1 Inhibitor |
| Formula | C29H28Cl2N6O |
| Molecular Weight | 547.48 |
| SMILES | ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.