hAChE-IN-7 is a mixed inhibitor targeting both the catalytic active site and peripheral anionic site of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE). It exhibits potent inhibitory activity with IC50 values of 69.8 nM for hAChE and 68.0 nM for hBuChE, along with a notable inhibitory effect on β-secretase-1 (BACE-1) at an IC50 of 3.6 μM. This compound is valuable for research related to Alzheimer's disease, facilitating studies on cholinergic system modulation and potential therapeutic strategies.
hAChE-IN-7 is a mixed inhibitor targeting both the catalytic active site and peripheral anionic site of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE). It exhibits potent inhibitory activity with IC50 values of 69.8 nM for hAChE and 68.0 nM for hBuChE, along with a notable inhibitory effect on β-secretase-1 (BACE-1) at an IC50 of 3.6 μM. This compound is valuable for research related to Alzheimer's disease, facilitating studies on cholinergic system modulation and potential therapeutic strategies.
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