Tris(2-chloroethyl) phosphate (TCEP) is an organic phosphorus compound that functions primarily as a flame-retardant plasticizer. It exhibits hepatotoxic effects characterized by an increase in reactive oxygen species (ROS) and calcium ion influx, leading to mitochondrial membrane potential disruption, DNA damage, and programmed cell death. TCEP has been shown to directly interact with the farnesoid X receptor (FXR), promoting obesity and fatty liver development in murine models. Additionally, TCEP activates the TLR4/NF-κB signaling pathway, contributing to liver inflammation, making it relevant for studies on metabolic disorders and toxicology.
Tris(2-chloroethyl) phosphate (TCEP) is an organic phosphorus compound that functions primarily as a flame-retardant plasticizer. It exhibits hepatotoxic effects characterized by an increase in reactive oxygen species (ROS) and calcium ion influx, leading to mitochondrial membrane potential disruption, DNA damage, and programmed cell death. TCEP has been shown to directly interact with the farnesoid X receptor (FXR), promoting obesity and fatty liver development in murine models. Additionally, TCEP activates the TLR4/NF-κB signaling pathway, contributing to liver inflammation, making it relevant for studies on metabolic disorders and toxicology.
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