Tris(2-chloroethyl)phosphate-d12 is a deuterium-labeled derivative of Tris(2-chloroethyl) phosphate, primarily utilized as a stable isotope in biological research. This compound serves as an organic phosphorus flame retardant and plasticizer, exhibiting hepatotoxicity through mechanisms such as increased reactive oxygen species (ROS) production, calcium ion influx, and mitochondrial membrane potential reduction. Additionally, it influences the TLR4/NF-κB signaling pathway, leading to liver inflammation and the development of obesity and fatty liver in experimental models. Tris(2-chloroethyl)phosphate-d12 is integral for studies focused on metabolic disorders and toxicity assessments.
Tris(2-chloroethyl)phosphate-d12 is a deuterium-labeled derivative of Tris(2-chloroethyl) phosphate, primarily utilized as a stable isotope in biological research. This compound serves as an organic phosphorus flame retardant and plasticizer, exhibiting hepatotoxicity through mechanisms such as increased reactive oxygen species (ROS) production, calcium ion influx, and mitochondrial membrane potential reduction. Additionally, it influences the TLR4/NF-κB signaling pathway, leading to liver inflammation and the development of obesity and fatty liver in experimental models. Tris(2-chloroethyl)phosphate-d12 is integral for studies focused on metabolic disorders and toxicity assessments.
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