Other inhibitors

Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, and increase gastrointestinal transit.

Magnolol (2,2'-Bichavicol) is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis).

Malotilate is a liver protein metabolism improved compound.

Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.

Mesna, is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.

Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.

Methacycline hydrochloride (Physiomycine) is a tetracycline antibiotic.

Methyl Hesperidin is a compound of the vitamin P group

Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter and prevent sodium and chloride, water as well, from leaving the lumen to enter the tubule cell.

Mitotane(Lysodren), is an antineoplastic medication used in the treatment of adrenocortical carcinoma.

Morin hydrate is a chemical compound. Morin can be used to test for the presence of aluminum or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.

Myricetin (Cannabiscetin) is a naturally occurring flavonol, a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants.

Nanchangmycin (dianemycin) is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for for mammals and plants.

Naringin (Naringoside) is a flavanone glycoside and is a major flavonoid in grapefruit and gives the grapefruit juice its bitter taste.

Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin.

Flavanone glycoside with neuroprotective and antioxidant properties. Does not inhibit oral carcinogenesis in a rat model unlike other citrus flavanones, but does exert a protective effect against gastritis and gastric lesions.

Neohesperidin dihydrochalcone (Nhdc) is a flavonoid sweetening agent with potent antioxidant activity.

Nepafenac is a non-steroidal anti-inflammatory agent.

Phenprocoumon is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism).

NXY-059 is the disulfonyl derivative of the neuroprotective spin trap pheny lbutynitrone or "PBN" with free radical-trapping properties. It substantially lessens the functional disability resulting from cerebral ischemia in a primate species.

Oleanolic acid (Caryophyllin) is a naturally occurring triterpenoid, widely distributed in food and medicinal plants, related to betulinic acid. It is relatively non-toxic, antitumor, and hepatoprotective, as well as exhibiting antiviral properties.

Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.

Paeonol (Peonol) is a major component extracted from Chinese herbs moutan cortex and Cynanchum paniculatum .

Palmatine chloride is a protoberberine alkaloid that is isolated from medicinal herbs like Coptis chinensis Franch.

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.

Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally.[1] It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide.

Pizotifen malate, a derivative of benzocycloheptathiophene, is a tricyclic compound found to be a potent inhibitor of SR-2 receptor activity.

Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

Quetiapine fumarate,an atypical antipsychotic,is used to treat either schizophrenia or bipolar disorder.

Rheochrysidin is one of the major components of Da-Cheng-Qi decoction used in the treatment of inflammation.

Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that very little of the drug will pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics.

Risedronate sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems.

Salicin(Salicoside, Salicine) is an alcoholic β-glycoside that contains D-glucose. Salicin is an anti-inflammatory agent that is produced from willow bark. Salicin is closely related in chemical make-up to aspirin. When consumed, it is metabolized to salicylic acid.

Salidroside (Rhodioloside) is a glucoside of tyrosol found in the plant Rhodiola rosea. It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant, along with rosavin.

Sclareol is a fragrant chemical compound found in clary sage (Salvia sclarea), from which it derives its name. It is classified as a bicyclic diterpene alcohol. Sclareol is used as a fragrance in cosmetics and perfumes and as flavoring in food. Sclareol and other similar substances may be prepared from sclareolide.Sclareol is also able to kill human leukemic cells and colon cancer cells by apoptosis.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product .

Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.

Silibinin (silybin) is the major active constituent of silymarina compound extracted from the seeds of the herb milk thistle.

Silymarin (Silibinin B) inhibits chemically induced urinary bladder tumor growth and progression possibly by inhibiting cell proliferation and enhancing apoptosis.

Sophocarpine could reverse isoprenaline-induced arrhythmia and inhibit I(Na), I(CaL), and I(Kr) currents. The electrophysiological effects of sophocarpine are similar to those of amiodarone, which might be regarded as a prospective antiarrhythmic agent.

Spectinomycin is an antibiotic useful for the treatment of the bacterial infection, gonorrhea.

Stigmasterol, which is readily obtainable from soybean oil, can be transformed easily to progesterone and to other hormones.

Cilastatin is a dipeptidase inhibitor that specifically inhibits DPEP1 (dehydrodipeptidase I), a renal membrane-bound glycoprotein involved in the hydrolytic metabolism of penem and carbapenem ??-lactam antibiotics.

Tangeretin (Tangeritin) is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeretin (Tangeritin) strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens. Tangeretin (Tangeritin) also shows enormous potential as an anti cancer agent.

Taurine is an organic acid widely distributed in animal tissues. It is a major constituent of bile and can be found in the large intestine and accounts for approximately 0.1% of total human body weight.

Isoindigotin is a potential antileukemic agent.

Tenoxicam belongs to the class of NSAIDs known as oxicams.

Terbinafine HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition.