Other inhibitors

Dimesna is an uroprotective agent used to decrease urotoxicity.

Dioscin (Collettiside III) is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.

Diosmin is a semisynthetic phlebotropic agent and a member of the flavonoid family.

Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic and sedative properties which is mainly used to treat allergies.

Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder.

DL-Carnitine hydrochloride is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. In living cells, it is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy.

D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

Docosanol is an antiviral agent for reducing the duration of cold sores caused by the herpes simplex virus. It is thought to act by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication.

Dofetilide is a class III antiarrhythmic agent. Dofetilide works by selectively blocking the rapid component of the delayed rectifier outward potassium current (Ikr).

Doxercalciferol is a synthetic analog of ergocalciferol (vitamin D2). It suppresses parathyroid synthesis and secretion.

Econazole nitrate is an antifungal medication of the imidazole class.

Ergosterol is a sterol and a biological precursor (a provitamin) to vitamin D2. Ergosterol is a component of fungal cell membranes, serving the same function that cholesterol serves in animal cells. Because ergosterol is present in fungal cell membranes yet absent in animal cell membranes, it is a useful target for antifungal drugs. .

Flucytosine is an antifungal used in the treatment of severe candidal and cryptococcal infections. It converted to fluorouracil after entering fungi, which inhibits DNA and RNA synthesis

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic drug.

Ipenoxazone is a potent and centrally acting muscle relaxant.

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity.

Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro.

nipradilol is an alpha(1),beta-blocker with a nitric oxide donative action

Nalbuphine is a semi-synthetic opioid agonist-antagonist analgesic of the phenanthrene series

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.

Stiripentol is an epilepsy drug. It has been used as co-therapy for treatment of epilepsy

Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

WF-11899A is a novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

RGH-5526 (GYKI-11679) is a new antihypertensive agent.

UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.

Mepixanox (Pimexone) is an analeptic drug used in respiratory and cardiorespiratory insufficiency.

20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).

Pirazolac is a non-steroidal anti-inflammatory drug.

Prifuroline is an antiarrhythmic agent.

Pirozadil is a hypolipidemic agent.

(±)-WS75624B is an endothelin converting enzyme (ECE) inhibitor with an IC50 of 0.03 μg/mL.

Clozic is a potential anti-arthritic agent.

Tepilamide fumarate (XP-23829) is an oral fumaric acid ester, acts as a prodrug of monomethyl fumarate, and is used in the research of moderate to severe chronic plaque psoriasis.

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.

BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme

Substituted piperidines-1 is a compound that can promote the release of growth hormone in humans and animals.

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors.

CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

(E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker.

Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities.

Carebastine is the active carboxylic acid metabolite of Ebastine.

Teglarinad chloride, also known as GMX1777, is a water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond.

Pyronaridine Tetraphosphate is a common antimalarial agent that has been found to enhance the antitumor activity of doxorubicin against multidrug-resistant cancers K562/A02 and MCF-7/ADR.

FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.

S107 is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.