SEC inhibitor KL-2

Catalog No.: A19043

SEC inhibitor

SEC inhibitor KL-2

SEC inhibitor KL-2 Chemical Structure

CAS NO. 900308-51-2

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation.

Availability: In stock

Package Price Qty
1 mg
$90.00
5 mg
$270.00
10 mg
$460.00
50 mg
$1,380.00
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Biological Activity

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.96 mL 149.82 mL 299.63 mL
0.5 mM 5.99 mL 29.96 mL 59.93 mL
1 mM 3 mL 14.98 mL 29.96 mL
5 mM 0.6 mL 3 mL 5.99 mL

*The above data is based on the productmolecular weight 333.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19043
Actions Inhibitor
M. Wt 333.74
Formula C17H13ClFNO3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 900308-51-2
Synonyms KL-2
SMILES O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O

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