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SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.96 mL | 149.82 mL | 299.63 mL |
| 0.5 mM | 5.99 mL | 29.96 mL | 59.93 mL |
| 1 mM | 3 mL | 14.98 mL | 29.96 mL |
| 5 mM | 0.6 mL | 3 mL | 5.99 mL |
*The above data is based on the productmolecular weight 333.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19043 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 900308-51-2 |
| Formula | C17H13ClFNO3 |
| M. Wt | 333.74 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | KL-2 |
| SMILES | O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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