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Biological Activity
MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.
| In vitro | DMSO | 52 mg/mL (193.83 mM) | |
| Water | 52 mg/mL (193.83 mM) | ||
| Ethanol | 52 mg/mL (193.83 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.28 mL | 186.38 mL | 372.76 mL |
| 0.5 mM | 7.46 mL | 37.28 mL | 74.55 mL |
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
*The above data is based on the productmolecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18839 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1382799-40-7 |
| Formula | C9H14F2N2O3S |
| M. Wt | 268.27 |
| Purity | >98% |
| Synonyms | MK-8719; MK 8719; MK8719; |
| SMILES | O[[email protected]]1[[email protected]](O)[[email protected]@]2([H])N=C(NCC)S[[email protected]@]2([H])O[[email protected]@H]1C(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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