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MK-8719

Catalog No.: A18839

OGA inhibitor

MK-8719

MK-8719 Chemical Structure

CAS NO. 1382799-40-7

MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.

Availability: In stock

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5 mg

Regular Price: $350.00

Special Price $280.00

10 mg

Regular Price: $650.00

Special Price $520.00

50 mg

Regular Price: $2,000.00

Special Price $1,600.00

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Biological Activity

MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.
In vitro DMSO 52 mg/mL (193.83 mM)
Water 52 mg/mL (193.83 mM)
Ethanol 52 mg/mL (193.83 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.28 mL 186.38 mL 372.76 mL
0.5 mM 7.46 mL 37.28 mL 74.55 mL
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL

*The above data is based on the productmolecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18839
Actions Inhibitor
CAS No. 1382799-40-7
Formula C9H14F2N2O3S
M. Wt 268.27
Purity >98%
Synonyms MK-8719; MK 8719; MK8719;
SMILES O[[email protected]]1[[email protected]](O)[[email protected]@]2([H])N=C(NCC)S[[email protected]@]2([H])O[[email protected]@H]1C(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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