MK-8719

Name: MK-8719
Brand: Adooq Bioscience
SKU: A18839
Rating: 5 (288 reviews)

Catalog No.: A18839

OGA inhibitor

MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.

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Grouped product items
Size	Price	Stock
1mg	$90.00	In stock
5mg	$190.00	In stock
10mg	$320.00	In stock
25mg	$550.00	In stock
50mg	$780.00	In stock
100mg	$1,115.00	In stock
*10mM 1mL in DMSO**	$285.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Biological Activity

Description	MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.

Product Information

Catalog Num	A18839
Formula	C9H14F2N2O3S
Molecular Weight	268.27
CAS Number	1382799-40-7
SMILES	O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F
Synonyms	MK-8719; MK 8719; MK8719;
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	52 mg/mL (193.83 mM)
	Water	52 mg/mL (193.83 mM)
	Ethanol	52 mg/mL (193.83 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.28 mL	186.38 mL	372.76 mL
0.5 mM	7.46 mL	37.28 mL	74.55 mL
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL

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