MK-8719

Catalog No.: A18839
OGA inhibitor
MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.
Grouped product items
Product Name Price Stock Qty
MK-8719 5mg
$280.00
In stock
MK-8719 10mg
$450.00
In stock
MK-8719 50mg
$1,250.00
In stock
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Biological Activity
Discription MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.
Product Information
Catalog Num A18839
Formula C9H14F2N2O3S
Molecular Weight 268.27
CAS Number 1382799-40-7
SMILES O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F
Synonyms MK-8719; MK 8719; MK8719;
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 52 mg/mL (193.83 mM)
Water 52 mg/mL (193.83 mM)
Ethanol 52 mg/mL (193.83 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.28 mL 186.38 mL 372.76 mL
0.5 mM 7.46 mL 37.28 mL 74.55 mL
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C1V1 = C2V2

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