Catalog No.
Product Name
Application
Product Information
Product Citation
- Isatoribine monohydrate is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro. This compound acts on different components of the immune system including B cells, natural killer (NK) cells and antigen-presenting cells (APC).
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PKR Inhibitor
PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.3 PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. - EC-17 is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity.
- Chu W, .et al. , Biosci Trends, 2018, Jul 17;12(3):298-308 PMID: 29899195
- N-(p-Coumaroyl) Serotonin is an antibacterial agent which inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes.
- N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity.
- 3-Methylcrotonyl Glycine is a metabolite found in 3-methylcrotonylglycinuria, a metabolic disorder.
- Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications.
- 6-Maleimido-1-hexanol is a maleimide compound with a pendant hexanol moiety.
- cis-Urocanic acid is a major ultraviolet-absorbing component of the stratum corneum.
- a-Hydroxyglutaric acid (2-HG) is an a-hydroxy acid. It is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.
- Phloroglucinol is a hygroscopic biochemical that is also potentially useful for bone decalcification in microscopy specimens or the detection of wood fibers.
- Levomefolic acid is the primary biologically active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine.
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N-cadherin antagonist
Exherin is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities.- Ariel Diaz, .et al. , J Cereb Blood Flow Metab, 2021, Mar 24 PMID: 33757316
- CM Madl, .et al. , Adv Sci, 2019, 1801716 PMID: 30828535
- Christopher M. Madl, .et al. , Nat Mater, 2017, Dec; 16(12): 1233-1242 PMID: 29115291
- Andrew J. Lindsay, .et al. , Oncotarget, 2017, Dec 1; 8(62): 104717-104732 PMID: 29285208
- Gemcitabine elaidate is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.
- Treprostinil is a stable analog of prostacyclin that is used clinically for the treatment of PPH.
- Bhat L, .et al. , Eur J Pharmacol, 2018, May 15;827:159-166 PMID: 29453947
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rRNA modificator
5S rRNA modificator is a suitable electrophile for 2?€?-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA RNA modification. - Cambendazole acts as an anthelmintic used in the treatment of Chagas?€? disease.
- ST 101 (ZSET1446) is a novel cognitive enhancer that promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice.
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AdipoR1 and AdipoR2 agonist
AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). IC50 value: 1.8/3.1 uM(AdipoR1/2, Kd)- Weidong Yan, .et al. , Pharmaceutics, 2022, Nov 15;14(11):2467 PMID: 36432657
- Yunjing Yan, .et al. , J Pathol, 2022, Jun;257(2):146-157 PMID: 35072951
- Uchida T, .et al. , J Ocul Pharmacol Ther, 2019, Aug 28 PMID: 31460821
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GPIIb/IIIa antagonist
Tirofiban, Hydrochloride Hydrate is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. -
Bioluminescent substrate
D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. - Clodronate disodium is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate.
- Atopaxar hydrobromide shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031 μM respectively.
- Lehmann M, .et al. , Arterioscler Thromb Vasc Biol, 2018, May;38(5):1052-1062 PMID: 29472230
- Photochlor is a lipophilic, second-generation, chlorin-based photosensitizer. Upon intravenous administration, HPPH selectively accumulates in the cytoplasm of cancer or pre-cancerous cells.
- Dobson J, .et al. , Vet J, 2018, Mar;233:8-18 PMID: 29486883
- Moghissi K, .et al. , Surg J (N Y)., 2015, Oct 15;1(1):e1-e15 PMID: 28824964
- (S)-Reticuline is the (S)-enantiomer of Reticuline. An enantiomer of a tetrahydrobenzylisoquinoline alkaloid. Reticuline is a chemical compound found in a variety of plants including Lindera aggregata, Annona squamosa, and Ocotea fasciculata.
- Ana Rubio, .et al. , Drug Test Anal, 2023, Jul 31 PMID: 37525530
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DCPS inhibitor
RG3039 (PF-06687859) is orally bioavailable, brain-penetrant small molecule that has been shown to be an inhibitor of the mRNA decapping enzyme, DcpS. -
morpholino antisense oligomer
Eteplirsen is an experimental drug, currently in clinical trials. - TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.
- Zewen Wen, .et al. , J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Fan Zhang, .et al. , BMC Microbiol, 2018, 18: 211 PMID: 30545293
- Jin-xin Zheng, .et al. , Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997
- Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. Doxepin is a tricyclic antidepressant.
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sympathetic ganglioblocker
Fluorocurarine chloride is a short-acting selective sympathetic ganglioblocker with weak antagonist activity on the nicotinic receptor at the neuromuscular junction.
