Catalog No.
Product Name
Application
Product Information
Citations
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NPY Receptor Y2 Agonist
Neuropeptide Y (3-36) (human, rat) is an agonist of the Neuropeptide Y receptor Y2 (NPY Y2). This neuropeptide Y metabolite, generated by the action of dipeptidyl peptidase-4 (DPP4), has been shown to reduce the release of norepinephrine through its interaction with the Y2 receptor. It is primarily utilized in research related to neurophysiology and metabolic disorders, providing insights into pathways associated with appetite regulation and anxiety. -
Neuropeptide Y2 Receptor Agonist
Neuropeptide Y (13-36), amide, human functions as a selective agonist for the neuropeptide Y2 receptor. This peptide is involved in various physiological processes, including appetite regulation, anxiety, and circadian rhythms. Researchers utilize this reagent to study neuropeptide signaling pathways and to explore therapeutic targets for metabolic and psychological disorders. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, human is a C-terminally amidated 36-amino acid peptide that functions as an agonist at the neuropeptide Y (NPY) Y4 and Y5 receptors. This compound is involved in the regulation of appetite and energy homeostasis, making it crucial for research in metabolic disorders and neurobiology. Its unique biological activity allows for valuable insights into the role of neuropeptides in physiological processes and potential therapeutic applications. -
Non-peptide Neuropeptide Neuropeptin Receptor Antagonist
SR 142948A is a non-peptide antagonist of neuropeptide neuropeptin receptors, exhibiting high affinity for NT1 and NT2 subtypes. This compound is primarily utilized in research to elucidate the role of neuropeptides within the neurotransmitter system, with particular emphasis on their interactions with the dopamine system. Its ability to selectively inhibit these receptors makes it a valuable tool for studies investigating neuropeptide signaling pathways and their physiological implications. -
Neuropeptide Y2 Receptor Agonist
Neuropeptide Y (13-36), porcine is a selective agonist of the neuropeptide Y2 receptor, known for its role in modulating appetite and stress response. This peptide fragment enhances neuropeptide Y signaling, making it a valuable tool for studying energy balance and neurophysiology. Its applications extend to research on metabolic disorders and neurobehavioral studies, facilitating a better understanding of neuropeptide interactions in various biological contexts. -
Pancreatic Peptide Secretion
Pancreatic Polypeptide primarily targets pancreatic peptide secretion. This peptide is produced by the endocrine PP cells of the pancreas and plays a crucial role in regulating pancreatic secretory activities. Additionally, it influences hepatic glycogen storage and modulates gastrointestinal secretions, making it valuable for research in metabolic processes and gastrointestinal physiology. -
Bioactive Peptide
Neuropeptide S (mouse) is a bioactive peptide that functions as a neurotransmitter and neuromodulator composed of 20 amino acids. This peptide plays a significant role in regulating various physiological processes, including arousal, anxiety, locomotion, feeding behaviors, memory, and substance addiction. It serves as an important tool for research in neurobiology and behavioral science, facilitating investigations into its impact on emotional and cognitive functions. -
Y5 Receptor Agonist
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective agonist for the neuropeptide Y Y5 receptor, exhibiting an IC50 of 0.24 nM for binding to the human Y5 receptor. This compound significantly stimulates food intake, making it valuable for research into appetite regulation and metabolic disorders. Its specific activity at the Y5 receptor allows for targeted investigations into neuropeptide signaling pathways and their implications in obesity and other related conditions. -
Neuropeptide S Receptor (NPSR) Antagonist
RTI-118 is a small-molecule antagonist of the neuropeptide S receptor (NPSR). This compound has demonstrated potential in mitigating addiction behaviors, including a selective reduction in self-administration of addictive agents. RTI-118 serves as a valuable tool for research investigating the role of NPSR in addiction and related neuropharmacological pathways. -
NPY Cardiac Receptor Antagonist
Neuropeptide Y (18-36) (porcine) serves as a competitive antagonist of neuropeptide Y (NPY) cardiac receptors. With an IC50 value of 158 nM and a Ki value of 140 nM, this compound effectively inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner. It is a valuable reagent for research focused on the pathophysiology and therapeutic interventions in congestive heart failure. -
Neuropeptide
Capa-2 is a neuropeptide that primarily targets calcium ion channels. It activates calcium ion influx, stimulates nitric oxide (NO) production, and activates soluble guanylate cyclase (sGC), resulting in elevated intracellular cGMP levels. This compound plays a crucial role in regulating ion and fluid secretion and is valuable in research focusing on diuresis and renal function. -
Endogenous Peptide Hormone
Uroguanylin (human) is an endogenous peptide hormone that acts as a natural ligand for the Guanylyl Cyclase receptor. This compound exhibits significant anti-tumor activity, particularly in the context of metastatic colorectal cancer. Uroguanylin (human) serves as a valuable tool for research applications focused on cancer biology and the exploration of signaling pathways related to gastrointestinal tumors. -
Eyelash Growth Stimulator
Myristoyl pentapeptide-17 acetate is a potent eyelash growth stimulator that enhances keratin production. This compound facilitates the delivery of essential components in serums, including growth factors and lysophosphatidic acid, promoting healthy eyelash development. Its application in cosmetic research underscores its potential in hair follicle biology and regenerative therapies for enhancing eyelash length and density. -
Eyelash Growth Stimulator
Myristoyl pentapeptide-17 is a peptide compound that stimulates eyelash growth primarily by enhancing keratin production. This reagent facilitates the delivery of essential growth factors and lysophosphatidic acid present in formulations, supporting hair follicle health and elongation. Its applications include cosmetic research on eyelash enhancement and the development of formulations targeting hair growth. -
mAChR Antagonist
Dipeptide diaminobutyroyl benzylamide diacetate functions as a muscarinic acetylcholine receptor (mAChR) antagonist. It induces muscle relaxation, making it relevant in studies related to skin aging and facial wrinkles, including crow's feet and periorbital creases. This compound can be utilized in research focused on dermatological applications and the physiological mechanisms underlying muscle tone regulation in the skin. -
Neuropeptide
KEMPFPKYPVEP is a 12-amino acid neuropeptide that targets neuropeptide receptors to enhance the levels of dopamine (DA) and norepinephrine (NE) in the prefrontal cortex. This compound has been shown to promote spatial and object recognition memory in mouse models of amnesia induced by Scopolamine. It serves as a valuable tool for research into cognitive enhancement and the underlying mechanisms of memory function. -
Peptide Hormone
Atrial natriuretic peptide (3-28) (human) is a peptide hormone primarily synthesized and secreted by the atrial myocardium. This bioactive peptide plays a critical role in the regulation of blood pressure, fluid balance, and electrolyte homeostasis. Research applications include studies on cardiovascular function, renal physiology, and the modulation of neurohormonal pathways. -
Peptide
Big endothelin-3 (Human, 1-41 amide) serves as a precursor molecule to the bioactive peptide Endothelin-3 (ET-3), consisting of 41 amino acids. This peptide is primarily involved in vasoconstriction and regulation of vascular tone. Its applications extend to studying cardiovascular function, understanding cellular signaling pathways, and exploring potential therapeutic targets in hypertension and heart failure research. -
Vasoactive Peptide
[Ala2] Endothelin-3 (ET-3) is a vasoactive peptide analog of endothelin-3, featuring alanine substitutions for cysteine residues. This peptide is primarily produced by human rhabdomyosarcoma cell lines and plays a crucial role in paracrine signaling by promoting endothelial cell migration. Research applications include studies on vascular biology, endothelial function, and the pathophysiology of muscle-origin tumors. -
ANP Peptide Fragment
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide that exhibits natriuretic, diuretic, and vasorelaxant properties. This compound is valuable for research in cardiovascular physiology and fluid homeostasis, as it plays a crucial role in regulating blood pressure and electrolyte balance. Its unique properties make ANP (1-30), frog an essential tool for investigations into cardiac function and therapeutic potential for hypertension-related disorders. -
Mitochondrial N-formyl Peptide
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that selectively targets calcium ion depletion in the endoplasmic reticulum. This compound effectively inhibits the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides, making it valuable for research in inflammation and immune response. Its utility in investigating mitochondrial function and leukocyte signaling pathways underscores its significance in the study of cellular calcium dynamics and immune modulation. -
FPRs Binding Peptide
N-Formyl-Met-Ala-Ser is a peptide that specifically binds to formyl peptide receptors (FPRs) on neutrophils. This interaction plays a crucial role in the regulation of immune responses and chemotactic activity. N-Formyl-Met-Ala-Ser is valuable for research applications related to inflammation, host defense mechanisms, and the study of neutrophil behavior. -
Bioactive Peptide
WRW4-OH is a bioactive peptide that selectively inhibits the binding of the FPRL1 agonist WKYMVm to its corresponding receptor. FPRL1 plays a crucial role as a classical chemoattractant receptor found in phagocytic cells within the peripheral blood and brain. The modulation of FPRL1 is of significant interest in research related to inflammatory responses and neurodegenerative disorders, making WRW4-OH a valuable tool for studies in immunology and neurobiology. -
Neuropeptide
Neuromedin S (human) is a neuropeptide comprising 33 amino acids, functioning primarily as a ligand for the orphan G-protein coupled receptor FM-4/TGR-1 and the neuromedin U receptor 2 (NMUR2). This peptide plays a crucial role in the regulation of body weight homeostasis, making it valuable for research in metabolic disorders and neurobiology. Its unique mechanism of action positions Neuromedin S as an essential tool for studying the signaling pathways associated with energy balance and obesity-related conditions. -
vasoactive Peptide
Endothelin-3 is a 21-amino acid vasoactive peptide that targets G-protein-coupled receptors, specifically ET-RA and ET-RB. This peptide plays a critical role in regulating vascular tone and blood pressure through its potent vasoconstrictive properties. It is primarily used in research applications related to cardiovascular physiology and pathology, as well as in studies investigating the role of endothelins in various disease models across human, mouse, rabbit, and rat systems. -
Neuropeptide Hormone
Corazonin is a conserved neuropeptide hormone that functions as a central regulator of caste identity and behavior in social insects. Its differential expression in worker and forager populations underscores its significant role in social organization and behavior within various insect species. This peptide is valuable for research into neurobiology, insect physiology, and social behavior dynamics. -
Pentapeptide
GLP-1(32-36)amide is a pentapeptide derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has been shown to inhibit weight gain and positively influence whole-body glucose metabolism in diabetic mouse models. It serves as a valuable tool for studying metabolic disorders and potential therapeutic strategies for diabetes management. -
GLP-1 Peptides
GLP-1 (1-36) amide (human, rat) is a molecular variant of the glucagon-like peptide 1 (GLP-1) family. This peptide demonstrates the ability to stimulate [14C]aminopyrine accumulation in enzymatically dispersed rat parietal cells, indicating its role in gut hormone regulation. It is useful for research applications focused on metabolic disorders, glucose homeostasis, and appetite suppression, providing insights into obesity and diabetes mechanisms. -
GCGR Agonist
Glucagon-like peptide 1 (1-37), human is a potent agonist of the glucagon receptor (GCGR). This peptide plays a critical role in glucose metabolism and insulin signaling, making it valuable for research in diabetes and metabolic disorders. Its biological activity includes enhancing insulin secretion, inhibiting glucagon release, and promoting satiety, which are important for studies on obesity and diabetes therapies. -
Glicentin-related Pancreatic Polypeptide
GRPP (human) is a 30 amino acid peptide derived from glucagon, targeting the Glicentin-related Pancreatic Polypeptide. It is known to induce modest increases in plasma insulin levels while decreasing plasma glucagon concentrations. GRPP (human) serves as a valuable tool for research into pancreatic function and the regulation of glucose metabolism. Its specific effects on insulin and glucagon make it pertinent for studies related to metabolic disorders. -
Peptide
Exendin-4 (3-39) is a peptide that functions as a selective agonist for the Glucagon-like peptide-1 receptor (GLP-1r). This truncated variant of Exendin-4 is missing the first two amino acids, while retaining its bioactivity. Exendin-4 (3-39) is primarily employed in research exploring metabolic diseases, diabetes, and the hypothalamic-pituitary-adrenal (HPA) axis. Its structural modifications allow for investigations into receptor interactions and signaling pathways related to GLP-1r. -
Polypeptide
PHI-27 (porcine) is a 27 amino acid polypeptide that serves as a crucial tool for investigating peptide hormones and other biologically active peptides. Its structural properties enable researchers to explore peptide interactions and functions, making it valuable in studies related to endocrinology and cellular signaling. This reagent supports the identification and characterization of peptide-based signaling pathways, contributing to advancements in peptide research and therapeutic developments. -
GCGR Agonist
Neuropeptide Y, porcine, is a peptide found in porcine brain that acts as a GCGR agonist. This compound is known for its ability to inhibit secretin-stimulated pancreatic secretion, making it a valuable tool for studying pancreatic function and regulation. Its applications extend to research on energy homeostasis, appetite regulation, and potential therapeutic interventions in metabolic disorders. -
Vasodilatory Neuropeptide
Helospectin I is a vasoactive neuropeptide belonging to the vasoactive intestinal peptide (VIP) family. It exhibits significant vasodilatory and antihypertensive effects, contributing to a reduction in blood pressure. Initially isolated from the salivary gland venom of the lizard Heloderma suspectum, Helospectin I is valuable for research involving cardiovascular physiology and neuropeptide signaling pathways. -
Polypeptide
Gastric Inhibitory Polypeptide (6-30) amide (human) is a polypeptide that functions as an incretin hormone, primarily targeting insulin secretion in the pancreas. This fragment plays a pivotal role in glucose metabolism and regulation. Its biological activity makes it valuable for research applications focused on diabetes, obesity, and related metabolic disorders. -
Vasodilatory Neuropeptide
Helospectin II is a vasodilatory neuropeptide belonging to the vasoactive intestinal peptide (VIP) family. It exhibits significant vasodilatory and antihypertensive properties, effectively reducing blood pressure. This peptide was originally isolated from the salivary gland venom of the lizard Heloderma suspectum and serves as a valuable tool for research into cardiovascular functions and neuropeptide signaling pathways. -
Auxin Releases Peptide Analog
AZP-531 is an analog of unacylated ghrelin, primarily targeting the ghrelin receptor to enhance glycemic control and promote weight reduction. This compound exhibits significant biological activity in metabolic studies, making it a valuable tool in obesity and diabetes research. Its application extends to exploring the mechanisms of appetite regulation and energy homeostasis. -
Neuropeptide Hormone
Somatostatin-25 is a naturally occurring neuropeptide hormone that primarily inhibits the secretion of growth hormone. This regulatory activity plays a crucial role in various physiological processes, including the modulation of endocrine functions and gastrointestinal activities. It is widely utilized in research to investigate growth hormone regulation and its implications in disorders related to endocrine signaling. -
Glucagon Peptide
(Asp28)-Glucagon (1-29) is a modified form of the glucagon peptide, where aspartic acid (Asp) has been introduced at position 28 to enhance its aqueous solubility in physiological pH buffers. This structural optimization preserves the biological activity characteristic of glucagon. It serves as a valuable reagent for research applications that investigate glucagon's role in glucose metabolism, diabetes, and other metabolic disorders in human, rat, and porcine models. -
Hormone-like Actions Peptide
Phoenixin-14 (PNX-14) is a hormone-like peptide that activates the AHA GnRH system, producing anxiolytic effects in murine models. Additionally, PNX-14 exhibits neuroprotective properties by inhibiting cytotoxicity induced by ischemia/reperfusion in microglial cells. This compound serves as a valuable tool for research into stress response and neuroinflammatory processes. -
PrRP Fragment
Prolactin-Releasing Peptide (12-31), rat is a fragment of prolactin-releasing peptide (PrRP) that selectively targets GPR10 receptors. This peptide exhibits significant biological activity by stimulating calcium mobilization in CHOK1 cells transfected with the PrRP receptor. It is useful for research applications involving neuropeptide signaling and the role of GPR10 in hormonal regulation. -
GPR10 Ligand
Prolactin Releasing Peptide (1-31), human is a potent ligand for the GPR10 receptor, facilitating the release of prolactin. This peptide exhibits high affinity binding, with Ki values of 1.03 nM for human GPR10 and 0.33 nM for rat GPR10. It is a valuable tool for investigating the hypothalamo-pituitary axis and studying prolactin-related physiological processes. -
Neuropeptide
Zebrafish Kisspeptin-1 is a key neuropeptide that primarily targets the regulation of gonadotropin-releasing hormone (GnRH) release. This peptide plays a crucial role in the modulation of the reproductive system in zebrafish. It is widely utilized in research related to reproductive biology, neuroendocrine signaling, and developmental studies, providing insights into the mechanisms underlying reproduction and hormonal regulation. -
Antireproductive Tripeptide
Threonyl-seryl-lysine is an antireproductive tripeptide that exhibits antigonadotropic activity by binding to luteinizing hormone-releasing hormone (LHRH) at a specific site within residues 2-5. This compound is instrumental in the study of reproductive biology, particularly in understanding the regulatory mechanisms of gonadotropin secretion. Its ability to modulate hormone levels makes it a valuable tool for research applications related to fertility and reproductive health. -
Polypeptide
(Des-Pyr1)-LHRH is a modified polypeptide designed for research into hormone receptor interactions. It plays a crucial role in the study of gonadotropin-releasing hormone (GnRH) and has applications in peptide screening for protein interactions, functional assays, and epitope mapping. This reagent is particularly valuable in agent research and development, contributing to advancements in reproductive biology and endocrinology. -
GAP
GnRH Associated Peptide (25-53), human targets gonadotropin-releasing hormone (GnRH) and serves as a crucial fragment of the human GnRH-associated peptide (hGAP-25-53). This peptide is suitable as an immunogen for the generation of specific antiserum including MC-1, MC-2, and MC-3. By connecting to the luteinizing hormone-releasing hormone (LH-RH) sequence via a three-amino acid processing site, it plays a significant role in reproductive hormone regulation and offers valuable applications in endocrinology and reproductive biology research. -
Peptide Hormone
(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is a synthetic peptide hormone designed to interact with the luteinizing hormone-releasing hormone (LHRH) receptor. This compound exhibits key biological activities related to hormone regulation and neuroendocrine function. Its applications include research in reproductive biology, endocrine signaling pathways, and potential therapeutic investigations in hormone-related disorders. -
Active Peptide
(Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) is an active peptide that targets the luteinizing hormone-releasing hormone (LHRH) receptor. This compound is known for its role in regulating gonadotropin release and influencing reproductive hormone signaling. It is valuable for biochemical studies related to reproductive biology, neuroendocrine signaling, and the development of therapeutic agents targeting reproductive disorders. -
Polypeptide
Glp-His-Pro-Gly-NH2 is a polypeptide that functions primarily as a stimulant for gonadotrophin release, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This peptide plays a crucial role in reproductive physiology and is valuable in research applications related to hormone regulation, fertility studies, and endocrine system investigations. Its ability to modulate hormone secretion makes it a useful reagent for studying pituitary function and related hormonal pathways. -
Polypeptide
LHRH (1-5) free acid is a polypeptide derived from the cleavage of luteinizing hormone-releasing hormone at the Tyr55-Gly66 site. This compound can be further processed into LHRH (1-3) and LHRH (4-5) fragments through the action of Angiotensin-converting enzyme. It serves as a valuable tool for studying neuroendocrine signaling and reproductive biology, facilitating research into hormone regulation and related physiological processes.
