Catalog No.
Product Name
Application
Product Information
Citations
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Neuropeptide
BNP(1-32), porcine is an atrial natriuretic peptide that primarily targets neuropeptide pathways. This cardiac hormone exhibits significant natriuretic, diuretic, and vasorelaxant effects, making it valuable for cardiovascular research. Furthermore, BNP(1-32) has been shown to influence passive avoidance learning in rodent models, highlighting its potential role in neurobiology studies involving dopaminergic and cholinergic systems, as well as adrenergic receptor interactions. -
Peptide
BNP (1-21), Pro (Human) is a 21-amino acid peptide and a member of the B-type natriuretic peptide family, a cardiac natriuretic hormone. It plays a crucial role in regulating cardiovascular function by promoting natriuresis, diuresis, and vasodilation. Research applications include studies on heart organogenesis and the physiological adaptations during the transition to extrauterine life. BNP serves as an important biomarker in various cardiovascular diseases and helps elucidate the underlying mechanisms of heart function and development. -
ANP Peptide Fragment
Atrial Natriuretic Peptide (7-28), human, canine is a bioactive peptide fragment derived from atrial natriuretic peptide (ANP). This fragment plays a crucial role in cardiovascular homeostasis by promoting natriuresis and vasodilation. It is primarily utilized in research applications focusing on cardiovascular function, heart failure, and the regulatory effects of natriuretic peptides. Additionally, this peptide can serve as a useful tag for various biochemical assays. -
Hypotensive and Diuretic Agent
Brain Natriuretic Peptide-45, rat is a potent hypotensive and diuretic agent derived from rat heart tissue. This circulating form of rat brain natriuretic peptide plays a critical role in regulating blood pressure and sodium homeostasis. Its biological activity is essential for research applications focusing on cardiovascular physiology, heart failure, and fluid balance in animal models. -
ANP Analog
[Tyr8]-Atrial Natriuretic Peptide (5-27), rat is an analog of atrial natriuretic peptide (ANP) that primarily targets smooth muscle relaxation. This peptide is characterized by its ability to induce vasodilation while maintaining stable cGMP levels. Its unique properties make it a valuable tool for research in cardiovascular physiology and pharmacology, particularly in studies examining the regulatory mechanisms of blood pressure and fluid homeostasis. -
Atrial Peptide
[Mpr7, DAla9] ANP (7-28), amide, rat is a modified atrial natriuretic peptide that acts on the NPR-A receptor. This reagent exhibits significant vasodilatory effects and plays a crucial role in regulating cardiovascular homeostasis. It is widely used in research to study cardiac function, blood pressure regulation, and the pathophysiology of heart failure. -
Peptide Neurotransmitter
Neurokinin A TFA is a peptide neurotransmitter belonging to the tachykinin family, primarily targeting the NK-2 receptor. This compound plays a significant role as a mediator in human airway and gastrointestinal tissues, influencing smooth muscle contraction and various physiological processes. It is extensively utilized in research applications exploring neurogenic inflammation, pain signaling, and gastrointestinal motility. -
Neurokinin Receptor Activator
Eledoisin Related Peptide is a neurokinin receptor activator that functions as an analog of Substance P. This peptide is known to stimulate neurons, resulting in various behavioral responses. It serves as a valuable tool for research applications focused on neurokinin signaling pathways and tachykinin receptor interactions. -
Neuropeptide Substance P Antagonist
Octahydroisoindole is a neuropeptide Substance P antagonist that effectively crosses the blood-brain barrier. This compound is vital for investigating movement disorders linked to central nervous system diseases, enabling researchers to explore its potential therapeutic applications in conditions such as pain and neurodegeneration. -
C-terminal Tripeptide of Substance P
Gly-Leu-Met-NH2 is a C-terminal tripeptide derived from Substance P, a neuropeptide known for its role in pain transmission and inflammation. This compound exhibits neuroactive properties that can be utilized in research applications related to neurobiology, pain mechanisms, and neuroinflammatory processes. Its structural similarity to Substance P makes it a valuable tool for studying receptor interactions and signaling pathways associated with neuropeptide functions. -
NK2 Receptor Agonist
γ-Neuropeptide (rabbit) is an endogenous peptide that acts as an agonist for the neurokinin 2 (NK2) receptor. It plays a significant role in regulating the hypothalamic-pituitary-adrenal (HPA) axis and the release of reproductive hormones. This reagent is valuable for studies investigating neurokinin signaling pathways and their implications in stress response and reproductive health. -
Neuropeptide
Substance P (6-11) is a neuropeptide specifically targeting the NK-1 tachykinin receptor. This C-terminal hexapeptideamide derivative of Substance P demonstrates significant biological activity, including the depolarization of motoneurons and a hypotensive effect. It serves as a valuable tool in research applications focused on neurobiology, pain modulation, and cardiovascular studies. -
Neuromessenger
Neuropeptide K is a tachykinin neuromessenger that plays a crucial role in facilitating intercellular communication within the central nervous system. It is involved in various biological activities, such as gallbladder contraction, protein extravasation, hypotension, and bronchial smooth muscle spasms. This reagent is derived from human, porcine, and rat sources, making it suitable for research applications aimed at exploring neuropeptide signaling and its implications in physiological and pathophysiological processes. -
Neuropeptide
Substance P (5-11) is a neuropeptide that primarily targets the NK-1 tachykinin receptor. As a C-terminal heptapeptide of the full Substance P, it plays a critical role in pain transmission and neurogenic inflammation. This compound is commonly used in research applications focused on pain pathways, neurobiology, and receptor pharmacology, providing insights into the functions and mechanisms of neuropeptide activity. -
Peptide
[Tyr8,Nle11] Substance P is an analog of the neuropeptide Substance P, which primarily targets neurokinin receptors. This peptide plays a significant role in various biological processes, including pain transmission and inflammatory responses. It is widely used in research to study nociceptive pathways and the modulation of inflammatory conditions. -
Octapeptide
[Glp5] Substance P (5-11) is an octapeptide that primarily targets neurokinin receptors. This fragment of substance P plays a significant role in the central nervous system (CNS) of rats, where it is known to modulate dopamine release in the striatum. Its ability to influence neurotransmitter dynamics makes it valuable for research in neuropharmacology and studies related to CNS functions and disorders. -
Neuropeptide
Substance P (alligator) is a neuropeptide that plays a crucial role in pain perception, inflammation, and various neurogenic processes. Its amino acid sequence is Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. This reagent is used in research to elucidate the mechanisms of neurogenic inflammation and to investigate the role of neuropeptides in signaling pathways related to pain and stress responses. Substance P (alligator) is valuable for studying neuropeptide interactions and their implications in various physiological and pathological conditions. -
Neuropeptide
Tyr0-Neurokinin A is a tachykinin neuropeptide that acts as an agonist for the Tachykinin receptor 2 (Tacr2). This compound is significant in the study of metabolic disorders, particularly in understanding the mechanisms underlying insulin resistance, obesity, and diabetes. Its biological activity positions it as a valuable tool for advancing research in neuropeptide signaling and associated therapeutic targets. -
Peptide
Kassinin is a neuropeptide derived from the Kassina frog, classified within the tachykinin family. It functions primarily as a signaling molecule in neuropeptide pathways and is released in response to stress as part of the organism's defense mechanism. This peptide is of interest in research focused on neurobiology, signaling pathways, and the study of amphibian defense mechanisms. -
NPBW1/2 Agonist
Neuropeptide W-23 (human) is an endogenous agonist specifically targeting the NPBW1 (GPR7) and NPBW2 (GPR8) receptors. This neuropeptide plays a significant role in various physiological processes, including appetite regulation and stress response. Neuropeptide W-23 is primarily used in research applications focusing on neurobiology and metabolic disorders, providing insights into neural signaling pathways and potential therapeutic targets. -
Neuropeptide
Biotinyl-neuropeptide W-23 (human) is a biotinylated analog of the neuropeptide W-23, which functions as an agonist of the NPBW1 (GPR7) and NPBW2 (GPR8) receptors. This compound modulates neuropeptide signaling pathways involved in various physiological processes, making it useful for investigating neuropeptide-related functions and signaling mechanisms in research applications. Biotinyl-neuropeptide W-23 facilitates the study of receptor interactions and offers potential insights into neurobiology and drug development. -
NPBW Agonist
(Des-Bromo)-Neuropeptide B (1-23) (human) is an agonist for G-protein coupled receptors GPR7 (NPBW1) and GPR8 (NPBW2). It exhibits high affinity binding with inhibition constants (Kis) of 1.2 nM and 341 nM, respectively. This compound is valuable for investigating the neuropeptide signaling pathways and their roles in various physiological processes. It has applications in studies related to neurobiology, metabolic regulation, and receptor pharmacology. -
Stress Mediator
Neuropeptide W-30 (human) is a significant stress mediator in the central nervous system, primarily targeting the hypothalamus-pituitary-adrenal (HPA) axis and modulating sympathetic outflow. As an endogenous ligand for the orphan G-protein-coupled receptors GPR7 and GPR8, Neuropeptide W-30 (human) binds and activates both receptors at comparable effective doses. This compound plays a crucial role in studies related to stress response and neuroendocrine regulation. -
Stress Mediator
Neuropeptide W-30 (rat) primarily targets the G-protein-coupled receptors GPR7 and GPR8, functioning as a key mediator of stress within the central nervous system. It plays a crucial role in modulating the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow, influencing stress responses. Neuropeptide W-30 (rat) acts as an endogenous ligand for both receptors, demonstrating similar effective doses for binding and activation. This peptide is pertinent for research into stress-related disorders and neuroendocrine functions. -
NPFF1/NPFF2 Receptor Agonist
Neuropeptide FF (NPFF) functions as an agonist for the NPFF1 and NPFF2 receptors, exhibiting Ki values of 2.82 nM and 0.21 nM, respectively. This octapeptide plays a crucial role in mediating various physiological processes, including the modulation of pain, opioids, autonomic function, and neuroendocrine responses. It is involved in the regulation of memory and the control of food and water intake, while also demonstrating significant antiopioid and analgesic properties. Neuropeptide FF is particularly relevant for research into opioid tolerance, morphine-induced analgesia, abstinence syndrome, and pain-related conditions, including inflammatory and neuropathic pain. -
NPFF-Related Peptides
Neuropeptide FF (5-8) is a derivative of Neuropeptide FF that acts as a potent antagonist of NPFF-related receptors. This peptide, with the sequence Q-P-Q-R-F-NH2, exhibits a Ki value of 20.9 nM, indicating its strong binding affinity. It is primarily used in research to study pain modulation, stress responses, and neuroendocrine functions in various biological models. -
PrRP Fragment
Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP), which is known for its role in modulating pain through RF-amide signaling. This peptide is primarily utilized in research focused on the nervous system, particularly in studies related to pain pathways and neurological disorders. Its specific biological activity makes it a valuable tool for exploring the mechanisms underlying nervous system diseases. -
Non-peptide NPSR Antagonist
SHA 68 is a potent and selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107. This compound exhibits limited blood-brain barrier penetration, making it suitable for research on peripheral applications and neuralgia. SHA 68 is valuable for studying the physiological roles of neuropeptide S and its potential implications in pain modulation and neurobiology. -
Neuropeptide
Buccalin is a neuropeptide that primarily targets synaptic transmission at the neuromuscular junction. It effectively reduces the amplitude of motor neuron-induced muscle contractions when externally administered, acting presynaptically without influencing the rate of muscle relaxation. Buccalin diminishes excitatory junction potentials at the ARC while preserving the contractile response elicited directly through acetylcholine. This selective modulation makes it a valuable tool for research on synaptic mechanisms and neuropeptide function in neuromuscular signaling. -
Active Compound
Neuropeptide Y (human, rat, mouse) is an active compound that plays a critical role in neuroprotection and modulation of neuronal activity. It has been shown to protect rat cortical neurons from β-Amyloid-induced toxicity, suggesting its potential relevance in Alzheimer's disease research. This peptide is commonly utilized in studies focused on neurodegenerative disorders and neuronal signaling pathways. -
Gut Hormone
Peptide YY (PYY) is a human gut hormone primarily involved in appetite regulation and the inhibition of pancreatic secretions. It exerts its biological effects by interacting with Neuropeptide Y receptors. This peptide is valuable for research focused on metabolic disorders, appetite control, and the physiology of gastrointestinal hormones. -
Neuropeptide S receptor (NPSR) Agonist
R06039-636 is a potent agonist of the Neuropeptide S receptor (NPSR), exhibiting an EC50 value of 94 nM. This compound plays a crucial role in modulating anxiety and stress responses, making it valuable for research into neuropsychiatric disorders. Its selective activation of NPSR provides insight into neuropeptide signaling pathways and can aid in the development of potential therapeutic strategies. -
NPY Y1 Receptor Agonist
[Leu31,Pro34]-Neuropeptide Y (porcine) is a selective agonist of the neuropeptide Y Y1 receptor. This analog exhibits significant anxiolytic effects, making it a valuable tool for studying anxiety-related disorders. It is predominantly utilized in neuropharmacological research to explore the role of NPY in stress and anxiety modulation. -
Peptide
Neuropeptide Y(29-64) is a peptide fragment comprising 36 amino acids derived from the larger neuropeptide Y. This fragment plays a critical role in modulating various physiological processes, including appetite regulation, anxiety, and stress response. Research applications include exploring neuropeptide signaling pathways and investigating the role of neuropeptides in neuropsychiatric disorders. -
NPY Receptor Y2 Agonist
Neuropeptide Y (3-36) (human, rat) is an agonist of the Neuropeptide Y receptor Y2 (NPY Y2). This neuropeptide Y metabolite, generated by the action of dipeptidyl peptidase-4 (DPP4), has been shown to reduce the release of norepinephrine through its interaction with the Y2 receptor. It is primarily utilized in research related to neurophysiology and metabolic disorders, providing insights into pathways associated with appetite regulation and anxiety. -
Neuropeptide Y2 Receptor Agonist
Neuropeptide Y (13-36), amide, human functions as a selective agonist for the neuropeptide Y2 receptor. This peptide is involved in various physiological processes, including appetite regulation, anxiety, and circadian rhythms. Researchers utilize this reagent to study neuropeptide signaling pathways and to explore therapeutic targets for metabolic and psychological disorders. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, human is a C-terminally amidated 36-amino acid peptide that functions as an agonist at the neuropeptide Y (NPY) Y4 and Y5 receptors. This compound is involved in the regulation of appetite and energy homeostasis, making it crucial for research in metabolic disorders and neurobiology. Its unique biological activity allows for valuable insights into the role of neuropeptides in physiological processes and potential therapeutic applications. -
Non-peptide Neuropeptide Neuropeptin Receptor Antagonist
SR 142948A is a non-peptide antagonist of neuropeptide neuropeptin receptors, exhibiting high affinity for NT1 and NT2 subtypes. This compound is primarily utilized in research to elucidate the role of neuropeptides within the neurotransmitter system, with particular emphasis on their interactions with the dopamine system. Its ability to selectively inhibit these receptors makes it a valuable tool for studies investigating neuropeptide signaling pathways and their physiological implications. -
Neuropeptide Y2 Receptor Agonist
Neuropeptide Y (13-36), porcine is a selective agonist of the neuropeptide Y2 receptor, known for its role in modulating appetite and stress response. This peptide fragment enhances neuropeptide Y signaling, making it a valuable tool for studying energy balance and neurophysiology. Its applications extend to research on metabolic disorders and neurobehavioral studies, facilitating a better understanding of neuropeptide interactions in various biological contexts. -
Pancreatic Peptide Secretion
Pancreatic Polypeptide primarily targets pancreatic peptide secretion. This peptide is produced by the endocrine PP cells of the pancreas and plays a crucial role in regulating pancreatic secretory activities. Additionally, it influences hepatic glycogen storage and modulates gastrointestinal secretions, making it valuable for research in metabolic processes and gastrointestinal physiology. -
Bioactive Peptide
Neuropeptide S (mouse) is a bioactive peptide that functions as a neurotransmitter and neuromodulator composed of 20 amino acids. This peptide plays a significant role in regulating various physiological processes, including arousal, anxiety, locomotion, feeding behaviors, memory, and substance addiction. It serves as an important tool for research in neurobiology and behavioral science, facilitating investigations into its impact on emotional and cognitive functions. -
Y5 Receptor Agonist
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective agonist for the neuropeptide Y Y5 receptor, exhibiting an IC50 of 0.24 nM for binding to the human Y5 receptor. This compound significantly stimulates food intake, making it valuable for research into appetite regulation and metabolic disorders. Its specific activity at the Y5 receptor allows for targeted investigations into neuropeptide signaling pathways and their implications in obesity and other related conditions. -
Neuropeptide S Receptor (NPSR) Antagonist
RTI-118 is a small-molecule antagonist of the neuropeptide S receptor (NPSR). This compound has demonstrated potential in mitigating addiction behaviors, including a selective reduction in self-administration of addictive agents. RTI-118 serves as a valuable tool for research investigating the role of NPSR in addiction and related neuropharmacological pathways. -
NPY Cardiac Receptor Antagonist
Neuropeptide Y (18-36) (porcine) serves as a competitive antagonist of neuropeptide Y (NPY) cardiac receptors. With an IC50 value of 158 nM and a Ki value of 140 nM, this compound effectively inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner. It is a valuable reagent for research focused on the pathophysiology and therapeutic interventions in congestive heart failure. -
Neuropeptide
Capa-2 is a neuropeptide that primarily targets calcium ion channels. It activates calcium ion influx, stimulates nitric oxide (NO) production, and activates soluble guanylate cyclase (sGC), resulting in elevated intracellular cGMP levels. This compound plays a crucial role in regulating ion and fluid secretion and is valuable in research focusing on diuresis and renal function. -
Endogenous Peptide Hormone
Uroguanylin (human) is an endogenous peptide hormone that acts as a natural ligand for the Guanylyl Cyclase receptor. This compound exhibits significant anti-tumor activity, particularly in the context of metastatic colorectal cancer. Uroguanylin (human) serves as a valuable tool for research applications focused on cancer biology and the exploration of signaling pathways related to gastrointestinal tumors. -
Eyelash Growth Stimulator
Myristoyl pentapeptide-17 acetate is a potent eyelash growth stimulator that enhances keratin production. This compound facilitates the delivery of essential components in serums, including growth factors and lysophosphatidic acid, promoting healthy eyelash development. Its application in cosmetic research underscores its potential in hair follicle biology and regenerative therapies for enhancing eyelash length and density. -
Eyelash Growth Stimulator
Myristoyl pentapeptide-17 is a peptide compound that stimulates eyelash growth primarily by enhancing keratin production. This reagent facilitates the delivery of essential growth factors and lysophosphatidic acid present in formulations, supporting hair follicle health and elongation. Its applications include cosmetic research on eyelash enhancement and the development of formulations targeting hair growth. -
mAChR Antagonist
Dipeptide diaminobutyroyl benzylamide diacetate functions as a muscarinic acetylcholine receptor (mAChR) antagonist. It induces muscle relaxation, making it relevant in studies related to skin aging and facial wrinkles, including crow's feet and periorbital creases. This compound can be utilized in research focused on dermatological applications and the physiological mechanisms underlying muscle tone regulation in the skin. -
Neuropeptide
KEMPFPKYPVEP is a 12-amino acid neuropeptide that targets neuropeptide receptors to enhance the levels of dopamine (DA) and norepinephrine (NE) in the prefrontal cortex. This compound has been shown to promote spatial and object recognition memory in mouse models of amnesia induced by Scopolamine. It serves as a valuable tool for research into cognitive enhancement and the underlying mechanisms of memory function.
