Catalog No.
Product Name
Application
Product Information
Citations
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CaM kinase II Polypeptide
Calmodulin-Dependent Protein Kinase II (281-309) is a peptide corresponding to the regulatory domain of calcium/calmodulin-dependent protein kinase II (CaM-kinase II). This peptide plays a critical role in the regulation of various physiological processes, including synaptic plasticity and memory formation. It is utilized in research applications involving calcium signaling pathways, protein phosphorylation, and the study of neuronal function. -
CaM Binding Peptide
MLCK Peptide is a high-affinity (pM) calcium/calmodulin (CaM)-binding peptide derived from smooth muscle myosin light-chain kinase. This peptide serves as a valuable tool for studying CaM-mediated signaling pathways and muscle contraction mechanisms. Its reversible binding properties make it suitable for various applications in biochemical and physiological research, particularly in investigations of calcium signaling and muscle physiology. -
Peptide Ligand for GABARAP
K1 peptide is a high-affinity ligand for GABAA receptor-associated protein (GABARAP). It plays a crucial role in mediating protein interactions involved in cellular processes such as autophagy and synaptic transmission. K1 peptide is valuable for research applications focused on GABARAP function and its implications in neurobiology and cellular signaling pathways. -
Peptide
Octadecaneuropeptide is an 18-residue peptide that functions as a ligand for the gamma-aminobutyric acid (GABA) receptor's regulatory site, which is modulated by beta-carbolines. This peptide demonstrates significant biological activity by facilitating the punishment-induced suppression of drinking behavior in a dose-dependent manner. It serves as a valuable research tool for investigating GABAergic transmission and its implications in behavioral studies and neuropharmacology. -
Peptide Fragment
Leptin (22-56), human is a peptide fragment that plays a critical role in energy homeostasis and appetite regulation, interacting with various isoforms of leptin receptors (Ob-Rs). This fragment can be utilized in research applications focused on obesity, metabolic disorders, and endocrine signaling pathways. Its ability to influence signaling contributes to the understanding of leptin’s physiological effects and therapeutic potential in weight-related conditions. -
NCED3 Inducer
CLE25 peptide functions as an inducer of NCED3, facilitating the transport from roots to leaves and modulating NCED3 expression in conjunction with receptor-like kinases BAM1 and BAM3. This peptide promotes stomatal closure by influencing abscisic acid accumulation, thereby enhancing plant resistance to dehydration stress. It serves as a valuable tool in research related to plant stress responses and water regulation mechanisms. -
B lymphocyte mitogen/polyclonal Activator
Mitogenic Pentapeptide (Tripalmitoyl pentapeptide) is a synthetic N-terminal analog of E. coli outer membrane lipoproteins that serves as a potent B lymphocyte mitogen and polyclonal activator. It plays a critical role in stimulating B cell proliferation and differentiation, making it valuable in the study of immune adjuvants. This reagent is useful for investigating immune responses and developing immunotherapeutic strategies. -
Bioactive Peptide
p70 S6 Kinase substrate is a bioactive peptide that serves as a specific substrate for p70 ribosomal S6 kinase (S6K). This peptide plays a critical role in cellular signaling pathways, particularly in protein synthesis and cell growth regulation. It is widely utilized in research applications focused on the mechanistic understanding of mTOR signaling and related cellular processes. -
Lamin Kinase
S6 peptide is a significant substrate of lamin kinase, playing a crucial role in cardiac hypertrophy induced by mechanical loading. This peptide is activated by various growth factors, making it a valuable tool for studying cellular signaling pathways related to cardiac remodeling and hypertrophic responses. Its use in research can enhance the understanding of mechanisms underlying cardiovascular diseases and developmental processes. -
Neuroprotective Peptide
TAT-EE3 is a neuroprotective peptide that disrupts the interaction between TRPM2 and N-methyl-D-aspartate receptors (NMDARs). By inhibiting TRPM2-induced increases in NMDAR surface expression and current amplitude, TAT-EE3 offers protective effects against neuronal damage. This reagent serves as an important tool for research focused on ischemic injury and related conditions, including the study of ischemic stroke both in vitro and in vivo. -
Modified TAT-CBD3 Peptide
TAT-CBD3A6K is a modified TAT-CBD3 peptide that primarily targets voltage-dependent calcium channels. This compound effectively reduces T- and R-type calcium currents in dorsal root ganglion (DRG) neurons, demonstrating notable anti-nociceptive properties. TAT-CBD3A6K has been shown to mitigate pain in a model of AIDS-induced peripheral neuropathy by preventing the CRMP-2-mediated enhancement of T- and R-type calcium channel activity, making it a valuable tool for studying pain mechanisms and peripheral neuropathy interventions. -
Depolarizing Agent
Mast cell degranulating peptide (28-49) is a depolarizing agent derived from bee venom that acts on mast cells to induce degranulation. It has been shown to elevate cyclic guanosine monophosphate (cGMP) levels in mouse cerebellar slices, implicating its role in modulating neurotransmission and signaling pathways. This peptide is valuable for research applications focused on mast cell biology and the study of neuropharmacological effects. -
Neuropeptide
YMRF-NH2 is a neuropeptide that specifically targets the FMRFa receptor (FMRFa-R), exhibiting an EC50 value of 31 nM. This compound plays a critical role in neurobiology, particularly in studies related to neuropeptide signaling pathways. YMRF-NH2 is valuable for research focusing on neurotransmission and the physiological effects of neuropeptides. -
Proatherosclerotic Peptide Hormone
GIP (22-51) human is a potent proatherosclerotic peptide hormone targeting the NF-κB signaling pathway. This 30-amino acid peptide promotes the expression of matrix metalloproteinase-8 (MMP-8) and induces proinflammatory and proatherosclerotic protein expression. Additionally, GIP (22-51) human elevates intracellular free calcium levels in THP-1-derived macrophages, making it a valuable tool for atherosclerosis research. -
Satiety Signaling Neuropeptide
Perisulfakinin is a satiety signaling neuropeptide that targets central nervous system pathways. It plays a crucial role in regulating appetite and energy balance by inhibiting the activity of neurons that promote general activity. This compound is valuable for research applications focused on understanding food intake regulation, metabolic processes, and neuropeptide functions in the context of obesity and related disorders. -
Antiwrinkle Peptide
Argireline acetate, also known as Acetyl hexapeptide-3 acetate, is a non-toxic peptide designed to target the neuromuscular junction by significantly inhibiting Ca2+-dependent neurotransmitter release, primarily acetylcholine. This mechanism leads to its notable antiwrinkle and anti-aging effects, making it valuable in cosmetic research focused on skin rejuvenation and wrinkle reduction. Further investigations can explore its applications in dermatological and cosmetic formulations aimed at improving skin texture and appearance. -
Sperm Activating Peptide
Ser-Ala-alloresact is a sperm activating peptide (SAP) that facilitates the initiation of sperm motility and fertilization processes. This peptide originates from the eggs of marine invertebrates, where it plays a crucial role in enhancing sperm activation and promoting successful fertilization events. Researchers can utilize Ser-Ala-alloresact to explore mechanisms of fertilization and assess sperm function, providing insights into reproductive biology and potential fertility treatments. -
Anorexigenic Neuropeptide
LPLRF-NH2 is an anorexigenic neuropeptide that functions as a member of the RFamide peptide family. It has demonstrated the ability to increase arterial blood pressure and modulate the electrical activity of brainstem neurons. This compound is valuable for research applications focusing on appetite regulation and central nervous system signaling pathways. -
Polypeptide Toxins
Sarafotoxin S6d is a polypeptide toxin derived from the venom of the Israeli sand boa constrictor, known for its cardiovascular effects. This compound induces significant electrocardiogram (ECG) alterations, including myocardial ischemia and hyperkalemia, while also promoting robust extracellular calcium-dependent vasoconstriction in rat aorta and positive inotropic effects in rat atria. Sarafotoxin S6d is valuable in the investigation of cardiovascular pathologies and related physiological mechanisms. -
Palmitoylated Peptide Derivative
Palmitoyl glutathione is a palmitoylated peptide derivative that serves as a liver-targeted liposome-forming agent. It effectively forms liposome-like vesicles in conjunction with cholesterol, enabling the encapsulation of water-soluble solutes while maintaining stability in fresh rat plasma at 37°C. This compound is particularly relevant for research applications related to acetaminophen-induced liver necrosis, providing a valuable tool for studying liver pathology and therapeutic interventions. -
Peptide Lipid
cKK-E15 is a peptide-lipid utilized for formulating lipid nanoparticles (LNP) such as LNP3, in combination with C14PEG2000, unmodified cholesterol, and DOPE. This compound facilitates effective encapsulation and delivery of nucleotides and other therapeutic agents, enhancing cellular uptake. Its unique structure supports applications in gene therapy and vaccine development, providing a versatile tool for researchers in lipid formulation and nanoparticle technology. -
Tetrapeptide Fluorescent Substrate
Ac-LVSR-AMC is a tetrapeptide fluorescent substrate designed to quantitatively assess the specific activity of Malt1 protease in vitro. This compound serves as a valuable tool for studying proteolytic processes and Malt1-related signaling pathways. Its fluorogenic properties enable sensitive detection, making it suitable for applications in biochemical assays and research on immune responses. -
Bioactive Peptide
SRC-1 (686-700) is a bioactive peptide that contains the second LXXLL motif, derived from the NR box II of steroid receptor coactivator 1 (SRC-1). This peptide functions by interacting with nuclear receptors in a ligand-dependent manner, enhancing transcriptional activity. SRC-1 (686-700) is valuable for studies investigating steroid receptor signaling and coactivation pathways, providing insights into gene regulation mechanisms in various biological contexts. -
Amyloid Precursor
Amyloid Precursor C-terminal peptide targets the Amyloid Precursor Protein (APP) and plays a significant role in the pathology of Alzheimer's disease (AD). This peptide, cleaved from the C-terminus of APP, is associated with alterations in mitochondrial morphology and impaired basal mitophagy, suggesting its involvement as a potential etiological trigger in AD. It is valuable for research focused on neurodegenerative diseases, neuroscience, and the molecular mechanisms underlying Alzheimer's pathology. -
MMP Peptide Substrate
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a quenched fluorescent peptide substrate specifically designed for matrix metalloproteinases (MMPs). This elongated MMP substrate exhibits enhanced activity against collagenases, including MMP-1, MMP-8, and MMP-13, as well as MT1-MMP, demonstrating higher specificity constants compared to its predecessor, FS-1. It is suitable for real-time quantification of MMP enzymatic activity, making it an essential reagent for studies in tissue remodeling and diseases involving MMP dysregulation. Excitation and emission wavelengths are 325 nm and 400 nm, respectively. -
Collagen II-Targeting Peptide
WYRGRL is a collagen II-targeting peptide that binds specifically to collagen II α1. This short peptide sequence enhances cartilage-targeting efficiency by approximately 72-fold when used in peptide-functionalized nanoplatforms in vivo. WYRGRL is valuable for applications in cartilage-related research, including tissue engineering and regenerative medicine. -
Peptide
Peptide 74 is a synthetic peptide derived from the prodomain sequence of matrix metalloproteinase (MMP). It effectively inhibits the activated form of the 72-kDa type IV collagenase in vitro, thereby playing a crucial role in modulating extracellular matrix remodeling. This peptide can be utilized in research focused on tissue remodeling, wound healing, and related pathological conditions involving MMP activity. -
Anti-Inflammatory Peptide
Collagen Type II Fragment is an anti-inflammatory peptide that effectively inhibits collagen-induced arthritis (CIA) in murine models. This fragment serves as a valuable tool for studying inflammation and immune responses, facilitating research aimed at understanding and developing therapies for autoimmune conditions. -
Peptide
GPLGLAGGWGERDGS is a peptide designed for responsiveness to matrix metalloproteinase (MMP) enzymes, facilitating tumor targeting. This peptide can be utilized in research to monitor enzyme-guided nanoparticle assembly within tumor microenvironments, contributing to advancements in targeted therapies and diagnostic methods. Its specificity for MMP activity offers valuable insights into tumor dynamics and therapeutic efficacy. -
Anti-aging Peptide
Palmitoyl tripeptide-5 is an anti-aging peptide that functions by promoting collagen synthesis and improving skin elasticity. This bioactive compound is commonly utilized in cosmetic formulations to enhance skin firmness and reduce the appearance of fine lines and wrinkles. Its efficacy makes it a valuable ingredient in research related to skin rejuvenation and the development of anti-aging skincare products. -
Fluorescent Peptide
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide designed as a substrate for TNF-α converting enzyme (TACE; ADAM17), ADAM9, and ADAM10. This peptide utilizes fluorescence resonance energy transfer to monitor enzymatic activity, enabling quantification through changes in fluorescence intensity. It is a valuable tool for studying the roles of these metalloproteinases in various biological processes and may facilitate research in cancer biology and inflammatory diseases. -
MMP9 Selective Cleavage Peptide
FFAGLDD is an MMP9 selective cleavage peptide designed for targeted drug delivery applications. This peptide facilitates the cytosolic delivery of Doxorubicin (DOX), enabling temporally and spatially controlled release of the chemotherapeutic agent. Its specificity for MMP9 makes it a valuable tool in cancer research, allowing for optimized therapeutic efficacy while minimizing off-target effects. -
Octapeptide
VPLSLYSG is an octapeptide that serves as a substrate for matrix metalloproteinases, specifically MMP-9, MMP-1, and MMP-2. This compound can be utilized to study the enzymatic activity and substrate specificity of these metalloproteinases. It is particularly relevant in research focused on tissue remodeling, wound healing, and cancer progression, where matrix metalloproteinases play a critical role. -
Polypeptide
YYRADDA is a polypeptide that targets collagen synthesis within the extracellular matrix of the skin. It exhibits biological activity by stimulating collagen growth, which enhances skin appearance and promotes the healing of damaged tissue. This compound is useful in research focused on skin regeneration and tissue engineering applications. -
MMP3 Peptide Substrate
Dnp-PYAYWMR is a peptide substrate specifically designed to target matrix metalloproteinase 3 (MMP3). Upon cleavage by MMP3, it produces Dnp-PYA, which is nonfluorescent, and YWMR, a fluorophore detectable at 360 nm. This reagent is ideal for assessing MMP3 activity in biochemical assays, with fluorescence intensity measured at excitation/emission wavelengths of 328/350 nm following a 2-hour incubation period. -
Crosslinking Peptide
TG-MMP-Lys is a crosslinking peptide designed to be sensitive to matrix metalloproteinases (MMPs). It facilitates the study of fibrotic diseases, such as liver fibrosis, by allowing researchers to investigate the dynamics of ECM remodeling and tissue-specific interactions. This reagent enables the exploration of MMP activity in fibrotic conditions, contributing to the understanding of disease mechanisms and potential therapeutic strategies. -
IDO Peptide
Imsamotide, also known as IDO194-214, is an Indoleamine 2,3-Dioxygenase (IDO) peptide with the sequence DTLLKALLEIASCLEKALQVF. This compound serves as an immunological agent for active immunization, contributing to the modulation of immune responses. Additionally, Imsamotide exhibits potential antineoplastic properties, making it a valuable tool in cancer research and immunotherapy applications. -
LDL Receptor Peptide Fragment
Milpocitide is a peptide fragment derived from the low-density lipoprotein receptor (LDLR), specifically corresponding to the EGF-like domain 1 (residues 293-333). This compound is crucial for studying the mechanistic roles of LDLR in cholesterol metabolism and atherosclerosis. Milpocitide serves as a valuable tool for researchers investigating LDL receptor functionality and its implications in lipid disorders. -
Lung Endothelial Targeted Peptide
GALA is a pH-responsive amphipathic peptide that specifically targets lung endothelium. It undergoes a conformational change from random coil to α-helix at pH 5.0, leading to endosomal membrane destabilization and fusion. GALA-modified liposomes utilize clathrin-dependent endocytosis and transcytosis for efficient delivery, accumulating in lung tissues post-intravenous administration. This peptide enhances the cytosolic release of therapeutic agents such as siRNA and plasmids, facilitating increased gene transfection efficiency while maintaining low cytotoxicity. GALA is a valuable tool for investigating lung cancer metastasis and developing lung-targeted drug delivery systems. -
Peptide
Furin Substrate is a peptide designed for the study of the furin enzyme, a proprotein convertase involved in the processing of various proteins. It serves as a valuable tool for investigating proteolytic cleavage and enzyme activity in biochemical research. Applications include studying the role of furin in disease mechanisms and identifying potential therapeutic targets in related pathways. -
Peptidoglycan pentapeptide
Ala-D-γ-Glu-Lys-D-Ala-D-Ala TFA is a synthetic peptidoglycan pentapeptide that serves as a crucial component of bacterial cell wall biosynthesis. This compound mimics the pentapeptide tail of the peptidoglycan precursor UDP-MurNAc-l-Ala-γ-d-Glu-l-Lys(Gly)(5)-d-Ala-d-Ala. It is primarily used in research focusing on antibiotic development and studies of bacterial growth, cell wall integrity, and resistance mechanisms. This reagent is essential for examining the biochemical pathways involved in peptidoglycan synthesis and the structural analysis of bacterial cell walls. -
Dipeptide
H-Val-Tyr-OH is a dipeptide composed of valine and tyrosine linked by a peptide bond. It has been identified as a potential inhibitor of IKKα, making it valuable for studying cancer and inflammatory diseases. This compound can aid in elucidating the role of IKKα in various biological processes and could contribute to the development of therapeutic strategies targeting related pathways. -
Glioblastoma-Targeting Nonapeptide
CooP is a linear glioblastoma-targeting nonapeptide that specifically binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) found in glioblastoma cells and their associated vasculature. This peptide facilitates the targeted delivery of chemotherapy agents and various nanoparticles, enhancing therapeutic efficacy while minimizing off-target effects. Its application in glioblastoma research provides insights into novel treatment strategies for this challenging cancer type. -
Anticoagulant Peptide
E-76 is an anticoagulant peptide that specifically inhibits blood coagulation by binding to exogenous coagulation factor VIIa (FVIIa). This interaction disrupts the coagulation cascade, making E-76 a valuable tool for studying blood coagulation disorders and related pathophysiological conditions. Its application extends to research focused on thrombotic diseases and therapeutics targeting coagulation pathways. -
Fluorescent Peptide
Boc-Ile-Glu-Gly-Arg-AMC is a fluorogenic peptide substrate specifically designed for the activated factor X (FXa). This compound exhibits key biological activity by enabling the quantification of FXa in various biological assays. It is particularly useful in research applications focused on coagulation, thrombin generation, and related hemostatic studies. -
Chromogenic Peptide Substrate
Bz-Pro-Phe-Arg-pNA hydrochloride is a chromogenic peptide substrate specifically designed for the detection of plasma and glandular Kallikrein, cysteine proteinase (Cruzipain), and Trypsin. This compound exhibits significant biological activity as it enables the quantification of enzymatic activities in various assays, including the Factor XII assay. Its application in enzymology provides valuable insights into proteolytic processes and enzyme kinetics. -
Pentapeptide
Angiotensin I/II (4-8) is a pentapeptide that corresponds to the C-terminal sequence of Angiotensin II. This compound has significant implications in cardiovascular research, specifically in studies involving blood pressure regulation and the renin-angiotensin system. Its biological activity includes the modulation of vasoconstriction and electrolyte balance, making it a valuable reagent for investigating related physiological and pathological processes. -
Immunomodulatory Octapeptide
Thymoctonan is an immunomodulatory octapeptide, also known as thymic humoral factor γ2. It plays a crucial role in modulating immune responses and has applications in research related to immunotherapy and autoimmune disorders. Thymoctonan exhibits a short half-life of less than 6 minutes at 37 °C in human, rat, and mouse blood, which should be considered when designing experiments. -
pGC-B Activator
C-Type Natriuretic Peptide (1-53), derived from porcine, rat, and mouse sources, acts as a specific activator of particulate guanylate cyclase B (pGC-B), a receptor prevalent in endothelial cells, kidneys, and cardiac tissues. This peptide is known to induce significant anti-fibrotic responses in human cardiac and renal fibroblasts by promoting the synthesis of the secondary messenger cGMP. It is valuable for research focusing on cardiovascular and renal pathophysiology, offering insights into therapeutic strategies for fibrotic diseases. -
Precursor Peptide
TRH Precursor Peptide is a precursor peptide for thyrotropin-releasing hormone (TRH), functioning primarily through its role in the production of TRH in the rat brain and pituitary. The synthesis of TRH from this precursor is zinc-dependent, highlighting its significance in neuroendocrine regulation. This peptide is valuable for research in neurological studies and the assessment of thyroid function.
