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Ala2 Endothelin-3, human

Catalog No.: A60276
Vasoactive Peptide
[Ala2] Endothelin-3 (ET-3) is a vasoactive peptide analog of endothelin-3, featuring alanine substitutions for cysteine residues. This peptide is primarily produced by human rhabdomyosarcoma cell lines and plays a crucial role in paracrine signaling by promoting endothelial cell migration. Research applications include studies on vascular biology, endothelial function, and the pathophysiology of muscle-origin tumors.
[Ala2] Endothelin-3, human 2243207-08-9 Vasoactive Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[Ala2] Endothelin-3 (ET-3) is a vasoactive peptide analog of endothelin-3, featuring alanine substitutions for cysteine residues. This peptide is primarily produced by human rhabdomyosarcoma cell lines and plays a crucial role in paracrine signaling by promoting endothelial cell migration. Research applications include studies on vascular biology, endothelial function, and the pathophysiology of muscle-origin tumors.
Product Information
Catalog NumA60276
FormulaC120H166N26O32S4
Molecular Weight2613.02
CAS Number2243207-08-9
SequenceCys-Ala-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15; Cys3-Cys11)
Sequence shorteningCACFTYKDKECVYYCHLDIIW (Disulfide bridge: Cys1-Cys15; Cys3-Cys11)
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H]([C@H](C)C)NC(=O)[C@]5(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@@](NC(=O)[C@H](C)NC(=O)[C@@H](N)CSSC2)(CSSC5)[H])[H])[H])=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=8C=9C(NC8)=CC=CC9
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