Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Bioactive Peptide
Salusin-α is an endogenous bioactive peptide that modulates hemodynamic responses and promotes cell proliferation. It effectively stimulates the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, resulting in a notable decrease in blood pressure and heart rate. Although its effects are less potent than those of Salusin-β, Salusin-α holds significant potential for applications in cardiovascular disease research and therapeutic exploration. -
Neuropeptide
APGW-amide is a neuropeptide that primarily targets neuronal signaling pathways. It has been shown to control the growth of imposex structures and promote growth in Haliotis asinina. In studies, APGW-amide inhibits Achatina neurons and modulates neuronal currents affected by neuroactive compounds. Additionally, it induces a rapid increase in intracellular calcium levels in Fura-2/AM-loaded PC12 cells, making APGW-amide valuable for research focused on the nervous system. -
Activation Peptide
Enterostatin (rat) is an activation peptide of procolipase that plays a significant role in modulating fat intake. This peptide selectively reduces body fat consumption and lowers serum cholesterol levels through a cholecystokinin 1 (CCK1) receptor-dependent mechanism. It serves as a valuable tool for research on energy balance, appetite regulation, and metabolic disorders. -
Dipeptide
L-Arginyl-L-alanine is a dipeptide that serves as a vascular smooth muscle-derived relaxing factor. It enhances the levels of cyclic GMP and nitrite in denuded arterial rings, contributing to smooth muscle relaxation. This compound is of interest in research applications related to vascular biology and cardiovascular disease mechanisms. -
Neuropeptide
Prokineticin 2 Isoform 2 (human) is a neuropeptide primarily involved in the regulation of energy metabolism and thermoregulation. This compound has been shown to decrease food intake in rodent models, making it relevant for research into hyperglycemia, metabolic syndrome, and obesity. Its role in influencing metabolic pathways makes it a valuable reagent for studies focused on appetite regulation and energy balance. -
Insect Neuropeptide
Leucomyosuppressin is an insect neuropeptide that acts as an inhibitory myotropic peptide. It is known to inhibit evoked transmitter release at the mealworm neuromuscular junction, making it a valuable tool for studying neuromuscular transmission and neuropeptide signaling in insects. This compound can be utilized in research applications focused on insect physiology and neurobiology. -
Myoactive Neuropeptide
NGFFFamide is a myoactive neuropeptide identified in sea urchins. This compound is known to regulate muscle activity by binding directly to receptor proteins on muscle cells or indirectly by stimulating nerve endings to release muscle-active factors. NGFFFamide serves as a valuable tool for investigating mechanisms of muscle contraction and relaxation in various biological and pharmacological studies. -
Tetrapeptide
Antiulcer Agent 2 is a tetrapeptide comprised of aspartic acid, alanine, histidine, and lysine, known for its potential role in ulcer treatment. This compound is located at the N-terminal of human albumin, suggesting its involvement in physiological processes related to ulcer healing. Its biological activity may extend to modulating active oxygen species, making it a valuable reagent for research in gastroenterology and oxidative stress studies. -
Bombesin-Like Peptide
Alytesin, a bombesin-like peptide derived from the skin of Alytes obstetricans, primarily targets neurokinin receptors. It is known to reduce gastric acid secretion and induce hypertension. Additionally, Alytesin demonstrates short-term anorexigenic effects in neonatal chicks, making it a valuable tool for research in gastrointestinal physiology and neuroendocrine regulation. -
Polypeptide
Glutathionylspermidine is a polypeptide that functions as a metabolite in Escherichia coli. This compound has been implicated in cellular stress response mechanisms, showcasing antioxidant properties that protect against oxidative damage. Its role in bacterial physiology makes it a valuable tool for studying bacterial metabolism and stress adaptation in various research applications. -
Neuropeptide
Allatotropin is a 13-amino acid neuropeptide that primarily activates the inositol 1,4,5-trisphosphate (IP3) signaling pathway. It plays a crucial role in the biosynthesis of juvenile hormone (JH) in the insect Manduca sexta, making it valuable for studies in insect physiology and hormonal regulation. This compound is suitable for research applications exploring neuropeptide signaling and developmental processes in arthropods. -
Antihypertensive Peptide
Salusin-β is an endogenous bioactive peptide that primarily functions as an antihypertensive agent. It exhibits significant hemodynamic and mitogenic activities, stimulating the proliferation of vascular smooth muscle cells and fibroblasts, which contributes to notable decreases in blood pressure and heart rate. Additionally, Salusin-β promotes the release of arginine vasopressin from the pituitary gland in animal models, highlighting its potential applications in cardiovascular disease research and the study of vascular dynamics. -
Thymosin β4-like Peptide
Thymosin β10Arg is a thymosin β4-like peptide modified by the addition of arginine after lysine-38. This structural modification enhances its biological activity, influencing cytoskeletal dynamics and cellular behavior. Thymosin β10Arg is applicable in research involving cell migration, wound healing, and tissue regeneration studies. -
Glycopeptide
7,8,7’,8’-Tetradehydroastaxanthin is a glycopeptide derived from the carotenoid protein of the red sea star (Asterias rubens). This compound exhibits antioxidant properties and plays a significant role in photoprotection. Its unique chemical structure and biological activity make it a valuable tool in studies related to marine biology and nutritional science. -
Peptide
Cyclic somatostatin acetate is a neuropeptide that primarily targets growth hormone release inhibition. It plays a critical role in cardiovascular research by modulating the contractile response of ventricular cardiomyocytes, with an IC50 value of 13 nM against isoprenaline. This reagent is utilized in studies investigating severe acute hemorrhages associated with gastroduodenal ulcers and provides insights into the mechanisms underlying cardiovascular diseases. -
Osteogenic Growth Peptide
Osteogenic Growth Peptide (OGP) is a naturally occurring 14-amino acid peptide that promotes osteogenesis primarily through its interaction with the receptor for advanced glycation end-products (RAGE). OGP plays a crucial role in stimulating bone formation and enhancing osteoblast activity. Research applications include studies on bone regeneration, osteoporosis, and potential therapeutic interventions for skeletal disorders. -
Dipeptide
H-Val-Ala-OH, also known as Valyl-alanine, is a dipeptide consisting of L-Valine and L-Alanine residues. It functions as a metabolite and may exhibit a bitter taste profile. This compound is utilized in biochemical research to study peptide interactions and metabolic pathways. -
Dipeptide
H-Hyp-Gly-OH is a dipeptide consisting of hydroxyproline and glycine. This compound enhances the proliferation of mouse primary fibroblasts cultured on collagen gel, suggesting its utility in skin regeneration studies. H-Hyp-Gly-OH may also contribute to metabolic research and has potential applications in improving skin health through hydrolyzed collagen supplementation. -
Dipeptide
H-Phe-Arg-OH is a dipeptide comprised of phenylalanine and arginine that serves as an important substrate in biochemical studies. This compound can be utilized to investigate the enzymatic activity of Angiotensin-converting enzyme (ACE). H-Phe-Arg-OH is valuable in metabolic research applications, particularly in understanding peptide processing and regulatory mechanisms within the renin-angiotensin system. -
Prebiotic Peptide
H-D-Trp-OH, the D-isomer of tryptophan, serves as a prebiotic peptide that enhances intestinal microbial diversity. This compound has demonstrated the ability to mitigate the adverse effects of allergic airway inflammation on gut microbial populations. Its unique properties make it a valuable tool for researching intestinal health and microbiome interactions. -
Tetradecapeptide
Mastoparan is a tetradecapeptide derived from wasp venom that primarily targets and stimulates the release of prolactin from cultured rat anterior pituitary cells. This compound is widely used in research to investigate endocrine signaling pathways and the physiological roles of prolactin. Additionally, Mastoparan may serve as a valuable tool for studying neuroendocrine processes and the regulation of hormone secretion. -
Bacterial Peptide Lipid Substance
D-Allothreonine is the D stereoisomer of allothreonine, targeting bacterial peptide lipid substances. This compound can be specifically oxidized by D-amino acid oxidase, illustrating its unique reactivity compared to its L counterpart. D-Allothreonine plays a crucial role as a component of bacterial polysaccharides, making it valuable for studies on bacterial pathogenicity, antigenic variation, and mechanisms of drug resistance. Its specific biochemical interactions and applications in microbiological research highlight its significance in advancing understanding of bacterial behavior and treatment strategies. -
Polypeptide
Systemin is an 18-amino acid polypeptide that functions as a significant inducer of defensive gene expression in plants. Isolated from tomato leaves, Systemin activates the expression of more than 15 genes involved in plant defense mechanisms. This compound is valuable for research applications focused on plant stress responses, signaling pathways, and the study of plant-pathogen interactions. -
dipeptide
Lysylglutamic acid is a dipeptide comprising the amino acids lysine and glutamic acid. It interacts with the membrane transporter PEPT1, exhibiting a Ki value of 1.3 mM. This compound is utilized in research focused on peptide transport and metabolism, providing insights into cellular uptake mechanisms of dipeptides. Its biochemical properties make it valuable for studies in nutrition, pharmacology, and drug delivery systems. -
Peptide
Thioether-cyclized helix B peptide, CHBP, targets the mTOR signaling pathway to modulate autophagy. This peptide enhances metabolic stability and exhibits renoprotective effects by inhibiting mTORC1 while activating mTORC2. Its unique properties make it a valuable reagent for researching cellular metabolism and kidney protection mechanisms. -
E3 Ligase Peptide Ligand
ErbB2 peptide is a ligand for E3 ubiquitin ligase that specifically targets the PI3K pathway. This peptide is crucial for the development of peptide-based PROTACs, enabling selective degradation of proteins involved in various cellular processes. It is valuable for research applications focused on targeted protein degradation and signaling pathway modulation. -
Prion Peptide Fragment
PrP (106-126) is a synthetic peptide corresponding to the amyloidogenic region of the prion protein (PrP). This fragment exhibits biochemical properties similar to the infectious form of prion protein, making it crucial for the study of prion diseases. It is commonly utilized in research applications involving prion biology, amyloid formation, and the mechanisms underlying neurodegenerative disorders. -
Peptide Mimics
ccβ is a 17-amino acid peptide designed to mimic the conformational transition of proteins from α-helix to β-sheet. This transition is crucial in the aggregation of proteins linked to various neurodegenerative diseases, including Alzheimer's disease and prion diseases. ccβ serves as a valuable tool for investigating mechanisms of protein aggregation and its implications in disease pathology. -
Tau fragment R2
Tau Peptide (275-305) targets the second repeat domain of the tau protein, which plays a critical role in microtubule binding and is implicated in Alzheimer's disease. This peptide specifically interacts with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), facilitating conformational changes and promoting pathological accumulation. Research applications include investigating the effects of heavy metals on tau protein dynamics and their contributions to neurodegenerative disease mechanisms. -
Tau Fragment
Tau Peptide (273-284) is a truncated fragment of the Tau protein, primarily involved in neurofibrillary tangles associated with tauopathies. This peptide is valuable for studying the molecular mechanisms of Alzheimer's disease and other related neurodegenerative disorders. It serves as a tool for elucidating Tau aggregation processes and investigating potential therapeutic interventions targeting Tau-related pathologies. -
Polypeptide
Tau Peptide (255-314) (Repeat 2 Domain) (human) is a polypeptide derived from the Tau-F protein, specifically the 255-314 fragment of this key isoform. This peptide encompasses critical aggregation sequences PHF6* (275-280, VQIINK) and PHF6 (306-311, VQIVYK), which play a significant role in Tau aggregation. It spans the C-terminal half of the repeat domain R1, the entire repeat domain R2, and the N-terminal half of repeat domain R3, making it vital for studies on Tau-related neurodegenerative processes and microtubule dynamics. -
Tau fragment
Tau Peptide (244-274) targets the Repeat 1 domain of the tau protein, a key player in neurodegenerative diseases such as Alzheimer's. This peptide fragment is commonly utilized in research to study tau pathology, including phosphorylation and aggregation processes associated with tau-mediated toxicity. Its role in modulating tau interactions makes it a valuable tool for investigating tau-related mechanisms in various cellular models. -
Tau fragment
Tau Peptide (245-274) (Repeat 1 Domain) is a specific fragment of the Tau protein that serves as a crucial target in neurodegenerative research. This peptide is involved in the formation of neurofibrillary tangles, which are characteristic of Alzheimer's disease and other tauopathies. It can be used in studies investigating tau aggregation and toxicity, as well as in the development of therapeutics aimed at modulating tau pathology. -
Tau fragment
Tau Peptide (294-305) (human) is a biologically active fragment of the Tau protein that plays a critical role in neurodegenerative diseases, particularly in Alzheimer’s disease. This peptide is instrumental in studying tau pathology, including tau aggregation and neurofibrillary tangles. It serves as an important tool for researchers investigating the mechanisms of tau-related neurodegeneration and developing potential therapeutic approaches. -
Tau fragment
Tau Peptide (45-73) (Exon 2/Insert 1 Domain) is a fragment of the Tau protein that plays a crucial role in stabilizing microtubules. This peptide is often used in research studies focusing on neurodegenerative diseases, particularly Alzheimer's disease, where Tau pathology is implicated. It serves as a valuable tool for investigating Tau aggregation, cellular interactions, and the effects of post-translational modifications on Tau function. -
Polypeptide
Tau Peptide (274-288) is a polypeptide that plays a significant role in neurobiology through its interaction with tau protein. This peptide is widely utilized in research applications focused on protein-protein interactions, functional analyses, and epitope mapping. It serves as a valuable tool in the exploration of tau-related pathologies, aiding in the understanding of neurodegenerative diseases such as Alzheimer's. -
Tau fragment
Tau Peptide (306-336) (Repeat 3 Domain) targets the Tau protein, specifically the repeat domain that plays a crucial role in microtubule stabilization. This peptide fragment facilitates studies on Tau's involvement in neurodegenerative diseases, particularly Alzheimer's disease, by helping to elucidate the mechanisms of Tau aggregation and function. It serves as a valuable tool for researchers investigating Tau-related pathology and potential therapeutic interventions. -
Tau fragment
Tau Peptide (379-408) is a specific fragment of the tau protein, which is integral to neurodegenerative research, particularly in the study of tauopathies. This peptide serves as a crucial tool for understanding tau aggregation, neurofibrillary tangles formation, and synaptic dysfunction. Its applications include investigating mechanisms of tau-related pathologies and evaluating therapeutic interventions targeting tau misfolding and toxicity. -
Tau Peptide
Acetyl-PHF5 amide is a tau peptide that demonstrates amyloidogenic properties, facilitating the polymerization into filamentous structures. This compound is valuable for research into tau-related pathologies, such as Alzheimer's disease, and is used to study the mechanisms of tau aggregation and neurodegeneration. Its ability to replicate key features of tau protein behavior makes it an essential tool for investigating therapeutic strategies targeting tauopathies. -
Tau fragment
Tau Peptide (1-16) (human) is a fragment of the Tau protein, primarily targeting Tau-mediated pathways involved in neurodegenerative diseases. This peptide is crucial for studying the role of Tau in processes such as microtubule stabilization and neurofibrillary tangle formation. It serves as an important tool for research applications focused on Alzheimer's disease and other tauopathies. -
Tau fragment
Tau Peptide (74-102) (Exon 3/Insert 2 Domain) is a specific fragment of the tau protein that plays a crucial role in stabilizing microtubules in neurons. This peptide is instrumental in research focusing on tauopathies, including Alzheimer’s disease, where tau aggregation and dysfunction are key pathological features. By utilizing this peptide, researchers can investigate tau-related mechanisms and develop potential therapeutic strategies for neurodegenerative disorders. -
α-Synuclein Knockdown Peptide
Tat-βsyn-degron is an α-synuclein knockdown peptide that promotes the degradation of α-synuclein through the proteasome pathway. This compound demonstrates significant efficacy in reducing α-synuclein protein levels in primary rat cortical neuron cultures. Additionally, Tat-βsyn-degron has shown potential in alleviating parkinsonian toxin-induced neuronal damage and movement disorders in a Parkinson's mouse toxicity model, making it a valuable tool for research into neurodegenerative diseases. -
Nrf2 Peptide
Nrf2 (69-84) is a peptide derived from the Nrf2 protein, featuring the essential ETGE motif critical for binding to the Kelch domain of the Keap1 protein. This peptide serves as a valuable tool for investigating the regulatory functions of Nrf2 in various biological processes, particularly in the context of cancer, neurodegenerative disorders, and inflammatory diseases. Its application aids in elucidating the mechanisms by which Nrf2 modulates cellular responses to oxidative stress and inflammation. -
Bioactive Peptide
Keap1-Nrf2-IN-16 is a bioactive peptide that targets the KEAP1 protein to disrupt its interaction with the Nrf2 transcription factor. This inhibition leads to the stabilization and activation of Nrf2, promoting the expression of antioxidant response elements and enhancing cellular defense mechanisms. Keap1-Nrf2-IN-16 is utilized in research applications related to oxidative stress, cellular protection, and neurodegenerative diseases. -
NF-κB Inhibitor
NBD peptide is a selective inhibitor of the NF-κB signaling pathway, acting by disrupting the interaction between NEMO and the IKK complex. This inhibition leads to reduced production of pro-inflammatory cytokines, showcasing its anti-inflammatory properties. Additionally, NBD peptide demonstrates immunosuppressive effects through modulation of immune cell activity. The incorporation of the cell-penetrating HIV-TAT peptide enhances its cellular uptake, facilitating its application in various research contexts. -
NF-κB Inhibitor
IKKγ NBD Inhibitory Peptide is a selective inhibitor of NF-κB signaling. It functions by disrupting the interaction between the IKKγ/NEMO-binding domain and IKKα/IKKβ, effectively blocking TNF-α-induced NF-κB activation. This peptide exhibits significant anti-inflammatory properties and has potential applications in studying cerebral ischemia and its associated neurological deficits. -
Control Peptide
SN50M is a mutant peptide derived from SN50 that serves as a cell membrane-permeable inactive control peptide. This reagent is primarily utilized in research to study the effects and mechanisms of active peptides targeting the nuclear transport pathway. Its role as a control allows for the differentiation of specific biological responses in cellular assays and molecular studies. -
β-Amyloid Peptide Fragment
β-Amyloid (1-38), mouse, rat is a peptide fragment consisting of the first 38 amino acids of the amyloid-beta (Aβ) peptide. This fragment plays a crucial role in the formation of amyloid plaques associated with Alzheimer's disease. It serves as an important tool for researchers studying the pathophysiology of neurodegeneration and the mechanisms of Alzheimer's pathology. Its use can provide insights into β-amyloid aggregation and the development of potential therapeutic strategies. -
Peptide Fragment
(D-Asp1)-Amyloid β-Protein (1-42) is a peptide fragment derived from amyloid β-protein (Aβ), which plays a crucial role in the pathogenesis of Alzheimer's disease. This fragment is implicated in the formation of amyloid plaques, a hallmark of neurodegeneration associated with the disease. The compound is utilized in research applications focused on studying amyloid aggregation, neuroinflammation, and potential therapeutic interventions in Alzheimer's disease. -
β-Amyloid Peptide Fragment
β-Amyloid (1-34) is a fragment of the β-Amyloid peptide consisting of 34 amino acids. This peptide is involved in the formation of extracellular plaques in Alzheimer's disease and serves as a critical target for studying neurodegenerative processes. β-Amyloid (1-34) is utilized in research applications focusing on the pathology of Alzheimer's, neuroinflammation, and potential therapeutic interventions targeting amyloid aggregation.
