Catalog No.
Product Name
Application
Product Information
Citations
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Peptide Hormone
Atrial natriuretic peptide (3-28) (human) is a peptide hormone primarily synthesized and secreted by the atrial myocardium. This bioactive peptide plays a critical role in the regulation of blood pressure, fluid balance, and electrolyte homeostasis. Research applications include studies on cardiovascular function, renal physiology, and the modulation of neurohormonal pathways. -
Peptide
Big endothelin-3 (Human, 1-41 amide) serves as a precursor molecule to the bioactive peptide Endothelin-3 (ET-3), consisting of 41 amino acids. This peptide is primarily involved in vasoconstriction and regulation of vascular tone. Its applications extend to studying cardiovascular function, understanding cellular signaling pathways, and exploring potential therapeutic targets in hypertension and heart failure research. -
Vasoactive Peptide
[Ala2] Endothelin-3 (ET-3) is a vasoactive peptide analog of endothelin-3, featuring alanine substitutions for cysteine residues. This peptide is primarily produced by human rhabdomyosarcoma cell lines and plays a crucial role in paracrine signaling by promoting endothelial cell migration. Research applications include studies on vascular biology, endothelial function, and the pathophysiology of muscle-origin tumors. -
IDO Peptide
Imsamotide, also known as IDO194-214, is an Indoleamine 2,3-Dioxygenase (IDO) peptide with the sequence DTLLKALLEIASCLEKALQVF. This compound serves as an immunological agent for active immunization, contributing to the modulation of immune responses. Additionally, Imsamotide exhibits potential antineoplastic properties, making it a valuable tool in cancer research and immunotherapy applications. -
LDL Receptor Peptide Fragment
Milpocitide is a peptide fragment derived from the low-density lipoprotein receptor (LDLR), specifically corresponding to the EGF-like domain 1 (residues 293-333). This compound is crucial for studying the mechanistic roles of LDLR in cholesterol metabolism and atherosclerosis. Milpocitide serves as a valuable tool for researchers investigating LDL receptor functionality and its implications in lipid disorders. -
Lung Endothelial Targeted Peptide
GALA is a pH-responsive amphipathic peptide that specifically targets lung endothelium. It undergoes a conformational change from random coil to α-helix at pH 5.0, leading to endosomal membrane destabilization and fusion. GALA-modified liposomes utilize clathrin-dependent endocytosis and transcytosis for efficient delivery, accumulating in lung tissues post-intravenous administration. This peptide enhances the cytosolic release of therapeutic agents such as siRNA and plasmids, facilitating increased gene transfection efficiency while maintaining low cytotoxicity. GALA is a valuable tool for investigating lung cancer metastasis and developing lung-targeted drug delivery systems. -
Peptide
Furin Substrate is a peptide designed for the study of the furin enzyme, a proprotein convertase involved in the processing of various proteins. It serves as a valuable tool for investigating proteolytic cleavage and enzyme activity in biochemical research. Applications include studying the role of furin in disease mechanisms and identifying potential therapeutic targets in related pathways. -
Prebiotic Peptide
H-D-Trp-OH, the D-isomer of tryptophan, serves as a prebiotic peptide that enhances intestinal microbial diversity. This compound has demonstrated the ability to mitigate the adverse effects of allergic airway inflammation on gut microbial populations. Its unique properties make it a valuable tool for researching intestinal health and microbiome interactions. -
Tetradecapeptide
Mastoparan is a tetradecapeptide derived from wasp venom that primarily targets and stimulates the release of prolactin from cultured rat anterior pituitary cells. This compound is widely used in research to investigate endocrine signaling pathways and the physiological roles of prolactin. Additionally, Mastoparan may serve as a valuable tool for studying neuroendocrine processes and the regulation of hormone secretion. -
Bacterial Peptide Lipid Substance
D-Allothreonine is the D stereoisomer of allothreonine, targeting bacterial peptide lipid substances. This compound can be specifically oxidized by D-amino acid oxidase, illustrating its unique reactivity compared to its L counterpart. D-Allothreonine plays a crucial role as a component of bacterial polysaccharides, making it valuable for studies on bacterial pathogenicity, antigenic variation, and mechanisms of drug resistance. Its specific biochemical interactions and applications in microbiological research highlight its significance in advancing understanding of bacterial behavior and treatment strategies. -
Polypeptide
Systemin is an 18-amino acid polypeptide that functions as a significant inducer of defensive gene expression in plants. Isolated from tomato leaves, Systemin activates the expression of more than 15 genes involved in plant defense mechanisms. This compound is valuable for research applications focused on plant stress responses, signaling pathways, and the study of plant-pathogen interactions. -
dipeptide
Lysylglutamic acid is a dipeptide comprising the amino acids lysine and glutamic acid. It interacts with the membrane transporter PEPT1, exhibiting a Ki value of 1.3 mM. This compound is utilized in research focused on peptide transport and metabolism, providing insights into cellular uptake mechanisms of dipeptides. Its biochemical properties make it valuable for studies in nutrition, pharmacology, and drug delivery systems. -
Bombesin-Like Peptide
Alytesin, a bombesin-like peptide derived from the skin of Alytes obstetricans, primarily targets neurokinin receptors. It is known to reduce gastric acid secretion and induce hypertension. Additionally, Alytesin demonstrates short-term anorexigenic effects in neonatal chicks, making it a valuable tool for research in gastrointestinal physiology and neuroendocrine regulation. -
Polypeptide
Glutathionylspermidine is a polypeptide that functions as a metabolite in Escherichia coli. This compound has been implicated in cellular stress response mechanisms, showcasing antioxidant properties that protect against oxidative damage. Its role in bacterial physiology makes it a valuable tool for studying bacterial metabolism and stress adaptation in various research applications. -
Neuropeptide
Allatotropin is a 13-amino acid neuropeptide that primarily activates the inositol 1,4,5-trisphosphate (IP3) signaling pathway. It plays a crucial role in the biosynthesis of juvenile hormone (JH) in the insect Manduca sexta, making it valuable for studies in insect physiology and hormonal regulation. This compound is suitable for research applications exploring neuropeptide signaling and developmental processes in arthropods. -
Antihypertensive Peptide
Salusin-β is an endogenous bioactive peptide that primarily functions as an antihypertensive agent. It exhibits significant hemodynamic and mitogenic activities, stimulating the proliferation of vascular smooth muscle cells and fibroblasts, which contributes to notable decreases in blood pressure and heart rate. Additionally, Salusin-β promotes the release of arginine vasopressin from the pituitary gland in animal models, highlighting its potential applications in cardiovascular disease research and the study of vascular dynamics. -
Thymosin β4-like Peptide
Thymosin β10Arg is a thymosin β4-like peptide modified by the addition of arginine after lysine-38. This structural modification enhances its biological activity, influencing cytoskeletal dynamics and cellular behavior. Thymosin β10Arg is applicable in research involving cell migration, wound healing, and tissue regeneration studies. -
Glycopeptide
7,8,7’,8’-Tetradehydroastaxanthin is a glycopeptide derived from the carotenoid protein of the red sea star (Asterias rubens). This compound exhibits antioxidant properties and plays a significant role in photoprotection. Its unique chemical structure and biological activity make it a valuable tool in studies related to marine biology and nutritional science. -
Peptide
Cyclic somatostatin acetate is a neuropeptide that primarily targets growth hormone release inhibition. It plays a critical role in cardiovascular research by modulating the contractile response of ventricular cardiomyocytes, with an IC50 value of 13 nM against isoprenaline. This reagent is utilized in studies investigating severe acute hemorrhages associated with gastroduodenal ulcers and provides insights into the mechanisms underlying cardiovascular diseases. -
Osteogenic Growth Peptide
Osteogenic Growth Peptide (OGP) is a naturally occurring 14-amino acid peptide that promotes osteogenesis primarily through its interaction with the receptor for advanced glycation end-products (RAGE). OGP plays a crucial role in stimulating bone formation and enhancing osteoblast activity. Research applications include studies on bone regeneration, osteoporosis, and potential therapeutic interventions for skeletal disorders. -
Dipeptide
H-Val-Ala-OH, also known as Valyl-alanine, is a dipeptide consisting of L-Valine and L-Alanine residues. It functions as a metabolite and may exhibit a bitter taste profile. This compound is utilized in biochemical research to study peptide interactions and metabolic pathways. -
Dipeptide
H-Hyp-Gly-OH is a dipeptide consisting of hydroxyproline and glycine. This compound enhances the proliferation of mouse primary fibroblasts cultured on collagen gel, suggesting its utility in skin regeneration studies. H-Hyp-Gly-OH may also contribute to metabolic research and has potential applications in improving skin health through hydrolyzed collagen supplementation. -
Dipeptide
H-Phe-Arg-OH is a dipeptide comprised of phenylalanine and arginine that serves as an important substrate in biochemical studies. This compound can be utilized to investigate the enzymatic activity of Angiotensin-converting enzyme (ACE). H-Phe-Arg-OH is valuable in metabolic research applications, particularly in understanding peptide processing and regulatory mechanisms within the renin-angiotensin system. -
Peptide-AMC Linked Substrate
Z-Leu-Leu-Glu-AMC is a peptide-AMC linked substrate designed to assess the hydrolytic activity of the proteasome. This compound is particularly useful in studies related to Parkinson's disease, enabling researchers to investigate the enzyme's role in protein degradation and cellular homeostasis. Its application facilitates the understanding of proteasome dysfunction in neurodegenerative disorders. -
Proteasome-Activating Peptide
Proteasome-activating peptide 1 is a peptide that enhances chymotrypsin-like activity of the proteasome, thereby increasing proteolytic rates in vitro and in cellular cultures. This compound plays a significant role in preventing protein aggregation, demonstrated in cellular models of amyotrophic lateral sclerosis. Its ability to modulate proteasomal activity makes it a valuable tool for research into neurodegenerative diseases and protein homeostasis. -
Bioactive Peptide
Calpastatin subdomain B is a bioactive peptide that specifically inhibits calpain activity. By effectively regulating calpain, this peptide plays a crucial role in cellular processes such as apoptosis, muscle contraction, and neuronal signaling. It is widely used in research applications involving proteolytic regulation and the study of calpain-related diseases. -
Peptide Substrate
Z-Gly-Gly-Arg-βNA is a synthetic peptide substrate designed to target trypsin-like activities within the proteasome. This substrate is utilized for studying proteolytic processes and enzyme kinetics, facilitating research on protein degradation and regulation. Its chemical structure allows for specific interactions with proteasomal active sites, making it an essential tool for investigating cellular mechanisms related to proteostasis and stress responses. -
Bioactive Peptide
Renin inhibitor peptide, rat is a biologically active peptide that specifically inhibits renin, an enzyme involved in the regulation of blood pressure and electrolyte balance. This peptide serves as a valuable tool for studying the renin-angiotensin system and its implications in cardiovascular research. Its application in experimental models can aid in the investigation of hypertension and related disorders. -
Renin Antagonist
Handle region peptide, rat is a prorenin receptor antagonist that effectively inhibits the activation of prorenin, thereby mitigating the progression of diabetic nephropathy. This compound demonstrates significant anti-inflammatory properties, particularly within ocular tissues. Its applications extend to research on renal disease models and ocular inflammation, providing valuable insights into therapeutic interventions for these conditions. -
Oligopeptide Renin Inhibitor
PD 125967 is an oligopeptide renin inhibitor that specifically targets the renin-angiotensin system. It exhibits significant activity in lowering blood pressure, making it a valuable tool for cardiovascular research. This compound is useful for studying hypertension and related disorders, providing insights into the regulation of blood pressure through renin inhibition. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC is a substrate peptide designed for the fluorescent monitoring of Cathepsin S activity. Labeled with AMC, this compound exhibits excitation and emission wavelengths of 354 nm and 442 nm, respectively. It is primarily utilized in biochemical assays to measure the enzymatic activity of Cathepsin S, providing valuable insights into its role in physiological and pathological processes. -
Phosphorylase Kinase Peptides Fragment
Phosphorylase Kinase β-Subunit Fragment (420-436) targets the β-Subunit of phosphorylase kinase, a serine/threonine-specific protein kinase. This fragment facilitates the activation of glycogen phosphorylase, regulating the release of glucose-1-phosphate from glycogen stores. It is widely used in research applications focused on glucose metabolism, enzymatic regulation, and the signaling pathways involved in energy homeostasis. -
Fluorogenic Peptide Substrate
Tos-Gly-Pro-Lys-AMC is a fluorogenic peptide substrate specifically designed for tryptase enzyme activity. This compound facilitates the detection and quantification of tryptase activity through fluorescence, making it a valuable tool in research related to protease biology and inflammation. Its application in biochemical assays allows for the exploration of tryptase's role in various physiological and pathological processes. -
Bioactive Peptide
Abz-HPGGPQ-EDDnp is a bioactive peptide designed as a selective substrate for cathepsin K, a lysosomal cysteine protease crucial for bone remodeling and resorption. This fluorescence resonance energy transfer (FRET) peptide is specifically cleaved at the Gly-Gly bond by cathepsin K, enabling precise monitoring of its activity in physiological fluids and cell lysates. The peptide demonstrates resistance to hydrolysis by other cathepsins, thereby facilitating targeted research into autoimmune diseases and osteoporosis. Abz-HPGGPQ-EDDnp is characterized by excitation/emission wavelengths of 340 nm/420 nm, making it a valuable tool for studying protease activity in cellular contexts. -
Polypeptide
Suc-Phe-Ala-Ala-Phe-pNA is a synthetic polypeptide designed as a substrate for various proteases, including the serine alkaline protease from Caldicoprobacter guelmensis (SAPCG strain D2C22T), the protease from Aeribacillus pallidus VP3 (SPVP), as well as Alcalase 2.5 L and thermolysin type X. This substrate is utilized in biochemical assays to study protease activity and kinetics, enabling researchers to investigate the mechanisms of proteolysis. Its structural composition allows for precise measurement of protease function in various experimental settings. -
Tridecapeptide
α-Factor Mating Pheromone is a tridecapeptide secreted by Saccharomyces cerevisiae α cells, targeting the Ste2p receptor. This pheromone plays a crucial role in yeast mating processes, facilitating cell signaling and attraction between α and a cells. It is widely utilized in studies of yeast biology, signal transduction, and the mechanisms of mating induction. -
Fibrinopeptide
Fibrinopeptide B, human is a 14-amino acid peptide generated at the amino-terminus of the β-chains of fibrinogen by the action of thrombin. This peptide plays a critical role in the coagulation process, serving as a marker for thrombin activity and fibrin formation. Fibrinopeptide B is utilized in various research applications, including studies on hemostasis, thrombosis, and the regulation of blood coagulation pathways. -
Thrombin Receptor Antagonist
Thrombin receptor peptide ligand is a selective antagonist of the thrombin receptor, inhibiting its activation and downstream signaling. This compound exhibits antithrombotic properties, making it suitable for research focused on thrombotic disorders and cardiovascular diseases. Its ability to modulate thrombin activity positions it as a valuable tool for studying platelet aggregation and related pathways. -
Thrombin Cleavable Peptide
Thrombin-cleavable peptide targets thrombin and is specifically designed for thrombin recognition and cleavage. Upon enzymatic cleavage, it releases thrombolytic peptides that play a crucial role in initiating thrombolysis. This reagent is valuable for research applications related to ischemic stroke and other thrombotic conditions. -
Polypeptide
Hirudin (55-65) sulfated is a polypeptide fragment that acts as a potent inhibitor of thrombin, demonstrating significant anticoagulant properties. This compound is essential for studies related to coagulation pathways and thrombin-mediated physiological processes. Its applications extend to the investigation of antithrombotic therapies and the development of pharmacological agents targeting blood coagulation disorders. -
Bioactive Peptide
TFLLRNPNDK-NH2 is a bioactive peptide that acts as a potent agonist of the protease-activated receptor 1 (PAR-1). By mimicking the tethered ligand generated by thrombin proteolytic cleavage, this peptide reversibly binds to PAR-1, modulating various cellular responses. Key biological activities include the enhancement of liquid and protein permeability, making it valuable for research applications in cardiovascular and inflammatory studies. -
Fibrin Knob Peptide
Knob A peptide GPRPFPAC is a fibrin knob peptide that interacts with the fibrinogen molecule to inhibit clot formation. This peptide exhibits enhanced anticoagulant activity, particularly when modified with polyethylene glycol (PEG). It is utilized in various research applications, including studies on thrombosis, hemostasis, and the development of anticoagulant therapies. -
Polypeptide
Acetyl-Hirudin (55-65) sulfated is a polypeptide fragment that functions as a potent inhibitor of thrombin. This compound exhibits significant anticoagulant properties, making it valuable in studies related to blood coagulation and thrombotic disorders. Acetyl-Hirudin (55-65) sulfated is utilized in various research applications, including the investigation of thrombin's role in physiological and pathological processes. -
Peptide Substrate
PS-915 dihydrochloride is a peptide substrate that specifically targets thrombin for use in colorimetric assays. This compound enables the assessment of plasma antithrombin III (ATIII) levels by undergoing enzyme hydrolysis, which results in the release of 3-carboxy-4-hydroxyaniline (CHA). The CHA then forms a complex with alkaline-pentacyanoammine ferroate, producing a distinct blue coloration, facilitating quantification in various research applications related to coagulation and thrombosis. -
Peptide Vinyl Sulfone
WRR139 is a peptide vinyl sulfone that targets N-glycanase 1 (NGLY1) and exhibits inhibitory activity against Nrf1. This compound is involved in key disease processes, including inflammation and cancer progression. WRR139 has been shown to enhance the cytotoxic effects of Carfilzomib on cancer cells, making it a valuable tool for research in cancer therapeutics and inflammation-related studies. -
TRP-2 Derived Peptide
mTRP-2 (180-188) is a peptide derived from murine tyrosinase-related protein 2 (TRP-2), specifically corresponding to the amino acid sequence of residues 180-188. This peptide serves as a key reactive epitope for recognition by anti-B16 cytotoxic T lymphocytes (CTLs). Its applications in research include the study of immune responses and the development of cancer immunotherapies, particularly in relation to melanoma. -
TRP-2 Derived Peptide
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from tyrosinase-related protein 2, corresponding to residues 181-188. This peptide contains the primary reactive epitope recognized by anti-B16 cytotoxic T lymphocytes (CTLs) and is designed to conform to the MHC class I H2-Kb binding motif. TRP-2 (181-188) is essential for studies in immunology and cancer research, particularly in the context of melanoma and anti-tumor immune responses. -
Tyrosinase Inhibitor
Cysteine peptide is a potent tyrosinase inhibitor that exhibits skin-whitening, antioxidant, and multi-regulatory properties. By inhibiting tyrosinase activity and obstructing melanin transport, it effectively reduces UV-B-induced skin erythema and pigmentation. Additionally, cysteine peptide plays a role in skin health by scavenging reactive oxygen species (ROS), mitigating oxidative stress, and promoting pheomelanin synthesis. This compound also functions as a plant signaling factor, influencing vegetative growth, development, and responses to environmental stressors. -
Peptide
[Asp371]-Tyrosinase (369-377), human is a peptide derived from the human tyrosinase protein and is characterized as an HLA-A2.1-restricted epitope. This peptide plays a crucial role in the development of tumor-targeted vaccines aimed at eliciting specific immune responses against melanoma. It has been utilized in research applications focused on cancer immunotherapy and cellular immune response studies. -
Nonapeptide
Tyrosinase (192-200), human mouse is a nonapeptide that serves as a significant target for cytolytic T cells (CTL) via the HLA-B44 molecule. This peptide is crucial for studying immune responses in melanoma-associated cancers. Its role in T cell recognition makes it valuable for research applications focused on cancer immunotherapy and the development of targeted treatments.
