Catalog No.
Product Name
Application
Product Information
Citations
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Substrate Peptide
Acetyltrialanine is a peptide substrate designed for Nα-acetyl alanine aminopeptidase, facilitating the investigation of enzyme activity and characteristics. This compound enables research into protein degradation and N-terminal regulation, making it a valuable tool for understanding proteolytic processes and related biological mechanisms. Its unique features allow for precise studies of enzyme kinetics and specificity in various biological contexts. -
Tripeptide
Suc-Ala-Ala-Pro-Leu-pNA is a tripeptidyl p-nitroanilide substrate that serves as a specific tool for studying the catalytic activity of acyl amidase-like leucine aminopeptidase in seminal plasma. This reagent enables the assessment of hydrolytic activity, making it valuable in investigations related to reproductive health, particularly in the context of azoospermia. Researchers can utilize Suc-Ala-Ala-Pro-Leu-pNA to explore the enzymatic mechanisms and potential therapeutic targets in male fertility disorders. -
Anti-angiogenic Peptide
Cartilostatin 1 is an anti-angiogenic peptide that inhibits the formation of new blood vessels. It exhibits significant potential in modulating angiogenesis, making it a valuable tool for research in cancer biology, wound healing, and other conditions where vascular growth regulation is crucial. Its biological activity may be leveraged in studies exploring therapeutic strategies for diseases characterized by aberrant angiogenesis. -
Apolipoprotein Peptide
APL180 is an apolipoprotein A-I mimic peptide that enhances the anti-inflammatory activity of high-density lipoprotein (HDL). This compound is valuable in research focused on cardiovascular diseases, leveraging its properties to study HDL's role in inflammation and lipid metabolism. -
Peptide
Dansyl-Ala-Arg is a synthetic peptide that serves as a fluorescent probe targeting various biochemical processes. It is commonly utilized in studies involving peptide interactions, protein conformation, and cellular imaging. Its unique fluorescent properties make it an effective tool for monitoring biological events in live cells and in vitro assays. -
Depsipeptide Substrate for DD-carboxypeptidases
Ac-Lys(Ac)-D-Ala-D-Lactic acid serves as a depsipeptide substrate specifically targeting DD-carboxypeptidases, which are penicillin-sensitive D-alanine carboxypeptidases. This compound is utilized in research to investigate the enzymatic activity and functionality of these peptidases, playing a crucial role in bacterial cell wall synthesis and maintenance. Its application in enzymatic studies provides insights into antibiotic action mechanisms and potential resistance pathways. -
Peptide Toxin
Poneratoxin is a peptide toxin that acts as a modulator of voltage-gated sodium channels (NaV), specifically NaV1.6 and NaV1.7, with EC50 values of 97 nM and 2.3 µM, respectively. It lowers the voltage threshold for channel activation and inhibits their inactivation, thereby enhancing neuronal excitability. This activity is relevant in studies of pain signal transmission and neuropathic pain research, making Poneratoxin a valuable tool in neurobiology and pharmacological investigations. -
Polypeptide Toxins
Sarafotoxin S6d is a polypeptide toxin derived from the venom of the Israeli sand boa constrictor, known for its cardiovascular effects. This compound induces significant electrocardiogram (ECG) alterations, including myocardial ischemia and hyperkalemia, while also promoting robust extracellular calcium-dependent vasoconstriction in rat aorta and positive inotropic effects in rat atria. Sarafotoxin S6d is valuable in the investigation of cardiovascular pathologies and related physiological mechanisms. -
Palmitoylated Peptide Derivative
Palmitoyl glutathione is a palmitoylated peptide derivative that serves as a liver-targeted liposome-forming agent. It effectively forms liposome-like vesicles in conjunction with cholesterol, enabling the encapsulation of water-soluble solutes while maintaining stability in fresh rat plasma at 37°C. This compound is particularly relevant for research applications related to acetaminophen-induced liver necrosis, providing a valuable tool for studying liver pathology and therapeutic interventions. -
Peptide Lipid
cKK-E15 is a peptide-lipid utilized for formulating lipid nanoparticles (LNP) such as LNP3, in combination with C14PEG2000, unmodified cholesterol, and DOPE. This compound facilitates effective encapsulation and delivery of nucleotides and other therapeutic agents, enhancing cellular uptake. Its unique structure supports applications in gene therapy and vaccine development, providing a versatile tool for researchers in lipid formulation and nanoparticle technology. -
Tetrapeptide Fluorescent Substrate
Ac-LVSR-AMC is a tetrapeptide fluorescent substrate designed to quantitatively assess the specific activity of Malt1 protease in vitro. This compound serves as a valuable tool for studying proteolytic processes and Malt1-related signaling pathways. Its fluorogenic properties enable sensitive detection, making it suitable for applications in biochemical assays and research on immune responses. -
Bioactive Peptide
SRC-1 (686-700) is a bioactive peptide that contains the second LXXLL motif, derived from the NR box II of steroid receptor coactivator 1 (SRC-1). This peptide functions by interacting with nuclear receptors in a ligand-dependent manner, enhancing transcriptional activity. SRC-1 (686-700) is valuable for studies investigating steroid receptor signaling and coactivation pathways, providing insights into gene regulation mechanisms in various biological contexts. -
Amyloid Precursor
Amyloid Precursor C-terminal peptide targets the Amyloid Precursor Protein (APP) and plays a significant role in the pathology of Alzheimer's disease (AD). This peptide, cleaved from the C-terminus of APP, is associated with alterations in mitochondrial morphology and impaired basal mitophagy, suggesting its involvement as a potential etiological trigger in AD. It is valuable for research focused on neurodegenerative diseases, neuroscience, and the molecular mechanisms underlying Alzheimer's pathology. -
MMP Peptide Substrate
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a quenched fluorescent peptide substrate specifically designed for matrix metalloproteinases (MMPs). This elongated MMP substrate exhibits enhanced activity against collagenases, including MMP-1, MMP-8, and MMP-13, as well as MT1-MMP, demonstrating higher specificity constants compared to its predecessor, FS-1. It is suitable for real-time quantification of MMP enzymatic activity, making it an essential reagent for studies in tissue remodeling and diseases involving MMP dysregulation. Excitation and emission wavelengths are 325 nm and 400 nm, respectively. -
Collagen II-Targeting Peptide
WYRGRL is a collagen II-targeting peptide that binds specifically to collagen II α1. This short peptide sequence enhances cartilage-targeting efficiency by approximately 72-fold when used in peptide-functionalized nanoplatforms in vivo. WYRGRL is valuable for applications in cartilage-related research, including tissue engineering and regenerative medicine. -
Peptide
Peptide 74 is a synthetic peptide derived from the prodomain sequence of matrix metalloproteinase (MMP). It effectively inhibits the activated form of the 72-kDa type IV collagenase in vitro, thereby playing a crucial role in modulating extracellular matrix remodeling. This peptide can be utilized in research focused on tissue remodeling, wound healing, and related pathological conditions involving MMP activity. -
Anti-Inflammatory Peptide
Collagen Type II Fragment is an anti-inflammatory peptide that effectively inhibits collagen-induced arthritis (CIA) in murine models. This fragment serves as a valuable tool for studying inflammation and immune responses, facilitating research aimed at understanding and developing therapies for autoimmune conditions. -
Peptide
GPLGLAGGWGERDGS is a peptide designed for responsiveness to matrix metalloproteinase (MMP) enzymes, facilitating tumor targeting. This peptide can be utilized in research to monitor enzyme-guided nanoparticle assembly within tumor microenvironments, contributing to advancements in targeted therapies and diagnostic methods. Its specificity for MMP activity offers valuable insights into tumor dynamics and therapeutic efficacy. -
Anti-aging Peptide
Palmitoyl tripeptide-5 is an anti-aging peptide that functions by promoting collagen synthesis and improving skin elasticity. This bioactive compound is commonly utilized in cosmetic formulations to enhance skin firmness and reduce the appearance of fine lines and wrinkles. Its efficacy makes it a valuable ingredient in research related to skin rejuvenation and the development of anti-aging skincare products. -
Fluorescent Peptide
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide designed as a substrate for TNF-α converting enzyme (TACE; ADAM17), ADAM9, and ADAM10. This peptide utilizes fluorescence resonance energy transfer to monitor enzymatic activity, enabling quantification through changes in fluorescence intensity. It is a valuable tool for studying the roles of these metalloproteinases in various biological processes and may facilitate research in cancer biology and inflammatory diseases. -
MMP9 Selective Cleavage Peptide
FFAGLDD is an MMP9 selective cleavage peptide designed for targeted drug delivery applications. This peptide facilitates the cytosolic delivery of Doxorubicin (DOX), enabling temporally and spatially controlled release of the chemotherapeutic agent. Its specificity for MMP9 makes it a valuable tool in cancer research, allowing for optimized therapeutic efficacy while minimizing off-target effects. -
Octapeptide
VPLSLYSG is an octapeptide that serves as a substrate for matrix metalloproteinases, specifically MMP-9, MMP-1, and MMP-2. This compound can be utilized to study the enzymatic activity and substrate specificity of these metalloproteinases. It is particularly relevant in research focused on tissue remodeling, wound healing, and cancer progression, where matrix metalloproteinases play a critical role. -
Polypeptide
YYRADDA is a polypeptide that targets collagen synthesis within the extracellular matrix of the skin. It exhibits biological activity by stimulating collagen growth, which enhances skin appearance and promotes the healing of damaged tissue. This compound is useful in research focused on skin regeneration and tissue engineering applications. -
MMP3 Peptide Substrate
Dnp-PYAYWMR is a peptide substrate specifically designed to target matrix metalloproteinase 3 (MMP3). Upon cleavage by MMP3, it produces Dnp-PYA, which is nonfluorescent, and YWMR, a fluorophore detectable at 360 nm. This reagent is ideal for assessing MMP3 activity in biochemical assays, with fluorescence intensity measured at excitation/emission wavelengths of 328/350 nm following a 2-hour incubation period. -
Crosslinking Peptide
TG-MMP-Lys is a crosslinking peptide designed to be sensitive to matrix metalloproteinases (MMPs). It facilitates the study of fibrotic diseases, such as liver fibrosis, by allowing researchers to investigate the dynamics of ECM remodeling and tissue-specific interactions. This reagent enables the exploration of MMP activity in fibrotic conditions, contributing to the understanding of disease mechanisms and potential therapeutic strategies. -
Opioid Peptide
Biphalin TFA is a potent opioid peptide analog designed for effective interaction with opioid receptors, demonstrating a dual enkephalin pharmacophore structure that facilitates blood-brain barrier penetration. This compound exhibits significant analgesic properties in various pain models, including acute, neuropathic, and chronic settings. Additionally, Biphalin TFA has been shown to possess antiviral, antiproliferative, anti-inflammatory, and neuroprotective activities, making it a valuable tool for research in pain management and related therapeutic areas. -
Neuropeptide
Dynorphin B (1-9) is a neuropeptide derived from the N-terminal cleavage of dynorphin B. This peptide is implicated in various neurological processes and has been shown to modulate pain and stress responses. Research applications include studies on opioid receptor interactions and investigations into the neurochemical pathways involved in nociception and behavioral responses. The formation of Dynorphin B (1-9) can be inhibited by N-ethylmaleimide (NEM), highlighting its relevance in studying cysteine peptidases. -
Contraceptive Tetrapeptide
Kentsin (Thr-Pro-Arg-Lys) is a contraceptive tetrapeptide that inhibits ovulation by preventing the maturation of Graafian follicles. This mechanism occurs without binding to opioid receptors, making Kentsin a unique compound of interest in reproductive biology. Additionally, it exhibits opiate-like effects on gastrointestinal motility, highlighting its potential applications in both fertility regulation and gastrointestinal research. -
Neuropeptide
Nocistatin is a neuropeptide that acts as an endogenous ligand for the orphan opioid receptor-like receptor. It functions as a functional antagonist of neuropeptide nociceptin/orphanin FQ (Noc/OFQ), inhibiting 5-HT release through a Gi/o protein-mediated pathway. Nocistatin has been shown to block nociceptin-induced allodynia and hyperalgesia, making it a valuable tool for research into pain mechanisms and neuropeptide signaling. -
Opioid Receptor Inhibitor
Neuropeptide AF (human) is an endogenous peptide that acts as an opioid receptor inhibitor. This neuropeptide plays a critical role in modulating pain and stress responses, making it a valuable tool for studies focused on opioid signaling pathways. Research applications include investigations into pain management, addiction, and the physiological effects of endogenous opioid peptides. -
Neuropeptide
β-Endorphin, rat is a neuropeptide that plays a significant role in cardiovascular regulation. This peptide induces profound muscular rigidity and immobility in rat models, mimicking a catatonic state. It is commonly used in research studies focused on pain modulation, stress response, and neurobiology. -
Opioid Peptide Derivative
[DAla2, DArg6] Dynorphin A (1-13) (porcine) is a modified opioid peptide targeting opioid receptors in the peripheral nervous system. This derivative exhibits enhanced stability compared to its parent compound, dynorphin (1-13), demonstrating increased resistance to enzymatic degradation. Its unique properties make it a valuable tool for studying opioid receptor signaling and evaluating potential therapeutic applications in pain management and neuropharmacology. -
Peptide
Acetalin-2 is an opioid peptide characterized by the sequence Ac-Arg-Phe-Met-Trp-Met-Arg-NH2. It exhibits selective binding to μ-opioid receptors, as indicated by a Ki value of 93.3 nM for [3H]DAMGO, demonstrating its potential for studying opioid receptor functions. This compound is applicable in research related to pain management, addiction, and neurobiology, providing valuable insights into opioid signaling pathways. -
Peptide
[DAla2] Dynorphin A (1-13), amide (porcine) is a peptide that primarily targets the κ opioid receptors. This compound exhibits potential agonist activity, making it valuable for exploring the physiological roles of dynorphins in the nervous system. Its utility spans various research applications, including studies on pain modulation, stress response, and neuropharmacology. -
Opioid Peptide
N-Acetyl-α-Endorphin is an acetylated form of the endogenous opioid peptide α-Endorphin, modified at the N-terminal. This compound primarily targets opioid receptors and exhibits significant analgesic properties. It is widely utilized in research focusing on pain management, addiction, and the modulation of neuronal signaling pathways associated with opioid activity. -
Neuromodulatory Peptide
Tyr-W-MIF-1 is a neuromodulatory peptide that exhibits both opiate and anti-opiate activities. This opioid tetrapeptide has been shown to induce analgesia, making it a valuable tool for pain research and neuropharmacology studies. Its unique properties allow researchers to explore the mechanisms underlying pain modulation and potential therapeutic applications for pain management. -
Peptides
Dynorphin A (1-13) amide is an endogenous opioid peptide that acts primarily as a kappa opioid receptor agonist. This peptide exhibits potent modulation of pain pathways, demonstrating the ability to antagonize morphine-induced analgesia. It is utilized in research applications focused on pain management, addiction studies, and the exploration of opioid signaling mechanisms. -
Opioid Peptide
β-Casomorphin is an opioid peptide that primarily acts as an agonist at opioid receptors. This compound exhibits biological activity associated with pain modulation, gastrointestinal function, and is relevant in studies of addiction and opioid signaling pathways. β-Casomorphin serves as a valuable tool in pharmacological research to understand the implications of opioid peptides in various physiological processes. -
Polypeptide
Orexin A (16-33) is a biologically active fragment of the orexin A peptide, functioning primarily as a polypeptide modulator. This compound has been shown to interact with orexin receptors, playing a crucial role in regulating various physiological processes such as appetite, arousal, and circadian rhythms. Research applications include studies on sleep disorders, metabolic regulation, and neurobiological pathways associated with energy homeostasis. -
Peptide
[D-Asn5]-Oxytocin is a peptide analog of oxytocin, primarily known for its low oxytocic and vasodepressor activities. Cumulative dose-response studies indicate that [D-Asn5]-Oxytocin exhibits intrinsic activity comparable to that of native oxytocin. This compound is valuable for research in neurobiology and cardiovascular physiology, allowing for the exploration of oxytocin's roles in various biological processes. -
Xenopus Peptide
Hydrin 1′ is a peptide derived from the neurohypophysis of Xenopus, targeting the oxytocin receptor. This compound exhibits significant steroid-releasing activity in vitro within the Xenopus adrenal gland. Hydrin 1′ serves as a valuable tool for research applications focused on oxytocin receptor interactions and fluorescent probing in neurological studies. -
Endogenous Neuropeptide
PACAP (1-38) free acid is a desamido derivative of the endogenous neuropeptide PACAP, specifically targeting the human PAC1 receptor. It is known to stimulate cyclic AMP (cAMP) production in both neuroendocrine NS-1 cells and non-neuroendocrine HEK293 cells. This compound is valuable for research involving neuropeptide signaling pathways and their physiological roles. -
RFamide Neuropeptide
Neuropeptide AF (cattle) is an amidated octadecapeptide that targets RFamide neuropeptide receptors. It serves as a ligand for Mas-related gene receptor A4 (MrgprA4) with an EC50 of approximately 60 nM and MrgprC11 with an EC50 around 300 nM. Additionally, it activates the G protein-coupled receptors NPFF1 and NPFF2, exhibiting EC50 values ranging from 25-325 nM and 1-5 nM, respectively. Neuropeptide AF (cattle) demonstrates anti-opiate properties and plays a significant role in pain modulation research applications. -
MCHR1 (GPR24) Antagonist
Neuropeptide EI (rat) serves as an antagonist of the melanin-concentrating hormone receptor 1 (MCHR1, also known as GPR24). It displays functional activity by antagonizing MCH and exhibiting agonistic properties towards melanocyte-stimulating hormone (MSH). This compound is useful in research applications focused on neuropeptide signaling, metabolism, and behaviors related to feeding and energy balance. -
Cosmetic Peptide
Acetyl hexapeptide-1 acetate is a biomimetic peptide that mimics the activity of α-melanocyte-stimulating hormone (α-MSH). This compound regulates muscle contraction, effectively reducing facial expression lines and serving as a key component in anti-aging skin care formulations targeting dynamic wrinkles. Additionally, Acetyl hexapeptide-1 acetate plays a role in improving premature graying of hair, although continuous usage is necessary to maintain its effects. This peptide is valuable in research focused on mild photo-aged facial skin and the mechanisms of hair pigmentation. -
Cosmetic Peptide
Acetyl hexapeptide-1 is a biomimetic peptide that mimics the action of α-melanocyte-stimulating hormone (α-MSH). It functions by regulating muscle contraction, thereby contributing to the reduction of facial expression lines. This peptide is utilized in anti-aging skincare research, specifically targeting dynamic wrinkles and the improvement of premature gray hair. Continued application over several months is recommended to achieve desired effects, which may reverse upon discontinuation. Acetyl hexapeptide-1 is valuable for studies focused on mild photoaged facial skin and mechanisms underlying premature gray hair. -
Peptide
Codactide is a synthetic octadecapeptide that mimics the action of corticotropin, targeting the corticotropin-releasing hormone receptor. This compound exhibits significant neuroendocrine activity that may modulate stress response pathways. Codactide is primarily utilized in research focused on stress-related disorders and the investigation of hypothalamic-pituitary-adrenal (HPA) axis functions. -
Tripeptide
α-MSH (11-13) is a C-terminal tripeptide of α-MSH that effectively crosses the blood-brain barrier. This compound exhibits notable antipyretic, anti-inflammatory, and antibacterial activities. Additionally, α-MSH (11-13) provides neuroprotective effects following traumatic brain injury by inhibiting excessive microglial activation and reducing neuronal apoptosis. It is applicable in research concerning traumatic brain injury, fever, and bacterial infections. -
MC1R-targeting peptide
DOTA-GGNle-CycMSHhex is a peptide that targets the melanocortin-1 receptor (MC1R), facilitating radionuclide labeling for imaging applications in melanoma. Its specificity for MC1R makes it an invaluable tool for advancing research in melanoma diagnostics and therapeutic monitoring. This compound is designed to aid in the development of targeted imaging techniques, enhancing the visualization of melanoma in research studies. -
Neurotrophic Peptide
ORG-2766 is an adrenocorticotropic hormone (ACTH) 4-9 analog that functions as a neurotrophic peptide. This compound enhances neuroprotective effects and significantly influences behavioral processes, including memory and attention, in animal models. Research has demonstrated its potential to alleviate symptoms associated with experimental allergic neuritis in rats, making it a valuable tool for studies on neuroprotection and cognitive function.
