Catalog No.
Product Name
Application
Product Information
Citations
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Bioactive Peptide
RERMS are bioactive peptides derived from the active regions of amyloid-β and A4 protein precursors, known to enhance fibroblast growth. These peptides serve as valuable tools in the investigation of neurodegenerative diseases, aiding in the understanding of cellular mechanisms and potential therapeutic pathways. Their ability to promote fibroblast proliferation highlights their significance in biomedical research. -
APP Peptide Fragment
β-Amyloid/A4 Protein Precursor (319-335) is a peptide fragment of the amyloid precursor protein (APP) that focuses on its crucial role in cell signaling and neuritotropic activity. This fragment targets a heparinase-insensitive site associated with the neurotrophic functions of APP, making it valuable for research into neurodegenerative diseases such as Alzheimer's. Its applications include studies on neurodevelopment, synaptic plasticity, and the mechanisms underlying amyloid pathology. -
Aβ Peptide Fragment
Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) is a peptide fragment that targets the amyloid β-protein (Aβ), a key component in the pathogenesis of Alzheimer's disease. This peptide is instrumental in studying the formation and aggregation of amyloid plaques, which are hallmark features of Alzheimer's pathology. Researchers can utilize this reagent to explore the mechanisms of neurodegeneration and potential therapeutic interventions in Alzheimer's disease. -
Aβ Peptide Binder
BTA-EG6 is a brain-penetrant binder that selectively targets aggregated amyloid-β (Aβ) peptides, exhibiting a dissociation constant (Kd) of 290 nM for Aβ1-42. This compound forms protective protein-resistive coatings that inhibit interactions between Aβ and catalase, thereby reducing neurotoxic effects. In functional assays, BTA-EG6 demonstrates protective effects against Aβ-induced cytotoxicity and oxidative stress, effectively decreasing hydrogen peroxide (H2O2) levels in neuroblastoma cells. This reagent is valuable for research focusing on Alzheimer’s disease (AD) and associated mechanisms of neurotoxicity. -
β-Amyloid Peptide Fragment
β-Amyloid (12-20) is a peptide fragment of the β-Amyloid protein, primarily targeting amyloid plaques involved in Alzheimer's disease pathology. This peptide is utilized in research to study the aggregation and toxicity of β-Amyloid in neural tissues. Its applications extend to understanding the molecular mechanisms underlying neurodegenerative disorders and assessing potential therapeutic interventions. -
β-amyloid Peptide
β Amyloid(28-35) human is a key fragment of the β-amyloid peptide (Abeta) that plays a critical role in Alzheimer's disease pathology. This peptide is known to form neurotoxic oligomers that interact with neuronal membranes, altering their secondary structure and contributing to neurodegenerative processes. Additionally, β Amyloid(28-35) human affects the fluidity of lipid membrane bilayers, particularly in relation to the acidic phospholipid DPH, making it valuable for research into amyloid-related neurotoxicity and membrane dynamics. -
Superoxide Dismutase Peptide
SOD1 (147-153) human is a peptide derived from the Cu/Zn superoxide dismutase (SOD1), known for its propensity to form amyloid fibrils. This peptide fragment is implicated in the aggregation of full-length SOD1, serving as a significant molecular determinant in both familial and sporadic amyotrophic lateral sclerosis (fALS and sALS). Research applications include studies on neurodegenerative disease mechanisms and the investigation of protein aggregation processes. -
Aβ Fibrillogenic Inhibitor
Acetyl-Tau Peptide (273-284) amide is an acetylated fragment of the Tau protein that acts as an inhibitor of Aβ fibrillogenesis. It effectively reduces the aggregation of Ac-Aβ(25–35)-NH2, facilitating studies on the interplay between Aβ and Tau proteins. This peptide serves as a valuable experimental tool for investigating the mechanisms underlying Alzheimer's disease and related neurodegenerative conditions. -
β-Amyloid Peptide Fragment
β-Amyloid (1-17) is a peptide fragment of β-Amyloid that is involved in the stabilization of amyloid fibrils. This fragment plays a crucial role in the formation and aggregation of amyloid-beta aggregates, which are implicated in neurodegenerative diseases such as Alzheimer's. Research applications include studies on amyloid fibril behavior and the investigation of β-Amyloid's role in neural pathologies. -
Bioactive Peptide
Scrambled β-amyloid (1-40) is a bioactive peptide that functions as a structural variant of the β-amyloid protein. This peptide mimics the assembly characteristics of the major C-terminal variants Aβ (1-40) and Aβ (1-42), both of which contribute to amyloid plaque formation in Alzheimer's disease. Research applications include the study of amyloid aggregation processes and examination of peptide interactions within neurodegenerative contexts. -
Neuroprotective Peptide
Pep63 is a neuroprotective peptide with the sequence VFQVRARTVA that acts primarily by competitively binding to Aβ1-42 oligomers. It effectively inhibits the formation of Aβ fibers and has been shown to enhance synaptic plasticity and memory retention. Pep63 is a valuable tool for research into Alzheimer's disease and other neurodegenerative disorders, facilitating the investigation of neuroprotective mechanisms and potential therapeutic interventions. -
β-amyloid Peptide
β-Amyloid (1-16) rat is a fragment of the β-amyloid peptide (Aβ) featuring a metal-binding domain. This synthetic peptide contains three amino acid substitutions that make it distinct from the human form, resulting in reduced susceptibility to amyloid-related neurodegeneration in rodent models. It is primarily utilized in research applications focused on Alzheimer's disease mechanisms and the study of amyloid pathology. -
insoluble amyloid β-peptide deposits
(Pyr3)-Amyloid β-Protein (3-42) targets insoluble amyloid β-peptide deposits, playing a critical role in the pathogenesis of Alzheimer's disease and Down's syndrome. This peptide variant is known to accumulate in the brain, potentially initiating the formation of pathological amyloid aggregates. It is useful in research applications focused on understanding amyloid-related neurodegeneration and developing therapeutic strategies. -
Aβ1-42 targeting peptide
QSH peptide is a targeting peptide that specifically binds to the amyloid-beta peptide Aβ1-42, a key player in Alzheimer's disease pathology. It is utilized in the development of siRNA delivery complexes, facilitating targeted therapeutic approaches. This peptide is essential for research focused on understanding and potentially mitigating the effects of amyloid-beta in Alzheimer's disease. -
β-Amyloid Peptide Fragment
β-Amyloid (13-27) is a peptide fragment derived from the β-amyloid protein, encompassing amino acids 13 to 27. This fragment plays a crucial role in studies related to Alzheimer's disease and neurodegenerative disorders. Its biological activity is relevant for research applications focusing on amyloid aggregation, neurotoxicity, and potential therapeutic interventions targeting amyloid pathology. -
Amyloid-β
Glp-Amyloid-β (3-40) peptide (human) specifically targets amyloid-β, a critical factor in Alzheimer's disease pathology. This peptide contains a pyroglutamate modification and is derived from 24-month-old transgenic mice expressing amyloid precursor protein (APP). It is useful for research applications involving the study of amyloid plaque formation, neuroinflammation, and the development of potential therapeutic strategies for neurodegenerative diseases. -
Mutant peptide of Aβ(25-35)
[Ala28]-β Amyloid(25-35) is a modified peptide variant of Aβ(25-35) that carries an electrically neutral charge. This alteration enhances the aggregation properties of the peptide, making it a valuable tool in studies of amyloid aggregation and Alzheimer’s disease pathology. It is particularly useful in research applications focused on therapeutic strategies that target amyloid-beta aggregation and its effects on cellular processes such as luciferase activity. -
Self-assembling Octapeptide
FEFEFKFK is a self-assembling octapeptide known for its ability to form fibrillar structures. At concentrations exceeding 7 mg/mL, FEFEFKFK exhibits gelation properties that are instrumental in investigating the mechanisms of amyloid fibril formation. This compound is particularly relevant for research into protein misfolding diseases, including Alzheimer's disease and Parkinson's disease, providing valuable insights into disease pathology and potential therapeutic approaches. -
Fluorescent Substrate Peptide
Mca-SEVNLDAEFK(Dnp) is a fluorescent substrate peptide specifically designed for the estimation of Beta-secretase 1 (BACE-1) activity. Featuring the 'Swedish' mutation of the amyloid precursor protein (APP) β-secretase cleavage site, this substrate undergoes cleavage at the -Leu-Asp- bond, releasing the highly fluorescent 7-methoxycoumarin (Mca) fragment. This release results in a significant increase in fluorescence intensity due to the removal of the quenching effect from the 2,4-dinitrophenyl (Dnp) moiety, making it a valuable tool for research applications in Alzheimer’s disease and related studies of amyloid pathology. -
Peptide
BACE1 (485-501) is a peptide corresponding to the carboxyl terminal region of Beta-site APP cleaving enzyme 1 (BACE1). This peptide serves as an effective antigen for the generation of anti-BACE1-C antibodies, facilitating the study of BACE1's role in Alzheimer's disease and other neurodegenerative conditions. Its utility in immunological assays aids researchers in elucidating the biochemical pathways associated with amyloid precursor protein processing. -
Calcium/calmodulin-dependent Protein Kinase I Peptide
CaMKI (299-320) is a peptide derived from the calcium/calmodulin-dependent protein kinase I, encompassing residues 299 to 320. This peptide exhibits a high-affinity interaction with Ca2+-calmodulin (Kd ≤ 1 nM) and is capable of phosphorylating target substrate proteins, thus modulating their biological activity. Due to its functional domains, including the calmodulin-binding and self-inhibition domains, CaMKI (299-320) is a valuable tool for investigating cellular physiological processes such as proliferation, differentiation, and apoptosis. -
CaMKII Active Peptide
[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) is a modified peptide fragment of calcium/calmodulin-dependent protein kinase II (CaMKII), featuring an alanine substitution at position 286. This alteration enhances its functional characteristics, making it a valuable tool for the development of potent CaMKII inhibitors. It is primarily used in research applications focused on understanding CaMKII's regulatory roles in cellular processes and signaling pathways. -
CaMKII Inhibitor
CaMKII inhibitory peptide KIIN is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). This peptide effectively disrupts CaMKII activity, making it a valuable tool for studying CaMKII-dependent signaling pathways. Its use in various research applications includes investigating cellular processes such as synaptic plasticity, memory formation, and cardiac function. -
Small Peptides
SP-10 is a small peptide that specifically targets the interaction between the spike (S) protein of SARS-CoV and the angiotensin-converting enzyme 2 (ACE2) receptor, exhibiting an IC50 value of 1.88 nM. This compound is valuable for research on SARS-CoV, particularly in studies investigating viral entry mechanisms and the development of therapeutic agents aimed at inhibiting this critical interaction. Its potent activity makes it an essential tool for exploring antiviral strategies. -
Polyglutamine Inhibitor
Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor that specifically targets polyglutamine sequences. It effectively inhibits polyQ protein aggregation in vitro and demonstrates the ability to suppress polyQ-induced cell death in cell culture models. This reagent is valuable for research focused on neurodegenerative disorders associated with polyglutamine expansion, providing insights into potential therapeutic interventions. -
Bioactive Peptide
LKBtide is a bioactive peptide that serves as a substrate for Serine/Threonine kinase 11 (STK11), also known as LKB1. This peptide is derived from the sucrose non-fermenting 1 (SNF1) protein kinase and plays a crucial role in the LKB1/AMP-activated protein kinase (AMPK) signaling pathway. LKBtide is commonly utilized in research focused on cellular energy regulation, metabolic signaling, and cancer biology. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC TFA is a substrate peptide for Cathepsin S, conjugated with the fluorescent indicator AMC (Excitation/Emission = 354 nm/442 nm). This reagent facilitates the measurement of Cathepsin S activity, enabling researchers to study proteolytic processes and assess enzyme function in various biological contexts. Its application is crucial for investigations into the role of Cathepsin S in physiological and pathological conditions. -
Bioactive Peptide
MeO-Suc-Arg-Pro-Tyr-pNA is a bioactive peptide that serves as a substrate for chymotrypsin. This compound is utilized in studies involving proteolytic enzyme activity and can be instrumental in understanding protease function in various biological processes. Its application extends to biochemical assays aimed at investigating protein digestion and regulation of enzymatic activity. -
Polypeptide
Activated Protein C (390-404), human is a polypeptide fragment derived from the vitamin K-dependent serine protease activated protein C (APC). This fragment specifically inhibits the anticoagulant function of APC by blocking its ability to inactivate factor Va. It serves as a valuable tool in studies of coagulation pathways and the regulation of anticoagulant mechanisms, contributing to research in thrombosis and hemostasis. -
Dipeptide
L-Isoleucyl-L-valine is a dipeptide that serves as a specific inducer of the transition from bovine trypsinogen to trypsin. This compound is significant in studying proteolytic enzyme activation and can be utilized in various biochemical assays focused on enzymology and protein processing. Its role in facilitating the conversion process makes it valuable for research into digestive enzyme activation mechanisms. -
Peptide
Eglin c (41-49) is a peptide fragment that acts as a potent inhibitor of cathepsin G and α-chymotrypsin, exhibiting Ki values of 42 μM and 20 μM, respectively. This compound is crucial for studies exploring protease inhibition and the regulation of inflammatory responses. Its specificity and efficacy make it an important tool for biochemical research involving serine proteases. -
Peptide
Pancreastatin (swine) is a 49-residue peptide that primarily inhibits glucose-induced insulin release by targeting pancreatic beta cells. This peptide is derived from the porcine pancreas and plays a significant role in the regulation of glucose metabolism and insulin secretion. It is useful in research applications focused on diabetes, metabolic disorders, and the physiological roles of peptide hormones. -
Cell-penetrating Peptide
(Arg)9, also known as Nona-L-arginine, functions as a cell-penetrating peptide due to its composition of nine arginine residues. This peptide acts as an inhibitor of the serine endoprotease Furin and demonstrates significant neuroprotective activity, with an IC50 of 0.78 μM in glutamic acid-induced models. (Arg)9 is valuable in research applications targeting cellular delivery systems and neuroprotection studies. -
Substrate Peptide Of Cathepsin S
Ac-KQKLR-AMC is a substrate peptide designed for the fluorescent monitoring of Cathepsin S activity. Labeled with AMC, this compound exhibits excitation and emission wavelengths of 354 nm and 442 nm, respectively. It is primarily utilized in biochemical assays to measure the enzymatic activity of Cathepsin S, providing valuable insights into its role in physiological and pathological processes. -
Phosphorylase Kinase Peptides Fragment
Phosphorylase Kinase β-Subunit Fragment (420-436) targets the β-Subunit of phosphorylase kinase, a serine/threonine-specific protein kinase. This fragment facilitates the activation of glycogen phosphorylase, regulating the release of glucose-1-phosphate from glycogen stores. It is widely used in research applications focused on glucose metabolism, enzymatic regulation, and the signaling pathways involved in energy homeostasis. -
Fluorogenic Peptide Substrate
Tos-Gly-Pro-Lys-AMC is a fluorogenic peptide substrate specifically designed for tryptase enzyme activity. This compound facilitates the detection and quantification of tryptase activity through fluorescence, making it a valuable tool in research related to protease biology and inflammation. Its application in biochemical assays allows for the exploration of tryptase's role in various physiological and pathological processes. -
Bioactive Peptide
Abz-HPGGPQ-EDDnp is a bioactive peptide designed as a selective substrate for cathepsin K, a lysosomal cysteine protease crucial for bone remodeling and resorption. This fluorescence resonance energy transfer (FRET) peptide is specifically cleaved at the Gly-Gly bond by cathepsin K, enabling precise monitoring of its activity in physiological fluids and cell lysates. The peptide demonstrates resistance to hydrolysis by other cathepsins, thereby facilitating targeted research into autoimmune diseases and osteoporosis. Abz-HPGGPQ-EDDnp is characterized by excitation/emission wavelengths of 340 nm/420 nm, making it a valuable tool for studying protease activity in cellular contexts. -
Polypeptide
Suc-Phe-Ala-Ala-Phe-pNA is a synthetic polypeptide designed as a substrate for various proteases, including the serine alkaline protease from Caldicoprobacter guelmensis (SAPCG strain D2C22T), the protease from Aeribacillus pallidus VP3 (SPVP), as well as Alcalase 2.5 L and thermolysin type X. This substrate is utilized in biochemical assays to study protease activity and kinetics, enabling researchers to investigate the mechanisms of proteolysis. Its structural composition allows for precise measurement of protease function in various experimental settings. -
Tridecapeptide
α-Factor Mating Pheromone is a tridecapeptide secreted by Saccharomyces cerevisiae α cells, targeting the Ste2p receptor. This pheromone plays a crucial role in yeast mating processes, facilitating cell signaling and attraction between α and a cells. It is widely utilized in studies of yeast biology, signal transduction, and the mechanisms of mating induction. -
Fibrinopeptide
Fibrinopeptide B, human is a 14-amino acid peptide generated at the amino-terminus of the β-chains of fibrinogen by the action of thrombin. This peptide plays a critical role in the coagulation process, serving as a marker for thrombin activity and fibrin formation. Fibrinopeptide B is utilized in various research applications, including studies on hemostasis, thrombosis, and the regulation of blood coagulation pathways. -
Thrombin Receptor Antagonist
Thrombin receptor peptide ligand is a selective antagonist of the thrombin receptor, inhibiting its activation and downstream signaling. This compound exhibits antithrombotic properties, making it suitable for research focused on thrombotic disorders and cardiovascular diseases. Its ability to modulate thrombin activity positions it as a valuable tool for studying platelet aggregation and related pathways. -
Thrombin Cleavable Peptide
Thrombin-cleavable peptide targets thrombin and is specifically designed for thrombin recognition and cleavage. Upon enzymatic cleavage, it releases thrombolytic peptides that play a crucial role in initiating thrombolysis. This reagent is valuable for research applications related to ischemic stroke and other thrombotic conditions. -
Polypeptide
Hirudin (55-65) sulfated is a polypeptide fragment that acts as a potent inhibitor of thrombin, demonstrating significant anticoagulant properties. This compound is essential for studies related to coagulation pathways and thrombin-mediated physiological processes. Its applications extend to the investigation of antithrombotic therapies and the development of pharmacological agents targeting blood coagulation disorders. -
Bioactive Peptide
TFLLRNPNDK-NH2 is a bioactive peptide that acts as a potent agonist of the protease-activated receptor 1 (PAR-1). By mimicking the tethered ligand generated by thrombin proteolytic cleavage, this peptide reversibly binds to PAR-1, modulating various cellular responses. Key biological activities include the enhancement of liquid and protein permeability, making it valuable for research applications in cardiovascular and inflammatory studies. -
Fibrin Knob Peptide
Knob A peptide GPRPFPAC is a fibrin knob peptide that interacts with the fibrinogen molecule to inhibit clot formation. This peptide exhibits enhanced anticoagulant activity, particularly when modified with polyethylene glycol (PEG). It is utilized in various research applications, including studies on thrombosis, hemostasis, and the development of anticoagulant therapies. -
Polypeptide
Acetyl-Hirudin (55-65) sulfated is a polypeptide fragment that functions as a potent inhibitor of thrombin. This compound exhibits significant anticoagulant properties, making it valuable in studies related to blood coagulation and thrombotic disorders. Acetyl-Hirudin (55-65) sulfated is utilized in various research applications, including the investigation of thrombin's role in physiological and pathological processes. -
Peptide Substrate
PS-915 dihydrochloride is a peptide substrate that specifically targets thrombin for use in colorimetric assays. This compound enables the assessment of plasma antithrombin III (ATIII) levels by undergoing enzyme hydrolysis, which results in the release of 3-carboxy-4-hydroxyaniline (CHA). The CHA then forms a complex with alkaline-pentacyanoammine ferroate, producing a distinct blue coloration, facilitating quantification in various research applications related to coagulation and thrombosis. -
Peptide Vinyl Sulfone
WRR139 is a peptide vinyl sulfone that targets N-glycanase 1 (NGLY1) and exhibits inhibitory activity against Nrf1. This compound is involved in key disease processes, including inflammation and cancer progression. WRR139 has been shown to enhance the cytotoxic effects of Carfilzomib on cancer cells, making it a valuable tool for research in cancer therapeutics and inflammation-related studies. -
TRP-2 Derived Peptide
mTRP-2 (180-188) is a peptide derived from murine tyrosinase-related protein 2 (TRP-2), specifically corresponding to the amino acid sequence of residues 180-188. This peptide serves as a key reactive epitope for recognition by anti-B16 cytotoxic T lymphocytes (CTLs). Its applications in research include the study of immune responses and the development of cancer immunotherapies, particularly in relation to melanoma. -
TRP-2 Derived Peptide
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from tyrosinase-related protein 2, corresponding to residues 181-188. This peptide contains the primary reactive epitope recognized by anti-B16 cytotoxic T lymphocytes (CTLs) and is designed to conform to the MHC class I H2-Kb binding motif. TRP-2 (181-188) is essential for studies in immunology and cancer research, particularly in the context of melanoma and anti-tumor immune responses.
